e-ISSN: Pending
WASTE Journal

Browse the failure-mode index

12,244 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Lack of Association Between Middle Cerebral Artery Diastolic Deceleration Area and Gestational Diabetes Mellitus: A Prospective Case-Control Study.

Emiralioglu Cakır Z, Ankara Aktaş H, Gercik Arzık I et al. · 2026 · Medicina (Kaunas, Lithuania)

Backgroud and Objectives : To evaluate conventional Doppler indices and the novel middle cerebral artery (MCA) diastolic deceleration area (DDA) in pregnancies complicated by gestational diabetes mellitus (GDM), and to explore their…

View details →
Negative / Null Result ReportMedicine

Lack of Association of Emotional Distress With Insulin Initiation in the GRADE Randomized Diabetes Comparative Effectiveness Trial.

Presley CA, Butera NM, Krause-Steinrauf H et al. · 2025 · The science of diabetes self-management and care

PurposeThe purpose of this study is to evaluate whether higher emotional distress (depressive symptoms or diabetes distress) was associated with a lower likelihood of basal or rapid-acting insulin initiation among participants enrolled in…

View details →
Negative / Null Result ReportMedicine

Relationship of the Wound, Ischemia, and Foot Infection Stage with Frailty, Disability, Quality of Life, and One-Year Outcomes in All-Comers with Chronic Limb-Threatening Ischemia: Single-Center Prospective Cohort Study.

Houghton JSM, Black I, Meffen A et al. · 2026 · Annals of vascular surgery

Background The wound, ischemia and foot infection (WIfI) classification system has been widely adopted in chronic limb-threatening ischemia (CLTI) management. Primary aim was to prospectively investigate the association of WIfI stage with…

View details →
Negative / Null Result ReportMedicine

Lack of Association between Vitamin D Genetic Polymorphism and Virological Characteristics of Hepatitis B Infection.

da Silva JC, Caetano AR, Mendonça ACDF et al. · 2025 · The journal of applied laboratory medicine

Background Exploring polymorphisms in vitamin D-related genes (VDR) within the Brazilian population provides a valuable model to contribute to the influence of the host genetic variants on chronic viral hepatitis B (CHB). Methods 126 CHB…

View details →
Negative / Null Result ReportMedicine

Is time interval from breastfeeding cessation to frozen single euploid embryo transfer cycle associated with pregnancy outcome?

Bergin K, Leibner L, Roger S et al. · 2026 · International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

Objective Prolactin (PRL) secretion during breastfeeding suppresses gonadotropin releasing hormone and ovulation. While PRL receptors are present in the endometrium, it is unknown whether transient rises in secretion during breastfeeding…

View details →
Negative / Null Result ReportOpen accessMedicine

The relational association between multiple sexual partners and HIV testing on cervical cancer screening among women of reproductive age in Ghana: A national population-based study.

Afaya A, Awunyo W, Udeoha MA et al. · 2026 · PloS one

Background Cervical cancer screening remains vital in the early detection of precancerous lesions and promotes better treatment outcomes. Though evidence suggested multiple sexual partners and HIV infection as risk factors for cervical…

View details →
Negative / Null Result ReportOpen accessMedicine

Visually assessed ischemia on cardiac magnetic resonance, but not quantitative perfusion metrics, predicts symptomatic improvement in coronary artery bypass.

Akbari T, Mach L, Hammersley DJ et al. · 2025 · Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance

Background Serial perfusion cardiovascular magnetic resonance (CMR) in symptomatic patients undergoing coronary artery bypass grafting (CABG) may provide mechanistic insight into dynamic abnormalities of the myocardium. Objectives To…

View details →
Negative / Null Result ReportMedicine

High levels of the adipokines leptin and metrnl in patients with paroxysmal atrial fibrillation and obstructive sleep apnea are not associated with the severity of sleep apnea or the burden of atrial fibrillation.

Ueland T, Traaen GM, Hunt TE et al. · 2025 · Sleep medicine

Study objectives Obstructive sleep apnea (OSA) and atrial fibrillation (AF) are highly prevalent conditions sharing multiple risk factors including obesity. Adipokines secreted from adipose tissue could modify pathways affecting atrial…

View details →
Negative / Null Result ReportMedicine

The Characteristics of Peripheral Blood Lymphocyte Subsets in HIV-related Diffuse Large B-cell Lymphoma Patients and Their Impact on Treatment Efficacy.

Xiang H, Lin C, Chen S et al. · 2025 · Current HIV research

Introduction Peripheral blood lymphocyte subsets have been shown to influence prognosis in HIV-associated Diffuse Large B-Cell Lymphoma (HIV-DLBCL), a rare and highly aggressive form of non-Hodgkin's lymphoma linked to immunosuppression…

View details →
Negative / Null Result ReportMedicine

Suicidal Communications in Adults with Borderline Personality Disorder: Clinical Correlates and Treatment Response to Dialectical Behavior Therapy.

Bitran AM, Kleiman EM, Rizvi SL · 2026 · Archives of suicide research : official journal of the International Academy for Suicide Research

Objective Suicidal communications (SCs)-also known as suicide threats or "gestures," whereby an individual verbally or behaviorally signals suicidal intent-present a serious challenge to clinicians and loved ones, who may struggle to…

View details →
Negative / Null Result ReportOpen accessMedicine

Comment on "Post-stroke cognitive impairment and fatigue in patients with white matter hyperintensities: A prospective cohort study".

Mehta R, Sah R · 2025 · Cerebral circulation - cognition and behavior

•SDMT drop at baseline linked to higher Fazekas (WMH) scores.•No follow-up MoCA/SDMT association after multiple correction.•Practice effects likely inflated cognitive test recovery scores.•High attrition biased against fatigue and…

View details →
Replication FailureOpen accessMedicine

Serum magnesium levels of children living with sickle cell anaemia at the Lagos University Teaching Hospital: a comparative cross-sectional study.

Akowundu PK, Salako AO, Akinsete AM et al. · 2025 · BMC pediatrics

Background Sickle cell anaemia (SCA) is a lifelong, chronic haemolytic disorder with episodic vaso-occlusive crises (VOC) and chronic end-organ damage. Red cell dehydration during a VOC changes permeability with loss of potassium and…

View details →
Replication FailureOpen accessMedicine

Lack of association between loneliness, social isolation and inflammation in people living with HIV aged ≥50 years: Results from the sub-study "No One Alone-Gesida Study".

Blanco JR, Albendin-Iglesias H, Negredo-Puigmal E et al. · 2025 · PloS one

Introduction Inflammation is linked to multiple health conditions. Emerging evidence suggest it may play a role in the association between social isolation - loneliness and health outcomes. People living with HIV (PLWH) exhibit chronic…

View details →
Replication FailureOpen accessMedicine

Prevalence and concomitance of diabetic peripheral sensory neuropathy and lower limb peripheral arterial disease in type II diabetics and its correlation with obesity.

Solanki JD, Shah AP, Lalwani N et al. · 2025 · Journal of family medicine and primary care

Introduction Among type 2 diabetics (T2D), macrovascular complication lower limb Peripheral Arterial Disease (PAD) and microvascular complication Diabetic Peripheral Sensory Neuropathy (DPSN) have scarcely studied concordance and their…

View details →
Negative / Null Result ReportMedicine

Association between exposure to pyrethroids and chlorpyrifos at age 5 years and IQ at age 7 years among children from the Odense Child Cohort, a prospective birth cohort study.

Normann SS, Andersen HR, Lund LC et al. · 2025 · Environmental research

Background Over the past decade, the use of organophosphate insecticides including chlorpyrifos has faced increasing restrictions due to health concerns, leading to a rise in use of pyrethroids. Concerns about neurodevelopmental insults…

View details →
Negative / Null Result ReportOpen accessMedicine

Effect of Osteocalcin on Insulin Sensitivity, Insulin Secretion, and β-cell Compensation in Mexican Americans.

Gao Y, Hsu V, Kil A et al. · 2026 · The Journal of clinical endocrinology and metabolism

Context Previous animal studies show association between osteocalcin (OC) and type 2 diabetes-related quantitative traits (QTs), with some suggesting these effects being mediated by adipokines. Replication in humans has been inconsistent.…

View details →
Negative / Null Result ReportMedicine

It is time to appreciate the value of processed foods

Fitzgerald M · 2024 · Trends in Food Science & Technology.

The messaging around processed food recently is that it is unhealthy and associated with the onset of chronic disease. However, food is processed for many reasons that range from preservation to safety, and then more recently in response…

View details →