Negative / Null Result ReportOpen accessImmunology and Microbiology
Mariane Nunes de Nadai, Carolina Sales Vieira, Cristina Falbo Guazzelli et al. · 2026 · Revista Brasileira Ginecologia e Obstetrícia
Key points• Breast cancer is the most common type of cancer among women worldwide.• There is concern regarding the use of hormonal contraceptives and their possible relationship with the risk of breast cancer.• Several studies have evaluated the association between hormonal contraceptives and breast cancer, achieving heterogeneous results.• Some observational studies and systematic reviews suggest an association between levonorgestrel intrauterine device (LNG-IUD) use and breast cancer.However, these findings are limited by confounding factors and methodological weaknesses in the studies.• Whe
View details →Replication FailureOpen accessImmunology and Microbiology
Tomoki Makino, Hiroshi Miyata, Takushi Yasuda et al. · 2024 · Esophagus
BACKGROUND: S-588410, a cancer peptide vaccine (CPV), comprises five HLA-A*24:02-restricted peptides from five cancer-testis antigens. In a phase 2 study, S-588410 was well-tolerated and exhibited antitumor efficacy in patients with urothelial cancer. Therefore, we aimed to evaluate the efficacy, immune response, and safety of S-588410 in patients with completely resected esophageal squamous cell carcinoma (ESCC). METHODS: This phase 3 study involved patients with HLA-A*24:02-positive and lymph node metastasis-positive ESCC who received neoadjuvant therapy followed by curative resection. After
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Weiye Chen, Yige Zeng, Jinxin Zheng et al. · 2026 · Nature Medicine
Antimicrobial resistance (AMR) poses a major global health threat, yet the effectiveness of national action plans (NAPs) remains uncertain. Here we developed a multidimensional One Health governance index through a structured Delphi expert…
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Nina Martino, Erin Sanders, Ramon Bossardi Ramos et al. · 2025 · Journal of Clinical Investigation
Severe systemic inflammatory reactions, including sepsis, often lead to shock, organ failure, and death, in part through an acute release of cytokines that promote vascular dysfunction. However, little is known about the vascular endothelial signaling pathways regulating the transcriptional profile in failing organs. Our work focused on signaling downstream of IL-6, due to its clinical importance as a biomarker for disease severity and predictor of mortality. Here, we show that loss of endothelial expression of the IL-6 pathway inhibitor SOCS3 promoted a type I IFN-like (IFNI-like) gene signat
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Rebecca D. Dodd, Amanda Scherer, Wesley Huang et al. · 2020 · Clinical Cancer Research
Abstract Purpose: Nanoparticle-encapsulated drug formulations can improve responses to conventional chemotherapy by increasing drug retention within the tumor and by promoting a more effective antitumor immune response than free drug. New…
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Ming Yi, Tianye Li, Yinhui Gu et al. · 2026 · Nature Communications
Antibodies targeting TGF-β and PD-L1 initially showed promise as second-generation PD-L1 agents. However, consecutive trial failures have limited their clinical success. Our study reveals that the efficacy of the TGF-β×PD-L1 bispecific…
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