12,241 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Boktor J, Jayaraju U, Joseph V et al. · 2024 · Cureus
Background In the UK, the vast majority of bilateral total knee replacements (BTKRs) are performed as staged procedures. Historically, the second-operated knee, in patients undergoing staged BTKRs, has poorer outcomes compared with the…
View details →Zhang B, Du X, Luo C et al. · 2026 · Clinical cardiology
Background and aims Vasovagal syncope (VVS) poses challenges despite therapy, and optimal cardioneuroablation (CNA) targeting ganglionated plexi (GPs) remains debated. This study compared long-term efficacy and safety between empirical…
View details →Sorenson S, Flyger SSB, Pingel L et al. · 2025 · British journal of anaesthesia
Background Peripheral and truncal nerve blocks provide effective analgesia facilitating perioperative care. However, thresholds for clinically relevant effects remain undetermined and are left for clinicians to choose. These choices are…
View details →McNamara DM, Cooper LT, Friedrich MG et al. · 2026 · ESC heart failure
Introduction Cannabidiol has been shown to exert significant anti-inflammatory effects and has demonstrated efficacy in murine models of autoimmune myocarditis, pericarditis, and heart failure. The ARCHER Study assessed whether a…
View details →Lau J, Wong GJ, Wan SW et al. · 2026 · Family practice
Background Colorectal cancer screening is an evidence-based preventive approach. Singapore has a national screening programme, but local studies suggest poor uptake. Gender differences in screening uptake exist in the literature, and women…
View details →Moffack Djuloun C, Al-Nosairy KO, Beyer R et al. · 2026 · Clinical ophthalmology (Auckland, N.Z.)
Purpose This study aimed to investigate the effects of a 12-week multimodal motor-cognitive and resistance training (MMI) compared to a unimodal resistance training intervention (UMI) on static and dynamic visual function in glaucoma (GLA)…
View details →Brown HS, Wall B, Mears SC et al. · 2024 · Geriatric orthopaedic surgery & rehabilitation
Introduction 1 mm cerclage cables have been introduced that can be placed under plates and hold reduction of periprosthetic femur fractures (PPFFx) around total hip arthroplasty (THA). Their utilization remains controversial due to the…
View details →Lima MR, Paiva MS, Maltês S et al. · 2025 · Current problems in cardiology
Background Atrial septal defects (ASD) often go unrecognized until very late in life. The impact of ASD closure on life expectancy in elderly patients remains unclear. This study compares the survival of patients≥65-years who underwent ASD…
View details →Nishikimi M, Ohshimo S, Nobayashi K et al. · 2026 · Critical care (London, England)
Background Neither the magnitude nor the timing of mean arterial pressure (MAP) increase after norepinephrine (NE) initiation is well defined, leaving clinicians without clear criteria for adequate starting doses. This study aimed to…
View details →Hviid CVB, Rasmussen NH, Røikjer J · 2025 · Acta diabetologica
Background Objective and easily applicable biomarkers for diabetic polyneuropathy (DPN) are warranted. Circulating nerve-specific proteins have emerged as valuable biomarkers for central nervous system disease but few of these have been…
View details →Zhao P, Zhao S, Huang C et al. · 2025 · Hematological oncology
Polatuzumab vedotin plus R-CHP (Pola-R-CHP) is approved as a new standard first-line therapy for diffuse large B-cell lymphoma (DLBCL) based on the POLARIX trial. However, real-world data on its efficacy and safety in unselected patients…
View details →Reindl N, Seitz S, Schleier M et al. · 2025 · Pediatric surgery international
Purpose Postoperative scarring remains a major concern for patients and parents following repair of congenital abdominal wall defects. This study evaluated perceptions of postoperative scars in children after omphalocele or gastroschisis…
View details →Thomas P, Kerrey B, Edmunds K et al. · 2024 · Pediatric emergency care
Background The lower clinical exposure of Pediatric Emergency Medicine (PEM) fellows to critical procedures may impede skill acquisition. We sought to determine the tracheal intubation learning curve of PEM fellows during training and…
View details →Pelzer F, Leisge K, Kaczmarek C et al. · 2025 · Scientific reports
We often perform motor tasks in front of other people, and this may help or hinder our performances. Previous research mainly focused on changes in motor performance, and less is known about spectator influences on performance predictions.…
View details →Panzer S, Hofstetter N, Schreiber M et al. · 2026 · Experimental brain research
The present study examined if a daytime nap of 90 min can further improve skill memory afforded by observation and physical practice. Moreover, we determined if a 'nap' benefit was restricted to a particular representational form (spatial…
View details →McNaughton DT, Mara P, Jones MP · 2024 · Australian health review : a publication of the Australian Hospital Association
Objective There is a need to undertake more proactive and in-depth analyses of general practice accreditation processes. Two areas that have been highlighted as areas of potential inconsistency are the self-assessment and surveyor…
View details →Alevi KCC, Ravazi A, de Oliveira J et al. · 2025 · Scientific reports
The diversification of Rhodnius species has been primarily attributed to vicariance events. Phylogenomic studies have proposed various evolutionary hypotheses - such as incomplete lineage sorting, hybrid speciation, and introgression - to…
View details →Srivastava S, Kharkar VR, More S et al. · 2024 · Journal of clinical and experimental dentistry
Background Absorbable gelatin sponges are able to reduce the incidence of post-extraction complications when soaked with antimicrobial agents. However, the drawbacks associated with the injudicious use of antibiotics warrant the need to…
View details →Tidblad L, Öberg Sysojev A, Delcoigne B et al. · 2025 · RMD open
Objective To examine whether obesity and/or overweight are independently associated with an increased risk of remission failure in patients with early rheumatoid arthritis (RA), treated with methotrexate as first disease-modifying…
View details →Medeiros CNA, Azevedo IG, Gomes Fernandes SG et al. · 2026 · PeerJ
Background Urinary incontinence (UI) is a common complaint among middle-aged and older women, associated with many negative impacts in health. The aim of this study was to analyze whether an association exists between UI and sarcopenic…
View details →Fowler TE, Bloomquist RF, James JN · 2025 · BMC oral health
Background The incidence of fascial space infections of the head and neck has long been suggested to correlate with weather patterns, though objective evidence is inconsistent, and a causative effect is difficult to prove. One issue in the…
View details →Viskupič F, Wiltse DL · 2025 · PLOS global public health
It is possible that the negative attitudes toward COVID-19 vaccination developed by some people, such as self-identified Republicans, might spill over toward other vaccines. We conducted a survey experiment to investigate if mentioning…
View details →Meade MJ, Jensen S, Ju X et al. · 2024 · International orthodontics
Objective The aim of the present study was to evaluate the quality and readability of content contained within clear aligner therapy (CAT) informed consent forms. Methods CAT informed consent forms were identified via an online search. The…
View details →Chhaya D, Gress M, Raja A et al. · 2024 · International journal of environmental research and public health
The objective of this study is to investigate the potential mutagenic effects of the exposure of mice to aerosols produced from the component liquids of an electronic nicotine delivery system (ENDS). The use of electronic cigarettes…
View details →Maier F, Luttenberger I, Dreisoerner A et al. · 2026 · Stress and health : journal of the International Society for the Investigation of Stress
Chronic stress has well-documented adverse effects on physical and psychological health. Beyond contributing to the development of fatigue, its impact is intensified by social stressors such as loneliness, making the development of…
View details →Al-Khalaifah H, Al-Nasser A, Al-Surrayai T · 2025 · Life (Basel, Switzerland)
There is growing interest in adding marine algae to poultry feed rations. The aim of the present study is to examine the effect of various inclusions of Sargassum sp., Gracilaria sp., and Spirulina sp. on productive performance, serum…
View details →Zamora Veliz HY, Paredes Cabanillas RY, Gomez Trejo JE et al. · 2025 · Cureus
Introduction Intestinal anastomotic leakage is a serious postoperative complication associated with high morbidity and mortality. Although acute-phase reactants such as procalcitonin (PCT) and CRP have been proposed as early biomarkers,…
View details →Halačová M, Mieresová M, Kubele J et al. · 2026 · Pharmacological reports : PR
BACKGROUND: Beta-lactams are the cornerstone of therapy for the treatment of the most serious infections in the intensive care unit (ICU) setting. However, individualization of dosing remains challenging because pharmacokinetics are highly…
View details →Dumont JR, Sheppard PAS, Fodor C et al. · 2025 · Genes, brain, and behavior
Alzheimer's disease is a debilitating neurodegenerative condition characterized by amyloid beta plaques and tau neurofibrillary tangles, which leads to progressive cognitive decline. Several new mouse models of fast amyloid deposition have…
View details →Langevin P, Frémont P, Fait P et al. · 2024 · Disability and rehabilitation
Purpose The objective of this study was to compare the effects of an in-clinic cervicovestibular rehabilitation program (education, home exercises, manual techniques, sub-symptom threshold aerobic exercise [STAE] program) to a similar…
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