e-ISSN: Pending
WASTE Journal

Browse the failure-mode index

12,240 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Erectile Function Before and After Elective Inguinal Hernia Repair: A Paired IIEF-5 Study Comparing Laparoscopic and Open Techniques.

Sayur, Avcı, Güler et al. · 2026 · Journal of clinical medicine

Objective: This study aimed to evaluate changes in erectile function, assessed using the International Index of Erectile Function-5 (IIEF-5), in male patients undergoing elective inguinal hernia repair and to compare outcomes according to…

View details →
Negative / Null Result ReportMedicine

Effect of a Prior Two-Hour Postural Test on Seated Saline Suppression Test Results in Patients Predominantly Evaluated for Adrenal Incidentalomas.

Lewandowski, Wojciechowska-Durczyńska, Krawczyk-Rusiecka et al. · 2026 · Journal of clinical medicine

Background/Objectives : The Seated Saline Suppression Test (SSST) is widely used for investigation of primary hyperaldosteronism (PA); however, the impact of a one-hour sitting period prior to SSST (as recommended by the Endocrine Society,…

View details →
Negative / Null Result ReportMedicine

Quality of Life and Associated Factors in Primary Caregivers of Children with Refractory Epilepsy on Long-Term Ketogenic Diet: A Cross-Sectional Study.

Li, Wang, Yi et al. · 2026 · Healthcare (Basel, Switzerland)

Background/Objectives: In ketogenic therapy for children with refractory epilepsy-a special patient group-the quality of life of primary caregivers is often overlooked. This study aimed to explore the current state of primary caregivers'…

View details →
Negative / Null Result ReportMedicine

Association of Ascending Aortic Aneurysm with NOX4 and miRNA 146a.

Çalışkan, Karpuzoğlu, Karpuzoğlu et al. · 2026 · Genes

Objective: To evaluate the efficacy of NADPH oxidase 4 and miR-146a-5p in current treatment planning for ascending aortic aneurysms, independent of aortic diameter, and to develop protocols that will ensure the treatment of ascending…

View details →
Negative / Null Result ReportMedicine

Multi-Omics Analysis Reveals the Gut-Mediated Mechanism Underlying the Seasonal Non-Laying Phenotype in Zhedong White Geese ( Anser cygnoides domesticus ).

Shi, Zhou, Li et al. · 2026 · Animals : an open access journal from MDPI

As a precious indigenous goose resource in China, the Zhedong white goose occupies an essential position in the domestic goose industry. However, this breed spontaneously enters a prolonged non-laying period of over two months per year,…

View details →
Negative / Null Result ReportMedicine

Effects of Different Fattening Periods on Slaughtering Performance, Meat Quality, and Muscle Histochemical Characteristics of Yanbian Cattle.

Sun, Sun, Liu et al. · 2026 · Animals : an open access journal from MDPI

This study aimed to elucidate the effects of different fattening stages on slaughtering performance, meat quality, muscle fiber characteristics, connective tissue properties, and intramuscular fat deposition in Yanbian cattle. A total of…

View details →
Negative / Null Result ReportMedicine

Comparative Health Assessment of Crassostrea belcheri from Breeding and Farming Sites in Thailand: Histopathological, Apoptotic, and Molecular Evidence.

Chooseangjaew, Tanyaros, Thaochan et al. · 2026 · International journal of molecular sciences

Oyster health is important for aquaculture productivity and sustainability. In Thailand, the white scar oyster, Crassostrea belcheri , is being promoted for cultivation, yet its health status has not been compared between research breeding…

View details →
Negative / Null Result ReportMedicine

Left Atrial Volumes and Strains in Healthy Mid-Term Pregnancy-A Detailed Investigation from a Three-Dimensional Speckle-Tracking Echocardiographic MAGYAR-Preg Study.

Nemes, Halcsik, Kormányos et al. · 2026 · Biomedicines

Introduction : Gestational physiology is characterized by an expansion of plasma volume and an elevation in cardiac output. Given the scarcity of existing data on pregnancy-related left atrial (LA) volumetric and functional features, this…

View details →
Negative / Null Result ReportMedicine

Association Between Systemic Inflammatory Response Biomarkers and Disease Activity in Systemic Lupus Erythematosus: A Multi-Center Retrospective Study.

Ma, Zhang, Kong et al. · 2026 · Diagnostics (Basel, Switzerland)

Objective : To evaluate the association of routine complete blood count (CBC)-derived inflammatory biomarkers, including neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), and…

View details →
Negative / Null Result ReportMedicine

Sentinel Lymph Node Mapping Compared with Selective Lymph Node Sampling in the Surgical Staging of Endometrial Cancer: A Prospective Observational Study.

Gâta, Ilieș, Mureșan-Bădescu et al. · 2026 · Diagnostics (Basel, Switzerland)

Background/Objectives : Nowadays, lymph node assessment represents a key component in the surgical staging of endometrial cancer, as sentinel lymph node (SLN) mapping increased in adoption as an alternative to lymphadenectomy. This study…

View details →
Negative / Null Result ReportMedicine

Diagnostic Value of Ocular Hemodynamics and Choroidal Thickness in Unilateral Sudden Sensorineural Hearing Loss: Non-Invasive Biomarkers of Systemic Microvascular Disease.

Findik, Kaim, Uzun et al. · 2026 · Diagnostics (Basel, Switzerland)

Background/Objectives: Although vascular mechanisms are increasingly implicated in the etiology of sudden sensorineural hearing loss (SSNHL), the inability to directly visualize the labyrinthine artery remains a diagnostic obstacle.…

View details →
Negative / Null Result ReportMedicine

Antimicrobial effect of 1064 nm Nd:YAG laser with flat-top homogeneous beam profile on oral fungal and bacterial biofilms: an in vitro study.

Grzech-Leśniak, Pyrkosz, Szwajkowski et al. · 2026 · Lasers in medical science

This in vitro study aimed to evaluate the antimicrobial effects of a 1064 nm Nd:YAG laser delivered through a novel handpiece designed to provide a flat-top, homogeneous energy distribution profile (MarcoM handpiece) against key oral…

View details →
Negative / Null Result ReportMedicine

Alveolar socket preservation with human umbilical cord mesenchymal stem cell-seeded hydroxyapatite-chitosan scaffolds: An in vivo assessment of osteoprotegerin and receptor activator of nuclear factor-κB expression.

Alshaibani, Kamadjaja, Sitalaksmi et al. · 2026 · Journal of molecular histology

Tooth extraction is a common procedure often followed by alveolar bone resorption, which may compromise future implant placement, prosthetic rehabilitation, esthetics, and periodontal support. Hydroxyapatite-chitosan (HA-Chi) scaffolds…

View details →
Negative / Null Result ReportMedicine

Metformin and renal dosimetry in patients undergoing [ 177 Lu]Lu-PSMA therapy: reduced kidney absorbed dose without impact on tumor dosimetry.

Siegmund, Delker, Widjaja et al. · 2026 · European journal of nuclear medicine and molecular imaging

Prostate-specific membrane antigen (PSMA)-targeted radiopharmaceutical therapy (RPT) is an established treatment for advanced prostate cancer, but renal radiation exposure remains a major safety concern, as no clinically established…

View details →
Negative / Null Result ReportMedicine

Deep Learning Reconstruction Specialized for Inner Ear: Improving Image Quality and Anatomical Structure Visualization as Compared with Conventional Hybrid-Type Iterative Reconstruction on High-Definition CT.

Nomura, Kimata, Ito et al. · 2026 · Diagnostics (Basel, Switzerland)

Background/Objectives: To directly compare the capabilities of hybrid-type iterative reconstruction (IR) with the newly developed deep learning reconstruction (DLR) for the inner ear on high-definition CT (HDCT) obtained using the…

View details →
Negative / Null Result ReportMedicine

Rural medical disparities in multimodal glioblastoma treatment.

Momii, Hata, Fudaba et al. · 2026 · Scientific reports

Glioblastoma continues to have a poor prognosis, although recent advancements in multimodal treatments have gradually improved outcomes. However, treatment options have become increasingly complex and highly specialized. In rural areas,…

View details →
Negative / Null Result ReportMedicine

Impact of hydrophobic ion pair type and self-nanoemulsifying drug delivery systems composition on the oral delivery of salmon calcitonin.

Al-Maghrabi, Müllertz, Rades · 2026 · Journal of controlled release : official journal of the Controlled Release Society

Salmon calcitonin (sCT) is a peptide with poor enzymatic stability and permeability, limiting its oral delivery. This study investigated how hydrophobic ion pair (HIP) type and self-nanoemulsifying drug delivery systems (SNEDDS)…

View details →
Negative / Null Result ReportMedicine

A multicenter randomized controlled trial comparing metallic stents with 10- versus 14-mm diameter for distal biliary obstruction caused by unresectable pancreatic carcinoma.

Ishiwatari, Nakahara, Kawaguchi et al. · 2026 · Gastrointestinal endoscopy

Endoscopic retrograde cholangiopancreatography with metal stent (MS) placement is the standard treatment for biliary drainage in patients with unresectable pancreatic cancer. A 10-mm diameter MS is generally used; however, a larger stent…

View details →
Abandoned HypothesisMedicine

Formaldehyde metabolism in the biocatalytic upgrading of lignin.

Lalande AT, Eltis LD · 2026 · Current opinion in biotechnology

Formaldehyde is a toxic metabolite generated in the bacterial catabolism of lignin-derived aromatic compounds (LDACs) through the oxidative O-demethylation of methoxylated aromatics. Microbial cell factories designed to convert LDACs to…

View details →
Negative / Null Result ReportMedicine

Prognostic markers, quality of life (QoL) and value of health (V-He) in advanced biliary cancers (ABC) treated with second-line active symptom control (ASC) alone or ASC with oxaliplatin-5-FU chemotherapy (ASC + FOLFOX) in the randomised phase III, multicentre, open-label ABC-06 clinical trial.

Lamarca, Palmer, Wasan et al. · 2026 · ESMO open

The ABC-06 trial established FOLFOX as the reference second-line regimen for patients diagnosed with advanced biliary tract cancer (ABC). Here we analysed the prognostic role of tumour markers carbohydrate antigen 19-9 (CA19-9),…

View details →