e-ISSN: Pending
WASTE Journal

Browse the failure-mode index

12,241 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

The impact of closed-incision negative-pressure therapy on donor-site outcomes in drainless abdominal free flap breast reconstruction.

Kim J, Park C, Woo KJ et al. · 2026 · Journal of plastic, reconstructive & aesthetic surgery : JPRAS

Concerns regarding donor-site healing persist in abdominal-based free flap breast reconstruction. Although closed-incision negative-pressure therapy (CINPT) has demonstrated wound-related benefits, its efficacy without the use of drains…

View details →
Negative / Null Result ReportMedicine

Comparing the Antimicrobial Resistance Crisis to the Coronavirus Disease 2019 Pandemic: A Randomized Public Health Messaging Experiment.

Thorpe A, Lee RA, Szymczak JE et al. · 2026 · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Background Antimicrobial resistance (AMR) is an urgent health threat. Effective communication about AMR and avoiding antibiotics for viral infections is a public health priority. Here, we evaluated whether comparing the AMR crisis to the…

View details →
Negative / Null Result ReportMedicine

Effect of two-session remote ischaemic preconditioning on myocardial injury after noncardiac surgery in patients undergoing abdominal surgery: a randomised clinical trial.

Zheng Z, Wang F, Wang X et al. · 2026 · British journal of anaesthesia

Background Myocardial injury after noncardiac surgery is associated with both short-term and long-term mortality. However, effective preventive strategies remain limited. Remote ischaemic preconditioning (RIPC) confers distinct early and…

View details →
Negative / Null Result ReportOpen accessMedicine

Efficacy of Liposomal Bupivacaine for Anterior Quadratus Lumborum Block in Laparoscopic Gynecological Surgery: A Randomized Controlled Trial.

Zhang YH, Xiao Y, Li YT et al. · 2026 · Drug design, development and therapy

Background Liposomal bupivacaine provides prolonged analgesia, but evidence for its efficacy in anterior quadratus lumborum block (QLB) for laparoscopic gynecological surgery remains limited. This study compared liposomal bupivacaine…

View details →
Negative / Null Result ReportMedicine

Association Between Early Initiation of Electroconvulsive Therapy and Length of Stay in Acute Psychiatric Inpatients: A Retrospective Cohort Study in Taiwan.

Su PL, Ho MF, Liu PH et al. · 2026 · The journal of ECT

Objectives Electroconvulsive therapy (ECT) provides rapid relief for severe psychiatric disorders, but its impact on hospital length of stay (LOS) remains unclear in Asian settings. We hypothesized that early ECT (≤7 d after admission)…

View details →
Negative / Null Result ReportMedicine

Plant functional diversity does not dilute virus infection, but community virus prevalence positively correlates with net C3 grass production

Aguirre BA, Mudrak EL, Wright AJ et al. · 2026 · Journal of Ecology.

Plant diversity in wild and agricultural plant communities has been shown to protect plant communities from pathogens, and the effects of many aspects of diversity (genetic diversity, species richness, evenness and their combination) on…

View details →
Negative / Null Result ReportMedicine

A Randomized Trial Evaluating Intraoperative Ischemic Preconditioning of Parathyroid Glands During Total Thyroidectomy: A Signal for Earlier Parathyroid Function Recovery.

Sheng Q, Zhang P, Zhang T et al. · 2026 · Journal of investigative surgery : the official journal of the Academy of Surgical Research

Background Ischemic preconditioning of parathyroid glands (IPCP) is biologically plausible but clinical evidence is limited. In this single-center randomized trial (ChiCTR2000039788), we compared IPCP versus control during total…

View details →
Negative / Null Result ReportMedicine

Intravenous dexmedetomidine and blood loss during cesarean delivery under neuraxial anesthesia: a single-center retrospective study (2012-2016).

Yoshimura M, Sakamoto S, Nakanishi T et al. · 2026 · International journal of obstetric anesthesia

Background Intravenous dexmedetomidine may be given to reduce shivering and discomfort during cesarean delivery under neuraxial anesthesia. Dexmedetomidine lowers heart rate and blood pressure, reduces catecholamine release, may have a…

View details →
Negative / Null Result ReportMedicine

The impact of tracheal intubation attempts on chest compression fraction during pediatric CPR: a report from the Videography in Pediatric Resuscitation (VIPER) collaborative.

Jariyasakoolroj T, O'Connell K, MacDonald T et al. · 2026 · Resuscitation

Aim To examine the association between tracheal intubation (TI) attempts and chest compression (CC) pauses on chest compression fraction (CCF) during pediatric CPR across a network of emergency departments. Methods Prospective…

View details →
Negative / Null Result ReportMedicine

Deciphering serotonin's functional role in postharvest: Fruit-specific preservation of red fruit quality.

Arabia A, Muñoz P, Álvarez-Real S et al. · 2026 · Plant science : an international journal of experimental plant biology

Serotonin is a widely conserved signaling molecule essential for plant development and stress responses, but its role in fruit postharvest physiology remains largely unexplored. This study aimed to evaluate the effects of 100 μM exogenous…

View details →
Negative / Null Result ReportMedicine

Lactated Ringer's Solution at a Standard Infusion Rate in Post-endoscopic Retrograde Cholangiopancreatography Pancreatitis Prevention: A Retrospective Comparative Study.

Ko T, Sakai A, Nakano R et al. · 2026 · Digestive diseases and sciences

Background Post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis is a common complication, and its prevention remains challenging. Although aggressive infusion of lactated Ringer's solution (hereafter Lactated Ringer's)…

View details →
Negative / Null Result ReportMedicine

Longitudinal Reliability of Rheumatology Patient Safety Measures and Implications for CMS Case Minimums.

Roberts ET, Schmajuk G, Fitzpatrick J et al. · 2026 · Joint Commission journal on quality and patient safety

Background Metrics with acceptable reliability are necessary to ensure that quality measures reward performance. Low metric reliability may result from a lack of differences between reporting entities or low numbers of eligible patients.…

View details →
Negative / Null Result ReportOpen accessMedicine

Long-term changes in overjet in individuals with and without orthodontic treatment : A 30-year cohort study.

Bokan J, Schmid JQ, Middelberg C et al. · 2026 · Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie

Purpose Large overjet increases the risk of traumatic dental injury (TDI). This study, part of the Münster Long-Term Study (MLS), aimed to investigate long-term changes in overjet with or without orthodontic treatment and to evaluate…

View details →
Negative / Null Result ReportMedicine

High-flow nasal cannula improves pulmonary gas exchange during endoscopic retrograde cholangiopancreatography: A single-center randomized controlled trial.

Martínez-Ocón J, Pérez M, Calvo A et al. · 2026 · Journal of clinical anesthesia

Background Sedation during endoscopic retrograde cholangiopancreatography procedures (ERCP) increases the risk of hypoxemia and the need for respiratory support in high-risk patients. High flow nasal cannula (HFNC) provides humidified gas…

View details →
Negative / Null Result ReportMedicine

Use of Virtual Reality for Pain Relief During Cervical Conization Under Local Anesthesia: A Randomized Controlled Trial.

Michaan N, Michaan N, Laskov I et al. · 2026 · Journal of lower genital tract disease

Objectives Cervical conization (loop electrosurgical excision procedure) under local anesthesia is often associated with anxiety and procedural pain. Virtual reality (VR) glasses may enhance patient experience and reduce discomfort during…

View details →
Negative / Null Result ReportMedicine

Incidence, Predictors, and Outcomes of Stroke Following Transcatheter Aortic Valve Implantation: A Multicenter Australian Experience.

Butala AD, Nanayakkara S, Johnston R et al. · 2026 · The American journal of cardiology

Stroke is a serious complication following transcatheter aortic valve implantation, associated with increased disability and mortality. Despite this, there is a lack of patient-level data examining stroke in contemporary, lower-risk…

View details →
Negative / Null Result ReportMedicine

Letter to the Editor: Comment on Adamovich-Zeitlina et al's "Clinical Outcomes of Boston Type 1 Keratoprosthesis With and Without Endophthalmitis During the Covid-19 Pandemic".

Geoffrion D, Mikhail D, Rizk M et al. · 2025 · Ocular immunology and inflammation

Authors reported an 18% rate of endophthalmitis in Boston type 1 keratoprosthesis (KPro) patients, higher than previously reported rates. Most cases occurred during the COVID-19 pandemic, likely due to reduced access to care. Bandage…

View details →