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WASTE Journal

Browse the failure-mode index

12,375 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

A pilot, randomized, placebo-controlled trial of rimegepant on visceral sensation and symptoms in nonconstipation IBS pain.

Halawi H, Matar A, Wang I et al. · 2026 · American journal of physiology. Gastrointestinal and liver physiology

Visceral hypersensitivity is a pivotal mechanism in pain associated with irritable bowel syndrome (IBS). Calcitonin gene-related peptide (CGRP) is expressed by visceral afferents. The aim of this study was to evaluate the efficacy of…

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Negative / Null Result ReportMedicine

Increasing Intrinsic Protein Disorder Improves CD8+ Immunogenicity for a SARS CoV2 Vaccine Candidate Antigen.

Wan L, Xie B, Shuda M et al. · 2026 · Molecular therapy : the journal of the American Society of Gene Therapy

CD8+ T cell targeting of the conserved SARS CoV2 RNA-dependent RNA polymerase (RdRp, nsp12) may offer a means for cross-protection against diverse coronavirus strains. Native RdRp, however, displays primary sequence immunoevasion (PSI)…

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Negative / Null Result ReportMedicine

Initial static, pseudo-static, dynamic, and cognitive fit evaluation of three passive shoulder exoskeletons while performing simulated manufacturing tasks.

Abbasi D, Schall M, Acosta-Sojo Y et al. · 2026 · Applied ergonomics

Shoulder disorders have been associated with repetitive overhead work and manual lifting. Passive exoskeletons may reduce exposure to physical risk factors associated with shoulder injuries. This repeated-measures study evaluated the…

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Negative / Null Result ReportMedicine

Impact of an educational video on the quality of bowel preparation prior to colonoscopy: a randomized controlled study.

Vidon M, Wang X, Costes L et al. · 2026 · Clinics and research in hepatology and gastroenterology

Background and study aims Educational interventions have been proposed to improve adherence to bowel preparation instructions. We evaluated whether adding a short instructional video to standard written and oral information improves bowel…

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Negative / Null Result ReportMedicine

Mechanisms Linking Bonding and Bridging Social Capital and Self-Rated Health Among U.S. Refugees: A Structural Equation Modeling Approach.

Thapa K, R Iyer A, A Cruz-Gonzalez M et al. · 2026 · Journal of racial and ethnic health disparities

Background Refugees often experience disruptions in social networks after resettlement. This study examined associations between bonding (within-group) and bridging (across-group) social capital and self-rated health among resettled U.S.…

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Negative / Null Result ReportMedicine

Effects of xylazine on blood biochemical, oxidative, and haematological to responses to transport distance stress in day-old broiler chicks.

Abdulameer HS, Zarrinkavyani K, Fathi M et al. · 2026 · Poultry science

Transport of day-old chicks is a major concern in the poultry industry, as it induces stress that can impair performance and health. This study investigated whether xylazine, an alpha-2 adrenergic agonist that reduces metabolic rate, could…

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Negative / Null Result ReportMedicine

Accuracy of full-arch digital implant impression and bite registration: effect of different reference object strategies and intraoral scanners.

Rutkūnas V, Kubilius A, Akulauskas M et al. · 2026 · Journal of dentistry

Objectives This in vitro study evaluated the accuracy of digital impressions for full-arch implantsupported restorations by assessing scan body (SB) positional accuracy and inter-arch registration under different intraoral scanners (IOS)…

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Negative / Null Result ReportMedicine

Effects of Benzo[a]pyrene on Targeted Therapy Response and Platelet-Activating Factor-Receptor-Mediated Microvesicle Particle Release in Non-Small Cell Lung Cancer.

Rawal R, Thyagarajan A, Sahu RP · 2026 · Medical sciences (Basel, Switzerland)

Background/objectives Non-small cell lung cancer (NSCLC) is a leading cause of cancer-related mortality, driven by invasive behavior and frequent resistance to systemic therapies. Epidermal growth factor receptor tyrosine kinase inhibitors…

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Negative / Null Result ReportMedicine

Effect of choice of instruction language on anatomy learning outcomes.

Alghamdi MA, Almasaad JM, Ahmed ME et al. · 2026 · Anatomical sciences education

The choice of instructional language in medical education continues to be debated across non-English-speaking nations. In Saudi Arabia, medical schools use English as the medium of instruction, which may challenge students who previously…

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Negative / Null Result ReportMedicine

A vest-based sling provides greater hip flexion and abduction than a traditional Ehmer sling, with limited tolerability in healthy dogs.

Huber AL, Picavet PP, Hamon M et al. · 2026 · American journal of veterinary research

Objective To measure hip flexion, abduction, and internal rotation in a static standing position with the limb maintained with a traditional Ehmer sling (TES), compare these with a commercially available vest-based sling (VBS), and…

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Negative / Null Result ReportMedicine

Effect of acupuncture on postoperative nausea and vomiting in lumbar disc herniation surgery.

Erdem G, Kavak Akelma F, Nalbant B et al. · 2026 · Acupuncture in medicine : journal of the British Medical Acupuncture Society

Objective Nausea, vomiting and pain are common postoperative complications. The aim of this study was to evaluate the effects of ondansetron combined with acupuncture at bilateral PC6 during the intraoperative period on the incidence of…

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Replication FailureMedicine

Is Combined Tranexamic Acid Administration Superior to Single-Route Protocols in Primary Total Knee Arthroplasty? A Prospective Cohort Study.

Stepanovic Z, Ristic B, Matic A et al. · 2026 · Journal of clinical medicine

Background : The optimal route of tranexamic acid (TXA) administration remains one of the most debated topics in total knee arthroplasty. This study aimed to compare the effects of intravenous (IV), intra-articular (IA), and combined TXA…

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Negative / Null Result ReportMedicine

Impact of inorganic nitrate on renal sodium excretion during saline loading in healthy adults; secondary endpoints from a randomized crossover trial.

Østergaard AM, Rosenbæk JB, Ejlersen JA et al. · 2026 · Physiological reports

Inorganic nitrate may lower blood pressure (BP) and enhance natriuresis through nitric oxide (NO) mediated mechanisms. Studies have found inconsistent effects of NO on sodium excretion. Nitric oxide synthase (NOS) inhibition suggests…

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Negative / Null Result ReportMedicine

Assessing the impact of an integrated health-system specialty pharmacy model on clinical disease activity index scores in patients with rheumatoid arthritis.

Phan T, Datt P, Zhao L et al. · 2026 · American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists

Purpose Rheumatoid arthritis (RA) is a chronic, autoimmune joint disorder necessitating the use of complex, specialty medications. Health-system specialty pharmacies (HSSPs) operate under closed-loop models that have been shown to minimize…

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Negative / Null Result ReportMedicine

Acute Effects of Taurine Supplementation on Energy Metabolism and Aerobic Capacity in Physically Active Young Adults.

Júnior FC, Santos WRD, Cordeiro Feitosa R et al. · 2026 · Research quarterly for exercise and sport

Taurine (TAU) is a conditionally essential amino acid whose consumption has recently increased, particularly among young people, through supplements and energy drinks. It has potential beneficial effects on physical performance; however,…

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Negative / Null Result ReportMedicine

Effect of horizontal and extended platelet-rich fibrin on soft tissue healing and outcomes after impacted mandibular third molar extraction: a controlled trial.

Haskic A, Hadziabdic N, Miron RJ · 2026 · International journal of oral and maxillofacial surgery

Postoperative sequelae such as pain, swelling, and trismus are common following mandibular third molar surgery. This single-blind controlled trial was performed to evaluate the effects of two newer platelet-rich fibrin (PRF) formulations,…

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Negative / Null Result ReportMedicine

Ensuring continuous buprenorphine access: A multi-component quality improvement initiative in a university-affiliated clinic and outpatient pharmacy.

Choo LY, Zheng W, Wen S et al. · 2026 · Journal of the American Pharmacists Association : JAPhA

Background Patients with opioid use disorder encounter challenges obtaining buprenorphine (BUP) at pharmacies, increasing their risk of treatment non-adherence and illicit drug use. Objectives The purpose of this quality improvement (QI)…

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Negative / Null Result ReportMedicine

Stage-specific disruption of host resistance and metabolic pathways following developmental PFAS exposure in marine medaka.

DiBona ER, Elliott J, Labeille RO et al. · 2026 · Aquatic toxicology (Amsterdam, Netherlands)

Per- and polyfluoroalkyl substances (PFAS) are persistent contaminants with immunotoxic potential, yet impacts on immune development remain poorly defined. We examined effects of developmental PFAS exposure on host resistance and…

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