12,241 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Maier LE, Douglas A, Foster K et al. · 2026 · The Journal of physiology
Parasympathetic activity is reduced in chronic hypoxia, but the underlying mechanism(s) are unclear. We investigated whether (i) arterial chemoreflex activation, (ii) increased pulmonary ventilation and/or (iii) pulmonary stretch, (iv)…
View details →Na K, Qiu MH, Wang ZH et al. · 2026 · Zhonghua xin xue guan bing za zhi
Objective: To evaluate the efficacy and safety of ticagrelor versus clopidogrel in real-world patients with acute coronary syndrome (ACS) without standard modifiable cardiovascular risk factors (SMuRF-less) following percutaneous coronary…
View details →Cui J · 2025 · Family process
Adverse childhood experiences (ACEs) are significant public health concerns with long-term consequences for children's mental health, physical well-being, and socioeconomic outcomes. This study examines whether younger maternal age at…
View details →de Freitas MDB, Rodrigues DC, de Paiva PEM et al. · 2026 · Parasites & vectors
Background Myiasis caused by Cochliomyia hominivorax larvae is a reemerging challenge in the Americas due to the recent reappearance of this species in areas where it had been eradicated and reports of doramectin inefficacy, despite its…
View details →Rouphael C, Saliba E, Moukarzel M et al. · 2026 · Respiratory care
Background High-flow nasal cannula (HFNC) is a noninvasive oxygenation method that delivers humidified and heated oxygen mixtures at high flows while generating PEEP. Therefore, its use during endoscopic procedures with intravenous deep…
View details →Meerman M, Buijser M, Neto AS et al. · 2026 · Critical care medicine
Objectives To determine whether perioperative IV magnesium sulfate infusion, targeting serum magnesium concentrations of 1.5-2.0 mmol/L, reduces the incidence of postoperative atrial fibrillation (POAF) in patients undergoing cardiac…
View details →Vaz CSL, Voss-Rech D, da Fonseca FN et al. · 2026 · Foodborne pathogens and disease
Oral phage therapy is a promising strategy for reducing harmful bacteria in broilers. However, it may lead to the spread of therapeutic phages in the farm environment, potentially increasing bacterial host tolerance. To determine the…
View details →Küçükatalay Ö, Kantarcı S, Dağlı U et al. · 2026 · JSLS : Journal of the Society of Laparoendoscopic Surgeons
Introduction Total laparoscopic hysterectomy (TLH) is widely performed for benign gynecologic conditions; however, postoperative pain particularly shoulder pain related to residual intraperitoneal CO 2 remains a clinical concern. This…
View details →Tamargo J, Agewall S, Ambrosio G et al. · 2026 · European heart journal. Cardiovascular pharmacotherapy
Despite recent advances in cardiovascular pharmacotherapy, prevention and treatment of many cardiovascular diseases remain limited with a clear need for more effective and safer pharmacological strategies. Here, we summarize the most…
View details →Saraiva S, McLean L · 2026 · Physiotherapy
Primary objectives (1) To evaluate whether hypopressive exercises (HEs) cause changes in intra-abdominal pressure (IAP) and/or electromyographic (EMG) activation of the levator ani muscles (LAMs), (2) to determine whether these effects…
View details →Arabia A, Muñoz P, Álvarez-Real S et al. · 2026 · Plant Science.
Serotonin is a widely conserved signaling molecule essential for plant development and stress responses, but its role in fruit postharvest physiology remains largely unexplored. This study aimed to evaluate the effects of 100 μM exogenous…
View details →Sárkány F, Priksz D, Juhász B et al. · 2026 · Basic research in cardiology
Clinical trial experience supports the use of myosin inhibitors in hypertrophic cardiomyopathy (HCM), while early proof-of-concept studies suggest potential benefit in selected patients with heart failure with preserved ejection fraction…
View details →Hsieh TH, Liang CC, Liang CY et al. · 2026 · Taiwanese journal of obstetrics & gynecology
Objective To explore whether preoperative overactive bladder (OAB) symptoms affect the outcome of single-incision slings (SIS) for urodynamic stress incontinence (USI). Materials and methods This retrospective study involved 106 patients…
View details →Oldham L, Arnott G, Briffa M et al. · 2026 · Biology letters
Skill is the ability to do a challenging behaviour well. We examined how contest skill influences contest success, costs and whether skilful behaviour enhances welfare. We measured skill across three domains: accuracy, appropriateness…
View details →Mangold MH, Kazmierczak J, Gerigk M et al. · 2026 · European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
INTRODUCTION: Patients undergoing radical cystectomy (RC) face a heightened risk of infectious complications around the time of ureteral stent removal. This study aimed to determine whether a culture-guided antimicrobial strategy reduces…
View details →Kim DH, Beathe J, Wetmore DS et al. · 2026 · Regional anesthesia and pain medicine
Background The adductor canal block (ACB), known for its motor-sparing properties, has gained popularity as part of the multimodal analgesic regimen in total knee arthroplasty (TKA) patients. However, the duration of single-injection…
View details →Jacquier M, Laroye C, Bensoussan D et al. · 2026 · Respiratory research
Background Although mesenchymal stromal cells (MSCs) have shown promising effects in preclinical pneumonia models, their ability to improve outcomes in ventilator-associated pneumonia (VAP) remains poorly explored, despite VAP being a…
View details →Guo Y, Hu S, Wang Z et al. · 2026 · Journal of neurotrauma
The formation of brain edema is one of the key factors that determine patient outcomes following traumatic brain injury (TBI). Despite decades of research, no causal treatment is available to date. Among the many factors discussed,…
View details →Björnsson O, Geirsson G, Leifsson ÁS et al. · 2026 · Scandinavian journal of urology
Introduction Transurethral resection of bladder tumor (TURBT) is the standard treatment for non-muscle-invasive bladder cancer (NMIBC), but early recurrences remain frequent. The objective of this study was to standardize TURBT management…
View details →Mauter F, Anton M, van Engen R et al. · 2026 · Physics in medicine and biology
Objective. Digital mammography (DM) and dual-energy contrast-enhanced mammography (CEM) use the same anti-scatter grid, despite their differences in x-ray spectra. This study investigated grid performance under clinically relevant…
View details →Szarpak L, Al-Jeabory M, Pecold J et al. · 2026 · The aging male : the official journal of the International Society for the Study of the Aging Male
Introduction Testosterone replacement therapy (TRT) is increasingly prescribed to older men with symptomatic testosterone deficiency, yet the balance of musculoskeletal benefits and harms remains uncertain. Objectives To synthesise current…
View details →Takeda Y, Nakai T, Okamoto T et al. · 2026 · The Journal of arthroplasty
Background Mirogabalin, a selective α2δ-1 ligand, has been proposed to exhibit potent analgesic effects with fewer central nervous system (CNS) side effects than prior gabapentinoids. Its effectiveness for acute postoperative pain after…
View details →Carnevali A, Chisari D, Mancini A et al. · 2026 · Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde
Introduction Inferior retinal detachment (I-RD) complicated by proliferative vitreoretinopathy (PVR) is challenging to treat and prone to recurrence (retinal detachment recurrence [RDR]). Heavy silicone oil (HSO) tamponades such as…
View details →Khera P, Jain S, Khurana S et al. · 2026 · European journal of pediatrics
Surfactant replacement therapy improves outcomes in preterm neonates with respiratory distress syndrome (RDS). While the less invasive surfactant administration (LISA) technique offers advantages over intubate-surfactant-extubate (INSURE),…
View details →Magno Serrano P, Barros P, Dores M et al. · 2026 · Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica
Introduction Antibiotic resistance represents a major public health problem driven by inappropriate antimicrobial use. Cystoscopy is a common urological procedure associated with a low risk of urinary tract infection (UTI), and the role of…
View details →Oreskovic NM, Erwin AE, Allon ZA et al. · 2026 · The American journal of managed care
Objectives Office-based care coordination programs are increasingly utilizing social work-trained care coordinators to manage high-cost, high-need (HCHN) patients with increased psychosocial risk, including patients covered by Medicaid.…
View details →Mølhave M, Olsen ZL, Svanesøe S et al. · 2025 · Acta oto-laryngologica
Background Tracheostomy is widely used in critically ill patients, yet limited clinical data exist from Danish ENT departments. Aims/objectives To describe clinical outcomes and perioperative care in patients undergoing tracheostomy at a…
View details →Bhardwaj A, Jain A, Jain N et al. · 2026 · Indian pediatrics
Objective To evaluate whether epinephrine nebulization, when used in addition to standard care, reduces extubation failure (EF) in term and preterm neonates. Methods A parallel, randomized controlled superiority trial was conducted in a…
View details →Chlebowski RT, Rapp S, Aragaki AK et al. · 2026 · Menopause (New York, N.Y.)
Objectives In the Women's Health Initiative (WHI) Dietary Modification (DM) randomized trial, the dietary intervention significantly reduced breast cancer mortality and, in a subgroup of women 65 years old or above, significantly lowered…
View details →Rozier R, Loiseleur A, Ciais C et al. · 2026 · Regional anesthesia and pain medicine
Background Total hip arthroplasty (THA) frequently causes postoperative pain, hindering recovery and prolonging hospital stays. While multimodal analgesia aims to minimize opioid use and enhance outcomes, the optimal regional anesthesia…
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