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WASTE Journal

Browse the failure-mode index

12,375 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Replication FailureOpen accessMedicine

Reproductive barriers confirm absence of hybrid speciation and introgression in the Rhodnius pictipes and R. pallescens groups (Hemiptera, Triatominae).

Alevi KCC, Ravazi A, de Oliveira J et al. · 2025 · Scientific reports

The diversification of Rhodnius species has been primarily attributed to vicariance events. Phylogenomic studies have proposed various evolutionary hypotheses - such as incomplete lineage sorting, hybrid speciation, and introgression - to…

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Failed Experiment ReportOpen accessMedicine

Efficacy of a novel combination of aloe vera gel and pineapple extracts in improving post-extraction pain and healing: A Randomized Controlled Trial.

Srivastava S, Kharkar VR, More S et al. · 2024 · Journal of clinical and experimental dentistry

Background Absorbable gelatin sponges are able to reduce the incidence of post-extraction complications when soaked with antimicrobial agents. However, the drawbacks associated with the injudicious use of antibiotics warrant the need to…

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Negative / Null Result ReportOpen accessMedicine

Effects of E-Cigarette (e-cig) Aerosols on Mutagenesis in Selected Organs in a C57 <i>lacI</i> (BigBlue<sup>TM</sup>) Mouse Model.

Chhaya D, Gress M, Raja A et al. · 2024 · International journal of environmental research and public health

The objective of this study is to investigate the potential mutagenic effects of the exposure of mice to aerosols produced from the component liquids of an electronic nicotine delivery system (ENDS). The use of electronic cigarettes…

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Negative / Null Result ReportOpen accessMedicine

Self-Soothing Touch Reduces Momentary Stress, Fatigue, and Loneliness Comparable to Brief Meditation: A Randomised Controlled Trial.

Maier F, Luttenberger I, Dreisoerner A et al. · 2026 · Stress and health : journal of the International Society for the Investigation of Stress

Chronic stress has well-documented adverse effects on physical and psychological health. Beyond contributing to the development of fatigue, its impact is intensified by social stressors such as loneliness, making the development of…

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Negative / Null Result ReportOpen accessMedicine

Investigating the Effect of Algal Inclusions in Broiler Chickens.

Al-Khalaifah H, Al-Nasser A, Al-Surrayai T · 2025 · Life (Basel, Switzerland)

There is growing interest in adding marine algae to poultry feed rations. The aim of the present study is to examine the effect of various inclusions of Sargassum sp., Gracilaria sp., and Spirulina sp. on productive performance, serum…

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Negative / Null Result ReportOpen accessMedicine

Achieving target plasma concentrations of beta-lactam antibiotics in critically ill patients: a retrospective study of full-dose administration in the first 24 hours.

Halačová M, Mieresová M, Kubele J et al. · 2026 · Pharmacological reports : PR

BACKGROUND: Beta-lactams are the cornerstone of therapy for the treatment of the most serious infections in the intensive care unit (ICU) setting. However, individualization of dosing remains challenging because pharmacokinetics are highly…

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Negative / Null Result ReportOpen accessMedicine

Impaired Cognitive Flexibility With Preserved Learning in an Amyloid Precursor Protein Knock-In Mouse Model of Amyloidopathy.

Dumont JR, Sheppard PAS, Fodor C et al. · 2025 · Genes, brain, and behavior

Alzheimer's disease is a debilitating neurodegenerative condition characterized by amyloid beta plaques and tau neurofibrillary tangles, which leads to progressive cognitive decline. Several new mouse models of fast amyloid deposition have…

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Negative / Null Result ReportMedicine

Moving from the clinic to telehealth during the COVID-19 pandemic - a pilot clinical trial comparing in-clinic rehabilitation versus telerehabilitation for persisting symptoms following a mild Traumatic brain injury.

Langevin P, Frémont P, Fait P et al. · 2024 · Disability and rehabilitation

Purpose The objective of this study was to compare the effects of an in-clinic cervicovestibular rehabilitation program (education, home exercises, manual techniques, sub-symptom threshold aerobic exercise [STAE] program) to a similar…

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Negative / Null Result ReportOpen accessMedicine

Trajectory of COVID-related tinnitus over the pandemic timeline.

Figueiredo RR, de Azevedo AA, Figueiredo GMR et al. · 2026 · Brazilian journal of otorhinolaryngology

Objectives COVID-19 is a respiratory disease caused by the coronavirus SARS-CoV-2. Previous studies reported cases of tinnitus following COVID infection, most of them mild and with similar characteristics to other forms of tinnitus. Our…

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Negative / Null Result ReportOpen accessMedicine

Can supplementation of tryptophan in parenteral nutrition increase melatonin and alleviate inflammatory response?

Yaşar NF, Badak B, Salış M et al. · 2024 · Revista da Associacao Medica Brasileira (1992)

Objective Endogenous melatonin is produced from tryptophan which is an essential amino acid. Besides its role in the regulation of sleep patterns, melatonin has anti-inflammatory effects. In this case-control study, we aimed to compare…

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Negative / Null Result ReportOpen accessMedicine

Manual and automated assessments of general movements in neonates are associated with early autism risk at 18 months.

Beaulieu A, Saint-Georges C, Hagbarth I et al. · 2026 · Scientific reports

General movements (GMs) refer to infants’ spontaneous motor activities before the emergence of voluntary motor activity. Abnormal GMs in neonates have been regarded as a marker of poor neurodevelopmental outcomes, with preliminary findings…

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Negative / Null Result ReportOpen accessMedicine

Discontinuing the recommendation of hip precautions does not increase the risk of early dislocation after primary total hip arthroplasty using 36-mm heads: a population-based study from the Danish Hip Arthroplasty Register.

Iljazi A, Sørensen MS, Winther-Jensen M et al. · 2024 · Acta orthopaedica

Background and purpose Dislocation is a severe complication following total hip arthroplasty (THA). Hip precautions have been recommended in the initial postoperative period but evidence supporting this practice is limited. We therefore…

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Negative / Null Result ReportMedicine

Frequent Sugar-Sweetened Beverage Consumption, Dental Caries, and the Federal Poverty Level in Children 1-18 Years, NHANES 2015-2020.

Wiener RC, Abuhalimeh B, Cochran J · 2025 · Community dentistry and oral epidemiology

Objective The objective of this research was to determine if the ratio of family income to poverty index is a modifier in the relationship of sugar-sweetened beverages (SSB) and dental caries in U.S. children. Methods A cross-sectional…

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Negative / Null Result ReportOpen accessMedicine

Replicability or revision? Further evidence on the psychometric quality of the German version of the epistemic trust, mistrust and credulity questionnaire.

Schwarzer NH, Behringer N, Dees P et al. · 2026 · BMC psychology

Background The Epistemic Trust, Mistrust, and Credulity Questionnaire (ETMCQ) assesses individual differences in epistemic stances. Although widely used, its German translation has not yet undergone an independent psychometric evaluation.…

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