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Browse the failure-mode index

12,246 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Level-specific impairment of the 10-second grip-and-release test and grip strength in degenerative cervical myelopathy: analysis of 39 surgical cases.

Kobayashi H, Watanabe K, Otani K et al. · 2026 · BMC musculoskeletal disorders

PURPOSE: To characterise the relationship between the 10-second grip-and-release test (GRT) and grip strength—simple measures of upper limb function in degenerative cervical myelopathy (DCM)—with the responsible level. METHODS: We…

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Negative / Null Result ReportOpen accessMedicine

Indocyanine green near-infrared fluorescence angiography in free parascapular flaps: Distal flap perfusion assessment in a retrospective study of 112 cases.

Knoedler L, Thomas B, Mayer S et al. · 2026 · JPRAS open

Background Reliable perfusion of the distal portion of free parascapular (PSC) flaps is essential for successful lower extremity reconstruction. We hypothesized that intraoperative indocyanine green near-infrared video angiography…

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Negative / Null Result ReportMedicine

Effects of vocal hygiene education program delivered via videoconference on acoustic and self-reported voice outcomes in Muslim religious officials in Turkiye.

Yesilli-Puzella G, Hanbal-İbooğlu E, Karataylı Özgürsoy S · 2026 · Scientific reports

This study examined the effects of a vocal hygiene education program delivered via videoconference on voice quality and self-perceived vocal outcomes among Muslim religious officials in Turkiye. The participants were 26 imams, aged between…

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Negative / Null Result ReportMedicine

Progression-Free Survival with PARP Inhibitors According to Clinical Risk in Patients with Ovarian Cancer: An Indirect Comparison Using Reconstructed Data.

Gasperoni L, Del Bono L, Farolfi A et al. · 2026 · Oncology research

Background: Poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi) are established maintenance treatments in ovarian cancer, but comparative efficacy across genetic profiles and relapse risk categories remains unclear. The aim of this…

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Negative / Null Result ReportMedicine

Gynecomastia: Etiological Analysis Beyond Hormonal Imbalance.

Kim JH, Song M, Lee K et al. · 2026 · Life (Basel, Switzerland)

Background: Gynecomastia is a benign enlargement of the male breast with multiple causes. This retrospective study evaluated whether serum estradiol (E2), testosterone (T), or the E2/T ratio differed between patients and controls, while…

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Negative / Null Result ReportMedicine

Regional Fascial Plane Blocks and Early Postoperative Complications in Reduction Mammaplasty: A Retrospective Cohort Study.

Derebaşınlıoğlu H, Avcı O, Çelik M et al. · 2026 · Aesthetic plastic surgery

Background Regional fascial plane blocks are widely used in breast surgery for postoperative analgesia. While analgesic benefits are established, their impact on early complications after reduction mammaplasty remains unclear. Objective To…

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Negative / Null Result ReportMedicine

Impact of a multidisciplinary care pathway on follow-up and emergency department utilisation in paediatric musculoskeletal infections.

Bouchard M, Galán-Olleros M, Ng K et al. · 2026 · European journal of pediatrics

To evaluate whether implementation of a multidisciplinary care pathway was associated with changes in unplanned emergency department (ED) visits in children with musculoskeletal infections, and to assess its impact on readmissions,…

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Negative / Null Result ReportMedicine

Key factors in the diagnosis of sesame allergy in children.

Hismiogullari A, Sancakli O, Ocak M et al. · 2026 · Allergy and asthma proceedings

Background: Sesame allergy (SA) is diagnostically challenging in childhood, and data on its natural course and clinical nonreactivity development are limited. Although oral food challenge (OFC) remains the diagnostic criterion standard,…

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Negative / Null Result ReportMedicine

Comparison between drug-eluting bead transarterial chemoembolization versus conventional TACE in elderly patients with colorectal cancer liver metastases: a cohort study.

Tian L, Hu B, Song M et al. · 2026 · Frontiers in oncology

Background Drug-eluting bead (DEB) transarterial chemoembolization (TACE) possesses several advantages over conventional TACE (cTACE) such as higher intratumor drug concentration and lower systemic toxicity, which has been widely applied…

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Negative / Null Result ReportOpen accessMedicine

Thyroid Function Tests and Serum Amylase Levels in Chronic Kidney Disease: A Cross-Sectional Study Correlating Biochemical Changes With Disease Severity at a Tertiary Care Centre in India.

Sharma P, Samaria A, Tak H et al. · 2026 · Cureus

Background Chronic kidney disease (CKD) represents a major and growing health concern in both global and Indian populations. In addition to progressive renal dysfunction, CKD is frequently accompanied by metabolic and endocrine…

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Negative / Null Result ReportMedicine

Aqueous Humor Angiotensin-Converting Enzyme and TGF-β1 Levels in Proliferative Vitreoretinopathy: A Prospective Clinical Study.

Koçak N, Özdemir A, Esenkaya M et al. · 2026 · Retina (Philadelphia, Pa.)

Purpose To evaluate plasma and aqueous humor angiotensin-converting enzyme (ACE) and transforming growth factor-β1 (TGFβ1) levels in patients with proliferative vitreoretinopathy (PVR) secondary to rhegmatogenous retinal detachment (RRD).…

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Negative / Null Result ReportMedicine

Cardiac Computed Tomography-Guided Procedural Planning for Percutaneous Mitral Paravalvular Leak Closure: Impact on Crossing Time.

Vella C, Romano V, Ricchetti G et al. · 2026 · The Canadian journal of cardiology

Mitral paravalvular leaks (PVLs) are a recognized complication of prosthetic valve implantation and may cause heart failure or hemolysis, often requiring percutaneous closure in patients at high surgical risk. Although transesophageal…

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Negative / Null Result ReportMedicine

Boric acid Attenuates premature ovarian insufficiency by Modulating oxidative stress in a Cyclophosphamide-Induced rat model.

Ozcakar TG, Kender Erturk N, Onguncan O et al. · 2026 · European journal of obstetrics, gynecology, and reproductive biology

Aim This study aimed to investigate whether boric acid (BA) exerts potential protective effects against cyclophosphamide (CYC)-induced premature ovarian insufficiency (POI) in rats through modulation of oxidative stress and preservation of…

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