12,375 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Artal JM, Randall L, Rubeck S et al. · 2025 · American journal of medical genetics. Part A
Parents of children with Down syndrome have historically reported poor experiences receiving a prenatal diagnosis. In a 2003 survey, mothers reported that their physicians pitied them, emphasized negative aspects of Down syndrome, and…
View details →Grant Owens R, Lockwood G, Storm D · 2025 · Urology
Prenatal diagnosis of left multicystic dysplastic kidney (MCDK) and ureterocele was made in a male fetus at 24-week gestation. The initial postnatal course was uneventful. At 4 weeks of age, he developed urosepsis and respiratory distress.…
View details →Pisljar Z, Markelc B, Brezar SK et al. · 2025 · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Radiotherapy is a standard therapy for oral squamous cell carcinoma (OSCC) with immunomodulatory potential. Due to high lymphocyte radiosensitivity, partial tumor-volume irradiation (pIR), targeting only part of the tumor, is being…
View details →Davis MP, Ulrich A, Segal R et al. · 2024 · Cancers
Background: Chemotherapy-induced peripheral neuropathy (CIPN) from oxaliplatin and taxane drugs is a bothersome toxicity. Palmitoylethanolamide (PEA) has been reported to improve myelinated nerve fiber function in patients experiencing…
View details →Paul N, Weiss B · 2025 · Die Anaesthesiologie
With a decrease in mortality of critically ill patients in recent years, intensive care medicine research has shifted its focus on functional impairments of intensive care units (ICU) survivors. ICU survivorship is characterized by…
View details →Aguila L, Castillo R, Pérez-García F et al. · 2026 · Animals : an open access journal from MDPI
Haploid embryos constitute a valuable model for genetic and epigenetic studies; however, their developmental competence is reduced compared with diploid counterparts. This study evaluated whether supplementation of the culture medium with…
View details →Bi X, Yu Y, Zhou S et al. · 2024 · Nephron
Introduction The renoprotective benefits of adding immunosuppressant therapy to corticosteroid (CS) treatment for immunoglobulin A nephropathy (IgAN) patients with less than 25% crescent formation (C1) remain uncertain, warranting further…
View details →Vicenti C, Cercone M, Nieman G et al. · 2025 · Veterinary Anaesthesia and Analgesia
To compare early versus late time-controlled adaptive ventilation (TCAV) for setting airway pressure release ventilation (APRV) on arterial oxygenation in dorsally recumbent anesthetized horses. A crossover, nonrandomized, experimental…
View details →Kaplan A, Malik S, Persaud NA et al. · 2025 · Cureus
Fragile X syndrome (FXS) is classified as a genetic disorder located in the fragile X messenger ribonucleoprotein-1 (FMR1) gene on the X chromosome. FXS is considered the most prevalent single-gene cause of intellectual disability and…
View details →Calvani R, Giampaoli O, Marini F et al. · 2024 · Clinical nutrition (Edinburgh, Scotland)
Background & aims Long-term effects of coronavirus disease 2019 (long COVID) develop in a substantial number of people following an acute COVID-19 episode. Red beetroot juice may have positive effects on multiple pathways involved in long…
View details →Tardif A, Boulay ME, Côté A et al. · 2026 · Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology
BACKGROUND: Tezepelumab is the most recent human monoclonal antibody in the therapeutic arsenal of patients with severe uncontrolled asthma. It neutralizes thymic stromal lymphopoietin (TSLP). Phase 2 and phase 3 studies showed a…
View details →Fu Y, Zhang Y, Deng Q et al. · 2025 · BMC psychiatry
Background Post-stroke depression (PSD) constitutes an important complication of stroke, affecting approximately one-third of stroke patients. PSD decreases rehabilitation motivation, delays function recovery, and increases the family and…
View details →Kateh Shamshiri M, Vakili-Ghartavol R, Aiyelabegan HT et al. · 2025 · Cytokine
While liposomes enhance the safety and pharmacokinetic profile of free drugs, they have not significantly improved therapeutic efficacy. To overcome this challenge, targeted depletion of tumor-associated macrophages (TAMs) shows…
View details →Lamboley Q, Fourcade Y · 2024 · Journal of biogeography
AIM: The continuous development of statistical tools applied to ecology has contributed to great advances for modelling species' niches and distributions from opportunistic observations. However, as these observations are subject to biases…
View details →Alghizzi TM, Alshahrani TM · 2024 · Heliyon
Despite considerable evidence that supports the use of grading rubrics (GRs) as tools for written corrective feedback, there is a paucity of research that investigates which of the different types of GRs best develops learners'…
View details →Bousamaki J, Maciag G, Petersen AG et al. · 2026 · Basic & clinical pharmacology & toxicology
Nintedanib, a multitargeted tyrosine kinase inhibitor, is approved for idiopathic pulmonary fibrosis (IPF) for its ability to slow lung function decline. This study systematically evaluated the effects of nintedanib across three…
View details →Güngör HS, Łabuz G, Yildirim TM et al. · 2024 · Journal of refractive surgery (Thorofare, N.J. : 1995)
Purpose To investigate how varying levels of longitudinal chromatic aberration (LCA) affect visual quality in patients with trifocal intraocular lenses (IOLs). Methods Twenty-nine patients implanted with trifocal IOLs were assessed for…
View details →Hui Q, Xiang T, Qinglan X et al. · 2026 · Food science & nutrition
The link between Vitamin D (Vit D) deficiency and sudden sensorineural hearing loss (SSNHL), especially regarding recurrence and age-related disparities, remains unclear. Recurrence and age-specific risks of SSNHL are under addressed,…
View details →Tanabe S, Shi Y · 2024 · The American journal of case reports
BACKGROUND Retained products of conception (RPOC) is a rare complication following second-trimester delivery or pregnancy termination, often leading to significant hemorrhage. Diagnosed via ultrasound or CT, RPOC requires surgical…
View details →Hyun J, Cerino ES, Katz MJ et al. · 2025 · The journals of gerontology. Series B, Psychological sciences and social sciences
Objectives Investigating social determinants of health and related outcomes may help identify effective and sustainable intervention targets. This study examined whether contextual-level social capital (bonding and bridging capital) and…
View details →Kumekawa T, Akaihata H, Natsuya H et al. · 2024 · IJU case reports
Introduction Human T-cell lymphotropic virus type 1 infection can cause HTLV-1-associated myelopathy/tropical spastic paraparesis, characterized by spastic paralysis of both lower limbs. More than 90% of HAM/TSP patients show lower urinary…
View details →Nikolaeva A, Vandeputte M · 2025 · Endocrinology, diabetes & metabolism case reports
Summary Semaglutide, a GLP-1 receptor agonist (RA), is approved for the treatment of type 2 diabetes and obesity. However, its increasing off-label use, particularly for cosmetic weight loss, raises concerns considering its potential…
View details →El Idrissi Y, El Moudden H, Belhoussaine O et al. · 2025 · Chemistry & biodiversity
This study investigates for the first time the effects of UV light exposure on the chemical composition of artisanal and cold-pressed culinary and cosmetic argan oils, as well as their quality and biological activities. We ascertained the…
View details →Jhaj J, Woolner B, Rankin S et al. · 2025 · Shoulder & elbow
This study evaluated the outcome and recurrence rates after hydrodilatation (HD) in patients with frozen shoulder (FS), comparing the effects of injecting 25 mL or more of fluid versus lower volumes. A total of 132 shoulders (130 patients)…
View details →Banerjee S, Berry Y, Fisher E et al. · 2025 · Neuroscience letters
Genetic leukoencephalopathy (gLE) is a white matter disorder affecting the central nervous system, causing hypomyelination, developmental delays, motor deterioration, and cognitive, visual, and hearing impairments. Its clinical variability…
View details →Alsheekh A, Kibrik P, Marks N et al. · 2025 · Vascular
BackgroundThe minimally invasive procedures of venous ablation and iliac vein stenting are evolving treatment options for venous insufficiency. Yet, there are no studies directly comparing the outcome of these procedures. We performed a…
View details →Altamirano F, Gonzalez E, Oke I · 2024 · Digital journal of ophthalmology : DJO
A healthy 4-year-old boy referred for evaluation of an abnormal red reflex in the left eye was noted, on fundus examination, to have extensive white, striated lesions surrounding the optic nerve that involved the superior and inferior…
View details →Hata Y, Iida O, Torii S et al. · 2026 · European heart journal. Case reports
Background The long-term vascular response to paclitaxel-eluting stents (PESs) in infrapopliteal (IP) lesions remains histologically uncharacterized. Case summary A 78-year-old woman with chronic limb-threatening ischaemia underwent…
View details →Agergaard J, Gunst JD, Schiøttz-Christensen B et al. · 2023 · International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
Objectives Knowledge is limited on how changing SARS-CoV-2 variants may translate into different characteristics and affect the prognosis of patients with long COVID, especially following Omicron variants. We compared long-term prognosis…
View details →Pyzer AR, Dillon LW, Sharon E et al. · 2025 · Blood advances
Abstract We conducted a multicenter, open-label, randomized phase 2 study to assess the efficacy of nivolumab (Nivo) as maintenance therapy for patients with acute myeloid leukemia (AML) in first complete remission (CR) or CR with…
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