12,375 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Aman, Gencer, Sağlam et al. · 2026 · Medicina (Kaunas, Lithuania)
Background and Objectives : This study was conducted to investigate the effects of fragment size on clinical and radiological outcomes and the development of complications during the surgical treatment of pediatric lateral condyle…
View details →Chausheva, Shefket, Bocheva et al. · 2026 · Medicina (Kaunas, Lithuania)
Background and Objectives : Individuals with long-standing type 1 diabetes (T1D) remain at elevated cardiovascular risk (CVR). Adiponectin (ADNC) and leptin (LEP) are adipokines involved in metabolic and vascular homeostasis, yet their…
View details →Akler, Gelman, Radomislensky et al. · 2026 · The Israel Medical Association journal : IMAJ
Age is a well-established prognostic factor in civilian trauma, where adverse outcomes increase with ages. Whether this pattern holds true in military trauma, where populations, injury mechanisms, and systems of care differ fundamentally,…
View details →Albayrak · 2026 · Revista da Associacao Medica Brasileira (1992)
Systemic inflammation is closely associated with acute exacerbations of chronic obstructive pulmonary disease and may reflect the risk of future exacerbations. Blood-based inflammatory biomarkers represent simple and practical tools for…
View details →Xiao, Wei, Zhang et al. · 2026 · Journal of visualized experiments : JoVE
Hip fracture is a common and serious condition in elderly individuals, often associated with altered TNF-α signaling. However, few studies have explored whether changes in TNF pathway biomarkers contribute to the risk of hip…
View details →Yoonhee Shin, Bohyun Park, Nam-eun Kim et al. · 2022 · Journal of Preventive Medicine and Public Health
Objectives The aim of this study was to evaluate the subjective level of health-related quality of life of Korean healthcare workers using various quality-of-life instruments. Methods This study included 992 participants, who were doctors and nurses. A survey was conducted between November 28 and December 4, 2019. Data from 954 participants divided into 3 groups (physicians, residents, and nurses) were analyzed. Four measurement tools (29 questions) were used in the survey to evaluate subjective health status and well-being. Results In the Mayo Well-being Index, burnout during work (88.5%) and
View details →Wade J. Chalker, Anthony J. Shield, David A. Opar et al. · 2018 · PeerJ
Background Hamstring strain injuries (HSI) are one of the most prevalent and serious injuries affecting athletes, particularly those in team ball sports or track and field. Recent evidence demonstrates that eccentric knee flexor weakness and between limb asymmetries are possible risk factors for HSIs. While eccentric hamstring resistance training, e.g. the Nordic hamstring exercise (NHE) significantly increases eccentric hamstring strength and reduces HSI risk, little research has examined whether between limb asymmetries can be reduced with training. As augmented feedback (AF) can produce sig
View details →Flávio Kapczinski, Jair Mari, Luiz Henrique Junqueira Dieckmann et al. · 2024 · BMJ Open
Objective This study aims to conduct an overview on the comparative efficacy of valproate in acute mania, bipolar depression and maintenance treatment of bipolar disorder (BD).Method We performed an overview of systematic reviews with meta-analyses of randomised controlled trials (RCTs), registered in PROSPERO (CRD42024497749). We searched Medline and Cochrane Database of Systematic Reviews. Summary measures comparing valproate with placebo or other active drugs were described.Results We included 26 systematic reviews. For acute mania (31 RCTs, n=4376), valproate showed a significantly better
View details →Zhao Jiandong, Yuan Yongyi, Chen Jing et al. · 2012 · Journal of Translational Medicine
Abstract Background Many patients with enlarged vestibular aqueduct (EVA) have either only one allelic mutant of the SLC26A4 gene or lack any detectable mutation. In this study, multiplex ligation-dependent probe amplification (MLPA) was used to screen for copy number variations (CNVs) of SLC26A4 and to reveal the pathogenic mechanisms of non-syndromic EVA (NSEVA). Methods Between January 2003 and March 2010, 923 Chinese patients (481 males, 442 females) with NSEVA were recruited. Among these, 68 patients (7.4%) were found to carry only one mutant allele of SLC26A4 and 39 patients (4.2%) lacke
View details →fatemeh marhemati, reza mir arab razi, mostafa azizi · 2020 · آموزش پزشکی
Background and Objective: Creating and developing self-directed learning skills has become one of the goals of education in recent decades, and today's students need to learn and acquire comprehensive information in this regard, or better to say, learn information and communication technology skills, to Be able to use electronic services. The purpose of this study was to investigate the relationship between electronic citizenship knowledge and self-directed learning of students of University of Mazandaran and Babol University of medical sciences. Methods: This study is descriptive-analytical i
View details →LIU Yanan, WANG Likai, LIU Sisi et al. · 2019 · 口腔疾病防治
Objective To compare the polishing effects of three different polishing systems on machinable compos⁃ ite resins and to provide a basis for the rational selection of polishing systems in the clinic. Methods Block HC, Cerasmart, and Hyramic were fabricated into 90 test pieces. Then, 30 test pieces for each material were randomly divid⁃ ed into 3 groups with 10 pieces per group. The pieces were polished with the Vita Enamic® Polishing Set (Vita group), EVE RA341 composite polishing set (Eve group), and Toboo M elastic ceramic polishing set (Tob group). The surface roughness and gloss of each tes
View details →Jaya Prishni Devi Thakoor, Huixi Dong, Xiaojie Zhang et al. · 2016 · PLoS ONE
Background Duration of untreated psychosis (DUP) is a potentially modifiable prognostic factor of course and prognosis of psychiatric disorders. Few studies have demonstrated that different cultural backgrounds or perspectives on psychosis may be important factors to the DUP. This study attempted to explore whether the DUP was different in Chinese and Mauritians and to clarify potential influencing factors to a long DUP (>3 months). Methods 200 patients from China and 100 patients from Mauritius were enrolled in the study. Their respective family members were also recruited. Demographic and cl
View details →Justin Fulkerson, MSN, Robert Lowe, BSN, Tristan Anderson, BSN et al. · 2016 · Western Journal of Emergency Medicine
Introduction: This study compared the effects of vasopressin via tibial intraosseous (IO) and intravenous (IV) routes on maximum plasma concentration (Cmax), the time to maximum concentration (Tmax), return of spontaneous circulation (ROSC), and time to ROSC in a hypovolemic cardiac arrest model. Methods: This study was a randomized prospective, between-subjects experimental design. A computer program randomly assigned 28 Yorkshire swine to one of four groups: IV (n=7), IO tibia (n=7), cardiopulmonary resuscitation (CPR) + defibrillation (n=7), and a control group that received just CPR (n=7).
View details →Jun Seok Lee, Ah Ra Jung, Jung Min Park et al. · 2018 · Clinical and Experimental Otorhinolaryngology
Objectives To analyze laryngopharyngeal reflux (LPR) as an acidic, nonacidic, or mixed type according to 24-hour multi-channel intraluminal impedance (MII) pH monitoring and the clinical characteristics of each type. Methods Ninety patients were prospectively enrolled in this study. All patients underwent 24-hour MII pH monitoring as a diagnostic tool. Eighty-three patients were diagnosed with LPR. The patients were classified into three groups according to the pH of the hypopharyngeal probe: the acid reflux group, nonacid reflux group, and mixed reflux group. Subjective symptoms and objective
View details →Saumya Srivastava, Charu Eapen, Harramb Mittal · 2018 · Journal of Clinical and Diagnostic Research
Introduction: Shoulder Impingement Syndrome (SIS) is one of the common cause of shoulder ailment which leads to pain and restriction of the movements. Though Mobilisation with Movement and cryotherapy, both are found to be effective in managing SIS, there is no comparison done between the two treatments. Aim: To compare the effectiveness of Mobilisation With Movement (MWM) and cryotherapy in SIS. Materials and Methods: A randomised clinical trial was conducted on 22 subjects who aged between 18-64 years, and those who had a positive painful arc, three positive tests out of five i.e., Neer’s Im
View details →Zainab Y. Ejam, Şevki Adem, Asmaa Kadhim Gatea · 2024 · Medical Journal of Babylon
Background: Vascular endothelial growth factor (VEGF) is crucial for the implantation of a fertilized egg and for the development of placental blood vessels. This study was conducted to detect the serum VEGF level of pregnant with different types of assisted reproductive techniques in relation to the age group, body mass index (BMI), and type of infertility. Objectives: The aim of this study was to determine the levels of serum VEGF in different types of assisted pregnancy. Materials and Methods: Enzyme-linked immunosorbent assay was used for the detection of VEGF levels in the serum of pregna
View details →Pius Pum Tseuguem, Télesphore Benoît Nguelefack, Elvine Pami Nguelefack-Mbuyo et al. · 2026 · Scientific Reports
Abstract Extracts of Paullinia pinnata have demonstrated therapeutic effects in monosodium urate (MSU)-induced gout in rats, notably by reducing inflammation and hyperalgesia, as well as enhancing antioxidant activity in vivo. However, their in vitro antioxidant potential and their effects on MSU-stimulated macrophages remain insufficiently explored. This study aims to investigate the in vitro antioxidant properties of P. pinnata, with a particular focus on MSU uptake in stimulated macrophages. The in vitro antioxidant activities of aqueous (AEPP) and methanolic (MEPP) extracts of P. pinnata l
View details →Yuchun Liu, Ning Wang, Changsong Jiang et al. · 2020 · Scientific Reports
Abstract Among surface irrigation systems, long border and furrow are more adaptive to mechanized farming but may cause a non-uniform distribution of water and nutrients. In this study, field experiments were carried out in a flat silage corn field in Hebei, China to investigate the uniformity along the length of border or furrow to understand the spatial and temporal distribution characteristics of soil water, electrical conductivity, and nitrate. This will guide irrigation and fertigation management recommendations, land consolidation, and high standard farmland construction. Border and furr
View details →Hakan Hasman, Orhan Cinar, Ahmet Uzun, Erdem Cevik, Loni Jay, Bilgin Comert · 2012 · International Journal of Medical Sciences
Study objective: To compare the effect of normal saline (NS), lactated Ringer's, and Plasmalyte on the acid-base status of dehydrated patients in the emergency department (ED). Method: We conducted a prospective, double-blind, randomized trial of consecutive adult patients who presented to the emergency department with moderate-severe dehydration. Patients were randomly allocated to blindly receive normal saline (NS), lactated Ringer's or Plasmalyte at 20 ml/kg/h for 2 hours. Outcome measures of the study were pH and changes in electrolytes, including serum potassium, sodium, chloride and bica
View details →Daniel Tchemerinsky Konieczny, Alexander Wieck Fjaeldstad, Kristian Sandberg · 2024 · PLoS ONE
While measures to detect psychophysical olfactory ability are a crucial part of clinicians' assessment of potential olfactory loss, it gives no indication of how olfaction is experienced by the patient and these different aspects often deviate substantially. To ensure quality and reproducibility of subjectively reported olfactory experience and significance, the Importance of Olfaction Questionnaire (IO-Q) was introduced around a decade ago, and while initial validations have produced promising results, important aspects remain nearly unexamined. For example, the test-retest reliability has ra
View details →Bing-Hui Li, Tong Deng, Qiao Huang et al. · 2019 · American Journal of Men's Health
The objective of this study was to evaluate association between body mass index (BMI) and prostate volume (PV), international prostate symptom scores (IPSS), maximum urinary flow rate ( Q max ), and post-void residual (PVR) of Chinese benign prostatic hyperplasia (BPH) patients. All newly diagnosed BPH patients between September 2016 and August 2018 were selected and 788 patients were included. According to BMI, the patients were categorized into four groups, while according to PV, IPSS, Q max , and PVR, they were categorized into two groups based on clinical significant cutoffs. Univariable a
View details →N. Malik, A. Abbas, S. Ali · 2020
Nephrotic syndrome is one of common glomerular disorder in children.Response to steroid therapy maybe associated with interleukin 4 promoter site gene polymorphisms.The aim is to investigate the role of IL-4 – gene polymorphisms in disease…
View details →Han Yuan, Maeng-Kyu KIM · 2025 · Scientific Reports
Abstract This study investigated neuromuscular variations across low to moderate target force levels, three knee joint angles and tibial rotation positions, examining their correlations with muscle morphology and their collective impact on force steadiness (FS). Twelve young adult males performed knee extension tasks under three different tibial rotation conditions: internal rotation (IR), neutral rotation (NR), and external rotation (ER). All tasks involved submaximal isometric contractions at the knee joint. Participants performed submaximal isometric contractions at three knee joint angles
View details →Akihiko Kimura, Yuko Ishida, Mizuho Nosaka et al. · 2023 · Scientific Reports
Abstract Estimating time of death is one of the most important problems in forensics. Here, we evaluated the applicability, limitations and reliability of the developed biological clock-based method. We analyzed the expression of the clock genes, BMAL1 and NR1D1, in 318 dead hearts with defined time of death by real-time RT-PCR. For estimating the time of death, we chose two parameters, the NR1D1/BMAL1 ratio and BMAL1/NR1D1 ratio for morning and evening deaths, respectively. The NR1D1/BMAL1 ratio was significantly higher in morning deaths and the BMAL1/NR1D1 ratio was significantly higher in e
View details →Ayoola Ibifubara Aiyegbusi, Bosede Abidemi Tella, Ganiyat Adebanke Sanusi · 2020 · Nigerian Postgraduate Medical Journal
Background: Achilles tendinopathy (AT) is one of the most frequently reported ankle and foot overuse injuries. Prior studies have reported altered biomechanical variables of the lower limb as risk factors for the prevalence and severity of AT in athletes, especially in Caucasians, but there are few reports on African elite athletes. Because it is established that anthropometric and biomechanical values vary with racial disposition, this study was designed to investigate the association between selected physical and biomechanical variables of the lower limb and the prevalence and severity of AT
View details →Maryam Rad, Arash Shahravan, Ali Akbar Haghdoost · 2017 · Journal of Oral Health and Oral Epidemiology
BACKGROUND AND AIM: Foods containing carbohydrates have a major effect on the pathogenesis of dental caries. There is a direct correlation between frequency of consumption of foods containing sugar and dental caries. The purpose of this study was to evaluate the dietary patterns of 12-year-old children and their awareness about the effect of diet on oral health in Iran. METHODS: A cross-sectional survey was conducted on 1554 children aged 12 years in 5 provinces in Iran. Subjects were selected based on a multistage stratified cluster random sampling procedure. Data were collected by a cultural
View details →Amrita S Kumar, A Geetha, Jim Joe et al. · 2021 · Journal of Clinical and Diagnostic Research
Introduction: Blood donation is one of the most significant contributions that a person can make towards the society. A donor generally donates maximum 450 mL of blood at the time of donation. If 450 mL of blood is taken in a donation, men lose 242±17 mg and women lose 217±11 mg of iron. Hence, adequate iron stores are very important in maintenance of the donor’s health. Aim: To assess the influence of frequency of blood donation on iron levels of blood donors by estimating Haemoglobin (Hb) and other blood indices which reflect iron status of blood and serum ferritin which reflects body iron s
View details →Giuseppe Carruba, Maria Luisa Calagna, Ildegarda Campisi et al. · 2022 · Diseases
This paper presents a multi-professional integrated approach toward the recognition and management of the nutritional and psychological needs of cancer patients. In particular, the patients undertook a multi-professional, multistep process that included the collection of both personal and clinical data, the evaluation of anthropometric measures, nutritional status and psychometric indices, and an ensuing personalized nutritional prescription and psychological support, ultimately leading to combined nutritional and psychological interventions to control their adherence to a nutritional program
View details →Davis C Woodworth, Adelle Dagher, Adam Curatolo et al. · 2018 · PLoS ONE
The Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network has yielded neuroimaging and urinary biomarker findings that highlight unique alterations in brain structure and in urinary proteins related to tissue remodeling and vascular structure in patients with Urological Chronic Pelvic Pain Syndrome (UCPPS). We hypothesized that localized changes in diffusion tensor imaging (DTI) measurements might be associated with corresponding changes in urinary protein levels in UCPPS. To test this hypothesis, we created statistical parameter maps depicting the linear corre
View details →Hana Wakasa, Satoshi Sunohara, Takashi Kimura et al. · 2025 · PLoS ONE
Obesity is a growing global health concern and has been associated with increased mortality from various cancer types, including hematological malignancies. However, evidence for this association in Asian populations, particularly among Japanese adults, remains limited. Thus, this study aimed to examine the association between obesity and mortality due to hematological malignancies. Data from 97,073 participants in the Japan Collaborative Cohort (JACC) Study were analyzed. The participants were followed for a mean duration of 17 years. Body mass index (BMI) was calculated using self-reported h
View details →