12,244 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Mhlana A, Milanes-Rodriguez G, Olojede SO et al. · 2026 · BMC endocrine disorders
Background Sleep is essential for maintaining the body's balance, particularly in regulating the Hypothalamic-pituitary-adrenal (HPA) axis, which controls cortisol, the main stress hormone. Cortisol follows a daily rhythm, but irregular…
View details →Mizuta I, Yamashita F, Sutoh Y et al. · 2026 · Geriatrics & gerontology international
Aim Cerebral small vessel disease (CSVD)-related MRI findings, including white matter hyperintensities (WMHs), are not rare in general elderly populations. The aim of this study was to elucidate the contribution of hereditary CSVD-related…
View details →Iturregui C, Liu CC, Carter RT et al. · 2026 · Veterinary ophthalmology
Justification Circadian variations in central corneal thickness (CCT) and their correlation with intraocular pressure (IOP) have not been reported in horses. This information may be clinically relevant when interpreting IOP readings.…
View details →Samim M, Jardon M, Vonck C et al. · 2026 · Journal of orthopaedics
Purpose To assess correlation of pre-operative symptoms, labral damage and chondrolabral junction pathology on MRI with intra-operative findings in patients undergoing hip arthroscopy for femoroacetabular impingement (FAI). Methods…
View details →Santo B, Romanello M, De Franco P et al. · 2026 · Journal of clinical medicine
Background/Objectives: The neutrophil-to-lymphocyte ratio (NLR) is a simple biomarker reflecting systemic inflammatory status and has been investigated in head and neck cancer (HNC) as a potential prognostic indicator. Its role in relation…
View details →Melek Ş, Orhun ÖT, Şenocak MG et al. · 2026 · The Journal of small animal practice
Objectives The present study evaluated the accuracy and agreement of heart rate and peripheral oxygen saturation measurements obtained using the Owlet Smart Sock in awake dogs with low activity levels, using a veterinary patient monitor as…
View details →Krishnamurthy P, Gnanaraj JP, Ganesan P · 2026 · JRSM cardiovascular disease
Background Diastolic wall strain (DWS) is based on linear elastic theory, which shows that impaired diastolic wall thinning reflects resistance to deformation in diastole and thus, increased diastolic myocardial stiffness. We aim to…
View details →Satishkumar SD, Meganathan S · 2026 · Physiotherapy research international : the journal for researchers and clinicians in physical therapy
Background and purpose Bharatanatyam, a venerable and highly structured classical dance form from India, requires significant physical strength, postural control, and precise movements. Dancers often begin to training during adolescence, a…
View details →U'wais MY, Al-Wahadni A, Tabnjh AK · 2026 · Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.]
Objective The aim of the present study was to evaluate the surface roughness and wear effect of three different ceramic materials. Materials and methods Thirty ceramic discs (10/group) were fabricated: Lithium disilicate (IPS e.max CAD,…
View details →Mitsia I, Matziou V, Polikandrioti M et al. · 2026 · Journal of clinical medicine
Background/Objectives : Pain is a common symptom in patients undergoing hemodialysis (HD) and may influence their quality of life. Pain self-efficacy may play an important role in self-management and adherence behaviors. This study aimed…
View details →Lu W, Waters M, Larby J et al. · 2026 · Pulmonary therapy
Introduction Cigarette smoking is a major driver of airway and systemic inflammation and contributes to the development and progression of chronic obstructive pulmonary disease (COPD). This study compared peripheral blood inflammatory…
View details →Okayasu I, Huang J, Fujita Z et al. · 2026 · Scientific reports
Prostaglandin E-major urinary metabolite (PGE-MUM) may be a useful biomarker for assessing muscle inflammation caused by physical exercise. To explore this, both male and female volunteer university students (n = 18) performed gradual…
View details →Nakano R, Ichisawa A, Saruta K et al. · 2026 · Nutrients
Background/Objectives: Serum 25-hydroxyvitamin D (25OHD) is a key determinant of calcium-phosphorus homeostasis and bone metabolism; however, its role as a modifier of the bone mineral density (BMD) response to romosozumab, a dual-action…
View details →Amini-Pozveh M, Nazarifar AM, Karimipoor M et al. · 2026 · BMC oral health
Background Patient satisfaction with complete dentures is multifactorial, with aesthetics being a key determinant. The color match between the denture base and the patient's natural gingiva is a critical aspect of denture aesthetics;…
View details →Wang L, Zhang X, Xia C et al. · 2026 · Interactive journal of medical research
Background Objective indicators are urgently needed to evaluate and monitor disease progression in patients with psoriasis. Objective This study aimed to verify the correlations between blood count-derived inflammatory markers and the…
View details →Selikhovkin A, Mamaev N, Martirova M et al. · 2026 · Insects
The European spruce bark beetle ( Ips typographus ) is the main pest of spruce in northwestern European Russia, particularly in the Leningrad Region. Its outbreaks occur quite frequently. However, the population dynamics of Ips typographus…
View details →Lam JR, Anastasopoulou C, Khattak ZE et al. · 2026
McArdle disease, also known as glycogen storage disorder (GSD) type 5, is a rare inherited metabolic disorder primarily affecting skeletal muscles. This condition arises from a deficiency or complete lack of the enzyme muscle glycogen…
View details →Konukçu-Kayar B, Karaalioğlu B, Demir B et al. · 2026 · The Journal of craniofacial surgery
Nasal skin thickness is a key determinant of surgical planning, postoperative healing, and aesthetic outcomes in rhinoplasty (RNP). However, objective assessment of nasal skin thickness is not always feasible in routine clinical practice.…
View details →Mattelaer N, David S, Steenackers N et al. · 2026 · International journal of endocrinology and metabolism
Background Dopamine is an essential neurotransmitter involved in motivation and reward. In obesity, altered dopaminergic responses to food may drive excess energy intake, implicating dopamine in the pathophysiology of obesity.…
View details →Zhu L, Thungjaroenkul P, Abhicharttibutra K et al. · 2026 · Journal of nursing measurement
Background and Purpose: Patient participation is fundamental to modern health care. No validated instrument exists to assess nurses' performance in enhancing patient participation within Chinese health care. This study developed and…
View details →Takla MKN, Rageh MRM, Aboalata MAM et al. · 2026 · Journal of back and musculoskeletal rehabilitation
BackgroundRecurrent hamstring strain injuries are associated with deficits in eccentric strength and altered muscle-tendon extensibility, which may persist and contribute to reinjury risk.ObjectiveTo examine the relationship between…
View details →Solera-de-Andrés C, Spang-Valencia P, Peralta-Calvo J · 2026 · The British journal of ophthalmology
Background Retinoblastoma (RB) treatment aims to ensure survival, globe preservation and visual function. Intra-arterial chemotherapy (IAC) has improved globe salvage, but there remains limited information on visual outcomes following this…
View details →Militsi E, Reingewirtz Y, Séverac F et al. · 2026 · Oral diseases
Background This study assessed the feasibility of remote halitosis diagnosis by evaluating VSC stability over 7 days and their association with periodontal parameters. Methods One hundred adult patients attending a periodontal examination…
View details →Wrobel J, Jablonska E, Matuk K et al. · 2026 · Life (Basel, Switzerland)
Background The aim of the study was to investigate whether red blood cell antigens (A, B, D, C w , C, c, E, e, K, k, Jk a , Jk b , Fy a , Fy b , Le a , Le b , M, N, S, s, and P1) from clinically relevant blood group systems were associated…
View details →Deniz-Şafak E, Adlım B · 2026 · BMC primary care
Objective As future healthcare providers, medical students play a critical role in the prevention, early recognition, and management of substance use disorders. However, the extent to which they are adequately prepared for this…
View details →Patel A, Meena DS, Santhosh K et al. · 2026 · Journal of neuroimmunology
Background Neurocognitive dysfunction remains an important complication among people living with HIV (PLWH). Early identification of neurocognitive dysfunction by using the International HIV Dementia Scale (IHDS) may help in the prevention…
View details →Yasuda H, Yokota K, Katabami T et al. · 2026 · Hypertension research : official journal of the Japanese Society of Hypertension
Primary aldosteronism (PA) causes biochemical abnormalities such as hypokalemia and metabolic alkalosis. This study aimed to compare the effects of aldosterone on serum potassium and corrected bicarbonate (cHCO 3 - , defined as Na - Cl -…
View details →Alotaibi W, Alrasheed S · 2026 · JPMA. The Journal of the Pakistan Medical Association
Objective To evaluate axial length, anterior chamber angle, anterior chamber depth, refractive errors and white-to-white corneal diameter, and to assess their inter-correlations with intraocular pressure among young individuals. Methods…
View details →Hsieh YT, Liao YC, Dulnuan HGP et al. · 2026 · Brain structure & function
Men typically display larger olfactory bulb (OB) volumes, while women demonstrate superior olfactory performance. Olfactory training (OT) has been shown to induce structural changes in OB, but whether sex influences OT-related plasticity…
View details →Baharnoori M, Glanz B, Polgar-Turcsanyi M et al. · 2026 · Journal of the neurological sciences
Background Serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) are promising biomarkers for Multiple Sclerosis (MS) disease activity. There is less known about their association with the symptomatic…
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