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WASTE Journal

Browse the failure-mode index

12,241 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Daily Chlorhexidine Bathing for the Prevention of Nosocomial Infections in Critically Ill Patients (CLEAN-IT): a multicentre, cluster-randomised, crossover trial.

Tomazini BM, Besen BAMP, Gales AC et al. · 2026 · Lancet regional health. Americas

Background Critically ill patients are at risk of nosocomial infections, acquisition of multidrug-resistant pathogens, and substantial antimicrobial consumption. We assessed whether bathing with chlorhexidine reduces these outcomes…

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Negative / Null Result ReportMedicine

Bio-based polyurethane coatings for controlled-release phosphorus fertilizers: Synthesis, characterization and effect on P use efficiency.

Cancellier EL, Degryse F, da Silva RC et al. · 2025 · The Science of the total environment

The use of petroleum-based coatings in controlled-release fertilizers (CRFs) raises environmental concerns and it is unclear if, and to what extent, CRFs can improve P use efficiency. This study explored the synthesis of bio-based…

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Negative / Null Result ReportOpen accessMedicine

The effects of balanced crystalloid versus plasma on endothelial injury, systemic inflammation, and coagulation in experimental endotoxaemia: a randomised human volunteer study.

van den Brink DP, Hilderink BN, Kleinveld DJB et al. · 2026 · British journal of anaesthesia

Background During shock, neutrophil-mediated glycocalyx degradation can lead to exposure of the procoagulant endothelial surface and consequent organ injury. Resuscitation using crystalloid fluids may augment this endothelial damage, while…

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Negative / Null Result ReportMedicine

Allyl isothiocyanate as a natural fumigant for protecting soybean and bean grains against Aspergillus parasiticus growth and aflatoxin production

Lopes LF, Favoretto VR, Evangelista AG et al. · 2025 · European food research & technology.

This study evaluated the efficacy of gaseous allyl isothiocyanate (AITC) in inhibiting Aspergillus parasiticus growth and aflatoxin production in soybeans and beans stored at 85% relative humidity for 35d. Samples of 50 g of soybeans or…

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Negative / Null Result ReportMedicine

Standard Monofocal Intraocular Lenses Versus Enhanced Monofocal Intraocular Lenses for Children 6 to 13 Years Old With Pediatric Cataract.

Elzawahry S, Elhilali H, Awadein A et al. · 2026 · Journal of pediatric ophthalmology and strabismus

Purpose To investigate whether using an enhanced monofocal intraocular lens (IOL) in the pediatric age group can improve the visual performance at varying distances in comparison to standard monofocal lenses. Methods Forty-five eyes of…

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Negative / Null Result ReportOpen accessMedicine

Systematic Notchplasty in Primary ACL Reconstruction Using Hamstring Autografts: A Prospective Cohort Study on the Rate of Secondary Arthrolysis.

Saint-Etienne A, Hardy A, Miele A et al. · 2025 · Journal of clinical medicine

Background: Arthrofibrosis requiring arthrolysis is a relevant complication after anterior cruciate ligament (ACL) reconstruction. It has been suggested that intercondylar notch impingement may contribute to this outcome. The aim of this…

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Negative / Null Result ReportOpen accessMedicine

Psychological Impact of AI-Simplified Brain MRI Reports: A Randomized Trial of Patient Understanding, Anxiety, and Health Literacy.

Alarifi M, Luo J, Jabour A et al. · 2026 · Journal of clinical medicine

Background/Objectives : Immediate patient access to radiology reports has increased the need for communication that patients can understand, yet it remains unclear whether simplifying report language improves comprehension without…

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Negative / Null Result ReportMedicine

Association of Stepping Up to High-Dose Inhaled Corticosteroids and Risk of Future Asthma Exacerbations: Data From the United States.

Tran TN, Kerkhof M, Le TT et al. · 2026 · The journal of allergy and clinical immunology. In practice

Background Real-world data on the benefit of high-dose inhaled corticosteroid (ICS) after exacerbation are limited. Objective To investigate whether stepping up to high-dose ICS after severe exacerbation reduces future asthma exacerbation…

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Negative / Null Result ReportOpen accessMedicine

Reducing Noise Induced by Cardiac Pulsatility in Brain Maps of R<sub>2</sub>* and Magnetic Susceptibility Using Tailored k-space Sampling.

Raynaud Q, Dardano T, Oliveira R et al. · 2026 · NMR in biomedicine

Maps of the transverse relaxation rate R 2 * and magnetic susceptibility (χ) are computed from gradient-echo data and are sensitive to signal instabilities induced by cardiac pulsation. Here, we introduce two k-space sampling strategies…

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Negative / Null Result ReportMedicine

Common channel length and implications to the weight loss.

Santoro S, Mota FC, de Aquino CGG et al. · 2025 · Updates in surgery

To present and analyze the results of sleeve gastrectomy with transit bipartition (SG + TB) with three different lengths of common channel (CC) and its implications for the weight loss and signals of residual malabsorption. A total of 790…

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Negative / Null Result ReportMedicine

Effect of albumin infusion in patients with predicted severe acute pancreatitis: A randomized controlled trial.

Shu W, Wan J, Xu H et al. · 2025 · Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]

Background Although previous studies have shown the potential advantages of albumin administration in critically ill patients, it has not been tested in patients with severe acute pancreatitis. Methods In this single-center trial, we…

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Negative / Null Result ReportMedicine

Effect of alirocumab on postprandial hyperlipidaemia in patients with type 2 diabetes: A randomized, double-blind, placebo-controlled, cross-over trial.

Cariou B, Thys A, Oliveira AR et al. · 2025 · Diabetes, obesity & metabolism

Aims Postprandial hyperlipidaemia (PPL), characterized by elevated triglyceride (TG) concentrations after a meal, is common in type 2 diabetes (T2D) and is often recognized as an independent cardiovascular risk factor. Here, we aimed to…

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Negative / Null Result ReportMedicine

Impact of an electronic clinical decision support algorithm (eCDSA) on antibiotic prescribing in primary care in Cambodia: A cluster randomised controlled trial.

Wynberg E, Mishra A, Liverani M et al. · 2026 · International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

Objectives Poorly targeted antibiotic use in primary care is a driver of antimicrobial resistance. Electronic clinical decision support algorithms (eCDSAs) integrating point-of-care tests may improve prescribing. We evaluated the impact of…

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Negative / Null Result ReportMedicine

Proactive versus standard support of labor in the latent phase - A randomized, controlled clinical trial.

Larsen M, Underdal M, Salvesen Ø et al. · 2025 · Sexual & reproductive healthcare : official journal of the Swedish Association of Midwives

Objective Long latent phase of labor with subsequent prolonged total labor duration increases the risk of obstetric interventions and complications. We explored whether Proactive Support of Labor (PSL) compared to Standard Support of Labor…

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Negative / Null Result ReportOpen accessMedicine

Impact of Pre-Elite Anterior Cruciate Ligament (ACL) Reconstruction on Draft Outcomes and Reinjury Risk in Elite Australian Football Players: A Retrospective Cohort Study.

Veale JP, Shawdon A, D'Alessandro P et al. · 2025 · Sports (Basel, Switzerland)

A history of anterior cruciate ligament reconstruction (ACLR) during the Australian Football (AF) talent pathway may impact draft prospects and increase the risk of a second injury during a professional career. This study investigated…

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Negative / Null Result ReportOpen accessMedicine

Magnesium supplementation did not reduce serum calciprotein crystallization and arterial stiffness in individuals with type 2 diabetes: a randomized, double-blind, placebo-controlled trial.

Meer R, Xu JY, Newsom SP et al. · 2026 · The American journal of clinical nutrition

Background Medial arterial calcification (MAC) and increased arterial stiffness contribute to cardiovascular disease risk in type 2 diabetes mellitus (T2DM). Experimental studies suggest that magnesium supplementation may halt arterial…

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Negative / Null Result ReportOpen accessMedicine

Effectiveness of a virtual hospital model of care for patients with low back pain presenting to emergency departments (Back@Home).

Sigera C, Oliveira CB, Melman A et al. · 2026 · NPJ digital medicine

This study evaluated the effectiveness of a virtual hospital model of care (Back@Home) for low back pain (LBP). We conducted an observational study across four hospitals in the Sydney Local Health District, Australia. We included patients…

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Negative / Null Result ReportMedicine

Does Reiki Therapy ReducePreoperative Anxiety and Postoperative Pain in Third Molar Surgery? A Randomized Controlled Trial.

Ozden Yuce M, Simsek B, Dadas OF et al. · 2026 · Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons

Background Preoperative anxiety in patients undergoing third molar extraction can influence pain perception. Limited evidence suggests Reiki therapy may help manage anxiety and pain, but its effectiveness in dentistry is unclear. Purpose…

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Negative / Null Result ReportMedicine

Impact of a Urogynecology Telehealth Consultation on Genital Self-Image and Sexual Function After Obstetric Anal Sphincter Injury.

Bonasia K, Luong S, Stairs J et al. · 2026 · International urogynecology journal

Introduction and hypothesis Obstetric anal sphincter injuries (OASIs) are associated with increased risk of postpartum complications, including short- and long-term dyspareunia and sexual dysfunction. The primary aim of this analysis is to…

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