Negative / Null Result ReportOpen accessMedicine
Xi Luo, Xiaodong Huang, Jingwei Luo et al. · 2022 · BMC Cancer
PURPOSE: Concurrent chemoradiotherapy (CCRT) is a standard treatment choice for locally advanced hypopharyngeal carcinoma. The aim of this study was to investigate whether induction chemotherapy (IC) followed by CCRT is superior to CCRT alone to treat locally advanced hypopharyngeal carcinoma. METHODS AND MATERIALS: Patients (n = 142) were randomized to receive two cycles of paclitaxel/cisplatin/5-fluorouracil (TPF) IC followed by CCRT or CCRT alone. The primary end point was overall survival (OS). The secondary end points included the larynx-preservation rate, progression-free survival (PFS),
View details →Negative / Null Result ReportOpen accessMedicine
Christine L. Nelson, Roderick S. Tang, Elizabeth A. Stillman · 2013 · Vaccine
MEDI-534 is the first live, attenuated and vectored respiratory syncytial virus (RSV) vaccine to be evaluated in seronegative children. It consists of a bovine/human parainfluenza virus type 3 (PIV3) backbone with the RSV fusion…
View details →Negative / Null Result ReportOpen accessMedicine
Helen L. Reeves, John Reicher, Georgia Priona et al. · 2022 · Frontline Gastroenterology
Objective: Hepatocellular carcinoma (HCC) deaths are rising alarmingly. Many patients are unsuitable for available therapies. Poor response rates further hamper outcomes for those that are. Selective internal radiation therapy (SIRT) offers hope, although which patients benefit over standard approaches remains unclear. Design/method: As a quality/service improvement, we audited consecutive patients treated with SIRT (2015-2020) by the Newcastle upon Tyne Hospitals National Health Service Foundation Trust HCC multidisciplinary team. Indications, Barcelona clinic liver cancer (BCLC) stage, treat
View details →Negative / Null Result ReportOpen accessMedicine
Shivani Baisiwala, Elisa Fazzari, Matthew Li et al. · 2026 · Cell Reports
A major obstacle to identifying effective therapies for the aggressive brain tumor glioblastoma is the lack of human-specific, immunocompetent models that reflect the human tumor microenvironment. To address this, we developed the…
View details →Negative / Null Result ReportOpen accessMedicine
Mitali Tyagi, Eric de Hoog, Matthew Grega et al. · 2026 · Cell
Abstract Intracellular neurofibrillary tangles that consist of misfolded tau protein 1 cause neurodegeneration in Alzheimer’s disease (AD) and frontotemporal dementia (FTD). Tau pathology spreads cell-to-cell 2 but the exact mechanisms of tau release and intercellular transmission remain poorly defined. Tau is released from neurons as free protein or in extracellular vesicles (EVs) 3–5 but the role of these different release mechanisms in intercellular tau transmission is unclear. Here, we show that the neuronal gene Arc is critical for packaging tau into EVs. Brain EVs purified from human tau
View details →Negative / Null Result ReportOpen accessMedicine
Atul Malhotra, R GRUNSTEIN, Ali Azarbarzin et al. · 2026 · Nature Medicine
Obstructive sleep apnea (OSA) is associated with obesity and cardiovascular risk. The SURMOUNT-OSA master protocol comprised two, 52-week, randomized, double-blind, placebo-controlled phase 3 studies (study 1 and study 2) and demonstrated…
View details →Negative / Null Result ReportOpen accessMedicine
Akram I. Ahmad, Samita Garg, Jeffrey Jacobs et al. · 2026 · JAMA Internal Medicine
Importance: Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are known to increase the risk of retained gastric contents. High-quality data are lacking to guide periprocedure management of GLP-1 and GIP agonists. Objective: To compare the risk of clinically significant residual gastric volume (RGV) in patients who continue vs hold 1 dose of weekly or daily GLP-1 and GIP agonists prior to sedation. Design, Setting, and Participants: This randomized, single-masked clinical trial conducted at 2 large tertiary referral centers in the US included patients under
View details →Negative / Null Result ReportOpen accessMedicine
Rosalyn Chi, Anthony J. Perkins, Yara Khalifeh et al. · 2024 · American Journal of Critical Care
BACKGROUND: Hypoalbuminemia has been associated with an increased risk of in-hospital delirium. However, the relationship between serum albumin levels and the duration and severity of delirium is not well defined. OBJECTIVE: To investigate…
View details →Negative / Null Result ReportOpen accessMedicine
Krithik Vishwanath, Anton Alyakin, Mrigayu Ghosh et al. · 2026 · Nature Medicine
Specialized clinical artificial intelligence (AI) tools are entering medical practice despite scarce independent evaluation. We quantitatively evaluate two clinical AI tools, OpenEvidence and UpToDate Expert AI, built on large language models (LLMs) against three frontier LLMs: GPT-5.2, Gemini 3.1 Pro and Claude Opus 4.6. Our evaluation has three stages: (1) 500 MedQA questions testing medical knowledge, (2) 500 HealthBench items measuring alignment with clinicians and (3) the real clinical queries (RCQ) benchmark, built from 100 de-identified queries from physicians to a general-purpose langu
View details →Negative / Null Result ReportOpen accessMedicine
Gabriela-Florentina Tapos, Ioan-Alexandru Cîmpeanu, Iasmina-Alexandra Predescu et al. · 2026 · Diseases
BACKGROUND/OBJECTIVES: Cardiovascular diseases (CVDs) remain the leading cause of morbidity and mortality worldwide and increasingly are recognized as a continuum of interconnected conditions rather than isolated entities. METHODS: A structured narrative literature search was performed in PubMed, Scopus, and Google Scholar for publications from 2015 to 2025 using combinations of different keywords: "cardiovascular disease spectrum", "multi-omics", "precision cardiology", "machine learning", and "artificial intelligence in cardiology". RESULTS: Evidence was synthesized across seven major cluste
View details →Replication FailureOpen accessMedicine
Xueying Chen, Xi Liu, Ruogu Li et al. · 2026 · JAMA Cardiology
Importance: Left bundle-branch pacing (LBBP) has been proposed as an alternative to biventricular pacing (BiVP) for patients with heart failure with left bundle-branch block (LBBB). However, robust clinical evidence from randomized clinical trials is lacking. Objective: To evaluate the long-term clinical outcomes of LBBP and BiVP. Design, Setting, and Participants: This multicenter, prospective, randomized clinical trial enrolled 200 patients at 6 centers in China with a left ventricular ejection fraction (LVEF) of 35% or less and LBBB from October 2020 to March 2022. This study was took place
View details →Negative / Null Result ReportOpen accessMedicine
Qiaojuan Jane Su, James R. Ashenhurst, Wanwan Xu et al. · 2026 · Nature
The development of glucagon-like peptide 1 (GLP1) receptor agonists, including semaglutide and tirzepatide, has transformed the clinical management of overweight and obesity. However, substantial inter-person variability exists in both…
View details →Negative / Null Result ReportOpen accessMedicine
M.a Cruces Souto-Gallardo, Arturo Jiménez–Cruz, Montserrat Bacardí‐Gascón · 2026 · Archivos Latinoamericanos de Nutrición
The aim of this study was to evaluate the ability of parents to estimate the weight status of preschool children attending the Instituto Mexicano del Seguro Social (IMSS) day-care centers using three different tools. A total of 100…
View details →Negative / Null Result ReportOpen accessMedicine
Edoardo Cipolletta, Tatiana Zverkova Sandström, D. Rozza et al. · 2026 · JAMA Internal Medicine
Importance: Gout is associated with increased cardiovascular risk. Whether achieving a target serum urate level lower than 6 mg/dL with urate-lowering treatment (ULT) would reduce cardiovascular risk in patients with gout is unknown. Objectives: To evaluate the association between achieving a serum urate treatment target lower than 6 mg/dL and cardiovascular events among patients with gout who were newly prescribed ULT. Design, Setting, and Participants: This new-user cohort study using emulated target trial framework with up to 5-year follow-up was performed using primary care data from the C
View details →Negative / Null Result ReportOpen accessMedicine
Lígia Ramos dos Santos, Jucimara Ferreira Figueiredo Almeida, Lúcia Helena Sagrillo Pimassoni et al. · 2019 · Genetics and Molecular Biology
Genome-wide associations studies (GWAS) are detecting new variants associated with late-onset of Alzheimer's disease (LOAD), a multifactorial neurodegenerative disorder. The variants rs744373 BIN1, rs11136000 CLU and rs3764650 ABCA7 uncovered by GWAS led to different AD pathways, such as metabolism, trafficking and endocytosis of lipids and inflammation. However, most of the association studies did not replicate these variants with significance. This could be due to a small power effect evident when these variants are tested independently with LOAD. Therefore, we aimed to investigate whether t
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Jia-Jie Guo, Qi-Qi Hang, Ting Xu et al. · 2025 · Lipids in Health and Disease
BACKGROUND: Periodontitis, a chronic inflammatory disease, is closely linked to cardiovascular health. While Life's Essential 8 (LE8) evaluates cardiovascular metrics, recent recommendations suggest incorporating psychological health (PHQ-9) to form Life's Crucial 9 (LC9). However, evidence regarding the utility of LC9 in periodontal disease remains limited. METHODS: We analyzed data from 7,674 adults in the 2009-2014 NHANES cycles. LC9 scores were calculated by integrating LE8 and PHQ-9 metrics, then categorized into quartiles. The association between LC9 and periodontitis was examined using
View details →Negative / Null Result ReportOpen accessMedicine
Kenta Watanabe, Sho Fukuda, Dai Kubota et al. · 2026 · Journal of Gastroenterology and Hepatology
BACKGROUND AND AIM: In Japan, gastric cancer (GC) and esophageal squamous cell carcinoma (ESCC) account for nearly all fatal upper gastrointestinal malignancies. A unified model that simultaneously predicts the incidence of these two…
View details →Negative / Null Result ReportOpen accessMedicine
Faith Hartley, Martin A. Ebert, Alistair Cook · 2025 · Clinical & Translational Immunology
The most successful immunotherapies for solid malignancies to date, immune checkpoint inhibitors, target the essential role of T cells in antitumor immunity. However, T-cell dysfunction presents a major hindrance to treatment efficacy, warranting research into combined treatment strategies for improving outcomes. The use of radiotherapy for this purpose has garnered much interest. Preclinical study has established that radiotherapy activates various immune mechanisms to improve T-cell activation, localisation and function within tumors, which improves response to immune checkpoint inhibitors.
View details →Negative / Null Result ReportOpen accessMedicine
Nemanja Maletin · 2026 · Frontiers in Immunology
The tumor microenvironment (TME) is increasingly recognized as a dynamic regulator of cancer progression and therapeutic resistance. Far from being a passive scaffold, the TME comprises diverse immune and stromal components, including cancer-associated fibroblasts, myeloid-derived suppressor cells, tumor-associated macrophages, dysfunctional vasculature, and metabolic stressors, that collectively shape tumor evolution and modulate treatment response. In this review, we explore how spatial immune exclusion, immune cell dysfunction, hypoxia, and metabolic reprogramming create barriers to effecti
View details →Negative / Null Result ReportOpen accessMedicine
André Zimerman, Alexander Dal Forno, Luis E. Rohde et al. · 2026 · JAMA Cardiology
Importance: Conduction system pacing (CSP) is a promising and potentially cost-effective alternative to biventricular pacing (BiVP) in patients with heart failure with reduced ejection fraction (HFrEF) and left bundle-branch block (LBBB), but its impact on heart failure (HF) outcomes remains uncertain. Objective: To compare CSP vs BiVP on an HF-related outcome in patients with HFrEF and LBBB. Design, Setting, and Participants: PhysioSync-HF (Conduction System Pacing Versus Biventricular Resynchronization in Patients With Chronic Heart Failure) was an investigator-initiated, multicenter, noninf
View details →Negative / Null Result ReportMedicine
Han Sang Kim, Jung Yong Hong, Jaekyung Cheon et al. · 2020 · Journal of Clinical Oncology
4584 Background: Previously, two phase III clinical trials of immune checkpoint inhibitors (ICI) failed to meet their primary endpoints, leading to doubts regarding the clinical activity of ICI monotherapy in patients with aHCC. Here, we…
View details →Negative / Null Result ReportMedicine
Mélissa De Regge, Koenraad G. Monsieurs, K. Vandewoude et al. · 2012 · PubMed
Automated external defibrillators (AEDs) have shown to improve survival after cardiopulmonary arrest (CPA) in many, but not all clinical settings. A recent study reported that the use of AEDs in-hospital did not improve survival. The…
View details →Negative / Null Result ReportOpen accessMedicine
Igor Strahovnik, Andrej Strahovnik, Samo K. Fokter · 2025 · Bioengineering
Whole-leg radiographs (WLRs) are widely used to assess coronal alignment before total knee arthroplasty (TKA), but may be inaccurate in patients with atypical morphotypes or malrotation. This study evaluated the discrepancy between WLR and 3D computed tomography (CT) scans across coronal plane alignment of the knee (CPAK) morphotypes and introduced a novel projection index—the femoral notch projection ratio (FNPR). In CPAK III knees, 19% of cases exceeded a clinically relevant threshold (>3° difference), prompting investigation of underlying projection factors. In 187 knees, coronal angles—
View details →Negative / Null Result ReportOpen accessMedicine
Xuefeng Jin, Zhaojie Su, Jian-Fa Zhong et al. · 2026 · Cardiovascular Diabetology
BACKGROUND: Metabolic dysfunction-associated steatotic liver disease (MASLD) is closely linked to cardiometabolic disorders, and cardiovascular disease is the leading cause of death among affected individuals. Identifying simple biomarkers…
View details →Negative / Null Result ReportOpen accessMedicine
Olena Garmish, Svitlana Smiyan, Fedir Hladkykh et al. · 2025 · Vascular Health and Risk Management
Patients with inflammatory joint diseases, including rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis, have an elevated risk of cardiovascular complications due to systemic inflammation, immune-mediated endothelial…
View details →Negative / Null Result ReportOpen accessMedicine
Andrew Wong, Danielle Currey, Megan Schwinne et al. · 2026 · JAMA Network Open
Importance: The Epic Sepsis Model version 2 (ESM v2) is a widely implemented proprietary sepsis prediction model, but no multicenter, external validation of its performance has been reported to guide adoption and use. Objective: To conduct a multicenter validation of the ESM v2 to compare performance against the original ESM v1, outline differences across heterogenous clinical sites, and compare model performance against clinician recognition of sepsis. Design, Setting, and Participants: This prognostic study included adult inpatient encounters at 4 large US health systems between August 31, 2
View details →Negative / Null Result ReportOpen accessMedicine
Edward Tyrrell, Suniljeet Sandhu, Kathryn Berry et al. · 2025 · JMIR Formative Research
Background: There is a need to increase health care professional training capacity to meet global needs by 2030. Effective communication is essential for delivering safe and effective patient care. Artificial intelligence (AI) technologies may provide a solution. However, evidence for high-fidelity virtual patient simulators using unrestricted 2-way verbal conversation for communication skills training is lacking. Objective: This study aims to compare a fully automated AI-driven voice recognition-based virtual patient simulator with traditional actor-based consultation skills simulated trainin
View details →Negative / Null Result ReportOpen accessMedicine
Fiona McPhee, Joseph Ueland, Vincent Vellucci et al. · 2019 · Antimicrobial Agents and Chemotherapy
[tested DAAs] of >5,000 nM) and were detected in evaluated GT-6b and -6f sequences. NS5A-L28A-R30A, observed in GT-6r, did not replicate. In conclusion, HCV GT-6b, GT-6f, and GT-6r sequences harbored highly resistant RASs to all evaluated…
View details →Replication FailureOpen accessMedicine
Johann Bauersachs, Scott D. Solomon, Stefan D. Anker et al. · 2026 · Nature Medicine
Abstract MicroRNA-132 (miR-132) is a central regulator of adverse cardiac remodeling. Here we evaluated CDR132L, a synthetic antisense oligonucleotide miR-132 inhibitor, in a multinational, randomized, double-blind, placebo-controlled phase 2 trial (HF-REVERT) in patients with recent myocardial infarction (MI) and left ventricular (LV) systolic dysfunction. Within 3–14 days after MI, 294 patients were randomized to receive CDR132L 5 mg kg −1 , CDR132L 10 mg kg −1 or placebo as three intravenous doses at 4-week intervals plus guideline-directed therapy. In total, 280 patients (245 men and 35 wo
View details →Negative / Null Result ReportOpen accessMedicine
Martin G Schultz, Petr Otahal, Philip Roberts-Thomson et al. · 2025 · European Heart Journal
BACKGROUND AND AIMS: A hypertensive response to exercise is independently associated with cardiovascular disease (CVD), but clinical interpretation may be confounded by aerobic capacity (fitness). The aim of this study was to determine the relationship between exercise blood pressure (BP) relative to fitness and CVD events. METHODS: Clinical exercise test records were analysed from 12 743 people (aged 53 ± 13 years, 60% male) who completed a standard exercise stress test (Bruce treadmill protocol, stages 1-4) at six Australian hospitals. Records were linked to administrative datasets (hospital
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