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Browse the failure-mode index

37 real negative results, null findings, and replication failures in Veterinary medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessVeterinary medicine

Evaluation of the effect of experimentally induced cartilage defect and intra-articular hyaluronan on synovial fluid biomarkers in intercarpal joints of horses

Tytti Maaria Niemelä, Riitta-Mari Tulamo, Jorge Uriel Carmona et al. · 2019 · Acta Veterinaria Scandinavica

Abstract Background Inflammatory and degenerative activity inside the joint can be studied in vivo by analysis of synovial fluid biomarkers. In addition to pro-inflammatory mediators, several anabolic and anti-inflammatory substances are produced during the disease process. They counteract the catabolic effects of the pro-inflammatory cytokines and thus diminish the cartilage damage. The response of synovial fluid biomarkers after intra-articular hyaluronan injection, alone or in combination with other substances, has been examined only in a few equine studies. The effects of hyaluronan on som

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Negative / Null Result ReportOpen accessVeterinary medicine

EFFECT OF USING DIFFERENT COLORED LED LIGHTS ON GONADS, EGG NUMBER AND WEIGHT IN JAPANESE QUAILS

İsmail Gökçe Yildirim, Ece Koc Yildirim, Firuze Turker Yavas · 2025 · Slovenian Veterinary Research

Artificial lighting plays a crucial role in regulating the maturation of the reproductive system of birds during puberty and thus affects their reproductive capacity. The aim of this study was to investigate the morphometric effects of the use of different coloured light-emitting diodes (LEDs) on the gonads of male and female Japanese quail (Coturnix coturnix japonica). The experimental groups were also examined with regard to egg count, weight, fertility and hatchability. A total of 240 quails of mixed sex were subjected to three different light colours, namely white, green and blue LEDs. The

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Negative / Null Result ReportOpen accessVeterinary medicine

Associations between bovine lactoferrin gene polymorphism and somatic cell count in milk

K. Wojdak-Maksymiec, M. Kmiec, J. Ziemak · 2006 · Veterinární Medicína

The study included 124 Polish Black-and-White dairy cows of various share of the Holstein-Friesian (HF) breed. Lactoferrin (LTF) gene polymorphism was obtained with PCR-RFLP method using EcoRI enzyme. Two alleles of LTF, A and B, were found in the studied population. Their frequencies were 67.74% and 32.56%, respectively. The alleles controlled the occurrence of three genotypes: AA, BB and AB, of frequencies equal to 37.90%, 2.42% and 59.68%, respectively. It was established that statistically significant associations exist between the somatic cell count (SCC) and LTF genotype, lactation month

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Negative / Null Result ReportOpen accessVeterinary medicine

Evaluation of primary wound healing and potential complications after perioperative infiltration with lidocaine without adrenaline in surgical incisions in dogs and cats

Erica Anna Gumpert Herlofson, Francesca Tavola, Karolina Siri Engdahl et al. · 2023 · Acta Veterinaria Scandinavica

Abstract Background Pre-emptive local analgesia with the use of lidocaine is practised increasingly in veterinary medicine as part of applied multimodal analgesia, despite its controversial impact on wound healing. The purpose of this prospective, randomised, double-blinded, placebo-controlled clinical study was to evaluate if preoperative subcutaneous infiltration of lidocaine has a negative impact on primary wound healing of surgical incisions. Fifty-two companion animals (3 cats and 49 dogs) were enrolled in the study. The inclusion criteria were as follows: American Society of Anaesthesiol

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Negative / Null Result ReportOpen accessVeterinary medicine

The incidence and trends of proteinuria, azotemia and hypertension in cats receiving toceranib phosphate

Kimberly Williams, Valerie MacDonald-Dickinson, Arata Matsuyama · 2024 · Journal of Feline Medicine and Surgery

Objectives This retrospective study aimed to determine the incidence and trends of proteinuria, elevations in serum creatinine and urea, and systolic blood pressure in cats undergoing treatment with toceranib. Methods In total, 32 cats treated with toceranib for malignancies were analyzed. Cats were included if urinalysis and urine protein:creatinine ratio (UPC) measurements were available at 28 days (T1) and 56 days (T2) after starting the treatment. Cats with concurrent lower urinary tract disease, including urinary tract malignancy, were excluded. Friedman’s ANOVA compared variables between

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Negative / Null Result ReportOpen accessVeterinary medicine

Exploring the relationship between calcitonin, ionized calcium, and bone turnover in cats with and without naturally occurring hypercalcemia

Evangelia Maniaki, Carmen Pineda, Angie Hibbert et al. · 2024 · Frontiers in Veterinary Science

ObjectivesThis case-control study aimed to evaluate calcitonin response in naturally occurring hypercalcemia in cats and assess the relationships between calcitonin and ionized calcium (iCa) and examine relationships between calcitonin, iCa and bone turnover.MethodsHypercalcemic cats (persistently increased iCa concentration [>1.40 mmol/l]) were identified retrospectively via a medical database search; additional hypercalcemic and normocalcemic cats were recruited prospectively. Data regarding routine biochemical and urine testing, diagnostic imaging and additional blood testing were obtained.

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Replication FailureOpen accessVeterinary medicine

The effect of lasalocid sodium on growth performance and possible coccidiosis in weaned akkaraman lambs

Şakir Doğan TUNCER, Behiç COŞKUN, Rıfat CANTORAY et al. · Eurasian Journal of Veterinary Sciences

This experiment was carried out to investigate the effects of Na -lasalocid that was added into concentrate mixtures in 25, 50 and 75 g per ton on growth performance and against the possible coccidia infection of lambs. In the experiment, 40 Akkaraman male lambs with 3.5 - 4 months old were used. The research works were conducted as 4 groups for the period of 84 days. The ratian of the control group did not contain any Na-lasalocid. The average of final weights of lambs in the groups were 47.41; 48.91; 49.98 and 49.96 kg respectively, (P>0.05). Average daily weight gain was found to be 260 g i

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