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Browse the failure-mode index

12,375 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Efficacy of 8% arginine associated with low-level laser therapy in the treatment of dentin hypersensitivity: randomized double-blind clinical trial.

Leal Barbosa V, Westenhofen D, Scherdien Silva P et al. · 2026 · Lasers in medical science

Purpose To evaluate the efficacy of 8% arginine-based desensitizing toothpaste and photobiomodulation (PBM), used alone or in combination, in the treatment of dentin hypersensitivity (DH). Materials and methods This randomized,…

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Negative / Null Result ReportMedicine

Diagnostic assessment of artificial intelligence reconstruction on accelerated prostate MRI: a retrospective, paired, multi-reader multi-case study.

van Lohuizen Q, Fransen SJ, Yiasemis G et al. · 2026 · European radiology

Objectives To determine whether AI-reconstructed prostate MRI at reduced acquisition times maintains prostate cancer (PCa) detection performance comparable to conventional scans. Materials and methods This multicenter, retrospective,…

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Negative / Null Result ReportMedicine

Age-related susceptibility to paraquat-induced neurotoxicity in male wistar rats: effects on neurobehaviour, substantia nigra cytoarchitecture, and alpha-synuclein levels.

Ichie K, Asomugha A, Okafor I · 2026 · BMC neuroscience

Background Parkinson's disease (PD) is a progressive neurodegenerative disorder strongly associated with dopaminergic neuronal degeneration and alpha-synuclein pathology. Paraquat (PQ) has been implicated in Parkinsonian neurodegeneration;…

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Negative / Null Result ReportMedicine

A Randomized Controlled Trial Analyzing the Likeability, Usability, and In-Use Efficacy of Mineral Sunscreens Across Diverse Skin Tones.

Shah M, Burshtein J, Zakria D et al. · 2026 · Journal of drugs in dermatology : JDD

Background Mineral sunscreens are increasingly favorable among consumers. However, mineral sunscreens typically cause a white cast that can impact consumer selection and application. Objective This study measured the whitening effect of…

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Negative / Null Result ReportOpen accessMedicine

Impact of Routine Intraoperative Lithotripsy on Surgical Strategy and Outcomes in Laparoscopic Bile Duct Exploration: A Single-Centre Cohort Study.

Elsamalouty I, Gupta A, Whitmore M et al. · 2026 · Cureus

Background Laparoscopic bile duct exploration (LBDE) enables single-stage management of common bile duct (CBD) stones. However, large or impacted stones often necessitate choledochotomy, which is associated with increased morbidity and…

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Negative / Null Result ReportMedicine

Long-Term Functional Outcomes After Prehabilitation in Frail Older Adults Undergoing Colorectal Cancer Surgery: A One-Year Prospective Cohort Study.

Dobrzycka M, Wołoszyn P, Prud M et al. · 2026 · Journal of clinical medicine

Background : Frailty is associated with adverse postoperative outcomes and functional decline in older adults undergoing colorectal cancer (CRC) surgery. The long-term course of frailty and functional outcomes among patients undergoing…

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Negative / Null Result ReportOpen accessMedicine

Early Weight Loss After Sleeve Gastrectomy Selectively Improves Intermetatarsal Angle Without Affecting Hallux Valgus Angle.

Türkoğlu F, Sarı S, Gencer EN et al. · 2026 · Journal of clinical medicine

Background/Objectives : While bariatric surgery is known to improve plantar pressure distribution and reduce foot-related symptoms, its impact on radiographic forefoot alignment parameters, such as the intermetatarsal angle (IMA) and…

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Negative / Null Result ReportMedicine

Temporal change in patients with mitral annular calcification after successful aortic valve intervention.

Abdul-Kafi O, Chedid M, Ansani T et al. · 2026 · Cardiovascular revascularization medicine : including molecular interventions

Background Patients with severe aortic valve stenosis and concomitant mild to moderate mitral stenosis (MS) or mitral regurgitation (MR) from mitral annular calcification (MAC) often undergo aortic valve replacement (AVR) while sparing the…

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Negative / Null Result ReportMedicine

Early impact of Japan's 2024 physician work hour reform on cardiovascular revascularization: a multi-center interrupted time series analysis using a National-Level DPC database.

Morishita T, Takada D, Itoshima H et al. · 2026 · Cardiovascular intervention and therapeutics

Japan introduced nationwide physician work-hour limits in April 2024. Because cardiovascular emergencies require continuous in-hospital availability, concerns existed that restricting duty hours could reduce access to revascularization or…

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Negative / Null Result ReportOpen accessMedicine

The Frontal QRS-T Angle Remains Unchanged in Patients Without Structural Heart Disease Receiving Flecainide Therapy.

Kucukosmanoglu M, Ardıc ML, Koca F et al. · 2026 · Journal of cardiovascular development and disease

Introduction: Prolongation of the QT interval and QRS duration, which are markers of ventricular repolarization and depolarization, has been reported in patients receiving flecainide therapy. However, the effects of flecainide on the QRS-T…

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Negative / Null Result ReportMedicine

Ocular Effects of Topical 1% Cyclopentolate in New Zealand White Rabbits: A Controlled Evaluation of Intraocular Pressure, Pupil Size, and Tear Production.

Arfaee F, Shariati S, Armin A · 2026 · Veterinary ophthalmology

Objective Mydriatic and cycloplegic agents are widely used in veterinary ophthalmology to enable posterior segment examination. This study evaluated the effects of topical 1% cyclopentolate on intraocular pressure (IOP), horizontal pupil…

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Negative / Null Result ReportMedicine

Metagenomic Insights into Gut Microbiota Alterations Following <i>Dendrobium huoshanense</i> Water Extract Intervention in Streptozotocin-Induced Type 1 Diabetic Rats.

Xu HJ, Liu QL, Zhang YF et al. · 2026 · International journal of molecular sciences

Dendrobium huoshanense water extract (DHWE) exhibits hypoglycemic effects in streptozotocin-induced type 1 diabetic (STZ-T1D) rats. However, its regulatory impact on the gut microbiota of T1D rats remains largely unclear. In this study,…

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Negative / Null Result ReportMedicine

The impact of postoperative calcaneocuboid joint articular surface gap and step on long-term outcomes in surgically treated calcaneal fractures: a brief report.

Sayyed-Hosseinian SH, Samadi S, Yazdi P et al. · 2026 · BMC musculoskeletal disorders

Background Calcaneal fractures, the most common tarsal fractures, often result in significant long-term disability and impose substantial healthcare burdens. Surgical intervention aims to restore hindfoot anatomy, but the role of…

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Negative / Null Result ReportMedicine

Effects of Combined Lipid-Based Nutrient Supplements and Malaria Preventive Treatment during Pregnancy on Malaria, Maternal Nutrition, and Birth Outcomes: A Scoping Review.

Parikh P, Zeilani M, Pieret A et al. · 2026 · Nutrition reviews

Malaria and malnutrition adversely affect maternal and neonatal health in Sub-Saharan Africa. While intermittent preventive treatment of malaria in pregnancy (IPTp) is widely used to reduce malaria incidence, the potential additional…

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Negative / Null Result ReportMedicine

Incidence of periprocedural myocardial injury and clinical outcomes after rotational atherectomy vs. intravascular lithotripsy.

Emori H, Shiono Y, Yamanobe H et al. · 2026 · International journal of cardiology

Background Intravascular lithotripsy (IVL) and rotational atherectomy (RA) are established plaque-modifying strategies for heavily calcified coronary lesions. Despite their different mechanisms, the incidence of significant periprocedural…

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