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Browse the failure-mode index

244 real negative results, null findings, and replication failures in Neuroscience. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessNeuroscience

Cognitive load, fatigue and aversive simulator symptoms but not manipulated zeitgebers affect duration perception in virtual reality

Magdalena Sabat, Bartosz Haładus, Michał Klincewicz et al. · 2022 · Scientific Reports

The perceived duration of an interval depends on numerous aspects of the passed event both endogenous, including physiological arousal, level of wakefulness, attention, and surprise, as well as exogenous such as valence, salience, or context in the environment. There is some evidence that "time-giving" cues from the environment (zeitgebers) are coupled with time perception. The movement of the sun on the horizon was demonstrated to affect interval perception in a study conducted by Schatzschneider et al. (2016) claiming that the sun's motion is a zeitgeber that influences time perception. In t

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Negative / Null Result ReportNeuroscience

The burden of secrecy? No effect on hill slant estimation and beanbag throwing.

Diane Pecher, Heleen van Mierlo, Rouwen Cañal‐Bruland et al. · 2015 · Journal of Experimental Psychology General

Slepian, Masicampo, Toosi, and Ambady (2012, Experiment 1) reported that participants who recalled a big secret estimated a hill as steeper than participants who recalled a small secret. This finding was interpreted as evidence that…

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Negative / Null Result ReportOpen accessNeuroscience

Regulation of LEAP2 by insulin and glucagon in mice and humans

Valdemar Brimnes Ingemann Johansen, Anna Katrina Jógvansdóttir Gradel, Stephanie Kjærulff Holm et al. · 2025 · Cell Reports Medicine

Liver-expressed antimicrobial peptide 2 (LEAP2) is an endogenous antagonist and inverse agonist of the ghrelin receptor, countering ghrelin's effects on cell signaling and feeding. However, despite an emerging interest in LEAP2's…

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