e-ISSN: Pending
WASTE Journal

Browse the failure-mode index

12,379 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Radiofrequency Fields at 2.45 GHz Reprogram Mitochondria-Lysosome Crosstalk and Modulate the Survival/Death of Macrophages Exposed to LPS and/or the SARS-CoV-2 Spike Protein.

Sueiro-Benavides RA, Leiro-Vidal JM, Rodríguez-González JA et al. · 2026 · International journal of molecular sciences

The redox mechanisms of RAW 264.7 macrophages exposed to 2.45 GHz RF-EMF at subthermal specific absorption rates and to lipopolysaccharide (LPS) and/or the SARS-CoV-2 spike protein (CSP) were investigated. To this end, cellular responses…

View details →
Negative / Null Result ReportOpen accessMedicine

Toxicological Relevance of Biogenic Amines in Honey: Dietary Exposure and Integrated Risk Indicators in Algerian and Moroccan Honeys.

Bruno F, Bruschetta G, Miller A et al. · 2026 · Foods (Basel, Switzerland)

Biogenic amines are nitrogenous compounds that may occur in foods through plant metabolism, bee enzymatic activity, or microbial decarboxylation. This study evaluated biogenic amines content in monofloral honeys from Algeria and Morocco,…

View details →
Negative / Null Result ReportMedicine

[Analysis of the prevalence characteristics and trends of allergen-specific IgE levels in a children's hospital in Wuhan City from 2019 to 2024].

Liu YH, Du Q, Zhang MR et al. · 2026 · Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]

Objective: To investigate the changes in the positive rate of specific immunoglobulin E (sIgE) for inhalant and ingestive allergens in children at a certain children's hospital in Wuhan City from 2019 to 2024, and to analyze the…

View details →
Negative / Null Result ReportMedicine

Local Delivery of Tranexamic Acid and Dexamethasone via Piezoelectric Irrigationin Rhinoplasty: A Prospective Double-Blind Comparative Study of Early Postoperative Morbidities.

Gunay G, Ece M, Beloglu Tonyali Y et al. · 2026 · The Journal of craniofacial surgery

This study aimed to evaluate the effects of adding tranexamic acid (TXA) and dexamethasone to the irrigation solution of a piezoelectric device during open rhinoplasty on postoperative periorbital edema, ecchymosis, and pain. In this…

View details →
Negative / Null Result ReportOpen accessMedicine

Microscopic and computational analysis of the stomach, duodenum, and liver of rats with induced hyperprolactinemia treated with exogenous melatonin.

da Silva JV, da Silva RC, Ferreira RGDS et al. · 2026 · Frontiers in veterinary science

Introduction This study evaluated the effects of exogenous melatonin (MEL) on morphological and computational alterations in the stomach, duodenum, and liver of hyperprolactinemic rats. Methods Twenty-four animals were divided into three…

View details →
Negative / Null Result ReportMedicine

The application of internal ring closure in laparoscopic transabdominal preperitoneal (TAPP) repair for large indirect inguinal hernias: a retrospective study of 162 cases.

Liu M, Shen X · 2026 · Langenbeck's archives of surgery

Purpose Patients with primary unilateral indirect inguinal hernias and large internal inguinal rings have a higher incidence of seroma formation following laparoscopic transabdominal preperitoneal (TAPP) hernia repair. This study aims to…

View details →
Negative / Null Result ReportMedicine

Acetabular cup orientation differs across surgical approaches in primary total hip arthroplasty: a retrospective analysis.

Chimeno-Pigrau C, Fernández-Valencia JA, Alías A et al. · 2026 · International orthopaedics

Purpose Accurate acetabular cup positioning is crucial in primary total hip arthroplasty (THA), as malposition is associated with instability and early failure. We hypothesized that acetabular cup orientation may differ according to the…

View details →
Negative / Null Result ReportOpen accessMedicine

Psychostimulant effects on motor and cognitive function in adults attention deficit hyperactivity disorder.

Cundari M, Kanold L, Bergwall D et al. · 2026 · The international journal of neuropsychopharmacology

Objectives This study aims to compare the performance on motor and cognitive functions of adult patients with attention deficit hyperactivity disorder (ADHD) with or without psychostimulant medication and controls. A secondary objective is…

View details →
Failed Experiment ReportOpen accessMedicine

The prognostic value of the Oocyte Maturation Index (OMI) on pregnancy outcomes in POSEIDON group 3 and 4 patients: a retrospective cohort study.

Bayram Y, Yildiz H, Ulger G et al. · 2026 · Journal of ovarian research

Background This study METHODS: A total of 662 patients treated at the Assisted Reproductive Techniques Unit of Mersin University Faculty of Medicine between 2016 and 2024 (Group 3: n=245; Group 4: n=417) were retrospectively analyzed.…

View details →
Negative / Null Result ReportMedicine

The role of gender in patients with developmental dysplasia of the hip treated with closed reduction and spica cast immobilization: does it affect prognosis?

Kang Z, Li Y, Canavese F et al. · 2026 · Journal of pediatric orthopedics. Part B

To investigate the impact of gender on the prognosis of children with developmental dysplasia of the hip (DDH) treated with closed reduction and spica cast immobilization (CR-SCI). A retrospective analysis was conducted on 302 DDH children…

View details →
Negative / Null Result ReportMedicine

The Effectiveness and Safety of Robotic-Assisted Bronchoscopy Across Diverse Patient Heights: A Subset Analysis of a Multicenter, Prospective, Observational Trial.

Gomes C, Gomes C, Cowan B et al. · 2026 · Journal of bronchology & interventional pulmonology

Background Outcomes of robotic-assisted bronchoscopy (RAB) in patients of small stature remain uncertain due to concerns about their potentially smaller lung volumes. We assess the effectiveness and safety of RAB across height variations.…

View details →
Negative / Null Result ReportMedicine

Lipid profile and angiogenic markers in the detection of preeclampsia: The RECLAMA study.

Ibarretxe D, Tameish S, González-Lleó A et al. · 2026 · Clinica e investigacion en arteriosclerosis : publicacion oficial de la Sociedad Espanola de Arteriosclerosis

Introduction and objectives Preeclampsia (PE) is a multisystem hypertensive disorder affecting 2-8% of pregnancies worldwide and represents a major cause of maternal and fetal morbidity and mortality. Its pathophysiology involves placental…

View details →
Negative / Null Result ReportOpen accessMedicine

Erenumab and OnabotulinumtoxinA in Chronic Migraine: A Comparative Analysis.

Garcés-Pellejero M, Torres-Ferrús M, Mas-de-Les-Valls R et al. · 2026 · European journal of neurology

Objectives To compare response (reduction in headache frequency and differences in patient-reported outcomes) between Erenumab and OnabotulinumtoxinA from two phase-IV trials after 6 months of treatment. Materials/methods A prospective…

View details →
Negative / Null Result ReportMedicine

Effect of the Multicomponent Exercise Program MoveUS on the Kinematic Fatigue of People With Glenohumeral Instability: A Secondary Analysis From a Randomized Controlled Trial.

Ramírez-Pérez L, Cuesta-Vargas AI · 2026 · Physiotherapy research international : the journal for researchers and clinicians in physical therapy

Kinematic movement analysis is highly relevant in patients with glenohumeral instability, a pathology characterized by fatigue-induced slowing of repetitive movements. However, the optimal exercise approach for this symptom remains…

View details →
Negative / Null Result ReportOpen accessMedicine

Fecal microbiota composition concerning body mass index and early-life factors in Mexican preschool-aged children: a cross-sectional study.

Hernández-Rodríguez D, Contreras A, Melgar Lalanne G et al. · 2026 · PeerJ

Background The gut microbiota maturation extends beyond the first two years of life. Early perinatal and postnatal factors may influence the child's nutritional status, which, in turn, can affect the composition of their gut microbiota.…

View details →
Failed Experiment ReportMedicine

Clinical Outcomes of First-Line Immune Checkpoint Inhibitor-Based Therapy for Postoperative Recurrence After Adjuvant Nivolumab in Esophageal Cancer.

Sugase T, Kanemura T, Matsuura N et al. · 2026 · Annals of surgical oncology

Background Adjuvant nivolumab has become a standard treatment after curative resection for locally advanced esophageal cancer; however, postoperative recurrence remains common. The efficacy of immune checkpoint inhibitor (ICI)-based…

View details →
Negative / Null Result ReportOpen accessMedicine

Effect of a One-Week Lubricant Pretreatment on Post-LASIK Dry Eye: Single-Center Randomized, Single-Masked Study With 1-Month Follow-Up.

Cañones-Zafra R, Allendes-Urquiza G, Muñiz C et al. · 2026 · Journal of ophthalmology

Purpose Our purpose is to report the results of a prospective study on ocular discomfort and objective tear film parameters (osmolarity and NIKBUT), in myopic patients, and observe the possible differences at 1 month between randomized…

View details →
Negative / Null Result ReportMedicine

Could Autism Spectrum Disorder Be Associated With Craniosynostosis?

Still MEH, Alberts A, Nagda P et al. · 2026 · The Journal of craniofacial surgery

Introduction Craniosynostosis is a common pediatric condition that results in variable symptoms that range from asymptomatic cosmetic deformities to severe signs of intracranial hypertension. Little is understood about the relationship…

View details →
Failed Experiment ReportMedicine

Electroacupuncture ameliorates gastrointestinal motility and modulates PLC-IP3 signaling in a rat model of functional dyspepsia.

Yang D, Fang L, Chen Q et al. · 2025 · Acupuncture in medicine : journal of the British Medical Acupuncture Society

Objective The aim of this study was to determine whether electroacupuncture (EA) modulates the phospholipase C-inositol-1,4,5-trisphosphate (PLC-IP3) pathway and platelet-derived growth factor receptor (PDGFR)α + cells in a rat model of…

View details →
Negative / Null Result ReportOpen accessMedicine

Delayed orocecal transit in pediatric gut-brain interaction disorders: A comparative study using the lactulose breath test.

Devanarayana NM, Rajindrajith S, de Silva DGH et al. · 2025 · World journal of gastrointestinal pathophysiology

Background Functional abdominal pain disorders (FAPDs) are common gut-brain interaction disorders with unclear pathophysiology. While impaired gastrointestinal motility is thought to play a key role, small intestinal dysmotility remains…

View details →