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WASTE Journal

Browse the failure-mode index

12,244 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

The Role of Oxidative Stress in Parkinson's Disease

Vera Dias, Eunsung Junn, M. Maral Mouradian · 2013 · Journal of Parkinson’s Disease

Oxidative stress plays an important role in the degeneration of dopaminergic neurons in Parkinson's disease (PD). Disruptions in the physiologic maintenance of the redox potential in neurons interfere with several biological processes, ultimately leading to cell death. Evidence has been developed for oxidative and nitrative damage to key cellular components in the PD substantia nigra. A number of sources and mechanisms for the generation of reactive oxygen species (ROS) are recognized including the metabolism of dopamine itself, mitochondrial dysfunction, iron, neuroinflammatory cells, calcium

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Negative / Null Result ReportOpen accessMedicine

Short-term interval aerobic exercise training does not improve memory functioning in relapsing-remitting multiple sclerosis—a randomized controlled trial

Lisa Baquet, Helge Hasselmann, Stefan Patra et al. · 2018 · PeerJ

Background Only few aerobic exercise intervention trials specifically targeting cognitive functioning have been performed in multiple sclerosis. Objective and Methods This randomized controlled trial with 34 patients in the intervention group (IG) (mean: 38.2 years (±9.6)) and 34 patients in the control group (CG) (mean: 39.6 years (±9.7)) aimed to determine the effects of aerobic exercise on cognition in relapsing-remitting multiple sclerosis (RRMS). The primary outcome was verbal learning assessed by the verbal learning and memory test (VLMT). Patients were randomized to an IG or a waitlist

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Negative / Null Result ReportMedicine

Migraine Features and Nociceptive Profile Do Not Influence Conditioned Pain Modulation in Women With Episodic and Chronic Migraine.

de-la-Llave-Rincón, Ambite-Quesada, Pacho-Hernández et al. · 2026 · Pain research & management

To determine the influence of sensitization-associated and neuropathic-like symptoms and clinical features in conditioned pain modulation (CPM) activity in women with episodic or chronic migraine. A cross-sectional study including 70 women…

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Negative / Null Result ReportMedicine

Do the printing orientation angle and layer thickness influence the radiopacity of 3D-printed dental resins?

Yersel, Ucan, Tekce · 2026 · Journal of prosthodontics : official journal of the American College of Prosthodontists

This in vitro study aimed to evaluate the effect of layer thickness, printing orientation angle, and resin type on the radiopacity of 3D-printed dental resins. Three dental 3D-printed resins (VarseoSmile TriniQ, Crowntec, and Primeprint…

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Negative / Null Result ReportOpen accessMedicine

Identifying early changes in imaging, plasma, and digital cognitive biomarkers that correspond to Alzheimer's disease pathology in the presence of autopsy-confirmed co-pathologies.

Chen CD, Aguero C, Melloni A et al. · 2026 · Alzheimer's & dementia : the journal of the Alzheimer's Association

Introduction Alzheimer's disease (AD) biomarkers are assessed on their ability to detect AD pathophysiology in vivo, with confirmation of AD neuropathology only at autopsy. Methods Positron emission tomography (PET), plasma, and cognitive…

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Negative / Null Result ReportMedicine

Expression patterns of risk genes associated with three evolutionarily relevant syndromes in rhesus macaque and human brains.

Karunakaran KB, Purushottam M, Balakrishnan N et al. · 2026 · Translational psychiatry

Depressive disorder (DD), Alzheimer's disease (AD), and schizophrenia (SZ) are evolutionarily relevant traits that disrupt neural networks supporting affect and cognition. While genome-wide association studies have identified risk-related…

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Negative / Null Result ReportMedicine

Quantification of retinal non-perfusion in eyes with diabetic retinopathy to study the association with retinal neovascularisation: INSPIRED study report 3.

Khalid H, Tsai WS, Lamanna F et al. · 2026 · The British journal of ophthalmology

Background/aims To characterise the distribution of retinal non-perfusion and its relationship with neovascularisation elsewhere (NVE) and visual acuity (VA) in referable diabetic retinopathy (DR) using ultra-widefield fluorescein…

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Negative / Null Result ReportOpen accessMedicine

Computer-navigated versus conventional total knee arthroplasty: no difference in implant survival at 15-year follow-up.

Longo G, Pacchiarotti G, Pizzigallo C et al. · 2026 · Journal of orthopaedic surgery and research

Introduction The introduction of computer-assisted navigation (CAS) in total knee arthroplasty (TKA) aimed to improve prosthetic alignment and potentially enhance long-term implant survival. However, the actual clinical benefit beyond 10…

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Negative / Null Result ReportMedicine

Assessment of intraoperative high frequency variability index as a predictor of postoperative pain after open liver or pancreatic surgery under combined general and epidural anesthesia: a prospective observational study.

Yoshida K, Hakozaki T, Hasegawa T et al. · 2025 · Journal of clinical monitoring and computing

The aim of the present study was to investigate the utility of the intraoperative high frequency variability index (HFVI) / Analgesia Nociception Index (ANI) for predicting postoperative pain in patients undergoing open liver or pancreatic…

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Replication FailureOpen accessMedicine

Radiotherapy Offered Limited Additional Benefits on Cancer-specific Survival for Patients with Resectable Subcutaneous Malignant Peripheral Nerve Sheath Tumors: A Population-based Retrospective Cohort Analysis.

Xiao Y, Li Z, Hu B et al. · 2025 · Neurologia medico-chirurgica

For resectable malignant peripheral nerve sheath tumors, the additional benefits of radiotherapy remain controversial. This study aims to investigate whether there is an additional benefit of radiotherapy for resectable malignant…

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Replication FailureOpen accessMedicine

When anticoagulant therapy is not enough: recurrent stroke.

Stazi F · 2026 · European heart journal supplements : journal of the European Society of Cardiology

Despite the use of oral anticoagulants, the residual risk of recurrent ischaemic stroke in patients with atrial fibrillation (AF) is ∼4% per year; however, in patients who experience a stroke despite oral anticoagulant therapy (OAT), this…

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Negative / Null Result ReportOpen accessMedicine

Most autophagic cell death studies lack evidence of causality.

Özkaya AB, Ghaseminejad Y · 2025 · FEBS open bio

Autophagy plays a critical role in maintaining cellular homeostasis and is implicated in various physiological and pathological processes, including cancer, neurodegeneration, and metabolic disorders. Although typically associated with…

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Negative / Null Result ReportMedicine

Knowledge, attitude, and practice on clear aligner therapy in mixed dentition among pediatric dentists of India: A cross-sectional survey.

Soral S, Bargale S, Dave B et al. · 2026 · Journal of the Indian Society of Pedodontics and Preventive Dentistry

Background Orthodontic treatment has long been associated with visible wires in the mouth. Clear aligners, once limited to mild crowding/spacing, are now supported for correcting more complex malocclusions. While Clear Aligner Therapy…

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Negative / Null Result ReportMedicine

Real-World Evidence: Cefiderocol Therapeutic Drug Monitoring in Critically Ill, Obese Patients with <i>Klebsiella pneumoniae</i> Infections.

Manca A, Palermiti A, Corcione S et al. · 2026 · Antibiotics (Basel, Switzerland)

Background/Objectives: Cefiderocol (FDC) is a siderophore-containing cephalosporin that retains activity against many β-lactamase-producing bacteria, such as New Delhi metallo-β-latamase-producing (NDM) K. pneumoniae . Its use in…

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Negative / Null Result ReportMedicine

Lumbar degenerative disease: association of serum complement levels with diagnosis, structural severity, and postoperative prognosis.

Deng, Zhu, Cao et al. · 2026 · European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

The clinical evaluation of lumbar degenerative disease (LDD) severity relies on symptoms and imaging, lacking biologically specific diagnostic markers. This study investigated the role of serum complements in LDD to assess their potential…

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Negative / Null Result ReportMedicine

Association of age and primary treatment with risk of non-lymphoma-related death and long-term survival outcomes in adult patients with early-stage follicular lymphoma: a population-based analysis.

Xu, Wu, Liu et al. · 2026 · Annals of hematology

In adult patients with early-stage follicular lymphoma (FL), age-related differences in the risk of non-lymphoma-related death (LRD) during the follow-up period after treatment are unclear. We aimed to investigate the interactive effects…

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Negative / Null Result ReportMedicine

Determinants of Speech Perception Outcomes After Hearing Aid Fitting in Conductive and Sensorineural Hearing Loss: A Prospective Longitudinal Observational Study.

Izbassarova, Imangaliyeva, Bakhshinyan et al. · 2026 · Audiology research

Background/Objectives: Hearing loss is a leading cause of disability worldwide, with speech perception representing a key functional outcome of auditory rehabilitation. While hearing aids improve audibility, outcomes vary substantially…

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