e-ISSN: Pending

Browse the failure-mode index

12,375 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Effects of tumour necrosis factor and interleukin-6 inhibitor therapy on exercise-related visceral adipose tissue reduction in rheumatoid arthritis.

Jønck S, Adamsen ML, Rasmussen IE et al. · 2026 · Experimental physiology

Excess visceral adipose tissue (VAT) mass increases cardiovascular disease risk. Exercise supports overall health and VAT mass reduction in rheumatoid arthritis (RA). Unlike tumour necrosis factor (TNF), interleukin-6 (IL-6) is upregulated…

View details →
Negative / Null Result ReportMedicine

Primary Prophylaxis for Clostridioides difficile Infection in Lung Transplant Recipients: A Retrospective Study.

Irwin M, Leedy N, Nandavaram S et al. · 2026 · Transplant infectious disease : an official journal of the Transplantation Society

Background Clostridioides difficile infection (CDI) is a common complication in patients receiving broad-spectrum antibiotics and causes significant morbidity, especially in solid organ transplant recipients. Oral vancomycin has shown…

View details →
Negative / Null Result ReportMedicine

Comparison of international league of associations for rheumatology and pediatric rheumatology international trials organization classification criteria for juvenile idiopathic arthritis: insights from an African multicenter cohort.

Hamdi W, Ben Nessib D, Hashad S et al. · 2025 · European journal of pediatrics

The International League of Associations for Rheumatology (ILAR) classification criteria for juvenile idiopathic arthritis (JIA) are currently widely used in clinical practice. However, new criteria have recently been proposed by the…

View details →
Negative / Null Result ReportMedicine

Biodegradable patch based on chitosan-collagen with glycerol plasticizer as scaffold for tympanic membrane perforation.

Widiyanti P, Putra AF, Rudyardjo DI · 2026 · The International journal of artificial organs

Perforation on tympanic membrane could decrease the hearing ability. In some cases, myringoplasty should be performed. Myringoplasty requires material as patch to cover tympanic membrane's hole. This study is aimed to create innovation…

View details →
Negative / Null Result ReportMedicine

Effect of neuromuscular blockade on opioid consumption in high-risk children undergoing adenotonsillectomy: A randomized-controlled trial.

Efune PN, Nakonezny PA, Pinales P et al. · 2026 · Journal of clinical anesthesia

Background Protective reflexes like coughing occur frequently during pediatric adenotonsillectomy (AT) and are difficult to blunt with anesthetics, potentially leading to higher than necessary opioid administration. Our objective was to…

View details →
Negative / Null Result ReportMedicine

Impact of Violet LED Light and High-Concentration Hydrogen Peroxide on Dentin Mechanical Properties, Collagen, and Enzymatic Activity.

Damázio AH, Carlos NR, Basting RT et al. · 2026 · Operative dentistry

Objective Because the application of violet light-emitting diode (LED) light may enhance the release of reactive oxygen species, and its combination with a high-concentration bleaching agents may accelerate collagen degradation, this study…

View details →
Negative / Null Result ReportMedicine

Impact of Vancomycin-Resistant Enterococci (VRE)-Active Perioperative Prophylaxis in Liver Transplant Patients Colonized by VRE.

Burastero GJ, Wey EQ, Guidetti V et al. · 2026 · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Background Data regarding the effectiveness of vancomycin-resistant Enterococci (VRE)-active prophylaxis for preventing early post-liver transplantation (LT) VRE infections in VRE-colonized patients are scarce. Methods 131 pre-LT…

View details →
Negative / Null Result ReportMedicine

Prostate cancer mortality among men with and without comorbidity: Long-term results from the European randomized study of screening for prostate cancer Rotterdam.

Westerhout SF, Remmers S, Bangma CH et al. · 2026 · European journal of cancer (Oxford, England : 1990)

Introduction Prostate-specific antigen (PSA)-based prostate cancer (PCa) screening can be improved by individualised, risk-stratified strategies. Comorbidity influences life expectancy, so may affect benefits of screening. We evaluated…

View details →
Negative / Null Result ReportMedicine

Telehealth education for patients with cancer: a standalone solution for symptom relief?

Ruegg T, Zhao X, Mount MS et al. · 2026 · Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

Background Telehealth-delivered education offers a practical approach to chemotherapy teaching and symptom self-management support. Advanced practice providers (APPs) play an increasingly vital role in guiding oncology patients through…

View details →
Negative / Null Result ReportMedicine

The impact of closed-incision negative-pressure therapy on donor-site outcomes in drainless abdominal free flap breast reconstruction.

Kim J, Park C, Woo KJ et al. · 2026 · Journal of plastic, reconstructive & aesthetic surgery : JPRAS

Concerns regarding donor-site healing persist in abdominal-based free flap breast reconstruction. Although closed-incision negative-pressure therapy (CINPT) has demonstrated wound-related benefits, its efficacy without the use of drains…

View details →
Negative / Null Result ReportMedicine

Comparing the Antimicrobial Resistance Crisis to the Coronavirus Disease 2019 Pandemic: A Randomized Public Health Messaging Experiment.

Thorpe A, Lee RA, Szymczak JE et al. · 2026 · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Background Antimicrobial resistance (AMR) is an urgent health threat. Effective communication about AMR and avoiding antibiotics for viral infections is a public health priority. Here, we evaluated whether comparing the AMR crisis to the…

View details →
Negative / Null Result ReportMedicine

Effect of two-session remote ischaemic preconditioning on myocardial injury after noncardiac surgery in patients undergoing abdominal surgery: a randomised clinical trial.

Zheng Z, Wang F, Wang X et al. · 2026 · British journal of anaesthesia

Background Myocardial injury after noncardiac surgery is associated with both short-term and long-term mortality. However, effective preventive strategies remain limited. Remote ischaemic preconditioning (RIPC) confers distinct early and…

View details →
Negative / Null Result ReportOpen accessMedicine

Efficacy of Liposomal Bupivacaine for Anterior Quadratus Lumborum Block in Laparoscopic Gynecological Surgery: A Randomized Controlled Trial.

Zhang YH, Xiao Y, Li YT et al. · 2026 · Drug design, development and therapy

Background Liposomal bupivacaine provides prolonged analgesia, but evidence for its efficacy in anterior quadratus lumborum block (QLB) for laparoscopic gynecological surgery remains limited. This study compared liposomal bupivacaine…

View details →
Negative / Null Result ReportMedicine

Association Between Early Initiation of Electroconvulsive Therapy and Length of Stay in Acute Psychiatric Inpatients: A Retrospective Cohort Study in Taiwan.

Su PL, Ho MF, Liu PH et al. · 2026 · The journal of ECT

Objectives Electroconvulsive therapy (ECT) provides rapid relief for severe psychiatric disorders, but its impact on hospital length of stay (LOS) remains unclear in Asian settings. We hypothesized that early ECT (≤7 d after admission)…

View details →
Negative / Null Result ReportMedicine

Plant functional diversity does not dilute virus infection, but community virus prevalence positively correlates with net C3 grass production

Aguirre BA, Mudrak EL, Wright AJ et al. · 2026 · Journal of Ecology.

Plant diversity in wild and agricultural plant communities has been shown to protect plant communities from pathogens, and the effects of many aspects of diversity (genetic diversity, species richness, evenness and their combination) on…

View details →
Negative / Null Result ReportMedicine

A Randomized Trial Evaluating Intraoperative Ischemic Preconditioning of Parathyroid Glands During Total Thyroidectomy: A Signal for Earlier Parathyroid Function Recovery.

Sheng Q, Zhang P, Zhang T et al. · 2026 · Journal of investigative surgery : the official journal of the Academy of Surgical Research

Background Ischemic preconditioning of parathyroid glands (IPCP) is biologically plausible but clinical evidence is limited. In this single-center randomized trial (ChiCTR2000039788), we compared IPCP versus control during total…

View details →
Negative / Null Result ReportMedicine

Intravenous dexmedetomidine and blood loss during cesarean delivery under neuraxial anesthesia: a single-center retrospective study (2012-2016).

Yoshimura M, Sakamoto S, Nakanishi T et al. · 2026 · International journal of obstetric anesthesia

Background Intravenous dexmedetomidine may be given to reduce shivering and discomfort during cesarean delivery under neuraxial anesthesia. Dexmedetomidine lowers heart rate and blood pressure, reduces catecholamine release, may have a…

View details →
Negative / Null Result ReportMedicine

The impact of tracheal intubation attempts on chest compression fraction during pediatric CPR: a report from the Videography in Pediatric Resuscitation (VIPER) collaborative.

Jariyasakoolroj T, O'Connell K, MacDonald T et al. · 2026 · Resuscitation

Aim To examine the association between tracheal intubation (TI) attempts and chest compression (CC) pauses on chest compression fraction (CCF) during pediatric CPR across a network of emergency departments. Methods Prospective…

View details →
Negative / Null Result ReportMedicine

Deciphering serotonin's functional role in postharvest: Fruit-specific preservation of red fruit quality.

Arabia A, Muñoz P, Álvarez-Real S et al. · 2026 · Plant science : an international journal of experimental plant biology

Serotonin is a widely conserved signaling molecule essential for plant development and stress responses, but its role in fruit postharvest physiology remains largely unexplored. This study aimed to evaluate the effects of 100 μM exogenous…

View details →
Negative / Null Result ReportMedicine

Lactated Ringer's Solution at a Standard Infusion Rate in Post-endoscopic Retrograde Cholangiopancreatography Pancreatitis Prevention: A Retrospective Comparative Study.

Ko T, Sakai A, Nakano R et al. · 2026 · Digestive diseases and sciences

Background Post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis is a common complication, and its prevention remains challenging. Although aggressive infusion of lactated Ringer's solution (hereafter Lactated Ringer's)…

View details →