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Browse the failure-mode index

12,244 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Prevalence and Clinical Relevance of Alström Syndrome Protein 1 Gene Variant and Feline Hypertrophic Cardiomyopathy in Sphynx Cats in Thailand.

Sussadee M, Jarudecha T, Muikaew R et al. · 2026 · Animals : an open access journal from MDPI

Feline hypertrophic cardiomyopathy (HCM) is the most common cardiac disease in cats, causing morbidity and mortality. Recently, a variant in the Alström syndrome protein 1 ( ALMS1 ) gene has been reported to be associated with HCM in…

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Negative / Null Result ReportMedicine

Shape and size of foveal avascular zone in normal subjects using optical coherence tomography angiography (OCTA) : A retrospective analysis.

Chaudhry A, Moin M, Malik TG et al. · 2026 · JPMA. The Journal of the Pakistan Medical Association

To determine the shape and size of foveal avascular zone in terms of perimeter, circularity, roundness and axial ratio using optical coherence tomography angiography. The retrospective study was conducted at the Yaqeen Vison Clinic,…

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Negative / Null Result ReportMedicine

Clinical Use of Inhibin B in Male Adolescent Childhood Cancer Survivors: Correlation With Cyclophosphamide Equivalent Dosing.

Wei W, Shaibi GQ, Temkit H et al. · 2026 · Journal of pediatric hematology/oncology

Introduction Alkylators are gonadotoxic in a cumulative manner, with overall exposure quantified as the cyclophosphamide equivalent dose (CED). Inhibin B is used as a surrogate marker of fertility in adult male childhood cancer survivors…

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Negative / Null Result ReportOpen accessMedicine

Medication reminder use and medication adherence among patients with chronic conditions in a Malaysian teaching hospital.

Md Kasim NA, Shirinal Izuan US, Karuppannan M · 2026 · BMC health services research

BACKGROUND: Healthcare providers commonly recommend medication reminders as a strategy to enhance adherence to prescribed medications. Patient demographic characteristics may influence medication adherence and incorporating patient-centred…

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Negative / Null Result ReportOpen accessMedicine

Tracheotomy Before Total Laryngectomy as a Risk Factor for Stoma Recurrence.

Prates AJ, Curioni OA, Ramos DM et al. · 2026 · Diagnostics (Basel, Switzerland)

Background/Objectives: Laryngeal cancer has a high incidence and mortality rate, especially in advanced stages. Stoma recurrence after total laryngectomy is rare but lethal, and its risk factors remain controversial. We aimed to assess…

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Negative / Null Result ReportMedicine

Periaortic inflammation after endoleak repair: a risk to watch.

Voigt MB, Böhner A, Bahaaeldin M et al. · 2026 · CVIR endovascular

To evaluate the occurrence of periaortic inflammation, including abscess formation, as a complication following endoleak repair after endovascular aortic repair. This retrospective single-center study analyzed 88 EVAR revisions for…

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Negative / Null Result ReportOpen accessMedicine

Association between Serum Vitamin D Levels and <i>VDR</i> <i>BsmI</i> Polymorphism in Temporomandibular Joint Dysfunction Patients (in the Iranian Population).

Mostafavi M, Rezazadeh F, Fattahi MJ et al. · 2026 · Journal of dentistry (Shiraz, Iran)

Background Multiple studies have revealed an association between vitamin D levels, genetic polymorphisms of the VDR (vitamin D receptor) gene, and the underlying causes of various bone and cartilage disorders. Purpose This study aimed to…

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Negative / Null Result ReportMedicine

The risk of type 1 diabetes mellitus after COVID-19 and influenza infection: A nationwide cohort and self-controlled case series study.

Ozaki K, Nishioka Y, Kamitani F et al. · 2026 · Diabetes research and clinical practice

It has been controversial whether COVID-19 increases the risk of new-onset type 1 diabetes mellitus. Using large-scale claims data, we found no statistically significant association between COVID-19 and incident type 1 diabetes mellitus in…

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Negative / Null Result ReportMedicine

Emotion Perception in Behavioral Variant Frontotemporal Dementia and Alzheimer Disease: The Parahippocampal Conundrum.

Morais RF, Duro D, Pires R et al. · 2026 · Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology

Background Emotion perception is the capacity that enables humans to correctly identify the cues that guide interpersonal interactions, forming the basis for social behavior. The parahippocampal cortex may contribute to emotion perception…

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Negative / Null Result ReportOpen accessMedicine

Changes in Upper Airway Anatomy and Apnea-Hypopnea Index in Patients with Obstructive Sleep Apnea Undergoing Bariatric Surgery: A Pilot Study.

Nithya M, Titiyal R, Ajayababu A et al. · 2026 · Journal of clinical medicine

Background: Obstructive sleep apnea (OSA) is common in individuals with obesity, largely due to increased soft tissue causing upper airway narrowing. However, mechanisms of OSA improvement following weight loss are incompletely understood,…

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Negative / Null Result ReportMedicine

Pd-L1 Expression in Oral Cavity Squamous Cell Carcinomas.

Nalwa A, Visakhan A, Elhence PA et al. · 2026 · Indian journal of surgical oncology

Programmed cell death ligand-1 (PD-L1) is involved in T-cell regulation by acting as an immune checkpoint inhibitor, and its expression is being widely studied in various malignancies. The following study was designed to examine the role…

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Negative / Null Result ReportMedicine

Significant Correlation Between White Matter Hyperintensity Volume and Rare NOTCH3 Variants in the General Japanese Population.

Mizuta I, Yamashita F, Sutoh Y et al. · 2026 · Geriatrics & gerontology international

Aim Cerebral small vessel disease (CSVD)-related MRI findings, including white matter hyperintensities (WMHs), are not rare in general elderly populations. The aim of this study was to elucidate the contribution of hereditary CSVD-related…

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Negative / Null Result ReportMedicine

Chondrolabral junction pathology in Femoroacetabular Impingement Syndrome is underestimated by pre-operative MRI and have no significant correlation with baseline outcomes.

Samim M, Jardon M, Vonck C et al. · 2026 · Journal of orthopaedics

Purpose To assess correlation of pre-operative symptoms, labral damage and chondrolabral junction pathology on MRI with intra-operative findings in patients undergoing hip arthroscopy for femoroacetabular impingement (FAI). Methods…

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Negative / Null Result ReportOpen accessMedicine

Exploratory Analysis of the Neutrophil-to-Lymphocyte Ratio (NLR) and Mucositis Severity in Head and Neck Cancer Patients Undergoing Radiotherapy-Based Treatment: A Retrospective Study.

Santo B, Romanello M, De Franco P et al. · 2026 · Journal of clinical medicine

Background/Objectives: The neutrophil-to-lymphocyte ratio (NLR) is a simple biomarker reflecting systemic inflammatory status and has been investigated in head and neck cancer (HNC) as a potential prognostic indicator. Its role in relation…

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