12,244 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Blackman J, Friesen D, Sikkel MB et al. · 2026 · Applied clinical informatics
Objectives The objective of this study is to evaluate whether ChatGPT models can reliably apply the DISCERN instrument, a 16-question human-scored rubric developed in 1999 to evaluate consumer health information, and assess the impact of…
View details →Stewart KM, Sawicki GS, Young AJ et al. · 2026 · Journal of biomechanics
Individuals post-stroke with hemiparetic gait often experience impaired mobility, which can be restored using powered exoskeletons. Specifically, hip exoskeletons can deliver positive work to the leg to help initiate leg swing; however, it…
View details →Norling M, Eriksson N, Westerberg E et al. · 2026 · Muscle & nerve
Introduction/aims Physical activity and sleep influence fatigue in myasthenia gravis (MG), and digital health technologies (DHT) enable objective monitoring of these behaviors in daily life. Using this approach, we evaluated whether a…
View details →Orlowska M, Saleh MHA, Decker A et al. · 2026 · Journal of periodontology
Background This randomized controlled trial aims to evaluate alveolar ridge preservation (ARP) with or without a biologically active amnion-chorion membrane (BACM). Methods Thirty patients requiring tooth extraction in the esthetic zone…
View details →Nehme Z, Mahony E, Nehme E et al. · 2026 · Resuscitation
Aim To determine whether defibrillation with manual pressure augmentation (MPA) reduces transthoracic impedance and improves cardioversion and survival from initially shockable out-of-hospital cardiac arrest (OHCA) compared with standard…
View details →Betat A, Santos VD, Oliveira CGA et al. · 2026 · Journal of hypertension
Background Arterial hypertension has been linked to cognitive decline, potentially through cerebrovascular alterations and associations with Alzheimer's disease. A positive correlation between elevated serum cholesterol levels and…
View details →Li Y, Yan X, Li J et al. · 2026 · Ultrasound in medicine & biology
Objectives This study aimed to establish a machine-learning model that integrates contrast-enhanced ultrasound (CEUS) radiomics, conventional ultrasound (US) radiomics and clinical features for distinguishing mummified thyroid nodules…
View details →Potkrajcic V, Wahl D, Frantz S et al. · 2026 · Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]
Background Postoperative radiotherapy following surgical stabilization in patients with bone metastases is commonly recommended. The aim of the study was to validate existing prognostic scores and parameters for local control and survival…
View details →Allende JB, Campos-Bijit V, Morales-Gómez C et al. · 2026 · Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.]
Objective To synthesize umbrella-level evidence on laser or light activation and photobiomodulation in in-office dental bleaching, including whitening efficacy, tooth sensitivity, and biological safety. Systematic reviews were searched in…
View details →Melamed A, Small K, McCourt C et al. · 2026 · Midwifery
Problem Antenatal risk assessment and classification dominates midwifery care but may not be improving outcomes and may introduce iatrogenic harm. Background Midwifery-led care and birth settings promote good birth outcomes and women's…
View details →Shibasaki S, Endo H, Yamamoto H et al. · 2026 · Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
Objective To evaluate contemporary short-term outcomes of robotic gastrectomy (RG) approximately 5 years after its widespread implementation, compared with laparoscopic gastrectomy (LG) using a nationwide Japanese database. Background RG…
View details →Franco-Ortega JA, Albertos-Alpuche PJ, Mora-Medina P et al. · 2026 · Journal of fish diseases
Immersion anaesthesia is widely used in fish handling and research, yet optimization of protocols requires not only effective immobilization but also consideration of internal physiological responses. This study evaluated the effects of…
View details →Cardon de Lichtbuer P, Declerck W, Rosseel Q et al. · 2026 · Journal of cataract and refractive surgery
Purpose To evaluate the effectiveness and usability of a safety-first, clinician-validated conversational artificial intelligence (AI) chatbot for cataract surgery education compared with standard brochures. Setting University Hospital (UZ…
View details →Ugail H, Howard N, Elmahmudi AA et al. · 2026 · Sensors (Basel, Switzerland)
Major depressive disorder remains difficult to diagnose objectively, as routine assessment is still largely dependent on clinical interview and rating scales. Resting-state electroencephalography (EEG) is an attractive complementary…
View details →Kiraly P, Lippera M, Ally N et al. · 2026 · Retina (Philadelphia, Pa.)
Purpose To assess whether external drainage of subretinal fluid (SRF) improves anatomical or visual outcomes in scleral buckle surgery for rhegmatogenous retinal detachment (RRD). Methods Retrospective review of 609 primary scleral buckles…
View details →Azulay N, Singstad BJ, Schirmer H et al. · 2026 · Scientific reports
In Norway, NORRISK2 is the government-recommended risk model for predicting an individual's 10-year probability of getting cardiovascular disease (CVD). This study aims to investigate the potential for improvement of CVD prediction by…
View details →Bröer S, Filor V, Bäumer W · 2026 · Journal of veterinary pharmacology and therapeutics
According to the European Association of Establishments for Veterinary Education (EAEVE), a graduate of veterinary medicine should be able to prescribe and dispense "medicines correctly and responsibly in accordance with legislation and…
View details →Jegarl AM, Martin M, Cormier NR et al. · 2026 · Anesthesiology
Background Whether adding a bilateral superficial cervical plexus block to a thyroidectomy enhanced recovery pathway improves postoperative quality of recovery remains uncertain. Methods In a single-center prospective, randomized,…
View details →Jecan A, Melinte RM, Tomoaia G et al. · 2026 · Journal of clinical medicine
Background : Vitamin K2 (menaquinone) has been studied as a molecule with important effects on bone metabolism and has been proposed as a potential adjuvant in fracture healing, particularly under osteoporotic conditions. However, its…
View details →Kılıç HS · 2026 · European journal of dentistry
Objective This article aims to compare the polymerization effectiveness of two curing modes of a polywave LED unit in four conventional resin composites at a 2-mm increment thickness, using bottom/top microhardness ratios as the evaluation…
View details →Chang JJ, Foreman B, Kepplinger D et al. · 2026 · Neurosurgical review
Pressure reactivity index (PRx) is a surrogate for cerebral autoregulation and has been used for prognostication in aneurysmal subarachnoid hemorrhage (SAH). We examined patient-specific temporal courses of PRx and identified time…
View details →Chun SH, Seo S, Cho JH et al. · 2026 · Head & neck
Background The benefit of consolidation programmed cell death protein 1 (PD-1) blockade after chemoradiotherapy in locoregionally advanced nasopharyngeal carcinoma (NPC) remains unclear. Methods Patients with stages II-IVB NPC were…
View details →Hongoro DJ, Kengne AP, Peer N et al. · 2026 · AIDS and behavior
Mobile health (mHealth) interventions offer scalable support for adherence and self-management, yet their effects on health-related quality of life (HRQoL) among people living with HIV (PLWH) and comorbid hypertension remain unclear. We…
View details →Yamamoto K, Shinno N, Omori T et al. · 2026 · Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
Background Older patients undergoing gastrectomy frequently exhibit sarcopenia and reduced physiologic reserve, increasing vulnerability to perioperative muscle loss. However, randomized evidence supporting multimodal exercise-nutrition…
View details →Dachy G, Mooyaart JE, Gabellier L et al. · 2026 · Bone marrow transplantation
Lymphodepleting conditioning (LD) with fludarabine and cyclophosphamide is critical to ensure optimal expansion and persistence of CD19 CAR T-cells. We conducted a retrospective EBMT registry study to assess the impact of fludarabine…
View details →Nasr MH, Abdulrasool Hassan B, Othman N et al. · 2026 · Journal of pharmaceutical policy and practice
Background Vitamin D deficiency is common among individuals with type 2 diabetes mellitus (T2DM) and has been linked to insulin resistance and poor glycaemic control. However, findings from randomised controlled trials remain inconsistent.…
View details →Zorko K, Munda A, Janež A et al. · 2026 · American journal of obstetrics and gynecology
Background Self-monitoring of blood glucose represents the standard for glycemic monitoring in gestational diabetes mellitus, while the role of continuous glucose monitoring remains uncertain. Objective To assess whether adjunctive flash…
View details →Kunz Coyne AJ, Gray R, Gonnabathula P et al. · 2026 · The Journal of antimicrobial chemotherapy
Background Stenotrophomonas maltophilia complex infections are difficult to treat because of intrinsic resistance mediated by the L1 metallo-β-lactamase and L2 serine β-lactamase. Although aztreonam/avibactam is clinically available,…
View details →Peretz-Kahlon M, Wood K, Harris A et al. · 2026 · Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
BACKGROUND: Branch retinal vein occlusion (BRVO) frequently results in macular edema (ME), impairing visual acuity (VA). Intravitreal anti-vascular endothelial growth factor (VEGF) injections are standard first-line therapy but the benefit…
View details →Mustafa YH, Keogh RJ, Barry SL et al. · 2026 · Irish journal of medical science
Background Glioblastoma is the most common malignant brain tumour in adults and carries a poor prognosis despite advances in molecular characterisation and therapy. The 2021 World Health Organisation classification redefined glioblastoma…
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