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Browse the failure-mode index

12,244 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Examination of the Diameter of the Rectum and the Thickness of the Anterior Wall of the Rectum by Ultrasound in Children With Chronic Constipation and Abdominal Pain in the Age Range of 2-18 Years.

Aldaghi MA, Yazdi NS, Abadi MEA et al. · 2025 · JGH open : an open access journal of gastroenterology and hepatology

Abdominal pain is one of the most common complaints to the pediatric clinic and can be challenging for the physician. Among children who present with abdominal pain, constipation is one of the main causes of abdominal pain, and its…

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Negative / Null Result ReportMedicine

Evaluating the Influence of Injury-Induced Microstructural Variations on the Efficacy of a Diffusion MRI-Derived Axon Diameter Surrogate.

Alderson HE, Mu C, Chen LM et al. · 2026 · Magnetic resonance in medicine

Purpose To investigate the utility of a recently demonstrated diffusion MRI derived axon diameter surrogate measure (∆D ⟂ ) under pathologic conditions induced by a spinal cord injury model. Methods Contusion injuries were performed on the…

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Negative / Null Result ReportMedicine

Maternal blood lead level and its association with birthweight and preterm birth in Adjara, Georgia: An inverse probability of selection weighting analysis of a population-based cohort study.

Manjavidze T, Anda E, Nedberg IH et al. · 2026 · International journal of hygiene and environmental health

Background Lead exposure poses significant health risks, particularly during pregnancy, as lead affects fetal development. This study aimed to evaluate the association between maternal blood lead levels (BLL), birthweight and preterm birth…

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Negative / Null Result ReportMedicine

Effect of age, sex, and BMI on serum olanzapine levels and their correlation with metabolic parameters and serum pro-inflammatory cytokine levels in schizophrenia patients.

Gao W, He X, Xu Y et al. · 2026 · BMC psychiatry

Objective Olanzapine is an atypical antipsychotic drug which is effective in the treatment of schizophrenia (SCZ). Olanzapine exhibits significant pharmacokinetic variability and is associated with a higher propensity for metabolic…

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Negative / Null Result ReportMedicine

Reversed sound symbolism in speech sound disorders: Evidence for atypical cross-modal integration in a transparent language (Turkish).

Sözüçok BA, Sözüçok T, Seven I et al. · 2026 · Cortex; a journal devoted to the study of the nervous system and behavior

This study examined sound-shape matching performance (the bouba-kiki effect) in Turkish-speaking children with speech sound disorders (SSD) and their typically developing (TD) peers. Participants included 60 children aged 51-71 months: 30…

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Negative / Null Result ReportMedicine

Impact of emergency medical services volume on outcomes and management in prehospital traumatic cardiac arrest: a retrospective cohort study.

Morcel B, Yordanov Y, Mercier E et al. · 2026 · Scandinavian journal of trauma, resuscitation and emergency medicine

Background While volume-outcome relationships for non-traumatic out-of-hospital cardiac arrest have been reported in hospital settings, the impact of prehospital exposure, particularly for the rare and clinically complex entity of…

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Negative / Null Result ReportOpen accessMedicine

Postoperative Consequences of Fear and Anxiety in Open Heart Surgery: A Comparative Analysis of Two Patient Groups.

Dizdar E, Kiliç A, Alkan Kayhan S et al. · 2026 · The journal of nursing research : JNR

Background Patients undergoing open heart surgery may experience negative emotions such as anxiety, fear, panic, and anger in the preoperative period that may negatively affect their postoperative recovery. Purpose This study was designed…

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Negative / Null Result ReportOpen accessMedicine

COVID-19 vaccination remains essential for healthcare professionals: clinical evidence from a Polish cross-sectional study.

Hoffmann K, Michalak M, Jarząb M et al. · 2026 · Frontiers in public health

Introduction Six years after the emergence of SARS-CoV-2, vaccination remains still central to preventing severe COVID-19. The aim was to determine the impact of the vaccine type and number of doses on the course of COVID-19 infection…

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Negative / Null Result ReportMedicine

A microplastic meal: A baseline assessment of microplastic polymer presence within manta-ray (Mobula alfredi) feeding grounds at D'Arros Island and the St. Joseph Atoll.

Choppy MT, Duncan MI, Gordon N et al. · 2026 · Marine pollution bulletin

Microplastic ingestion by reef manta rays (Mobula alfredi) is a threat to their health and population stability. Seychelles' outer islands are vital habitats for M. alfredi but nothing is known about marine microplastic pollution in the…

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Negative / Null Result ReportMedicine

The effect of physiological changes in estradiol hormone during the follicular phase of the menstrual cycle in healthy women on retinal ganglion cell function, retinal and optic nerve vascularization and structure.

Hamurcu M, Gültekin BP, Göçmen M et al. · 2026 · Documenta ophthalmologica. Advances in ophthalmology

Purpose This study aimed to investigate the effects of estradiol changes occurring during the early follicular phase of the menstrual cycle on retinal ganglion cell function, retinal and optic nerve vascularity and structure in healthy…

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Negative / Null Result ReportMedicine

No Association Between Anatomic Factors and Non-Contact ACL Injury Risk in 217 Female Team Sport Players: A Prospective 4.5-Year Study.

Leppänen M, Jarske H, Krosshaug T et al. · 2026 · Scandinavian journal of medicine & science in sports

The purpose of this explorative study was to investigate the association between anatomic factors and risk for non-contact anterior cruciate ligament (ACL) injuries among female team sport players. A total of 225 players from basketball,…

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Negative / Null Result ReportMedicine

Visual Outcomes and the Impact of Intermediate Segment Orientation on the Performance of an Asymmetric Multifocal Intraocular Lens.

McLintock C, Uprety S, McKelvie J et al. · 2026 · Journal of refractive surgery (Thorofare, N.J. : 1995)

Purpose To evaluate the visual outcomes and the impact of intermediate segment orientation on the performance of an asymmetric multifocal intraocular lens (IOL) in patients who have cataract. Methods In this retrospective single-center…

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