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Browse the failure-mode index

12,368 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Occurrence of acrylamide and 4-methylimidazole in roasted and ground coffee and the effect of L-asparaginase treatment of green coffee on their levels.

da Costa, Ramirez, de Carvalho et al. · 2026 · Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment

Acrylamide and 4-methylimidazole (4-MEI) are heat-induced contaminants formed during coffee roasting, raising concerns due to their potential toxicological effects. Considering the limited information about the occurrence of these…

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Negative / Null Result ReportMedicine

The effectiveness of a cognitive behavioural therapy for insomnia based intervention to improve sleep quality in nursing home residents, a cluster randomised controlled trial.

Lahaye, Haegdorens, Franck et al. · 2026 · European geriatric medicine

To evaluate the effectiveness of a structured, team-delivered intervention based on cognitive behavioural therapy for insomnia (CBT-I) on sleep and related outcomes in nursing home residents. A cluster randomised controlled trial with…

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Negative / Null Result ReportMedicine

Clinical Implications of ChatGPT-assisted Multimodal Pre-operative Assessment in Elderly Pertrochanteric Fracture Patients: An Exploratory Study.

Noda, Takahara, Hayashi et al. · 2026 · Journal of orthopaedic case reports

Given the high mortality associated with femoral trochanteric fractures, reliable pre-operative estimation of post-operative death risk is essential. Commonly used scoring systems demonstrate only moderate predictive ability, largely…

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Negative / Null Result ReportMedicine

Clinical characteristics, antithrombotic strategies, and outcomes in patients with atrial fibrillation and coronary heart disease undergoing percutaneous coronary intervention: a multicenter real-world study in Chongqing, China.

Bao, Wu, Li et al. · 2026 · BMC cardiovascular disorders

Atrial fibrillation (AF) with coronary artery disease (CAD) requiring percutaneous coronary intervention (PCI) - including both acute and chronic presentations - is common, yet the optimal antithrombotic regimen remains unclear. This study…

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Negative / Null Result ReportOpen accessMedicine

Voir La Vie Sans Rose-Colored Glasses.

Paap K, Majoubi J · 2025 · Experimental psychology

In a recent article, Ellen Bialystok argued that bilingual experience enhances nonverbal cognition, that its effects are continuous rather than categorical, and that selective attention is the key mechanism underlying cognitive changes in…

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Negative / Null Result ReportMedicine

Parental oral health knowledge and sociodemographic influences in children aged 2-12 years: a cross-sectional study in Valencia, Spain.

Borrell-García, Mestanza-Tocto, Boo-Gordillo et al. · 2026 · European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry

The present study aimed to assess parental knowledge of paediatric oral health among parents and guardians of children aged 2-12 years in Valencia, Spain, and to analyse its association with key sociodemographic variables. A…

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Negative / Null Result ReportMedicine

Quality of life and gender identity in females with congenital adrenal hyperplasia after genital restoration surgery: A single-center experience.

Heidtmann, Umbreit, Eckoldt · 2026 · Journal of pediatric urology

Legislation restricting surgical interventions in children with differences of sex development (DSD) has intensified debate about female genital restoration surgery (FGRS) in patients with congenital adrenal hyperplasia (CAH). Long-term…

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Negative / Null Result ReportMedicine

Effect of polymerase chain reaction-based antifungal stewardship on candidemia management in small- and medium-sized hospitals.

Miyazaki, Ishigo, Yamada et al. · 2026 · Journal of pharmaceutical health care and sciences

Candidemia has high mortality and requires early antifungal stewardship (AFS). Management by non-infectious disease specialists has been associated with worse outcomes, particularly in small- and medium-sized hospitals where infectious…

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Negative / Null Result ReportMedicine

The cortisol awakening response (CAR) of elite athletes is elevated before a competition, but no interaction with sport type.

Jiménez, Lopez-Lluch, Barón-López et al. · 2026 · Psychoneuroendocrinology

The cortisol awakening response (CAR) is thought to represent an anticipatory mechanism to prepare for upcoming demands. In sport, competition increases in the CAR have been reported, although findings remain inconsistent. A study on…

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Negative / Null Result ReportOpen accessMedicine

Study preregistration: an early example and analysis.

Wiseman R, Watt C · 2026 · PeerJ

Preregistration is commonly seen as an effective way of reducing questionable research practices within psychology. This procedure happens prior to data collection/analysis and usually involves either sending in a research plan to a study…

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Negative / Null Result ReportMedicine

Uncharted Waters: Effects of Maritime Emission Regulation.

Hansen-Lewis J, Marcus M · 2025 · American economic journal. Economic policy

Maritime shipping emits as much fine particulate matter as half of global road traffic. We are the first to measure the consequences of US maritime emissions standards on air quality, human health, racial exposure disparities, and…

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Negative / Null Result ReportMedicine

On the Accuracy of Replication Failure Rates.

Schauer JM · 2023 · Multivariate behavioral research

A prominent approach to studying the replication crisis has been to conduct replications of several different scientific findings as part of the same research effort. The reported proportion of findings that these programs determined…

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Negative / Null Result ReportMedicine

Amuc_1100 alleviates HFD-induced hepatic lipid accumulation via gut microbiota in zebrafish: insights from the role of intestinal 14-3-3β/α-A.

Ding, Lou, Liang et al. · 2026 · Journal of animal science and biotechnology

Amuc_1100, the most abundant outer membrane protein of Akkermansia muciniphila, alleviates high-fat diet (HFD)-induced hepatic lipid accumulation and modulates gut microbiota in fish; however, its mechanism and mediators remain unknown.…

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