12,375 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Aitken D, Cai G, Hill CL et al. · 2026 · JAMA internal medicine
Importance Knee osteoarthritis (OA) is disabling, with few effective treatments. Anti-inflammatory treatments may be effective for patients with an inflammatory phenotype. Objectives To evaluate the efficacy of the interleukin-1β blocker…
View details →Najjar-Debbiny R, Cohen R, Arbel A et al. · 2026 · European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
BACKGROUND: Mycobacterium simiae is an emerging cause of non-tuberculous mycobacterial pulmonary disease (NTM-PD) in the Middle East, yet treatment outcomes remain unclear. We aimed to evaluate clinical and microbiologic outcomes of M.…
View details →Rhyu KH, Cho YJ, Chun YS et al. · 2026 · Clinical orthopaedics and related research
Background Cementing a new liner into a well-fixed acetabular cup with a deficient locking mechanism has been reported as a viable option, but concerns remain regarding complications such as dislocation and late loosening.…
View details →Fatima H, Schaffert J, Carlew AR et al. · 2025 · The Clinical neuropsychologist
Objective Cognitive dispersion (CD) or neuropsychological test score variability has been associated with more rapid cognitive decline, and the development of mild cognitive impairment (MCI) and Alzheimer's disease (AD). The predictive…
View details →Agyeman AA, Buggiotti L, Brown LK et al. · 2026 · British journal of clinical pharmacology
Aims The repurposed use of favipiravir in COVID-19 has been reported to have limited clinical efficacy, yet it has been widely used in some countries. Favipiravir causes mutagenesis in RNA viruses, and it is currently unknown whether it…
View details →Khoshnevis A, Zayernouri M, Malete L et al. · 2026 · Journal of voice : official journal of the Voice Foundation
Objective Voice-based biomarkers have been proposed as objective tools for anxiety assessment, yet existing research relies on small, demographically homogeneous samples and shows inconsistent associations between fundamental frequency (F…
View details →Kwon Y, Park J, Kim D et al. · 2026 · Obesity surgery
Background While bariatric surgery (BS) is an effective treatment for gout in patients with morbid obesity, little is known about how BS influences subsequent use of gout medications. We investigated the impact of BS on gout medication…
View details →Golparian A, Anbarian M, Golparian M · 2026 · Journal of biomechanics
Anterior cruciate ligament deficiency (ACLD) leads to knee instability and altered gait patterns. Individuals with ACLD can be classified as copers or noncopers. Lower-limb coordination and coordination variability may reflect compensatory…
View details →Sınır B, Ortan P, Sayin SS et al. · 2026 · Respiratory medicine
Purpose Obstructive sleep apnea syndrome (OSAS) causes intermittent hypoxia and sleep fragmentation, which may alter gut microbiota composition. We primarily aimed to compare intestinal Desulfovibrio detection/abundance between patients…
View details →Okumura M, Yamagami S, Akiyama M et al. · 2026 · Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing
Introduction Pulsed field ablation (PFA) is a non-thermal ablation modality, but repeated high-voltage applications can still cause Joule heating at the electrode-tissue interface. We evaluated the effects of application repetition and…
View details →Xiang F, Lin J, Chen B et al. · 2026 · The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons
Background To compare the superthin (3-5 mm) versus conventional (≥10 mm) anterolateral thigh (ALT) flap for post-traumatic ankle reconstruction. Methods Retrospective cohort (2020-2024): superthin ALT (n=26) vs conventional ALT (n=34).…
View details →Sabharwal P, Kaur N, Kaur R et al. · 2026 · Journal of ultrasound
Objectives To determine the incremental diagnostic value of multiparametric quantitative ultrasound-integrating B-mode, Color Doppler, Strain, and Shear Wave Elastography (SWE)-in differentiating benign and malignant breast lesions, using…
View details →Wang L, Pulgrossi RC, Anderson J et al. · 2026 · The journal of applied laboratory medicine
Background Acute graft-versus-host disease (aGVHD) is a common complication of allogenic hematopoietic cell transplantation (HCT). The aGVHD presymptomatic algorithm is comprised of 2 serum biomarkers, suppression of tumorigenicity 2 and…
View details →Delaye-Martínez MA, Aguilar-Rodea BP, Cardona-Ortiz AF et al. · 2026 · European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
Purpose Nebulized colistin has shown promise in treating ventilator-associated pneumonia (VAP) due to carbapenem-resistant strains; evidence in burn patients is limited. This study evaluated the efficacy of nebulized colistin as an adjunct…
View details →Rusa AM, Schmidlin PR, Sarkar P et al. · 2026 · Swiss dental journal
Large language models (LLMs) are increasingly used in clinical and educational settings. However, there is a paucity of data on LLMs' performance in specialized dental domains. This study assessed the performance of four LLMs, including…
View details →Zou Q, Huang Q, Li J et al. · 2026 · International urology and nephrology
Background The optimal treatment strategy for androgen receptor pathway inhibitor (ARPI)-pretreated and chemotherapy-naïve metastatic castration-resistant prostate cancer (mCRPC) remains unclear. Chemotherapy has limited efficacy as a…
View details →van Boven M, Bennis F, Onland W et al. · 2025 · IEEE journal of biomedical and health informatics
Machine learning models predicting neurodevelopmental outcome in preterm infants have great potential, but have often relied on inaccessible brain magnetic resonance imaging measurements. This study aimed to build models using readily…
View details →Hoyle JD Jr, Ekblad G, Dunwoody S et al. · 2026 · Prehospital emergency care
Objectives We sought to decrease pediatric prehospital dosing errors by implementing a bundled drug dosing safety system (DDSS). Multiple studies have demonstrated that pediatric prehospital drug-dosing errors occur at rates of > 30% for…
View details →Ivanov AL, Reshetnyak EI, Sukacheva SA · 2026 · Stomatologiia
Objective To evaluate mandibular donor site healing after cortical bone graft harvesting in cleft patients, comparing outcomes of osteotomies performed with rotary burs and piezosurgery. Material and methods Fifty-three patients (64 bone…
View details →Marshall PW, Benatar JR, O'Halloran P et al. · 2026 · Heart, lung & circulation
Aim Suboptimal enrolment and engagement in cardiac rehabilitation remains a persistent issue worldwide. This study evaluated the impact of a nurse-specialist-delivered motivational interviewing (MI) and cognitive behavioural therapy (CBT)…
View details →Jeong Y, Park KH, Jeoung JW · 2026 · The British journal of ophthalmology
Background/aims This study evaluates the relationship between the iridotrabecular contact (ITC) index and various anterior segment parameters, with a particular focus on lens-related parameters, given their clinical relevance in primary…
View details →Kang Y, Workneh F, Yibeltal K et al. · 2026 · The Journal of nutrition
Background Suboptimal gestational weight gain (GWG) is associated with adverse pregnancy outcomes; however, evidence on the impact of nutritional interventions on GWG in low-income settings remains limited. Objectives This study aims to…
View details →Allotey J, Junaid F, Peréz T et al. · 2026 · BMJ neurology open
Background Serum lamotrigine concentrations fall during pregnancy, and therapeutic drug monitoring is often used to guide dose adjustment. We do not know whether serial antenatal measurements improve prediction of seizure risk in pregnant…
View details →Khan A, Islam I, Mannakkara N et al. · 2026 · Future cardiology
Background Echocardiography after myocardial infarction (MI) provides clinically useful information through assessment of regional wall motion abnormalities, but interpretation requires expertise and remains subject to observer…
View details →Ystrøm IK, Jensen SK, Andersen IT et al. · 2026 · Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
Background and hypothesis IgA nephropathy (IgAN) is the leading cause of primary glomerulonephritis; however, reported incidences and prevalences vary substantially across countries. This study assessed the epidemiology of IgAN including…
View details →van de Bovenkamp AA, Nassiri S, de Man FS et al. · 2026 · European journal of heart failure
Aims Iron deficiency (ID) is common in patients with heart failure with preserved ejection fraction (HFpEF). The IRON-HFpEF trial aimed to evaluate the mechanistic effects of intravenous iron supplementation on cardiovascular function and…
View details →Yi Y, Yano K · 2025 · Physiologia Plantarum.
Elevated CO₂ (eCO₂) can enhance plant growth, but it may also accelerate senescence, which could offset the growth benefits. Phosphorus (P) supply can enhance the photosynthetic rate under eCO₂ conditions and promote biomass accumulation.…
View details →Hagger V, Hendrieckx C, Cotterill A et al. · 2026 · Diabetic medicine : a journal of the British Diabetic Association
Aim To examine changes in psychological and clinical outcomes among adolescents and parents after structured type 1 diabetes education delivered in routine care. Methods Teens Empowered to Actively Manage Type 1 Diabetes (TEAM T1) is a…
View details →Nakatsuka M, Pelletier-Roy R, Paturi A et al. · 2026 · Spine
Study design Retrospective cohort study of patients undergoing single-level L5-S1 anterior or transforaminal lumbar interbody fusion between 2012 and 2024 at a single academic institution, with preoperative and one-year postoperative…
View details →Perrier Q, Lablanche S, Moro C · 2026 · Lasers in medical science
Photobiomodulation (PBM) has been shown to protect pancreatic islets under inflammatory or metabolic stress, but its effects during hypoxia-reperfusion remain unclear. We evaluated PBM applied as preconditioning or during…
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