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Browse the failure-mode index

12,240 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Pulmonary Effects of Sustained Periods of High-G Acceleration Relevant to Suborbital Spaceflight

Ross D. Pollock, Caroline J. Jolley, N. Abid et al. · 2021 · Aerospace Medicine and Human Performance

Abstract BACKGROUND: Members of the public will soon be taking commercial suborbital spaceflights with significant G x (chest-to-back) acceleration potentially reaching up to 6 G x . Pulmonary physiology is gravity-dependent and is likely…

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Negative / Null Result ReportMedicine

Confirming Savoring’s Link to Fewer Cannabis Problems

Maha N. Mian, Brianna R. Altman, Luna F. Ueno et al. · 2020 · Journal of Psychoactive Drugs

Savoring has covaried inversely with cannabis problems and moderated the association between cannabis use and negative consequences related to use. Research has not yet addressed the acceptability of savoring interventions for cannabis…

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Negative / Null Result ReportOpen accessMedicine

Food preferences throughout the menstrual cycle – A computer-assisted neuro-endocrino-psychological investigation

Marie Lefebvre, Michael P. Hengartner, Enrico Tronci et al. · 2022 · Physiology & Behavior

BACKGROUND: As eating behavior changes in relation to the menstrual cycle and weight changes with menopausal transition, ovarian hormones appear to be involved in regulating eating behavior. However, observations are contradictory and are difficult to compare, due to methodological problems related to nutritional epidemiology. To better understand the relationship between ovarian steroid hormones and eating behavior, our study evaluates women's responses to visual food cues at different points in the menstrual cycle with their specific serum estrogen/progesterone levels and women's responses i

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Negative / Null Result ReportOpen accessMedicine

“Fast track” rehabilitation after gastric cancer resection: experience with 80 consecutive cases

Jingxiang Song, Xiaohuang Tu, Bing Wang et al. · 2014 · BMC Gastroenterology

BACKGROUND: To evaluate the safety, efficacy and outcomes of fast-track rehabilitation applied to gastric cancer proximal, distal and total gastrectomy. METHODS: Eighty consecutive patients undergoing gastric cancer resection performed by a single surgeon, received perioperative multimodal rehabilitation. Demographic and operative data, gastrointestinal function, postoperative hospital stays, surgical and general complications and mortality were assessed prospectively. RESULTS: Of the 80 patients (mean age 56.3 years), 10 (12.5%) received proximal subtotal gastrectomy (Billroth I), 38 (47.5%)

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Negative / Null Result ReportOpen accessMedicine

A phase II study of ENMD-2076 in advanced soft tissue sarcoma (STS)

Zachary Veitch, Alona Zer, Herbert H. Loong et al. · 2019 · Scientific Reports

ENMD-2076, an aurora-A kinase inhibitor with anti-angiogenic properties, has shown activity in solid and hematologic malignancies. We investigated oral ENMD-2076 in an open-label, single-arm phase II study using 275 mg daily on a 28-day cycle in patients with advanced soft-tissue sarcomas (STS) receiving ≤1 line of prior therapy. Primary endpoint was 6-month progression-free survival (PFS) with ≤15% indicating no interest, and ≥40% indicating further interest in ENMD-2076. Secondary/exploratory endpoints included clinical benefit (CBR ≥6-months) and objective response (ORR) rates, PFS, OS, saf

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Negative / Null Result ReportOpen accessMedicine

Development of a measuring app for systemic sclerosis-related digital ulceration (SALVE: Scleroderma App for Lesion VErification)

Adrian K. Davison, Ashma Krishan, Robert P New et al. · 2024 · Lara D. Veeken

OBJECTIVES: To test the hypothesis that photographs (in addition to self-reported data) can be collected daily by patients with SSc using a smartphone app designed specifically for digital lesions, and could provide an objective outcome measure for use in clinical trials. METHODS: An app was developed to collect images and patient-reported outcome measures including Pain score and the Hand Disability in Systemic Sclerosis-Digital Ulcers (HDISS-DU) questionnaire. Participants photographed their lesion(s) each day for 30 days and uploaded images to a secure repository. Lesions were analysed both

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Negative / Null Result ReportOpen accessMedicine

A phase II trial of nivolumab followed by ipilimumab and nivolumab in advanced non‐clear‐cell renal cell carcinoma

Ciara Conduit, Ian D. Davis, Jeffrey C. Goh et al. · 2023 · British Journal of Urology

OBJECTIVE: To evaluate the efficacy of sequential treatment with ipilimumab and nivolumab following progression on nivolumab monotherapy in individuals with advanced, non-clear-cell renal cell carcinoma (nccRCC). MATERIALS AND METHODS:…

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Negative / Null Result ReportMedicine

First-line immune checkpoint inhibitors alone or in combination with chemotherapy in real-life elderly patients with advanced non-small cell lung cancer (NEJ057).

Mao Uematsu, Yoko Tsukita, Takehiro Tozuka et al. · 2023 · Journal of Clinical Oncology

9012 Background: Immune checkpoint inhibitor (ICI) plus chemotherapy is now a standard treatment for non-small cell lung cancer (NSCLC) without targetable oncogene alternations. However, the efficacy and safety of ICI plus chemotherapy…

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Negative / Null Result ReportOpen accessMedicine

Physicians’ knowledge, attitude, and prescribing behavior regarding stress ulcer prophylaxis in China: a multi-center study

Xiao Xuan Xing, Chen Zhu, Yan Chu et al. · 2021 · BMC Gastroenterology

BACKGROUND: Perioperative patients are at risk of developing stress ulcers (SU), which can cause clinically important bleeding. Stress ulcer prophylaxis (SUP) is widely applied to the patients in Intensive care unit (ICU) as well as the general ward, so it may lead to overmedication. However, there have been no surveys regarding SUP knowledge or prescribing habits. OBJECTIVE: Our study assessed the knowledge, attitudes, and prescribing behavior of the surgeons toward perioperative patients regarding SUP and determined factors associated with low knowledge and high level of prescribing behavior

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Negative / Null Result ReportOpen accessMedicine

Effectiveness of early awake self proning strategy in non-intubated patients with COVID-19 hypoxemia: An open-labelled randomized clinical trial from Jodhpur, India

Maya Gopalakrishnan, Satyendra Khichar, Suman Saurabh et al. · 2022 · Monaldi Archives for Chest Disease

Awake self-proning is being used widely as respiratory support in COVID-19 hypoxemia, in resource-limited settings. We aimed to investigate the effectiveness of early awake self-proning in preventing mortality and the need for intubation…

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Negative / Null Result ReportOpen accessMedicine

Effects of Acyclovir and IVIG on Behavioral Outcomes after HSV1 CNS Infection

Chandran Ramakrishna, Mari S. Golub, Abby J. Chiang et al. · 2017 · Behavioural Neurology

Herpes simplex virus 1 (HSV) encephalitis (HSE) has serious neurological complications, involving behavioral and cognitive impairments that cause significant morbidity and a reduced quality of life. We showed that HSE results from dysregulated central nervous system (CNS) inflammatory responses. We hypothesized that CNS inflammation is casually involved in behavioral abnormalities after HSE and that treatment with ACV and pooled human immunoglobulin (IVIG), an immunomodulatory drug, would improve outcomes compared to mice treated with phosphate buffered saline (PBS) or ACV alone. Anxiety level

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Replication FailureOpen accessMedicine

CAR T-Cell Targeting of Macrophage Colony-Stimulating Factor Receptor

Daniela Achkova, Richard Beatson, John Maher · 2022 · Cells

Macrophage colony-stimulating factor receptor (M-CSFR) is found in cells of the mononuclear phagocyte lineage and is aberrantly expressed in a range of tumours, in addition to tumour-associated macrophages. Consequently, a variety of cancer therapies directed against M-CSFR are under development. We set out to engineer chimeric antigen receptors (CARs) that employ the natural ligands of this receptor, namely M-CSF or interleukin (IL)-34, to achieve specificity for M-CSFR-expressing target cells. Both M-CSF and IL-34 bind to overlapping regions of M-CSFR, although affinity of IL-34 is significa

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Negative / Null Result ReportOpen accessMedicine

Low EGFR/MET ratio is associated with resistance to EGFR inhibitors in non-small cell lung cancer

Silvia Park, Emma Langley, Jong‐Mu Sun et al. · 2015 · Oncotarget

// Silvia Park 1, * , Emma Langley 2, * , Jong-Mu Sun 1 , Steve Lockton 2 , Jin Seok Ahn 1 , Anjali Jain 2 , Keunchil Park 1 , Sharat Singh 2 , Phillip Kim 2 , Myung-Ju Ahn 1 1 Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea 2 Prometheus Laboratories Inc, A Nestlé Health Science Company, Department of Research and Development, San Diego, CA, USA * These authors have contributed equally to this work Correspondence to: Myung-Ju Ahn, e-mail: silkahn@skku.edu Phillip Kim, e-mail: pkim@prometheuslabs.co

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Negative / Null Result ReportOpen accessMedicine

Thought-provoking Molecules for Drug Discovery: antioxidants

İpek Komşuoğlu Çelikyurt · 2011 · Pharmaceutica Analytica Acta

Affirmative influence of antioxidant vitamins may be observed in atherosclerosis and endothelial dysfunction, male infertility, Parkinson's disease (especially via lipoic acid), diabetes, brain tumors and skin maturation There is not yet…

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Negative / Null Result ReportMedicine

Effect of Warfarin on Survival in Patients with Concomitant Left Ventricular Systolic Dysfunction and Pulmonary Hypertension: A Population Cohort Study

Andrew Goudie, Douglas H.J. Elder, Harshal Deshmukh et al. · 2014 · European Journal of Heart Failure

BACKGROUND: The use of oral anticoagulation in patients with heart failure in sinus rhythm remains controversial as previous large randomized controlled trials (RCTs) have not shown a survival benefit. However, heterogeneity exists among…

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Negative / Null Result ReportMedicine

Real-world data on melanoma brain metastases and survival outcome

Sidsel Pedersen, Søren Møller, Marco Donia et al. · 2022 · Melanoma Research

Novel medical therapies have revolutionized outcome for patients with melanoma. However, patients with melanoma brain metastases (MBM) still have poor survival. Data are limited as these patients are generally excluded from clinical…

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Negative / Null Result ReportOpen accessMedicine

Addition of chemotherapy to intensity-modulated radiotherapy does not improve survival in stage II nasopharyngeal carcinoma patients

Fangzheng Wang, Jiang Chuner, Quanquan Sun et al. · 2018 · Journal of Cancer

In this study, we examined whether combining neoadjuvant chemotherapy (NAC) and/or concurrent chemotherapy (CC) with intensity-modulated radiotherapy (IMRT) improved survival in patients with stage II nasopharyngeal carcinoma (NPC). Two hundred forty-two stage II NPC patients were enrolled between May 2008 and April 2014 and received radical IMRT with simultaneous integrated boost technique using 6 MV photons; some patient groups also received chemotherapy every 3 weeks for 2-3 cycles. The median follow-up duration was 69 months for all patients. At the last follow-up, 18 patients had experien

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Negative / Null Result ReportOpen accessMedicine

EFFECTS OF ROUTINE PHYSICAL THERAPY WITH AND WITHOUT HIGH INTENSITY INTERVAL TRAINING ON BALANCE, QUALITY OF LIFE AND FUNCTION IN PARKINSON’S DISEASE PATIENTS

Muhammad Junaid Tahir, Komal Tehzeeb, Farah Javaid et al. · 2023

Background: Parkinson's disease, is a degenerative neurological disorder, may have an adverse effect on movement, balance, and coordination. Physical therapy, a frequent Parkinson's disease treatment, tries to improve the patient's…

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Negative / Null Result ReportOpen accessMedicine

Results of the Kigali Imbereheza Project: A 2-Arm Individually Randomized Trial of TI-CBT Enhanced to Address ART Adherence and Mental Health for Rwandan Youth Living With HIV.

Geri R. Donenberg, Jessica Fitts, Charles Ingabire et al. · 2022 · PubMed

BACKGROUND: Adolescents living with HIV have elevated mental distress and suboptimal antiretroviral therapy (ART) adherence. SETTING: Two urban clinics in Kigali, Rwanda. METHODS: A 2-arm individual randomized controlled trial compared…

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Negative / Null Result ReportOpen accessMedicine

Histogram analysis from stretched exponential model on diffusion-weighted imaging: evaluation of clinically significant prostate cancer

Eun-Ju Kim, Chan Kyo Kim, Hyun Soo Kim et al. · 2020 · British Journal of Radiology

Objective: To evaluate the usefulness of histogram analysis of stretched exponential model (SEM) on diffusion-weighted imaging in evaluating clinically significant prostate cancer (CSC). Methods: A total of 85 patients with prostate cancer…

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