Negative / Null Result ReportOpen accessMedicine
Nadine Haase, Julianna Rugor, Łukasz Przybył et al. · 2014 · PLoS ONE
Relaxin is a corpus-luteum produced protein hormone with vasodilatatory, anti-fibrotic, and angiogenic properties that are opposite to angiotensin (Ang) II. We investigated whether or not relaxin ameliorates Ang II-induced target-organ damage. We used double transgenic rats harboring both human renin and angiotensinogen genes (dTGR) that develop severe hypertension, target-organ damage, and die untreated within 7-8 weeks. Recombinant relaxin at a low (26 μg/kg/d) and a high dose (240 μg/kg/d) was given to 4 week-old dTGR and age-matched Sprague-Dawley rats (SD). Systolic blood pressure increas
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Taeyong Kwon, Jessie D. Trujillo, Mariano Carossino et al. · 2025 · Emerging Microbes & Infections
Since the first emergence of highly pathogenic avian influenza (HPAI) H5N1 viruses in dairy cattle, the virus has continued to spread, reaching 17 states and at least 1000 dairy herds in the United States. Subsequently, spillovers of the…
View details →Negative / Null Result ReportMedicine
Shahid Habib, Nehali Patel, Sandeep Yarlagadda et al. · 2018 · Journal of Gastroenterology and Hepatology
BACKGROUND AND AIM: Infection is a leading precipitant of acute-on-chronic liver failure. This study aims to determine the safety and efficacy of antibiotics within acute-on-chronic liver failure. METHODS: Retrospective study of 457…
View details →Negative / Null Result ReportOpen accessMedicine
Yuh‐Feng Wang, Tzyy‐Ling Chuang, Mei‐Hua Chuang et al. · 2019 · Tzu Chi Medical Journal
OBJECTIVE: To examine the biofactors associated with bone mineral density (BMD) in southern Taiwanese adults. MATERIALS AND METHODS: The medical records of 3242 adults who underwent health examinations between June 2014 and February 2018…
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James W. Price · 2014 · Journal of Addictive Diseases
Although the decriminalization of recreational marijuana and medical marijuana laws provide a compassionate answer for treatment-related issues in patients' lives, they leave questions open as to the impact on other realms of life, such as…
View details →Negative / Null Result ReportOpen accessMedicine
Johan Jirholt, Bengt Åsling, Paul Hammond et al. · 2011 · PLoS ONE
Gastro-esophageal reflux disease (GERD) is partly caused by genetic factors. The underlying susceptibility genes are currently unknown, with the exception of COL3A1. We used three independent GERD patient cohorts to identify GERD susceptibility genes. Thirty-six families, demonstrating dominant transmission of GERD were subjected to whole genome microsatellite genotyping and linkage analysis. Five linked regions were identified. Two families shared a linked region (LOD 3.9 and 2.0) on chromosome 16. We used two additional independent GERD patient cohorts, one consisting of 219 trios (affected
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Xu Yang, Lina Zhao, Anhui Shi et al. · 2023 · The American Journal of Gastroenterology
INTRODUCTION: Adjuvant radiotherapy is recommended for pT1b esophageal squamous cell cancer (ESCC) after endoscopic submucosal dissection (ESD). However, it is unclear whether additional radiotherapy can improve patient survival. This…
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Mathilde Ruggiu, Bruno Cassinat, Jean‐Jacques Kiladjian et al. · 2020 · Biology of Blood and Marrow Transplantation
BCR-ABL-negative myeloproliferative neoplasms (MPNs) in transformation have a dismal prognosis, and allogeneic hematopoietic stem cell transplantation (allo-HSCT) is considered the sole curative therapeutic option. We retrospectively…
View details →Negative / Null Result ReportOpen accessMedicine
Jennifer M. Yentes, Jessie M. Huisinga, Sara A. Myers et al. · 2012 · Journal of Applied Biomechanics
Peripheral arterial disease (PAD) is a manifestation of atherosclerosis resulting in intermittent claudication (IC) or leg pain during physical activity. Two drugs (cilostazol and pentoxifylline) are approved for treatment of IC. Our…
View details →Failed Experiment ReportOpen accessMedicine
Anne Kopp, Alexandra Hübner, Florian Zirkel et al. · 2019 · Viruses
. Orthobunyaviruses and pacuviruses are mainly transmitted by blood-feeding insects and infect a variety of vertebrates whereas herbeviruses and shangaviruses have a host range restricted to insects. Here, we tested mosquitoes from a tropical rainforest in Mexico for infections with peribunyaviruses. We identified and characterized two previously unknown viruses, designated Baakal virus (BKAV) and Lakamha virus (LAKV). Sequencing and de novo assembly of the entire BKAV and LAKV genomes revealed that BKAV is an orthobunyavirus and LAKV is likely to belong to a new genus. LAKV was almost equidis
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Adnan Taş, Seyfettin Köklü, İlhami Yüksel et al. · 2011 · PubMed
BACKGROUND: Previous studies have focused on the relationship between halitosis, gastroesophageal reflux disease and Helicobacter pylori. In this study we aimed to investigate the interaction between halitosis and upper gastrointestinal…
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Jeremiasz Jagiełła, Efthimios Dardiotis, Jerzy Gąsowski et al. · 2014 · Neurologia i Neurochirurgia Polska
BACKGROUND AND PURPOSE: Spontaneous intracerebral haemorrhage (ICH) is the most fatal form of stroke with the highest morbidity and disability rate of all stroke types. Recent data suggest that the genetic background has a sizeable and…
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Minesh Khatri, David M. Charytan, Sam Parnia et al. · 2021 · Kidney360
Abstract Key Points Patients with ESKD had higher crude mortality rates than those without CKD, but thiswas no longer significant after multivariate adjustment. Patients with ESKD, when directly compared with those with nondialysis CKD,…
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Danfeng Xu, Rong Na, Da Huang et al. · 2020 · Asian Journal of Andrology
To evaluate whether prostate volume (PV) would provide additional predictive utility to the prostate health index (phi) for predicting prostate cancer (PCa) or clinically significant prostate cancer, we designed a prospective,…
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Joël Mercier, Massimo Bani, Anny‐Odile Colson et al. · 2023 · Molecular Imaging and Biology
Abstract Purpose Minzasolmin (UCB0599) is an orally administered, small molecule inhibitor of ASYN misfolding in development as a potential disease-modifying therapy for Parkinson’s disease. Here we describe the preclinical development of a radiolabeled tracer and results from a phase 1 study using the tracer to investigate the brain distribution of minzasolmin. Procedures In the preclinical study, two radiolabeling positions were investigated on the S -enantiomer of minzasolmin (UCB2713): [ 11 C]methylamine UCB2713 ([ 11 C- N -CH 3 ]UCB2713) and [ 11 C]carbonyl UCB2713 ([ 11 C-CO]UCB2713). Ma
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Joon Lee, Sapna Govindan, Leo Anthony Celi et al. · 2013 · World Journal of Cardiovascular Surgery
OBJECTIVE: To develop a customized short LOS (<6 days) prediction model for geriatric patients receiving cardiac surgery, using local data and a computational feature selection algorithm. DESIGN: Utilization of a machine learning algorithm in a prospectively collected STS database consisting of patients who received cardiac surgery between January 2002 and June 2011. SETTING: Urban tertiary-care center. PARTICIPANTS: Geriatric patients aged 70 years or older at the time of cardiac surgery. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Predefined morbidity and mortality events were collec
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Masatoshi Uchida, Toshikazu Abe, Kazuyuki Ono et al. · 2017 · Acute Medicine & Surgery
Aim Our aim was to evaluate the effect of ulinastatin on 28‐day mortality in patients who developed multiple organ failure ( MOF ) related to their acute illness and were admitted to the intensive care unit ( ICU ). Methods We carried out a retrospective observational study of MOF patients in a general ICU of a tertiary care hospital in Japan from January 2009 to December 2012. The primary outcome was 28‐day all‐cause mortality. Secondary outcomes were ventilator‐free days, ICU ‐free days, and vasopressor‐free days at day 28. We investigated the association between ulinastatin treatment and ou
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Cecile A. Feldman, Janine Fredericks-Younger, Paul J. Desjardins et al. · 2025 · The Journal of the American Dental Association
BACKGROUND: Opioids are still being prescribed to manage acute postsurgical pain. Unnecessary opioid prescriptions can lead to addiction and death, as unused tablets are easily diverted. METHODS: To determine whether combination nonopioid analgesics are at least as good as opioid analgesics, a multisite, double-blind, randomized, stratified, noninferiority comparative effectiveness trial was conducted, which examined patient-centered outcomes after impacted mandibular third-molar extraction surgery. Participants were randomized to receive 5 mg of hydrocodone with 300 mg of acetaminophen (opioi
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Jing Cheng, Carl Gao, Reeta Ala‐Jaakkola et al. · 2024 · JAMA Network Open
Importance: Probiotic supplementation may improve bowel movements. However, large, properly designed studies are lacking. Objective: To evaluate the potential benefit of Bifidobacterium animalis subsp lactis HN019 on constipation,…
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Timothy S. Pardee, Bayard L. Powell, Richard A. Larson et al. · 2024 · Blood Neoplasia
Acute myeloid leukemia (AML) is an aggressive cancer of the myeloid lineage. Outcomes in older patients are poor with high rates of resistant and relapsed disease. Devimistat is a lipoic acid analog that inhibits mitochondrial metabolism.…
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Leonardo Calza, Isabella Bon, Marco Borderi et al. · 2020 · JAIDS Journal of Acquired Immune Deficiency Syndromes
Calza, Leonardo MD; Bon, Isabella PhD; Borderi, Marco MD; Colangeli, Vincenzo MD; Viale, Pierluigi MD Author Information
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Emma Weeding, Andrea Fava, Chandra Mohan et al. · 2022 · Lupus Science & Medicine
Objective Urine proteomic approaches have shown promise in identifying biological pathways in lupus nephritis (LN) which are not captured on renal histopathology or by measurement of proteinuria alone. We investigated how the urine…
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Jennifer Chun-Li Wu, Tung‐liang Chiang · 2015 · Early Child Development and Care
Low birthweight (LBW) children tend to have higher risks of developmental problems. According to differential susceptibility hypothesis, these putatively vulnerable children may also disproportionately benefit from positive environmental…
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Luís Alberto de Pádua Covas Lage, Rita Novello de Vita, Lucas Bassolli de Oliveira Alves et al. · 2024 · Cancers
Background: Diffuse large B-cell lymphoma (DLBCL) especially affects the older population. Old (≥60 years) and very old age (≥80 years) DLBCL patients often present high-risk molecular alterations, lower tolerability to conventional immunochemotherapy, and poor clinical outcomes. In this scenario, attenuated therapeutic strategies, such as the R-MiniCHOP and R-MiniCHOP of the elderly regimens, have emerged for this particularly fragile population. However, the responses, clinical outcomes, and toxicities of these regimens currently remain poorly understood, mainly because these individuals are
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Sarah N. Rigby, Lorna S. Jakobson, Pauline M. Pearson et al. · 2020 · Frontiers in Psychology
Alexithymia is a personality trait characterized by difficulties identifying and describing feelings (DIF and DDF) and an externally-oriented thinking style (EOT). The primary aim of the present study was to investigate links between alexithymia and the evaluation of emotional scenes. We also investigated whether viewers’ evaluations of emotional scenes were better predicted by specific alexithymic traits or by individual differences in sensory processing sensitivity (SPS). Participants (N = 106) completed measures of alexithymia and SPS along with a task requiring speeded judgments of the ple
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Tonia C. Carter, Scott J. Hebbring, Jixia Liu et al. · 2017 · Journal of Medical Virology
Host response to influenza is highly variable, suggesting a potential role of host genetic variation. To investigate the host genetics of severe influenza in a targeted fashion, 32 single nucleotide polymorphisms (SNPs) within viral immune…
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Muhammad Jasim Uddin, Willy W. Suen, Angela M. Bosco‐Lauth et al. · 2016 · Veterinary Research
West Nile virus (WNV) is one of the most common causes of epidemic viral encephalitis in horses worldwide. Peripheral blood mononuclear cells (PBMCs) are amongst the first to encounter the virus following a mosquito bite. This study aimed to elucidate the transcription kinetics of cytokine, Toll-like receptor (TLRs) and TLRs-associated genes following WNV challenge of equine PBMCs. PBMCs were challenged with an Australian strain of WNV (WNVNSW2011) and transcriptomes were quantified at 2, 6, 12 and 24 h post-infection (pi) using qRT-PCR. Type I and II interferons (IFNα, β and γ) mRNA transcrip
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Enzo M. Scutigliani, Edwin R. Scholl, Anita E. Grootemaat et al. · 2018 · Frontiers in Microbiology
Tuberculosis is once again a major global threat, leading to more than 1 million deaths each year. Treatment options for tuberculosis patients are limited, expensive and characterized by severe side effects, especially in the case of multi-drug resistant forms. Uncovering novel vulnerabilities of the pathogen is crucial to generate new therapeutic strategies. Using high resolution microscopy techniques, we discovered one such vulnerability of Mycobacterium tuberculosis. We demonstrate that the DNA of M. tuberculosis can condense under stressful conditions such as starvation and antibiotic trea
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Pilar Fernández‐Martín, Rocío Rodríguez‐Herrera, Rosa Cánovas et al. · 2023 · European Child & Adolescent Psychiatry
In the past two decades, the traditional nosology of attention-deficit/hyperactivity disorder (ADHD) has been criticized for having insufficient discriminant validity. In line with current trends, in the present study, we combined a data-driven approach with the advantages of virtual reality aiming to identify novel behavioral profiles of ADHD based on ecological and performance-based measures of inattention, impulsivity, and hyperactivity. One hundred and ten Spanish-speaking participants (6-16 years) with ADHD (medication-naïve, n = 57) and typically developing participants (n = 53) complete
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Allyson L. Anding, Sofia Kinton, Kaitlyn Baranowski et al. · 2023 · Journal of Pharmacology and Experimental Therapeutics
Pompe disease is a rare glycogen storage disorder caused by a deficiency in the lysosomal enzyme acid α-glucosidase, which leads to muscle weakness, cardiac and respiratory failure, and early mortality. Alglucosidase alfa, a recombinant…
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