12,375 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Singhal M, Nidadavole K, Murphy DS et al. · 2026 · Journal of pharmaceutical sciences
Dissolution testing is performed to understand the rate and extent of drug release for assurance of in vivo bioavailability. In this case study, an immediate-release tablet of an investigational BCS Class II compound exhibited slow and…
View details →Dolak KD, Davila S, White PC · 2026 · BMC pediatrics
Background Procalcitonin is a useful screen for bacterial infection, but its utility in pediatric diabetic ketoacidosis (DKA) is unknown. Methods We conducted a retrospective study of DKA patients admitted to two pediatric hospitals in…
View details →Drake C, Buckman C, Brucker A et al. · 2026 · JAMA internal medicine
Importance Patients with diabetes and food insecurity are at greater risk of adverse health outcomes. Effective strategies to promote healthy food access are urgently needed. Objective To evaluate the effect of a produce prescription (PRx)…
View details →Tamás S, György H, András M et al. · 2026 · The international journal of lower extremity wounds
IntroductionThe treatment of chronic non-healing wounds represents a great challenge in healthcare, especially in rehabilitation medicine, as it contributes significantly to increased patient mortality and morbidity. Various types of laser…
View details →Anfosso M, Schubert M, Cremers JF et al. · 2026 · Andrology
Background Non-obstructive azoospermia (NOA) represents the most severe form of male infertility. Hypogonadism is common in NOA patients, and normal testosterone (T) levels are considered essential for spermatogenesis. Fertility-preserving…
View details →de Wasseige S, Mainguy-Seers S, Lavoie JP · 2026 · Equine veterinary journal
Background During clinical remission of severe equine asthma (SEA), affected animals can be challenging to distinguish from healthy horses. In humans, the degree of bronchodilation achieved with a β 2 -adrenergic bronchodilator is helpful…
View details →Untan I, Sabur V · 2026 · International journal of general medicine
Background Flank pain is a common emergency department (ED) presentation with a wide differential diagnosis. The albumin-to-globulin ratio (AGR) reflects both nutritional status and systemic inflammation, but its utility in…
View details →Lee-Miller CA, Kairalla JA, Hibbitts E et al. · 2026 · Blood advances
Abstract Patients with central nervous system (CNS) disease at diagnosis on Children's Oncology Group (COG) B-acute lymphoblastic leukemia (B-ALL) trials AALL0331 and AALL0232 had inferior outcomes, largely secondary to CNS relapse. In…
View details →Kong BH, Dillon K, Brady CM et al. · 2026 · The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
ObjectiveTo determine whether the Centers for Disease Control and Prevention's Social Vulnerability Index (SVI) influences models of adherence to speech evaluations beyond individual demographic and clinical factors.DesignRetrospective…
View details →Matsuo A, Kanaya M · 2026 · Psychoneuroendocrinology
Stress contributes significantly to visceral pain hypersensitivity in irritable bowel syndrome (IBS). Although stress during critical developmental periods, such as chronic social defeat stress (CSDS) in adolescence or early-life…
View details →Wamsley EJ, Barron J, Livingston WH · 2026 · Journal of cognitive neuroscience
Memory is consolidated during "offline" states of reduced attention to the external stimulus environment, including sleep and resting wakefulness. While consolidation is usually studied on a timescale of hours to days, accumulating…
View details →Piazza FRG, Schuch JB, Ferreira DNSDS et al. · 2025 · Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)
Objective N-acetylcysteine (NAC) is a medication known for its hepatoprotective properties and potential to reduce cravings and psychoactive substance use. Vitamin D is metabolized in the liver, and individuals with alcohol abuse often…
View details →Chen PA, Hsueh YC, Lin YC et al. · 2026 · The Journal of arthroplasty
Background Whether the addition of magnesium sulfate (MgSO 4 ) to intra-articular analgesic cocktails improves early pain after total knee arthroplasty (TKA) remains uncertain. Methods This prospective, double-blind, within-patient…
View details →Leak M, Giambini H, Cheever K et al. · 2026 · Journal of sport rehabilitation
Context Thoracic mobility is integral to respiratory function and mobility of the neck, shoulder, and spine. The efficacy of thoracic mobility exercises in enhancing respiratory function and spinal range of motion (ROM) is well documented…
View details →Mayer J, Al-Sheikhli J, Wang X et al. · 2026 · JACC. Clinical electrophysiology
Background Functional extra-stimulus (ES) substrate mapping has been shown to reduce the recurrence of ventricular tachycardia (VT) compared with intrinsic rhythm mapping. However, there is no standardized approach to functional ES…
View details →Mattila N, Meinberg M, Juppo A et al. · 2026 · Scandinavian journal of gastroenterology
Objective To assess whether a gargled articaine solution makes gastroscopy more tolerable for the patient. Background Gastroscopy is an unpleasant experience for most people. A drug that is easy to use, has a fast onset, enables quick…
View details →Hoberstorfer T, Nopp S, Steiner D et al. · 2026 · Journal of thrombosis and haemostasis : JTH
Growth differentiation factor-15 (GDF-15) has been proposed as a bleeding biomarker. To evaluate the predictive value of GDF-15 for clinically relevant bleeding (CRB, major bleeding and clinically relevant non-major bleeding [CRNMB])…
View details →Asmundo L, Pansini V, Monti CB et al. · 2026 · Abdominal radiology (New York)
To evaluate the diagnostic performance of hepatic extracellular volume (ECV) fraction derived from delayed single-energy CT for identifying graft rejection in liver transplant recipients and its added value over clinical parameters. This…
View details →Khadanga S, Yant B, Savage PD et al. · 2026 · Journal of cardiopulmonary rehabilitation and prevention
Purpose Despite the benefits, cardiac rehabilitation (CR) is underutilized, particularly in women. Case management (CM) has been shown to reduce the risk of cardiovascular disease and improve health outcomes. The purpose of this study was…
View details →Kikkawa K, Takeuchi M, Sakaguchi D et al. · 2026 · Journal of anesthesia
Purpose Monitored anesthesia care (MAC) is increasingly used for various procedures, but sedation-related upper airway obstruction may lead to hypoxemia or conversion to general anesthesia. This study evaluated whether preoperative tongue…
View details →Jin Z, Ueda K, Higo F et al. · 2026 · Anesthesia and analgesia
Background Prehabilitation during unavoidable surgical delay after an acute femoral neck fracture may mitigate rapid functional decline but is often limited by movement-evoked pain. The pericapsular nerve group (PENG) block is a…
View details →Navarro LP, Combes X, Galinski M et al. · 2026 · BMC emergency medicine
Introduction We aimed to assess the relationship between arterial partial pressure of carbon dioxide (PaCO 2 ) and end-tidal carbon dioxide (EtCO 2 ) according to three prehospital hemodynamic status and to evaluate whether…
View details →Jorritsma R, Bijkerk HJC, Martina R et al. · 2026 · Irish veterinary journal
In September 2023, the official national reference laboratory confirmed the presence of BTV serotype 3 in The Netherlands. In the following weeks, it appeared that the infection caused very severe clinical signs in sheep, but it was…
View details →Burtnett SL, Bomberger RA, Harvatine KJ · 2026 · Journal of dairy science
Oleic acid has a lower risk for biohydrogenation-induced milk fat depression (MFD) than linoleic acid and can act as an emulsifier to aid fatty acid (FA) digestion in the small intestine. Our objective was to evaluate the effect of high…
View details →Alachkar MN, Schlegl J, Bannehr M et al. · 2026 · Journal of cardiovascular development and disease
Background The TRI-SCORE was developed to predict mortality after tricuspid valve surgery and has demonstrated prognostic value in patients undergoing transcatheter tricuspid valve interventions (TTVI). Right ventricular-pulmonary arterial…
View details →Ptaszek B, Kurek O, Podsiadło S · 2026 · Lymphatic research and biology
Purpose In times when health and physical activity are gaining in value, the search for effective methods to support fitness and improve quality of life is becoming a priority. One of the therapies that is gaining increasing popularity is…
View details →Eves R, Deppe M, Kandler C et al. · 2026 · Journal of child psychology and psychiatry, and allied disciplines
Background Past studies indicate significant associations between birth anthropometrics, such as relative birthweight or head circumference, and later cognitive performance. Using twin data, we investigated whether these associations are…
View details →Toillon I, Badoud I, Ferrari S et al. · 2026 · Bone
Type 1 diabetes is associated with increased fracture risk, yet the respective contributions of insulin deficiency and replacement to skeletal fragility remain poorly understood. Using insulin-deficient male Akita mice, we characterized…
View details →Kabuga E, Nandi D, Burrell S et al. · 2026 · The Journal of the Acoustical Society of America
Individual animal identification is essential for wildlife conservation and management, aiding in estimating abundance and related parameters. The feasibility of identifying individual field crickets (Plebeiogryllus guttiventris) from…
View details →Garitaonaindia Y, Witteveen S, Dionisio E et al. · 2026 · Journal of the National Cancer Institute
Background Pathological complete response (pCR) and circulating tumor DNA (ctDNA) clearance are increasingly used as intermediate endpoints in neoadjuvant and perioperative immunotherapy (IO) trials. However, whether complete pathological…
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