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Browse the failure-mode index

12,375 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Effects of high-definition transcranial direct current stimulation for the treatment of chronic insomnia: a randomized, double-blind, controlled trial.

Li J, Li A, Jiao J et al. · 2025 · Scientific reports

To evaluate effects of 10-day high-definition transcranial direct current stimulation (HD-tDCS) over the dorsal medial prefrontal cortex (DMPFC) in patients with chronic insomnia. Fifty-five chronic insomnia patients were randomized into…

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Negative / Null Result ReportOpen accessMedicine

Men talk less than women during multitasking.

Szameitat AJ, Szameitat DP · 2026 · Psychological research

Contrary to the widespread stereotype that women are better at multitasking than men, no consistent sex differences in multitasking abilities between males and females have been found. We developed a novel multitasking paradigm consisting…

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Negative / Null Result ReportMedicine

Plasmatic variability of direct oral anticoagulants in people with atrial fibrillation and previous gastric surgery: a pilot case series.

Romoli M, Vitiello M, Lotti EM et al. · 2025 · Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

Background Data on cardioembolic prevention with direct oral anticoagulants (DOAC) in atrial fibrillation (AF) patients with previous gastric surgery are lacking. We report inter- and intra-individual differences in DOAC concentration in…

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Negative / Null Result ReportOpen accessMedicine

Association between Vitamin D Receptor Polymorphisms, Tight Junction Proteins and Clinical Features of Adult Patients with Atopic Dermatitis.

Grieco T, Moliterni E, Paolino G et al. · 2024 · Dermatology practical & conceptual

Introduction Few studies have explored the intricate connections between vitamin D receptor (VDR) gene polymorphisms, VDR, tight junction (TJ) protein expression and clinical features of atopic dermatitis (AD). Methods From 43 adult AD…

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Negative / Null Result ReportMedicine

A qualitative study on perceptions of adolescents' sexual and reproductive health education in Yogyakarta, Indonesia.

Sikoki B, Larastiti C, Suriastini NW et al. · 2024 · International journal of adolescent medicine and health

Introduction Sexual and reproductive health (SRH) education in Yogyakarta, Indonesia, is contentious due to societal and religious taboos in the Javanese Muslim community and being misunderstood as a potential catalyst for the premarital…

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Negative / Null Result ReportOpen accessMedicine

Real-world effectiveness of vonoprazan-based regimen versus rabeprazole-based dual therapy for <i>Helicobacter pylori</i> eradication in a high-resistance, multi-ethnic region: a multicenter study in Guizhou, China.

Huang Y, Zheng J, Yang Z et al. · 2026 · Frontiers in medicine

Introduction While vonoprazan-amoxicillin dual therapy has achieved > 90% eradication rates for Helicobacter pylori (H. pylori) in clinical trials, its effectiveness in "real-world" regions with high primary antibiotic resistance and…

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Negative / Null Result ReportOpen accessMedicine

A consensus exercise to inform the future of National Health Service General Dental Services using a modified-Delphi technique.

Chestnutt IG, Pattinson R, Brocklehurst P et al. · 2026 · British dental journal

Background Problems relating to the commissioning and delivery of National Health Service (NHS) General Dental Services (GDS) have been well-documented.Objectives This study aimed to gain consensus on issues deemed of importance to the…

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Negative / Null Result ReportMedicine

Primary outcomes and anticipated effect sizes in randomised clinical trials assessing peripheral and truncal nerve blocks: a systematic scoping review.

Sorenson S, Flyger SSB, Pingel L et al. · 2025 · British journal of anaesthesia

Background Peripheral and truncal nerve blocks provide effective analgesia facilitating perioperative care. However, thresholds for clinically relevant effects remain undetermined and are left for clinicians to choose. These choices are…

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Negative / Null Result ReportOpen accessMedicine

Effects of Multimodal and Unimodal Physical Training Interventions on Visual Function in Glaucoma and Elderly Controls - A Pilot Study.

Moffack Djuloun C, Al-Nosairy KO, Beyer R et al. · 2026 · Clinical ophthalmology (Auckland, N.Z.)

Purpose This study aimed to investigate the effects of a 12-week multimodal motor-cognitive and resistance training (MMI) compared to a unimodal resistance training intervention (UMI) on static and dynamic visual function in glaucoma (GLA)…

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Negative / Null Result ReportMedicine

Efficacy and Safety of Polatuzumab Vedotin Plus Rituximab, Cyclophosphamide, Doxorubicin and Prednisone for Previously Untreated Diffuse Large B-Cell Lymphoma: A Real-World, Multi-Center, Retrospective Cohort Study.

Zhao P, Zhao S, Huang C et al. · 2025 · Hematological oncology

Polatuzumab vedotin plus R-CHP (Pola-R-CHP) is approved as a new standard first-line therapy for diffuse large B-cell lymphoma (DLBCL) based on the POLARIX trial. However, real-world data on its efficacy and safety in unselected patients…

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Negative / Null Result ReportOpen accessMedicine

Long-term follow-up of scar quality and satisfaction after surgical closure of congenital abdominal wall defects: a single center perspective.

Reindl N, Seitz S, Schleier M et al. · 2025 · Pediatric surgery international

Purpose Postoperative scarring remains a major concern for patients and parents following repair of congenital abdominal wall defects. This study evaluated perceptions of postoperative scars in children after omphalocele or gastroschisis…

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Negative / Null Result ReportMedicine

The impact of self-assessment and surveyor assessment on site visit performance under the National General Practice Accreditation scheme.

McNaughton DT, Mara P, Jones MP · 2024 · Australian health review : a publication of the Australian Hospital Association

Objective There is a need to undertake more proactive and in-depth analyses of general practice accreditation processes. Two areas that have been highlighted as areas of potential inconsistency are the self-assessment and surveyor…

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