Increasing Intrinsic Protein Disorder Improves CD8+ Immunogenicity for a SARS CoV2 Vaccine Candidate Antigen.
Wan L; Xie B; Shuda M; O'Malley ME; Camacho CJ; Delgoffe GM; Chang Y; Moore PS · 2026 · Molecular therapy : the journal of the American Society of Gene Therapy
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
CD8+ T cell targeting of the conserved SARS CoV2 RNA-dependent RNA polymerase (RdRp, nsp12) may offer a means for cross-protection against diverse coronavirus strains. Native RdRp, however, displays primary sequence immunoevasion (PSI)…
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Metadata source: Europe PMC · DOI 10.1016/j.ymthe.2026.06.027