e-ISSN: Pending
WASTE Journal

Browse the failure-mode index

12,375 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Hyaluronidase activity of Indian ornamental tarantula (Poecilotheria regalis) venom is significantly reduced by commercial Latrodectus mactans and American scorpion antivenoms

García-García M, Mosqueda J, Escobar Cabrera JE et al. · 2025 · Toxicon

A recent clinical case involving a Poecilotheria regalis bite was treated with Mexican L. mactans antivenom (Aracmyn Plus, Silanes, Mexico), resulting in the improvement of some of the symptoms. This could be attributed to cross-reactivity…

View details →
Negative / Null Result ReportMedicine

Artificial intelligence reliability in implant dentistry: A comparative analysis of clinical accuracy and hallucination patterns across multiple language models.

Hooshiar MH · 2026 · The Journal of prosthetic dentistry

Statement of problem Artificial intelligence (AI) language models have been increasingly used for clinical decision-making in implant dentistry and for scholarly writing. Yet, their reliability, fabrication rates, and comparative…

View details →
Negative / Null Result ReportMedicine

Reducing Artifact Preprocessing in Heart Rate Variability-Based Personalized Psychosis Prediction Using Adaptive Long Short-Term Memory Models.

Tsakmaki PV, Tasoulis S, Georgakopoulos SV et al. · 2025 · International journal of neural systems

This research looks at the use of long-short-term memory (LSTM) networks to predict psychosis, in patients within the schizophrenia spectrum, based on Heart Rate Variability (HRV) data acquired from wearable devices. Our primary objective…

View details →
Negative / Null Result ReportMedicine

Optimized Autologous Serum and Activated Leukocyte-Poor Platelet-Rich Plasma Eye Drops Production Protocol: Effect of Fasting, Filtering, and Complement Inactivation on the Concentration of Growth Factors and Lipids.

Sanak F, Iselin K, Kaufmann C et al. · 2026 · Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics

Purpose To analyze the effect of fasting on volume, growth factor, and lipid concentration in eye drops derived from autologous serum (AS) and leukocyte-poor platelet-rich plasma (LP-PRP). To assess changes in protein and growth factor…

View details →
Negative / Null Result ReportMedicine

Reducing inappropriate vitamin D testing: an analysis of three sequential diagnostic stewardship interventions and the carbon footprint implications.

Hughes C, Myers MA, Tickell-Painter M et al. · 2026 · Clinical biochemistry

Introduction The climate crisis is a health crisis, and healthcare contributes to this via consumption of resources, the release of greenhouse gases, and the generation of waste. Pathology testing underpins most healthcare, and the vast…

View details →
Negative / Null Result ReportMedicine

West Nile Virus-Neutralizing Plasma for West Nile Virus Disease.

Regev-Yochay G, Barda N, Shusterman Y et al. · 2026 · NEJM evidence

Background In 2024, Israel faced a major West Nile virus (WNV) disease outbreak. We aimed to evaluate the efficacy and safety of WNV-neutralizing plasma for hospitalized patients with WNV disease. Methods We conducted a randomized,…

View details →
Negative / Null Result ReportMedicine

Using Compression Stockings to Prevent Recurrence of Vasovagal Syncope: A Randomized Sham-Controlled Trial.

Tavolinejad H, Bozorgi A, Emkanjoo Z et al. · 2025 · Journal of the American College of Cardiology

Background Vasovagal syncope (VVS) is a common yet challenging condition with limited effective treatments. Elastic compression stockings (ECS) have been proposed as a potential therapy, but their real-world effectiveness remains unclear.…

View details →
Negative / Null Result ReportMedicine

Effects of routine invasive management on reinfarction risk in older adults with frailty and non-ST-segment elevation myocardial infarction: a subanalysis of a randomised clinical trial.

Sanchis J, Bueno H, Martí Sánchez D et al. · 2025 · Heart (British Cardiac Society)

Background Clinical trials and meta-analyses indicate a reduced reinfarction risk with invasive management in older patients with non-ST-segment elevation myocardial infarction (NSTEMI). This study investigated whether similar benefits…

View details →
Negative / Null Result ReportOpen accessMedicine

Virtual Nursing for the Care of Hospitalized Patients.

Muir KJ, Maye A, McHugh MD et al. · 2025 · JAMA network open

Importance It is unknown if virtual nursing (VN) enhances care quality or improves the workload of bedside nurses in hospitals. Objective To describe what services VNs provide to patients and nurses in hospitals; to evaluate whether the…

View details →
Negative / Null Result ReportMedicine

Managing visceral leishmaniasis-associated hemophagocytic lymphohistiocytosis in pediatric patients: Clinical insights and treatment strategies.

Zhang J, Suo T, Cheng Y et al. · 2026 · Journal of investigative medicine : the official publication of the American Federation for Clinical Research

Hemophagocytic lymphohistiocytosis (HLH) secondary to visceral leishmaniasis (VL-HLH) is a severe and often fatal condition marked by systemic inflammation and immune dysfunction. In this retrospective cohort study at Shanxi Children's…

View details →
Negative / Null Result ReportMedicine

Extended use of point-of-care technology by acute community nurses during in-home assessment of older adults with potential acute respiratory conditions: a parallel-group, open-label, randomised controlled trial.

Smedemark SA, Jarbøl DE, Laursen CB et al. · 2026 · The lancet. Healthy longevity

Background Diagnosing acute respiratory conditions in adults older than 65 years is challenging due to age-related physiological changes, which increase diagnostic complexity and the risk of hospital admission. We investigated whether…

View details →
Negative / Null Result ReportOpen accessMedicine

C4/5 Facetectomy Is Associated With Improved Recovery of C5 Palsy in Severe Foraminal Stenosis After Posterior Cervical Decompression and Fusion.

Nakamura Y, Murata S, Yabe T et al. · 2026 · Cureus

Introduction C5 palsy is a disabling complication after posterior cervical decompression and fusion (PCDF). Whether C4/5 facetectomy reduces the incidence or improves the outcomes of C5 palsy remains uncertain. Therefore, this study aimed…

View details →
Negative / Null Result ReportMedicine

Questioning routine antibiotic prophylaxis in sialendoscopy: a single-surgeon 164-case analysis.

Holland K, Gomeniouk O, Owen GS et al. · 2026 · European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

Purpose Determine if there is a difference in post-operative infection rates in patients undergoing sialendoscopy who received pre-, post-operative, both pre and post, or no antibiotics. Methods Retrospective chart review of patients who…

View details →
Negative / Null Result ReportMedicine

Safety, Efficacy, and Immunogenicity of a Multivalent Adjuvanted S. aureus Vaccine in Adults with Recent Skin And Soft Tissue Infections: An Observer-blind, Randomized, Placebo-controlled, Multinational Phase 1/2 Trial.

Athan E, Greenberg RN, Baker DA et al. · 2026 · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Background A vaccine that prevents Staphylococcus aureus skin and soft tissue infections (SA-SSTIs) would have a major impact on public health. Methods A two-part randomized study began with a phase 1, first-in-human, dose-escalation that…

View details →
Negative / Null Result ReportMedicine

Prevention of premature birth: Impact of the Explicit Health Guarantee.

Carvajal-Encina F, Carvajal Rojas L · 2025 · Andes pediatrica : revista Chilena de pediatria

Prematurity is a challenge due to its high morbidity and mortality. The Explicit Health Guarantees (GES) for Premature Birth Prevention, implemented in 2005, have not been evaluated. Objective To evaluate the impact of the GES on perinatal…

View details →
Negative / Null Result ReportOpen accessMedicine

Effect of Erector Spinae Plane Block Applied to Painful Herpes Zoster Patients Who Failed to Respond to Pregabalin Treatment on Immunological Marker Levels and Postherpetic Neuralgia Incidence Rate.

Büyükbezirci G, Demiralp N, Keles S et al. · 2026 · Journal of pain research

Purpose Postherpetic neuralgia (PHN) is one of the most debilitating complications of herpes zoster and represents a major cause of chronic neuropathic pain. Increasing evidence suggests that immune dysregulation plays a critical role in…

View details →
Negative / Null Result ReportOpen accessMedicine

Intraoperative hypotension after remimazolam or propofol induction with sevoflurane maintenance in angiotensin II receptor blockers-treated patients: a randomized controlled trial.

Kim HJ, Kim N, Kim J et al. · 2025 · Scientific reports

Robot-assisted laparoscopic prostatectomy (RALP) is associated with hemodynamic shifts; patients on angiotensin receptor blockers (ARBs) are especially susceptible to intraoperative hypotension. We investigated whether induction with…

View details →
Negative / Null Result ReportMedicine

Increase in Diaphragm and Expiratory respiratory muscles thickness is not associated with postoperative pulmonary complications after thoracic surgery: A prospective ultrasound cohort study.

Berthoud V, Nguyen M, Vinay J et al. · 2026 · Anaesthesia, critical care & pain medicine

Introduction In thoracic surgery, all respiratory muscles have a significant increase in workload, and recruitment of these muscles may be important, especially in the presence of diaphragmatic dysfunction. Evaluating diaphragmatic and…

View details →