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Browse the failure-mode index

12,368 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Diagnostic accuracy of tuning fork weber test and audiometric weber test in school-aged children with conductive hearing loss.

Peng, Nik Othman, Zakaria et al. · 2026 · European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

While the application of tuning fork Weber (TFW) test in adult is well-documented, its accuracy in the paediatric population remains uncertain although conductive hearing loss is frequently identified in children. Similarly, the…

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Negative / Null Result ReportMedicine

Effect of build orientation, sintering schedule, and resin cement on the bond strength of additively manufactured zirconia to dentin.

Sabatini, Molinero-Mourelle, Limones et al. · 2026 · The Journal of prosthetic dentistry

Whether the manufacturing protocol (build orientation and sintering schedule) of additively manufactured (AM) zirconia impacts the bond strength compared with subtractively manufactured (SM) zirconia remains unclear. The purpose of this in…

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Failed Experiment ReportMedicine

[Prokaryotic expression of Echinococcus granulosus Polo-like kinase 2 and immunoprotective efficacy of its recombinant protein].

Wang, Yan, Qi et al. · 2026 · Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control

To prepare the recombinant Echinococcus granulosus Polo-like kinase 2 (rEgPLK2) protein and evaluate its immunoprotective efficacy against cystic echinococcosis, so as to provide insights into research and development of novel vaccines…

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Negative / Null Result ReportMedicine

Effect of sleep quality on physical performance in the elderly.

Roy, Jahagirdar, Kumar et al. · 2026 · Journal of bodywork and movement therapies

Deteriorating physical performance with ageing increases the risk of falls, loss of independence, institutionalisation and mortality amongst elderly. Apart from multisystem body decline, poor quality sleep, being a common complaint amongst…

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Negative / Null Result ReportMedicine

Effect of Inulin-Type Fructans on Body Composition, Carbohydrate Metabolism and Energy Expenditure in Patients with Psoriasis: Results of INGUTSKIN Randomized Controlled Trial.

Bieglecka, Kęszycka, Czerwińska et al. · 2026 · Nutrients

Patients with psoriasis, a non-contagious, chronic, systemic inflammatory skin disease, often suffer from carbohydrate metabolism disorders, which can exacerbate systemic inflammation. This randomized, double-blind, placebo-controlled…

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Negative / Null Result ReportMedicine

Inhibitory Effects of Oxytocin on Jejunal Migrating Myoelectric Complex Activity in Fasted Rats: Role of Oxytocin and GLP-1 Receptors.

Balcı, Saltık, Aktemur et al. · 2026 · Life (Basel, Switzerland)

The migrating myoelectric complex (MMC) is the electrical basis of fasting small intestinal motility. Although oxytocin (OT) regulates gastrointestinal functions through oxytocin receptors (OTRs), its effect on jejunal MMC activity during…

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Negative / Null Result ReportMedicine

[Impact of tirofiban on outcomes in STEMI patients across different levels of inflammation: a stratified analysis based on complete blood count-derived inflammatory markers].

Lin, Dong, Yang et al. · 2026 · Zhonghua xin xue guan bing za zhi

Objective: To investigate through stratified analyses based on complete blood count-derived inflammatory markers, the effects of tirofiban on in-hospital all-cause mortality and one-year composite endpoint events in patients with…

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Negative / Null Result ReportMedicine

Olfactory notes in the mind space: A registered report.

Caldana M, Rusconi E · 2026 · Cortex; a journal devoted to the study of the nervous system and behavior

Olfaction is an archaic sense but its central mechanisms are lesser known than those of other senses. Here we address a possible link between olfactory stimuli and mental spatial representations. Although olfactory percepts are not…

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Negative / Null Result ReportMedicine

Toxicity assessment of green energy by-product, lithium, using a novel suite of eight Australian aquatic-species tests from a Global Biodiversity Hotspot.

Nice, Storer, Fisher et al. · 2026 · Environmental toxicology and chemistry

Due to recent advances in green energy initiatives in response to climate change impacts, lithium exploration and production are rapidly increasing, with concomitant elevated lithium in discharges to waterways. However, lithium toxicity to…

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Negative / Null Result ReportMedicine

Effect and safety of Neiguan acupoint injection with astragalus injection for chronic heart failure with qi-deficiency and blood-stasis syndrome: a randomized controlled trial.

Gou, He, Zhuo · 2026 · Frontiers in medicine

To investigate the effect and safety of astragalus injection at Neiguan (PC6) for chronic heart failure (CHF; HF) with qi-deficiency and blood-stasis syndrome, and its effect on the renin-angiotensin-aldosterone system (RAAS). A…

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Negative / Null Result ReportMedicine

Does Gestational Diabetes Increase Urinary Incontinence During Pregnancy? A Cross-Sectional Study of Symptom Patterns and Incontinence-Related Quality of Life.

Özel, Efiloğlu, Cim et al. · 2026 · Neurourology and urodynamics

This study aimed to evaluate the association between gestational diabetes mellitus and urinary incontinence during pregnancy, including symptom subtype, symptom severity, and incontinence-related quality of life. This cross-sectional study…

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Negative / Null Result ReportMedicine

Overcoming donor-specific anti-human leukocyte antigen antibodies with desensitisation in adult ex-vivo T-cell depleted haploidentical haematopoietic stem cell transplantation: a real-world analysis.

Tham, Linn, Koh et al. · 2026 · Transplantation and cellular therapy

The presence of anti-human leukocyte antigen (HLA) antibodies directed against donor HLA (HLA-DSA) in HLA-mismatched haematopoietic stem cell transplantation (HCT) can affect engraftment and transplant outcomes. Desensitisation treatment…

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Negative / Null Result ReportMedicine

Knowledge of oxygen therapy among healthcare professionals in non-intubated patients: a cross-sectional study in Somalia.

Duman Aydin, Küçükosman, Mohamed et al. · 2026 · BMC medical education

Although oxygen therapy (OT) is a fundamental and life-saving intervention in the management of hypoxemia, it may lead to serious complications when applied incorrectly or in an uncontrolled manner. The aim of this study is to evaluate the…

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