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WASTE Journal

Browse the failure-mode index

12,240 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

A Comparative Analysis of the Hinotori and da Vinci Robotic Systems in Total Hysterectomy for Benign Uterine Gynecological Diseases Using Propensity Score Matching.

Torii, Oshima, Aoki et al. · 2026 · Asian journal of endoscopic surgery

The hinotori surgical robot system, the first Japanese-made robotic-assisted surgical system to receive Japanese regulatory approval in 2020, is now being applied clinically in gynecology. This study aimed to comprehensively compare the…

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Negative / Null Result ReportMedicine

Clinical and radiological outcomes of unilateral biportal endoscopy and percutaneous endoscopic interlaminar discectomy for highly downward-migrated lumbar disc herniation: a retrospective study.

Liu, Zhang, Zhang et al. · 2026 · BMC surgery

To compare the clinical efficacy and safety of unilateral biportal endoscopy (UBE) versus percutaneous endoscopic interlaminar discectomy (PEID) in the treatment of highly downward-migrated lumbar disc herniation (HDM-LDH). A retrospective…

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Negative / Null Result ReportMedicine

Modeling the Effects of Gravity and Patient Positioning on Stone Migration During Ureteroscopy with Laser Lithotripsy in a Physics-Based Simulator.

Velasquez Ospina, Gordon, Ojalvo et al. · 2026 · Urologia internationalis

Introduction Residual lower pole fragments are a common limitation of ureteroscopy, yet the optimal patient positioning to minimize stone migration remains undefined. This study aimed to evaluate the impact of Trendelenburg (HeadTilt) and…

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Negative / Null Result ReportMedicine

Proton FLASH preserves neurocognition across delivery techniques: implications for clinical translation in pediatric brain tumors.

Miles, Sforza, Tan et al. · 2026 · bioRxiv : the preprint server for biology

Radiation therapy is integral to the curative treatment of childhood brain tumors but contributes to late neurocognitive impairment in survivors. FLASH (ultra-high dose rate, >40Gy/s) reduces normal-tissue toxicity in preclinical models,…

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Negative / Null Result ReportMedicine

Middle Eastern male ACL-deficient patients exhibit steeper posterior tibial slope than European counterparts: A cross-cultural matched cohort study.

Romandini, AlKhelaifi, Macchiarola et al. · 2026 · Journal of experimental orthopaedics

The posterior tibial slope (PTS) is a key anatomical factor influencing anterior cruciate ligament (ACL) stability. Steeper slopes have been associated with increased anterior tibial translation (ATT) and a higher risk of graft failure…

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Negative / Null Result ReportMedicine

Prognostic value of hematological ratios in sepsis: A prospective observational study of neutrophil-to-lymphocyte, platelet-to-lymphocyte, and monocyte-to-lymphocyte ratios.

Deokate, Acharya, Patil et al. · 2026 · International journal of critical illness and injury science

Early identification of high-risk sepsis patients remains a clinical priority. Hematological ratios such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR) have emerged as…

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Negative / Null Result ReportMedicine

Nanostructure and Collagen-Stimulating Activity of Cationic Pentapeptide Lipopeptides.

de Mello, Castelletto, Seitsonen et al. · 2026 · Journal of peptide science : an official publication of the European Peptide Society

The self-assembly in aqueous solutions, cytocompatibility, and collagen production of lipopeptide C 16 -KTTKS and a variant with arginine substitution for lysine, C 16 -RTTRS, are investigated. C 16 -KTTKS is known commercially as Matrixyl…

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Negative / Null Result ReportMedicine

Efficacy of Nurse-Led WIKAP Intervention on Hypoglycemia Coping Confidence and Outcomes in Adolescents with Type 1 Diabetes Mellitus: A Quasi-Experimental Study in Zhijiang, China.

Xiao, Zheng, Guo et al. · 2026 · Patient preference and adherence

Hypoglycemia is a frequent and burdensome complication in adolescents with type 1 diabetes mellitus (T1DM). Despite its high prevalence, structured interventions targeting hypoglycemia coping confidence remain scarce, especially in China.…

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Negative / Null Result ReportMedicine

Occurrence of acrylamide and 4-methylimidazole in roasted and ground coffee and the effect of L-asparaginase treatment of green coffee on their levels.

da Costa, Ramirez, de Carvalho et al. · 2026 · Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment

Acrylamide and 4-methylimidazole (4-MEI) are heat-induced contaminants formed during coffee roasting, raising concerns due to their potential toxicological effects. Considering the limited information about the occurrence of these…

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Negative / Null Result ReportMedicine

The effectiveness of a cognitive behavioural therapy for insomnia based intervention to improve sleep quality in nursing home residents, a cluster randomised controlled trial.

Lahaye, Haegdorens, Franck et al. · 2026 · European geriatric medicine

To evaluate the effectiveness of a structured, team-delivered intervention based on cognitive behavioural therapy for insomnia (CBT-I) on sleep and related outcomes in nursing home residents. A cluster randomised controlled trial with…

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Negative / Null Result ReportMedicine

Clinical Implications of ChatGPT-assisted Multimodal Pre-operative Assessment in Elderly Pertrochanteric Fracture Patients: An Exploratory Study.

Noda, Takahara, Hayashi et al. · 2026 · Journal of orthopaedic case reports

Given the high mortality associated with femoral trochanteric fractures, reliable pre-operative estimation of post-operative death risk is essential. Commonly used scoring systems demonstrate only moderate predictive ability, largely…

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Negative / Null Result ReportMedicine

Clinical characteristics, antithrombotic strategies, and outcomes in patients with atrial fibrillation and coronary heart disease undergoing percutaneous coronary intervention: a multicenter real-world study in Chongqing, China.

Bao, Wu, Li et al. · 2026 · BMC cardiovascular disorders

Atrial fibrillation (AF) with coronary artery disease (CAD) requiring percutaneous coronary intervention (PCI) - including both acute and chronic presentations - is common, yet the optimal antithrombotic regimen remains unclear. This study…

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