e-ISSN: Pending
WASTE Journal

Browse the failure-mode index

12,375 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

The effect of prenatal stressor exposure on child cognitive functioning: the importance of timing of stress and domain of cognition.

Roberts E, Francesconi M, Flouri E · 2025 · Stress (Amsterdam, Netherlands)

Prenatal stress has been associated with poor cognitive outcomes in offspring, but the evidence about the role of exact timing of exposure is mixed and that about causal mechanisms is limited. Using the Avon Longitudinal Study of Parents…

View details →
Negative / Null Result ReportOpen accessMedicine

Nocturnal Cardiac Arrhythmias in Sleep Apnoea After Acute Myocardial Infarction and the Effect of Adaptive Servo-Ventilation: An Ancillary Study of the TEAM-ASV I Trial.

Pec J, Nigl M, Fox H et al. · 2026 · Journal of cardiovascular development and disease

(1) Background: Early treatment of sleep-disordered breathing (SDB) with adaptive servo-ventilation (ASV) after acute myocardial infarction (AMI) has been shown to improve myocardial salvage. This analysis evaluates nocturnal…

View details →
Negative / Null Result ReportMedicine

Exploring the Long-Lasting Effect of Mindfulness-Based Intervention in Very Preterm Adolescents on Executive and Socio-Emotional Competencies.

Siffredi V, Liverani MC, Fernandez NB et al. · 2025 · Child: care, health and development

Background Very preterm (VPT) adolescents show executive and socio-emotional difficulties that persist into adulthood. Beneficial effect of mindfulness-based intervention (MBI) has been found in VPT young adolescents immediately after the…

View details →
Negative / Null Result ReportMedicine

Impact of Tourniquet Type on Outcomes in ORIF of Pediatric Distal Radius Fractures.

Conteduca J, Longo D, Casto A et al. · 2025 · Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina

Purpose   The objective of this study was to assess the benefits of utilizing a silicone ring tourniquet in relation to traditional pneumatic cuff tourniquets and scenarios without any tourniquet intervention. The tested hypothesis…

View details →
Negative / Null Result ReportMedicine

[Two Cases of Node-Positive Breast Cancer in Which the Oncotype DX Test Was Performed but Yielded Inconclusive Results].

Terakawa H, Kawata C, Kurokawa Y et al. · 2025 · Gan to kagaku ryoho. Cancer & chemotherapy

Oncotype DX is performed to predict prognosis and the added benefit of chemotherapy in hormone receptor-positive, HER2-negative breast cancer, with the goal of individualizing chemotherapy decisions. Here, we report 2 cases of early- stage…

View details →
Methods Dead-EndMedicine

Machine learning for predicting chaotic systems.

Schötz C, White A, Gelbrecht M et al. · 2026 · Chaos (Woodbury, N.Y.)

Predicting chaotic dynamical systems is critical in many scientific fields, such as weather forecasting, but challenging due to the characteristic sensitive dependence on initial conditions. Traditional modeling approaches require…

View details →
Negative / Null Result ReportMedicine

Chemical and visual compatibility of dexmedetomidine injection with parenteral medications used in neonatal intensive care settings.

De Silva DTN, Hamilton AJ, Strunk T et al. · 2026 · European journal of hospital pharmacy : science and practice

Objective To investigate the chemical and visual compatibility of dexmedetomidine injection with 44 secondary intravenous (IV) drugs and six 2-in-1 parenteral nutrition (PN) solutions used in neonatal intensive care unit settings. Methods…

View details →
Negative / Null Result ReportMedicine

The evaluation of Copy Number Variants in an unselected population of patients with Inherited Cardiac Conditions: The INTERACTION Study.

Giulia C, Simona M, Monia M et al. · 2026 · Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology

Background and aims The current diagnostic approach to inherited cardiac conditions (ICCs) is primarily focused on the analysis of single-nucleotide variants (SNVs) and small insertions/deletions (InDels). However, as recommended for other…

View details →
Negative / Null Result ReportMedicine

Effects of continuous vs. intermittent transcutaneous electrical stimulation of the auriculotemporal nerve on nociceptive processing: a pilot randomized controlled double-blind crossover trial in asymptomatic volunteers.

Barone M, Guli L, Centurión J et al. · 2026 · Cranio : the journal of craniomandibular practice

Objective To compare the effects of two transcutaneous electrical stimulation (TES) patterns applied to the auricular branches of the auriculotemporal nerve on nociceptive processing. Methods Twelve asymptomatic volunteers received…

View details →
Negative / Null Result ReportMedicine

Comparative analysis of PTH Washout and 99mTc-MIBI SPECT/CT in presurgical localization for patients with primary hyperparathyroidism.

Cieślewicz M, Szczepanek-Parulska E, Witowska A et al. · 2026 · Journal of endocrinological investigation

Purpose Our study aimed to evaluate the performance and concordance of parathyroid hormone wash-out (PTHw) and 99m Tc-MIBI+SPECT/CT (MIBI) in preoperative localization for patients with primary hyperparathyroidism (PHPT), and assess…

View details →
Negative / Null Result ReportMedicine

'White autopsies': an overview of cases with inconclusive results of post-mortem examinations in the Department of Forensic Medicine of the Jagiellonian University Medical College in Kraków, Poland.

Zwierzewicz Z, Szpakowska A, Bistroń D et al. · 2025 · Archiwum medycyny sadowej i kryminologii

The aim of the study The aim of the study was to accurately determine the incidence of white autopsies and to identify possible conditions responsible for such autopsies by means of analyzing confirmed causes of death in the same age…

View details →
Negative / Null Result ReportMedicine

COMPARING THE ABILITY OF GENETIC TESTING TO PROVIDE A DEFINITIVE DIAGNOSIS IN PATIENTS WITH PERIPHERAL AND MACULAR INHERITED RETINAL DISEASE.

Dones AM, Bou Ghanem G, Kessler C et al. · 2026 · Retina (Philadelphia, Pa.)

Purpose We performed a retrospective cross-sectional study to determine whether there is a significant difference in the percentage of patients with diagnosed inherited macular or peripheral disease who receive more definitive genetic…

View details →
Negative / Null Result ReportMedicine

Robotic arm-assisted <sup>18</sup>F-FDG PET/CT-guided biopsy in febrile patients with biopsy accessible FDG-avid lesions: a single-centre experience.

Aggarwal P, Singh H, Kumar R et al. · 2026 · European journal of nuclear medicine and molecular imaging

Purpose Fever of unknown origin (FUO) is a prolonged fever with unknown etiology after an extensive outpatient or inpatient workup. 18 F-Flurodeoxyglucose (FDG) positron emission tomography (PET) with computed tomography (CT) has shown a…

View details →
Negative / Null Result ReportMedicine

Development and validation of a nomogram model for predicting negative/indeterminate HIV-1 antibody confirmation: a strategy to streamline the diagnostic pathway.

Liao G, Zhang S, Wei Y et al. · 2026 · BMC medical informatics and decision making

Background The standard HIV diagnostic algorithm comprises sequential serological screening, confirmatory antibody testing, and nucleic acid confirmation when necessary. This multi-step process often causes diagnostic delays, particularly…

View details →
Negative / Null Result ReportMedicine

Changes in Attitudes After Suicide Prevention Media Campaigns in Three Norwegian Regions.

Mohn C, Haga E, Nilsson HSW et al. · 2026 · Archives of suicide research : official journal of the International Academy for Suicide Research

Background In a recent Norwegian regional suicide prevention media campaign, we found small and inconclusive results regarding changes in attitudes to suicide and help-seeking. In this exploratory study we add the data from two other…

View details →
Negative / Null Result ReportMedicine

Biomagnetism of oral tissues and external magnetic field interactions with cell membranes, oral microflora, and orthodontic magnetic therapies: A review.

Itabaiana Sobrinho S, Meira-Belo LC, Mohallem NDS · 2026 · Progress in biophysics and molecular biology

Various rare earth magnets have been successfully applied in clinical orthodontics; however, their interactions with the oral environment remain only partially understood. Various controversies remain regarding magnetic fields (MFs) in…

View details →
Negative / Null Result ReportMedicine

Effects of Glucagon-Like Peptide-1 Receptor Agonists (Mono and Combination Therapy) on Energy Expenditure: A Scoping Review.

Vieira FT, Deng Z, Muller MJ et al. · 2026 · Obesity reviews : an official journal of the International Association for the Study of Obesity

Introduction Weight loss results in reduced energy expenditure (EE) due to body composition alterations (e.g., fat-free mass and fat mass losses) and mass-independent adaptations in EE (e.g., hormones). Glucagon-like peptide-1 receptor…

View details →
Negative / Null Result ReportMedicine

Intraoperative biopsy challenges: Cavernous sinus meningioma mimic.

Pérez Serena A, Martínez Betancourt DP · 2026 · Neurocirugia

We report the case of a 56-year-old female patient with controlled Human Immunodeficiency Virus (HIV) who presented with binocular diplopia and a known sixth cranial nerve palsy. Imaging revealed a lesion centered in the right cavernous…

View details →
Negative / Null Result ReportMedicine

Lost in submission? Investigating publication bias in regional anaesthesia: A pilot case study of the erector spinae plane block.

De Cassai A, Dost B, Karapinar YE et al. · 2026 · Revista espanola de anestesiologia y reanimacion

Background The Erector Spinae Plane (ESP) block is a regional anaesthesia technique with a growing range of clinical applications due to its short learning curve, low complication rate, and effectiveness. However, publication bias can…

View details →
Negative / Null Result ReportOpen accessMedicine

Glomerular Yield in Ultrasound-Guided Native Kidney Biopsies in Pediatric and Adult Populations With Age-Stratified Subgroups.

Ravizzini PC, Lino HA, de Faria Castro Fleury E et al. · 2025 · Cureus

Background This study compares the glomerular yield, mean number of biopsy cores, and complication rates between pediatric and adult populations undergoing ultrasound-guided native kidney biopsies. Additionally, the adult population was…

View details →
Negative / Null Result ReportMedicine

Association between hemodynamically significant patent ductus arteriosus and fluid intake in the first week of life in a cohort of very low birth weight preterm infants: the COOL study.

Mayer A, Bresesti I, Francescato G et al. · 2025 · European journal of pediatrics

The amount of fluid to give in preterm infants with patent ductus arteriosus (PDA) is still highly debated, with no robust evidence that fluid restriction provides a clear benefit. The aim of the study is to evaluate if spontaneous closure…

View details →