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WASTE Journal

Browse the failure-mode index

12,244 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Variations in Pulse-Oxygen Saturation and Physical Development within the First 2 Hours after Birth Among Healthy Term Neonates Different Altitudes.

Du K, Yang YL, Li GY et al. · 2026 · Physiological research

This study aimed to examine early postnatal changes in pulse oxygen saturation (SpO2) and physical growth parameters during the first 2 hours following birth among healthy term neonates born at varying altitudes. A total of 963 healthy…

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Negative / Null Result ReportMedicine

Effectiveness, Sex Differences, and Patient Experience in Real-World Use of Long-Acting Cabotegravir and Rilpivirine: Results from a Prospective Study.

González-Cordón A, Calvo J, Berrocal L et al. · 2026 · Infectious diseases and therapy

Introduction Long-acting intramuscular cabotegravir plus rilpivirine (LA-CAB/RPV) administered every 2 months (Q2M) has been available in Spain since January 2023 as a switch strategy for HIV treatment. We evaluated characteristics,…

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Negative / Null Result ReportOpen accessMedicine

Clinical outcomes of preimplantation genetic testing for structural rearrangements in couples with chromosomal inversions: a retrospective analysis.

Li Y, Keqie Y, Peng C et al. · 2026 · Frontiers in genetics

Chromosomal inversion is one of the common types of chromosomal structural rearrangements. For couples with chromosomal inversions, the appropriate recommendations for preimplantation genetic testing (PGT) remain a subject of ongoing…

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Negative / Null Result ReportOpen accessMedicine

Impact of different endometrial preparation protocols on pregnancy outcomes in frozen-thawed embryo transfer cycles among patients ≤35 years with a history of intrauterine adhesion separation surgery: a retrospective cohort study.

Sun H, Du M, Guo S et al. · 2026 · Frontiers in endocrinology

Objective To investigate the impact of three endometrial preparation protocols-hormone replacement therapy (HRT), natural cycle (NC), and down-regulation HRT-on pregnancy outcomes in frozen embryo transfer (FET) cycles among patients with…

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Negative / Null Result ReportOpen accessMedicine

Associations of new intracranial haemorrhage, ischaemic stroke and survival with dual antiplatelet therapy regimen or duration after endovascular treatment for ruptured cerebral aneurysm.

Perng PS, Chang Y, Chuang MT et al. · 2026 · Stroke and vascular neurology

Background Dual antiplatelet therapy (DAPT) is often necessary following endovascular treatment for ruptured cerebral aneurysms; however, the optimal drug combination and treatment duration remain uncertain. Method Patients with…

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Negative / Null Result ReportOpen accessMedicine

Association Between MTHFR Gene Polymorphisms and Subclinical Hypothyroidism in Early Pregnancy: A Retrospective Case-Control Study.

Liu L, Wang C, Chen X et al. · 2026 · International journal of women's health

Objective To investigate the association between methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and subclinical hypothyroidism (SCH) in early pregnancy. Methods This retrospective case-control study included 100 pregnant…

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Negative / Null Result ReportMedicine

[Effects of oliceridine versus sufentanil for anesthesia induction and postoperative analgesia on postoperative nausea and vomiting in patients undergoing gynecological laparoscopic surgery: a randomized controlled trial].

Wang Y, Xu X, Shen WJ et al. · 2026 · Zhonghua yi xue za zhi

Objective: To investigate the effects of oliceridine versus sufentanil for anesthesia induction and postoperative patient-controlled intravenous analgesia (PCIA) on postoperative nausea and vomiting (PONV) in patients undergoing…

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Negative / Null Result ReportMedicine

Immersive Haptic Simulation for Psychomotor Skill Acquisition in Preclinical Prosthetic Dentistry: A Randomized Study.

Bandiaky ON, Volteau C, Bihan A et al. · 2026 · The International journal of prosthodontics

Purpose The aim of this study was to evaluate the effect of using the VirTeaSy Dental simulator in conjunction with a virtual reality headset on student performance in conventional fixed prosthodontics simulations. Material and methods The…

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Negative / Null Result ReportOpen accessMedicine

Does closed suction drainage reduce postoperative hematoma and muscle swelling after total hip arthroplasty? A retrospective comparative study using computed tomography.

Asano T, Uemura K, Higuchi R et al. · 2026 · Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs

Purpose Closed suction drainage has been used after total hip arthroplasty (THA) to prevent hematoma, muscle swelling, and complications, but its effectiveness remains controversial. This study evaluated the effects of drains on…

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Negative / Null Result ReportMedicine

Constrained acetabular liner total hip arthroplasty versus conventional hemiarthroplasty for unstable comminuted femoral intertrochanteric fractures in elderly patients with neurological disorders.

Dong M, Liu Y, Wei C · 2026 · BMC surgery

Background To evaluate whether constrained acetabular liners (CAL) used in total hip arthroplasty (THA) reduce the risk of dislocation and related complications in patients with neuromuscular disorders and unstable comminuted femoral…

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Failed Experiment ReportMedicine

Electroacupuncture ameliorates gastrointestinal motility and modulates PLC-IP3 signaling in a rat model of functional dyspepsia.

Yang D, Fang L, Chen Q et al. · 2025 · Acupuncture in medicine : journal of the British Medical Acupuncture Society

Objective The aim of this study was to determine whether electroacupuncture (EA) modulates the phospholipase C-inositol-1,4,5-trisphosphate (PLC-IP3) pathway and platelet-derived growth factor receptor (PDGFR)α + cells in a rat model of…

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Negative / Null Result ReportOpen accessMedicine

Delayed orocecal transit in pediatric gut-brain interaction disorders: A comparative study using the lactulose breath test.

Devanarayana NM, Rajindrajith S, de Silva DGH et al. · 2025 · World journal of gastrointestinal pathophysiology

Background Functional abdominal pain disorders (FAPDs) are common gut-brain interaction disorders with unclear pathophysiology. While impaired gastrointestinal motility is thought to play a key role, small intestinal dysmotility remains…

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Negative / Null Result ReportOpen accessMedicine

Effect of different feed particle size on digestive tract morphology, digesta viscosity, nutrient retention, and blood biochemical parameters in slow-growing broiler chickens.

Novotný J, Čumplík L, Horáková L et al. · 2026 · Veterinary and animal science

The study evaluated the effect of feed particle size on health and performance indicators in slow-growing broiler chickens. Performance traits, digestive tract morphology, digesta viscosity, nutrient retention, and blood biochemical…

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Negative / Null Result ReportOpen accessMedicine

Culture medium influences detectability of antimicrobial effects of autologous platelet concentrates against anaerobic periodontal pathogens.

Jansen EE, Braun A, Jansen P et al. · 2026 · BMC oral health

Background Autologous platelet concentrates (PRP, PRF, i-PRF) represent blood-derived biomaterials that have been reported to exhibit antimicrobial activity against oral microorganisms in vitro. In diffusion-based assays, visualization of…

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