12,241 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Spotts EK, Chatterjee A, Coleman L et al. · 2026 · Psychology & health
Objective Informing individuals about the nocebo effect, termed nocebo education, can minimise the experience of side effects. One untested possibility is that nocebo education promotes behaviour change, such that it decreases the…
View details →Cheung LC, Mao F, Rydzak G et al. · 2026 · Annals of internal medicine
Background Cervical intraepithelial neoplasia (CIN) grade 2 (CIN 2) is an equivocal diagnosis of cervical precancer, and appropriate management continues to be debated. Objective To estimate the effect of immediate (by 6 months) versus…
View details →Kam MK, Kim JW, Choi JY et al. · 2026 · Biochemical and biophysical research communications
Tau aggregation in neurons is a pathological hallmark of Alzheimer's disease (AD). The development of therapeutic drugs that inhibit tau aggregation in tauopathies, including AD, remains challenging. Herein, we developed a tau…
View details →Lopez DE, Carmalt JL · 2026 · Frontiers in veterinary science
Background The equine temporomandibular joint (TMJ) is divided into two non-communicating joint (discotemporal DTJ and discomandibular DMJ) compartments. Ultrasound has been extensively used as a diagnostic tool in the horse, but previous…
View details →Lex JR, Ekhtiari S, Entezari B et al. · 2026 · The Journal of bone and joint surgery. American volume
Background Obesity is an independent risk factor for complications following total hip arthroplasty (THA). Preoperative bariatric surgery to facilitate weight loss has been used to reduce complication risk, but its effectiveness remains…
View details →Giaccari LG, Brunetti S, Coppolino F et al. · 2026 · Medical sciences (Basel, Switzerland)
Background : Obesity increases the risk of postoperative pulmonary complications (PPCs), and active smoking may further amplify this risk. Whether smoking status identifies a subgroup of obese surgical patients with differential PPC risk…
View details →Jdidi H, de Bisschop C, Dugué B et al. · 2026 · European journal of applied physiology
Purpose Whole-body cryostimulation (WBC) has recently been shown to improve autonomic nervous control of the cardiovascular system. This study aimed to investigate the acute and repeated effects of WBC on baroreflex sensitivity (BRS),…
View details →Meco M, Carreira RP, Ochota M et al. · 2026 · Theriogenology
This study describes embryo developmental progression and morphokinetic patterns in embryos derived from oocytes of young and aged domestic cats, a model for endangered felids, using a time-lapse monitoring system. Because maternal aging…
View details →Pittmann R, Herring E, Pennington S et al. · 2026 · Frontiers in health services
Introduction Telehealth etiquette refers to professional behaviors that support effective virtual communication between patients and providers. While telehealth has become a lasting part of healthcare delivery, most health professions…
View details →Glenthøj LB, Vernal DL, Mariegaard LS et al. · 2026 · Schizophrenia (Heidelberg, Germany)
Virtual reality (VR)-assisted avatar therapy has shown promising effects for reducing voice-related distress and overall severity of persistent auditory verbal hallucinations (AVH) in psychosis, yet the mechanisms underlying these…
View details →Brar MS, Park JJ, de Buck van Overstraeten A · 2026 · Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
Background and aims Fertility and mode of delivery are major concerns for women with ulcerative colitis (UC) undergoing ileal pouch-anal anastomosis (IPAA). Although infertility after IPAA has been attributed to pelvic adhesions, the…
View details →Caunca M, Gutierrez S, Wheeler K et al. · 2026 · Neurology
Background and objectives The mechanisms underlying racial/ethnic differences in dementia incidence and pathology are multifactorial, and hypertension represents an actionable target for reducing these differences. We aimed to estimate the…
View details →Parlak Insel B, Guven Y, Sepet E et al. · 2026 · BMC oral health
Within the concept of minimal invasive dentistry, the progression of initial caries lesions can be inhibited with preventive measures. This study evaluated the microleakage and remineralization potential of a bioactive fissure sealant (FS)…
View details →Christian P, Ali H, Zavala E et al. · 2026 · BMJ global health
Antenatal balanced energy-protein (BEP) dietary supplementation is a WHO recommendation in undernourished settings, but limited evidence exists on targeting individuals based on nutritional status. We assessed the impact of untargeted and…
View details →Duje ML, Scharlovsky HR, Crivelli A et al. · 2026 · Nutricion hospitalaria
Background home enteral nutrition (HEN) maintains nutritional status in patients unable to feed orally. While established globally, data on its costs in Argentina are scarce. This study aimed to describe HEN costs and analyze differences…
View details →Takeda Y, Sakakibara T, Horiuchi K et al. · 2026 · Brain & development
Background We previously reported that adrenocorticotropic hormone (ACTH) therapy for infantile epileptic spasm syndrome (IESS) decreases plasma fibrinogen (Fbg) levels. However, the underlying mechanism(s) has not been elucidated. An…
View details →Li C, Shu L, Teng YL et al. · 2026 · Inorganic chemistry
To exploit the electron-sponge properties of polyoxometalates (POMs) and elucidate the mechanistic impact of doping with saturated versus metal-substituted Dawson-type POMs on electrocatalytic CO 2 reduction, P 2 W 18 @PCN-222 and P 2 W 17…
View details →Shaposhnikov MM, Trmcic A, Martin NH · 2026 · Journal of dairy science
The microbial quality of fluid milk is improved via processing steps, such as pasteurization which reduces the overall microbial population of milk and in particular is effective against Gram-negative, heat sensitive bacteria. Therefore,…
View details →Cook DP · 2025 · Annals of internal medicine
Clinical impact ratings GIM/FP/GP: [Formula: see text] Critical Care: [Formula: see text] Pulmonology: [Formula: see text].
View details →Cirlak A, Kacan H · 2026 · Irish journal of medical science
BACKGROUND: Parent-supported psychosocial development programs aim to strengthen the parent-child relationship and promote healthy early childhood development, particularly in settings where access to structured preventive interventions is…
View details →Iepsen LB, Griebeler LB, de Almeida ICA et al. · 2026 · Topics in companion animal medicine
This study aimed to evaluate the sedative effects of acepromazine and dexmedetomidine in dogs and their influence on propofol requirements for anesthetic induction, electrocardiographic findings, heart rate and arterial blood pressure.…
View details →Alallah J, Mohtisham F, Ahmed A et al. · 2026 · Journal of neonatal-perinatal medicine
BackgroundThe study examined the medical impact of tahneek with dates on hypoglycemia in high-risk newborns. Tahneek, an Islamic tradition, may offer benefits such as stimulating mouth muscles and aiding in breastfeeding initiation. The…
View details →Elenjickal EJ, Mavrakanas TA · 2026 · American journal of nephrology
Background Aldosterone regulates genes controlling fluid and electrolyte balance through mineralocorticoid receptor (MR) activation. Sustained MR activation promotes inflammation, fibrosis, sodium retention, and myocardial remodeling. MR…
View details →Awwad A, Das Adhikari U, Burdo TH et al. · 2026 · AIDS (London, England)
Objective To determine whether pitavastatin reduces enterocyte injury, assessed by intestinal fatty acid-binding protein (I-FABP), among antiretroviral therapy-treated people with HIV (PWH) enrolled in the REPRIEVE mechanistic substudy.…
View details →Li J, Dai W, Alavi R et al. · 2026 · Journal of the American Heart Association
Background Empagliflozin, a sodium-glucose cotransporter 2 inhibitor, has demonstrated cardioprotective and neuroprotective effects in preclinical myocardial infarction (MI) and ischemic stroke settings by reducing acute myocardial and…
View details →Sosnowski KJ, Ranse KL, Mitchell ML et al. · 2026 · Critical care medicine
Objectives To test whether the ABCDEF bundle, compared with usual care, decreases delirium incidence and duration, improves functional status in the ICU, and enhances 90-day post-ICU discharge quality of life in critically ill Australian…
View details →Thorman IB, Sacknovitz A, Li AG et al. · 2026 · Annals of neurology
Objectives The objective of this study was to evaluate the effectiveness and adverse effect profile of prophylactic levetiracetam in preventing epilepsy after traumatic brain injury (TBI). Methods This retrospective cohort study used the…
View details →Niiya F, Satoh T, Kobayashi Y et al. · 2026 · Digestive diseases and sciences
Background Clinical evidence on whether acute cholangitis accelerates early stent failure via rapid bacterial adhesion and biofilm formation remains limited. We assessed the influence of pre-endoscopic retrograde cholangiopancreatography…
View details →Chow EJ, Chen Y, Yasui Y et al. · 2026 · JAMA network open
Importance Survivors of childhood cancer have an increased risk of cardiovascular disease (CVD). However, many survivors at high risk do not receive recommended CVD screening tests as young adults. Objective To assess whether a…
View details →Nersesian G, Rauch M, Lewin D et al. · 2026 · Artificial organs
Background Surgically implanted microaxial flow pumps (mAFP) are increasingly used for cardiogenic shock treatment. Standard mAFP explantation is performed bedside with a shortening of the vascular prosthesis, which may represent a…
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