12,241 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Stelmashook EV, Genrikhs EE, Alexandrova OP et al. · 2025 · Biomeditsinskaia khimiia
Copper ions (Cu2+) at concentrations of 25-50 μM stimulate lipopolysaccharide (LPS)-induced nitric oxide (NO) production in glial cell cultures derived from rat cerebral cortex and containing both astrocytes and microglia. Addition of a…
View details →Hamaya R, Li S, Lau J et al. · 2026 · American journal of hypertension
Background Multivitamin-multimineral (MVM) supplements have been associated with lower blood pressure (BP) in several small trials. We investigated the effects of a MVM on incident hypertension and BP in a secondary analysis of the COcoa…
View details →Detelich J, Martin GS · 2025 · Annals of internal medicine
Clinical impact ratings Emergency Med: [Formula: see text] GIM/FP/GP: [Formula: see text] Critical Care: [Formula: see text].
View details →Dubrovsky L, Pushkarsky T, Brichacek B et al. · 2026 · Microorganisms
Trained immunity (TRIM) enhances innate immune responses through epigenetic and metabolic reprogramming but may become maladaptive, contributing to chronic inflammation. In people living with HIV (PLWH), maladaptive TRIM has been proposed…
View details →Tamoto M, Kai S, Yoshida H et al. · 2026 · Journal of cardiothoracic and vascular anesthesia
Objectives To compare the real-world effectiveness of combined propofol and dexmedetomidine (PRODEX) sedation with propofol monotherapy on survival and postoperative delirium (POD) in a large nationwide cohort of patients undergoing…
View details →Khun Jush B, Biswas MAAJ, Lim HJJ et al. · 2026 · Pancreas
Background Routine feeding tube (FT) placement during pancreaticoduodenectomy (PD) has not reduced complication rates. Nonetheless, FTs are often selectively placed in patients with poor nutritional status such as those with significant…
View details →Bücken CA, Riesthuis P, Caon G et al. · 2026 · Memory (Hove, England)
False autobiographical memories can have serious implications in legal settings, where the case outcomes may hinge entirely on memory-based eyewitness testimony. This study investigated whether a sensitisation memory training could reduce…
View details →Ruiz-Tagle C, Seguel R, Villarroel L et al. · 2026 · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Background The duration of infectiousness following pulmonary tuberculosis treatment initiation remains uncertain. We aimed to assess whether a bundled intervention designed to decrease respiratory exposure was feasible and would reduce…
View details →Ringer AJ, Hanel RA, Baig AA et al. · 2025 · Journal of neurointerventional surgery
Background The optimal duration for dual antiplatelet therapy (DAPT) after stent-assisted coiling (SAC) of intracranial aneurysms is unclear. Longer-term therapy may reduce thrombotic complications but increase the risk of bleeding…
View details →Bierer JD, Stanzel R, Henderson M et al. · 2026 · The Annals of thoracic surgery
Background Pediatric cardiac surgery with cardiopulmonary bypass (CPB) is associated with systemic inflammation. This trial aimed to determine whether continuous high-exchange ultrafiltration during CPB has a clinical immunomodulatory…
View details →Khueangchiangkhwang S, Oida Y, Taguchi A et al. · 2026 · Parasitology international
Trichinella is a nematode that causes chronic infection via its larvae in muscle cells and remains a global health concern. Drug sensitivity, including to ivermectin (IVM), differs between intestinal adult worms (AW) and muscle larvae…
View details →Dunkel K, Moroz MS, Suares B et al. · 2025 · The Journal of dairy research
This research article aimed to evaluate the effect of a commercial nutraceutical additive in milk replacer on the health and weight gain of dairy calves during the pre-weaning phase. A total of 126 female Holstein calves were randomly…
View details →Meves V, Chamieh A, Mohamed M et al. · 2026 · Endoscopy international open
Background and study aims Previous studies in esophagogastroduodenoscopy or colonoscopy have demonstrated positive effects of music on patient anxiety and comfort. This study prospectively evaluated the effect of functional music on…
View details →Kashtiara A, Pauptit J, Thijs D et al. · 2025 · European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
Objectives Enhanced Recovery After Surgery (ERAS) protocols aim to improve surgical outcomes, by mitigating postoperative stress through multimodal perioperative care. In spinal surgery, such protocols may reduce pain, hospital length of…
View details →Sielski W, Osęka T, Antolak A et al. · 2026 · Frontiers in endocrinology
Background Parathyroid preservation during total thyroidectomy with central neck dissection in papillary thyroid carcinoma remains challenging due to the glands' delicate vascular anatomy and risk of inadvertent devascularization or…
View details →Palmier M, Ghorayeb G, Arhant G et al. · 2026 · Annals of vascular surgery
Background Supraceliac aortic cross-clamping can induce remote organ injury, particularly affecting the lungs through ischemia-reperfusion mechanisms. Pulmonary endothelial dysfunction plays a central role in acute lung injury, potentially…
View details →García-García M, Mosqueda J, Escobar Cabrera JE et al. · 2025 · Toxicon
A recent clinical case involving a Poecilotheria regalis bite was treated with Mexican L. mactans antivenom (Aracmyn Plus, Silanes, Mexico), resulting in the improvement of some of the symptoms. This could be attributed to cross-reactivity…
View details →Grover V, Acharya SR, Chatra A et al. · 2026 · BMC oral health
BACKGROUND: Resin-based composites (RBCs) are commonly used in restorative dentistry, but bleaching agents may compromise their mechanical integrity. The effect of in-office bleaching with 25% hydrogen peroxide (HP) on the flexural…
View details →Hooshiar MH · 2026 · The Journal of prosthetic dentistry
Statement of problem Artificial intelligence (AI) language models have been increasingly used for clinical decision-making in implant dentistry and for scholarly writing. Yet, their reliability, fabrication rates, and comparative…
View details →Tsakmaki PV, Tasoulis S, Georgakopoulos SV et al. · 2025 · International journal of neural systems
This research looks at the use of long-short-term memory (LSTM) networks to predict psychosis, in patients within the schizophrenia spectrum, based on Heart Rate Variability (HRV) data acquired from wearable devices. Our primary objective…
View details →Szabó D, Tóth A, Nagy CB et al. · 2025 · Orvosi hetilap
Introduction The glomus caroticum, located at the carotid bifurcation, contains chemoreceptors and is essential for the rapid physiological adaptation to changes in blood oxygen, carbon dioxide, and pH levels. Paragangliomas of the glomus…
View details →Sanak F, Iselin K, Kaufmann C et al. · 2026 · Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics
Purpose To analyze the effect of fasting on volume, growth factor, and lipid concentration in eye drops derived from autologous serum (AS) and leukocyte-poor platelet-rich plasma (LP-PRP). To assess changes in protein and growth factor…
View details →Hughes C, Myers MA, Tickell-Painter M et al. · 2026 · Clinical biochemistry
Introduction The climate crisis is a health crisis, and healthcare contributes to this via consumption of resources, the release of greenhouse gases, and the generation of waste. Pathology testing underpins most healthcare, and the vast…
View details →Regev-Yochay G, Barda N, Shusterman Y et al. · 2026 · NEJM evidence
Background In 2024, Israel faced a major West Nile virus (WNV) disease outbreak. We aimed to evaluate the efficacy and safety of WNV-neutralizing plasma for hospitalized patients with WNV disease. Methods We conducted a randomized,…
View details →Tavolinejad H, Bozorgi A, Emkanjoo Z et al. · 2025 · Journal of the American College of Cardiology
Background Vasovagal syncope (VVS) is a common yet challenging condition with limited effective treatments. Elastic compression stockings (ECS) have been proposed as a potential therapy, but their real-world effectiveness remains unclear.…
View details →Zhang F, Yu Z, Pan J et al. · 2026 · Jornal de pediatria
Objective This study aimed to investigate the risk factors for acute neurological complications (ANCs) in neonates with bacterial meningitis (NBM). Methods This retrospective study analyzed 68 neonates (aged 0-28 days) with bacterial…
View details →Sanchis J, Bueno H, Martí Sánchez D et al. · 2025 · Heart (British Cardiac Society)
Background Clinical trials and meta-analyses indicate a reduced reinfarction risk with invasive management in older patients with non-ST-segment elevation myocardial infarction (NSTEMI). This study investigated whether similar benefits…
View details →Muir KJ, Maye A, McHugh MD et al. · 2025 · JAMA network open
Importance It is unknown if virtual nursing (VN) enhances care quality or improves the workload of bedside nurses in hospitals. Objective To describe what services VNs provide to patients and nurses in hospitals; to evaluate whether the…
View details →Zhang J, Suo T, Cheng Y et al. · 2026 · Journal of investigative medicine : the official publication of the American Federation for Clinical Research
Hemophagocytic lymphohistiocytosis (HLH) secondary to visceral leishmaniasis (VL-HLH) is a severe and often fatal condition marked by systemic inflammation and immune dysfunction. In this retrospective cohort study at Shanxi Children's…
View details →Smedemark SA, Jarbøl DE, Laursen CB et al. · 2026 · The lancet. Healthy longevity
Background Diagnosing acute respiratory conditions in adults older than 65 years is challenging due to age-related physiological changes, which increase diagnostic complexity and the risk of hospital admission. We investigated whether…
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