12,240 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Hsien-Wu Kuo, Chung‐Yu Huang, Chun‐Kai Fu et al. · 2014 · PubMed
BACKGROUND AND AIM: Gastric cancer is one of the most common malignant tumors worldwide. Due to the complex initiation and intricate progression mechanisms, early detection and effective treatment of gastric cancer are both difficult to…
View details →Luca Testa, J M De La Torre Hernandez, Giovanni Luigi De Maria et al. · 2026 · New England Journal of Medicine
BACKGROUND: Percutaneous coronary intervention (PCI) is increasingly used for revascularization of unprotected left main coronary artery disease. Whether intravascular ultrasonographic (IVUS) guidance during PCI results in better clinical…
View details →Jiacheng Ma, Shengrui Liu, Yuting Pei · 2025 · Scientific Reports
Sports injury prediction is crucial for university football player health, yet existing research predominantly focuses on professional athletes and lacks interpretability. Using the Kaggle "University Football Injury Prediction Dataset"…
View details →Anna Kankaanpää, Asko Tolvanen, Laura Joensuu et al. · 2025 · European Journal of Epidemiology
OBJECTIVES: The association between leisure-time physical activity (LTPA) and a lower risk of mortality is susceptible to bias from multiple sources. We investigated the potential of biological ageing to mediate the association between long-term LTPA and mortality and whether the methods used to account for reverse causality affect the interpretation of this association. METHODS: Study participants were twins from the older Finnish Twin Cohort (n = 22,750; 18-50 years at baseline). LTPA was assessed using questionnaires in 1975, 1981 and 1990. The mortality follow-up lasted until 2020 and biol
View details →Soichiro Sasaki, Takayuki Matsuura, Rei Takahashi et al. · 2026 · PubMed
Regular exercise has recognized health benefits, partly because it reportedly lowers the levels of the oxidation products of proteins and DNA at rest, in contrast with the effect of acute exercise. However, when we compared oxidative…
View details →Yu Zhang, Yuxi Liu, Yanping Li et al. · 2026 · JAMA
Importance: Evidence linking coffee and tea to cognitive health remains inconclusive, and most studies fail to differentiate caffeinated from decaffeinated coffee. Objective: To investigate associations of coffee and tea intake with…
View details →Liangsuo Ma, Larry Keen, Joel L. Steinberg et al. · 2024 · NeuroImage
• Resting- state fMRI data were acquired from 34 healthy participants. • Effective connectivities (ECs) associated with HRV and heart rate were investigated. • Regression DCM and ICA were used to identify most relevant network nodes. • ECs…
View details →Bethan Cracknell Daniels, Neil M. Ferguson, Ilaria Dorigatti · 2025 · Nature Medicine
Dengue is the most common arboviral infection, causing substantial morbidity and mortality globally. The licensing of Qdenga, a second-generation vaccine developed by Takeda Pharmaceuticals, is therefore timely, but the potential public health impact of vaccination across transmission settings needs to be evaluated. To address this, we characterized Qdenga's efficacy profile using mathematical models calibrated to published clinical trial data and estimated the public health impact of routine vaccine use. We find that efficacy against both virologically confirmed dengue and hospitalization dep
View details →Megan Duffy, Christie Anderson, Kevin Choy et al. · 2018 · PubMed
= 0.84), at 184 +/- 17 days for patients which received ML, and 154 +/- 20 days for those which did not. Metronomic lomustine administration was well-tolerated, but it did not improve survival in dogs with palliatively treated osteosarcoma.
View details →Peter A. Merkel, Michael George, Huibin Yue et al. · 2025 · ACR Open Rheumatology
OBJECTIVE: This study aimed to report the safety of avacopan, an oral selective complement C5a receptor antagonist, using pooled data from clinical trials in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis…
View details →Yuting Tan, Rui Xue, Yuwei Pan et al. · 2026 · Signal Transduction and Targeted Therapy
The dynamic interplay between neoplastic cells and the host has been increasingly recognized as important players in the pathogenesis of cancer cachexia, a syndrome affecting ~50-80% of cancer patients with various incidences of different types of malignancies. Despite its prevalence, a comprehensive understanding of cancer cachexia progression, with a holistic view at the cross-organismal, cellular and molecular levels, remains elusive. In this review, we undertake an in-depth exploration of the relevant target organs and their regulatory roles in cancer cachexia, with a particular focus on m
View details →Elisa Alonso‐Perez, Marian Suarez-Gestal, Manuel Calaza et al. · 2014 · Arthritis Research & Therapy
INTRODUCTION: We aimed to replicate a recent study which showed higher genetic risk load at 15 loci in men than in women with systemic lupus erythematosus (SLE). This difference was very significant, and it was interpreted as indicating that men require more genetic susceptibility than women to develop SLE. METHODS: Nineteen SLE-associated loci (thirteen of which are shared with the previous study) were analyzed in 1,457 SLE patients and 1,728 healthy controls of European ancestry. Genetic risk load was calculated as sex-specific sum genetic risk scores (GRS(s)). RESULTS: Our results did not r
View details →Adam La Caze, Stephen B. Duffull · 2010 · Journal of Clinical Pharmacy and Therapeutics
WHAT IS KNOWN AND OBJECTIVE: The importance of statistical power is widely recognized from a pre-trial perspective, and when interpreting results that are not statistically significant. It is less well recognized that poor power can lead…
View details →Katherine L. Ford, Michael B. Sawyer, Sunita Ghosh et al. · 2024 · ESMO Open
•Patients were able to increase and sustain dietary protein intake from preintervention levels.•Over one-half of patients in the 2.0 g/kg/day group maintained or gained MM with a 12-week targeted nutrition intervention.•This work…
View details →Rickard Strandberg, Fredrik Åberg, Juho Asteljoki et al. · 2025 · BMJ
OBJECTIVE: To develop and validate a novel risk prediction model for incident major adverse liver outcomes (MALO) in a primary care setting. DESIGN: Population based cohort study. SETTING: Sweden, with validation in Finland and the UK.…
View details →M Berg · 2026 · Acta Dermato Venereologica
Only in Sweden is skin disease reputedly caused by working at visual display units (VDUs) a considerable problem. In the present work facial skin complaints in VDU-exposed persons have been studied by means of epidemiological, clinical and…
View details →Susan Rowell, Eric N. Meier, Tatiana Hoyos Gomez et al. · 2024 · The Journal of Trauma: Injury, Infection, and Critical Care
BACKGROUND: In the prehospital tranexamic acid (TXA) for traumatic brain injury (TBI) trial, TXA administered within 2 hours of injury in the out-of-hospital setting did not reduce mortality in all patients with moderate/severe traumatic…
View details →Christos Koros, Athina‐Maria Simitsi, Dimitra Papadimitriou et al. · 2020 · Journal of Parkinson s Disease
BACKGROUND: Blood uric acid level represents an emerging biomarker in Parkinson's disease (PD). Whether uric acid levels change in genetic forms of PD is just beginning to be explored. OBJECTIVE: The aim of the present study was to assess differences in serum uric acid level among PD patients harboring the p.A53T mutation in the alpha-synuclein gene, idiopathic PD, and healthy controls. METHODS: Longitudinal 5-year serum uric acid measurement data of 369 de novo idiopathic PD patients and 174 age- and gender-matched healthy controls have been downloaded from the Parkinson's Progression Markers
View details →Fiona Carty, Hazel Dunbar, Ian J. Hawthorne et al. · 2021 · Stem Cells Translational Medicine
Cell-based therapy for the treatment of inflammatory disorders has focused on the application of mesenchymal stromal cells (MSCs) and multipotent adult progenitor cells (MAPCs). Despite the recent positive findings in industry-sponsored…
View details →Neil A. Duncan, Sabina B. Bruehlmann, Christopher Hunter et al. · 2012 · Computer Methods in Biomechanics & Biomedical Engineering
Designing biomaterials to mimic and function within the complex mechanobiological conditions of connective tissues requires a detailed understanding of the micromechanical environment of the cell. The objective of our study was to measure…
View details →Colleen Lacey, Lisa Ohlhauser, Jodie R. Gawryluk · 2019 · Frontiers in Neurology
Background Clarifying the neuropathology of depression as a symptom of Parkinson's disease (PD) has been the goal of recent neuroimaging studies; however, results have been conflicting and lack replication. The purpose of the current study was to replicate recent methods that have used diffusion tensor imaging (DTI) to compare individuals with PD with and without depression and to extend previous findings to allow for a better understanding of the results. Methods Thirty-seven participants with de novo PD were retrieved from the Parkinson's Progression Marker's Initiative (PPMI) and were separ
View details →Lionel Perrier, Frédéric Balusson, Magali Morelle et al. · 2024 · Radiotherapy and Oncology
BACKGROUND AND PURPOSE: We performed a cost-effectiveness analysis (CEA) comparing an adaptive radiotherapy (ART) strategy, based on weekly replanning, aiming to correct the parotid gland overdose during treatment and expecting therefore…
View details →Junichi Kitagawa, Ryo Kobayashi, Yasuyuki Nagata et al. · 2020 · International Journal of Cancer
Oral mucositis is a common and distressing complication in patients receiving high-dose chemotherapy followed by hematopoietic stem cell transplantation (HSCT). We reported previously in a single-center retrospective analysis that…
View details →Vanja Vaccaro · 2013 · World Journal of Gastroenterology
AIM: To investigate activity, toxicity, and prognostic factors for survival of erlotinib and fixed dose-rate gemcitabine (FDR-Gem) in advanced pancreatic cancer. METHODS: We designed a single-arm prospective, multicentre, open-label phase…
View details →В. Т. Ивашкин, М. V. Maevskaya, Е. Н. Широкова et al. · 2021 · Drugs - Real World Outcomes
While no “gold-standard” pharmacotherapy for nonalcoholic fatty liver disease (NAFLD) is yet established, essential phospholipids (EPLs) are reported to decrease steatosis and improve laboratory parameters. This analysis evaluated…
View details →Helena Lam, Nakul Katyal, Catherine D. Parker et al. · 2018 · Cureus
Thromboelastography with platelet mapping (TEG-PM) is a modality to measure platelet function, especially in patients taking antiplatelet medications. It consists of two components: arachidonic acid (AA), which is sensitive to aspirin, and adenosine diphosphate (ADP), which is sensitive to clopidogrel. In patients with spontaneous intracerebral hemorrhages (sICH), the clinical interpretation of platelet mapping is unclear. The objective of this study was to evaluate TEG-PM in patients with sICH on aspirin and/or clopidogrel who receive platelet transfusions. This study was an IRB-approved, ret
View details →Michelli Marcela Dadam, Aline Braz Pereira, Mariane R. Cardoso et al. · 2024 · Respiratory Care
BACKGROUND: Re-intubation is necessary in 2% to 30% of cases of patients receiving a planned extubation. This procedure is associated with prolonged mechanical ventilation, a greater need for tracheostomy, a higher incidence of…
View details →Dominika Szalewska, Renata Główczyńska, Ryszard Piotrowicz et al. · 2021 · ESC Heart Failure
AIMS: The aim of our study was to analyse the benefits of a 9 week hybrid comprehensive telerehabilitation (HCTR) programme in heart failure (HF) patients according to aetiology, as a subanalysis of the Telerehabilitation in Heart Failure…
View details →Lu Zhao, Caroline Mwaliko, Evans Atoni et al. · 2019 · Frontiers in Microbiology
Globally, mosquitoes are known to be competent vectors to various arboviruses that cause serious and debilitating diseases to humans and animals. Conversely, mosquitoes harbor a wide array of insect specific viruses (ISVs) that are generally neglected. Extensive characterization of these ISVs is important in understanding their persistence infection effect on host behavior and arbovirus transmission. Herein, we report first time isolation of Tanay virus (TANAV) isolate YN15_103_01 in Anopheles sinensis mosquitoes from Yunnan Province, China. Phylogenetically, the isolate’s nucleotide identity
View details →Harold E. Lebovitz, Bernhard Ludvik, Jarosław Kozakowski et al. · 2015 · Physiological Reports
Gastric electrical stimulation with the implanted DIAMOND device has been shown to improve glycemic control and decrease weight and systolic blood pressure in patients with type 2 diabetes inadequately controlled with oral antidiabetic agents. The objective of this study was to determine if device implantation alone (placebo effect) contributes to the long-term metabolic benefits of DIAMOND(®) meal-mediated gastric electrical stimulation in patients with type 2 diabetes. The study was a 48 week randomized, blinded, cross-over trial in university centers comparing glycemic improvement of DIAMON
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