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WASTE Journal

Browse the failure-mode index

12,244 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Effect of Powder-to-Liquid Ratio on pH, Calcium Ion Release, and Solubility Behaviors of Endodontic Bioceramics: An In Vitro Study.

Aka A, Matsuura T, Yoshimura A · 2026 · Journal of functional biomaterials

This study investigated the physicochemical properties of three endodontic bioceramics: MTA Flow White (F), MTA Repair HP (HP), and Nishika Canal Sealer BG multi (BG). Disc-shaped samples were immersed in deionized water for 28 days to…

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Negative / Null Result ReportOpen accessMedicine

Association between changes in blood eosinophil levels and alterations in olfactory function in asthma.

Rhyou HI, Bae WY, Nam YH · 2026 · Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology

Olfactory dysfunction has been observed in asthma, but its underlying mechanisms are poorly understood. This prospective study assessed olfactory function using the YSK Olfactory Function Test in 30 patients with moderate to severe asthma,…

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Negative / Null Result ReportMedicine

Face-To-Face Vs. Online Behavioral Parent Training for Young Children with ADHD: Child and Parent Outcomes.

DuPaul GJ, Kern L, Dever BV et al. · 2026 · Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53

Objective Behavioral parent training is a first-line psychosocial intervention for young children with Attention-Deficit/Hyperactivity Disorder. Traditional face-to-face delivery is limited by access to therapists, feasibility, and/or…

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Negative / Null Result ReportOpen accessMedicine

The rise and fall of glucocorticoids and immunosuppressants in idiopathic pulmonary fibrosis: a historical paradigm shift driven by mechanistic understanding.

Wen B, Wu X, Ma X et al. · 2026 · Frontiers in immunology

The therapeutic strategy for Idiopathic Pulmonary Fibrosis (IPF) has undergone a fundamental transformation over recent decades. Combination therapy with glucocorticoids and immunosuppressants, particularly the "triple therapy" regimen…

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Negative / Null Result ReportMedicine

PD-L1 subpopulations of metastatic urothelial carcinoma demonstrate heterogeneity to chemotherapy: an integrated analysis of digitized trial results.

Zhou J, Jiang X, Liu Q et al. · 2026 · Cancer metastasis reviews

Efforts to translate advances in immunology into anti-cancer immunotherapies have progressed rapidly in recent years. Six antibodies acting on programmed death ligand 1 or programmed death 1 pathways were approved in 75 cancer indications…

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Failed Experiment ReportMedicine

Efficacy of low dose colchicine on left ventricular hypertrophy in patients with coronary artery disease: A randomized controlled trial.

Chichareon P, Suwannanon R, Thungthienthong M et al. · 2026 · British journal of clinical pharmacology

Background Left ventricular hypertrophy (LVH) contributes to a substantial risk of adverse outcomes in patients with coronary artery disease (CAD). Inflammation is one of the mechanisms responsible for LVH progression. The study aimed to…

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Failed Experiment ReportMedicine

ALSUntangled #82: N-acetylcysteine.

Yerraguntla S, Bakshi B, Chandran K et al. · 2026 · Amyotrophic lateral sclerosis & frontotemporal degeneration

N-acetylcysteine is a thiol-containing compound and a precursor of glutathione, with mechanistic plausibility for ALS, including reducing oxidative stress, regulating neuroinflammation, and mitigating mitochondrial dysfunction. Preclinical…

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Negative / Null Result ReportMedicine

Optimal endoscopic treatment for rectal neuroendocrine tumors, confirmed after forceps biopsy: a Korean Association for the Study of Intestinal Diseases multicenter, randomized noninferiority trial.

Gweon TG, Kim SJ, Myung DS et al. · 2026 · Gastrointestinal endoscopy

Background and aims Insufficient submucosal lifting because of pretreatment with forceps biopsy frequently complicates endoscopic treatment of rectal neuroendocrine tumors (NETs) and potentially affects procedural outcomes. Despite…

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Negative / Null Result ReportMedicine

Anti-inflammatory agents for the management of COPD - Quo Vadis?

Bakakos A, Sotiropoulou Z, Anagnostopoulos N et al. · 2025 · Respiratory medicine

Chronic obstructive pulmonary disease (COPD) remains a leading cause of morbidity and mortality around the globe. Its main characteristics are persistent respiratory symptoms and progressive airflow limitation, both of which are driven by…

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Negative / Null Result ReportOpen accessMedicine

A Retrospective Study of a Postoperative Inflammation-Based Score for Predicting Disease-Free Survival in Locally Advanced Rectal Cancer After Neoadjuvant Chemoradiotherapy.

Yang Q, Li J, Ding L et al. · 2026 · Cancer management and research

Background Growing research findings highlight the potential of inflammatory markers measured after surgery as prognostic indicators for survival outcomes in rectal carcinoma patients. However, their precise clinical significance remains…

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Negative / Null Result ReportOpen accessMedicine

The fluid paradox: dissociation between clinical and ultrasound parameters of fluid overload - results of the INCIVEX exploratory study.

Wong A, Cheah K, Papathanakos G et al. · 2026 · Anaesthesiology intensive therapy

Introduction Fluid management in critically ill patients relies on clinical assessment, fluid balance calculations and, increasingly, point-of-care ultrasound. However, the rela-tionships between these assessment modalities remain poorly…

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Negative / Null Result ReportMedicine

Survival outcomes of the use of adjuvant chemotherapy in resected esophagus cancer after neoadjuvant chemoradiotherapy.

Ke TM, Lin T, Chow WH et al. · 2026 · European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

Introduction Neoadjuvant chemoradiotherapy (nCRT) followed by surgery is the standard treatment for esophageal cancer, but the role of adjuvant chemotherapy remains unclear. This study investigates the survival benefits of adjuvant…

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Negative / Null Result ReportMedicine

Does the Timing of Lysis of Adhesions After Anterior Cruciate Ligament Reconstruction Affect Final Range of Motion?

Schneble CA, Miltenberg B, Jurgensmeier K et al. · 2025 · The American journal of sports medicine

Background Arthrofibrosis is seen in 1.7% to 38% of patients after anterior cruciate ligament reconstruction (ACLR) and has been associated with worse postoperative patient-reported outcomes. There are limited data regarding the optimal…

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Negative / Null Result ReportMedicine

Collaborative Navigation Improves Spatial Learning Across Symmetric and Asymmetric Locomotion in Virtual Reality.

Chakraborty S, Gagnon H, McNamara TP et al. · 2026 · IEEE transactions on visualization and computer graphics

Multi-user virtual reality (VR) systems support multiple locomotion methods, but coordination may be challenging when partners use different methods. We studied dyads navigating a shared virtual maze using symmetric (same) or asymmetric…

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Abandoned HypothesisOpen accessMedicine

Navigating the distal vasculature: Challenges and lessons learned from failed Thrombectomy trials.

Sporns PB, Almohammad M, Minnerup J et al. · 2025 · Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences

BackgroundWhile endovascular thrombectomy (EVT) is firmly established for large vessel occlusion stroke, recent enthusiasm for extending EVT to distal medium vessel occlusions (DMVOs) has been tempered by the neutral results of three major…

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Negative / Null Result ReportOpen accessMedicine

Comparing continuous bilateral quadratus lumborum block with continuous epidural block for analgesia and perioperative outcomes in colorectal cancer surgery: A noninferiority randomized controlled trial.

Roy S, Gupta N, Bharti SJ et al. · 2026 · Journal of anaesthesiology, clinical pharmacology

Background and aims Managing acute postsurgical pain following midline exploratory laparotomy in colorectal cancer patients involves various approaches, such as central neuraxial blockade, patient-controlled intravenous analgesia with…

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Negative / Null Result ReportOpen accessMedicine

Colchicine therapy in cardiovascular medicine: A literature review.

Trube J, Sabina M, Khanani A et al. · 2025 · American heart journal plus : cardiology research and practice

Introduction Inflammation is a key risk factor in cardiovascular diseases, such as atherosclerosis, and has been linked to increased mortality following myocardial infarction. While inflammation promotes tissue repair, sustained…

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Negative / Null Result ReportOpen accessMedicine

Quick glance at 'metabolic dysfunction associated steatotic liver disease' therapeutics: Targets, trials, and trends.

Zacharia GS, Ashraf MH, Sosa F et al. · 2025 · World journal of gastrointestinal pharmacology and therapeutics

Metabolic dysfunction-associated steatotic liver disease (MASLD), recognized as the most prevalent liver disease worldwide and a leading cause of liver transplantation, is closely associated with type 2 diabetes, cardiovascular disease,…

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