12,384 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Li X, Li Y, Wang T et al. · 2025 · Stroke
Background Previous trials have failed to demonstrate the benefits of extracranial-intracranial (EC-IC) bypass surgery for patients with carotid or middle cerebral artery occlusion. However, little evidence has focused on the effect of age…
View details →Woittiez AJ, Postma CT, de Leeuw PW · 2026 · Kidney medicine
Atherosclerotic renal artery stenosis (ARAS) remains a complex contributor to hypertension and kidney disease. Although randomized trials failed to show benefit of revascularization on top of medical therapy over medical therapy alone,…
View details →Peker Y, Saygin M, Celik Y et al. · 2026 · Annals of the American Thoracic Society
Rationale Recent randomized controlled trials failed to show cardiovascular benefits of treating obstructive sleep apnea (OSA) in intention-to-treat analyses which has been a matter of debate since publication of the results. Objectives To…
View details →Gaub M, Shaffer KV, Patel P et al. · 2026 · Clinical neurology and neurosurgery
Objective EC-IC bypass for symptomatic atherosclerotic internal carotid and middle cerebral artery chronic occlusion (AIMCAO) failed to show benefit over medical management in previous randomized controlled trials. We explored how a…
View details →Hajime T, Shiota M, Fukuchi G et al. · 2026 · Annals of surgical oncology
Background Although lymph node involvement (LNI) is a critical prognostic factor guiding adjuvant therapy, randomized trials have failed to show a survival advantage of extended versus standard pelvic lymph node dissection (PLND) but have…
View details →Dintakurti A, Parikh MA, Silver RJ et al. · 2025 · Cardiology in review
Large-scale clinical trials of intensive glycemic control have failed to show cardiovascular benefit, with hypoglycemia implicated as a key factor. Increasing evidence suggests hypoglycemia is not merely a complication of diabetes therapy…
View details →Pieracci FM, Doben A, Eriksson E et al. · 2026 · The journal of trauma and acute care surgery
Abstract The use of surgical stabilization of rib fractures (SSRF) for non-flail fracture patterns continues to rise. However, multiple, recent randomized controlled trials in this patient population have failed to show a clear benefit to…
View details →Bhardwaj A, Saili A, Yadav DK et al. · 2025 · Journal of neonatal-perinatal medicine
BackgroundThe prolonged ductal patency in preterm newborns despite being associated with short- and long-term morbidities has failed to show significant improvement in the long-term outcome with routine ductal treatment. Echocardiography…
View details →Van Gent JM, Clements TW, Gurney JM et al. · 2025 · The journal of trauma and acute care surgery
Background Empiric cryoprecipitate administration has recently failed to show survival benefit in hemorrhaging trauma patients. However, a recent Trauma Quality Improvement Program query suggested a survival benefit in massive transfusions…
View details →Sant VR, Zhou H, Zhou MM et al. · 2025 · The Journal of clinical endocrinology and metabolism
Context Primary hyperparathyroidism (PHPT) has initially been implicated in adverse maternal and neonatal outcomes, while subsequent population studies have failed to show an association. Objective This work aimed to compare maternal,…
View details →Wang X, Men C, Shan S et al. · 2025 · Gene
Chemoresistance is a considerable challenge for gastric cancer (GC), and the combination of cisplatin (DDP) and anti-EGFR therapy failed to show remarkable benefit. So other targets in EGFR-overexpressed and DDP-resistant GC need to be…
View details →Drieghe B, De Buyzere M, Bové T et al. · 2024 · Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions
Randomized clinical trials failed to show additional benefit of renal artery stenting on top of medical therapy. Instead of writing an obituary on renal artery stenting, we try to explain these disappointing results. A transstenotic…
View details →Iatropoulos S, Dandrieux PE, Navarro L et al. · 2024 · Scandinavian journal of medicine & science in sports
Despite exercise-based injury prevention programs (EIPPs) being widely researched and used, several randomized controlled trials (RCTs) have failed to show their protective effect on injury risk. This is potentially due to…
View details →Morimoto J, Satogami K, Naraoka T et al. · 2024 · International heart journal
Deficiency of vitamin B 1 (VB1), an essential micronutrient, causes heart failure (HF). A recent randomized controlled trial failed to show any improvement in HF prognosis after short-term VB1 supplementation. In the current study, we…
View details →Canning C, McCormack T, Clifford E et al. · 2024 · The British journal of developmental psychology
Previous studies have failed to show an effect of episodic future thinking (EFT) on children's delay of gratification (DoG), contrasting strikingly with adult findings. Recent findings from a sample of 8-11-year-old children by Canning et…
View details →Danahay H, McCarthy C, Schofield T et al. · 2025 · Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society
Background Inhibiting ENaC in the airways of people with cystic fibrosis (pwCF) is hypothesized to enhance mucociliary clearance (MCC) and provide clinical benefit. Historically, inhaled ENaC blockers have failed to show benefit in pwCF…
View details →Cornell CA, Norman KA, Griffiths TL et al. · 2024 · Psychological science
We often use cues from our environment when we get stuck searching our memories, but prior research has failed to show benefits of cuing with other, randomly selected list items during memory search. What accounts for this discrepancy? We…
View details →Wan H, Myerson J, Green L et al. · 2025 · The journals of gerontology. Series B, Psychological sciences and social sciences
Objectives Previous studies failed to find age-related differences in the discounting of delayed, monetary losses, potentially due to their failure to examine the effects of income and their use of relatively small loss amounts.…
View details →Gibb RD, Brum JM, Sloan KJ et al. · 2025 · Journal of travel medicine
What can be concluded from a clinical trial that spanned 5 years yet failed to achieve target enrollment, generated flat results that contradict the existing body of knowledge and has a primary efficacy endpoint confounded by a…
View details →Chevalley S, Wängberg V, Åhlén M et al. · 2024 · The Journal of hand surgery
Purpose There is no consensus on the optimal postoperative rehabilitation program following flexor tendon repair. Some studies suggest a faster recovery after active mobilization, whereas other studies have failed to find any differences…
View details →Madill-Thomsen KS, Gauthier PT, Abouljoud M et al. · 2025 · Transplantation
Background Initial analysis of liver transplant biopsies in the INTERLIVER study ( ClinicalTrials.gov ; unique identifier NCT03193151) using rejection-associated transcripts failed to find an antibody-mediated rejection state (ie, rich in…
View details →Stone BM, Hammersley JJ, Rabinovich NE et al. · 2024 · Experimental and clinical psychopharmacology
In contrast to overnight deprivation versus satiety studies, a small number of placebo-controlled studies have failed to find that nicotine administration reduces attentional bias (AB) to smoking cues. To assess the reliability of this…
View details →Catling FJR, Nagendran M, Festor P et al. · 2024 · Critical care explorations
Large randomized trials in sepsis have generally failed to find effective novel treatments. This is increasingly attributed to patient heterogeneity, including heterogeneous cardiovascular changes in septic shock. We discuss the potential…
View details →Saki F, Shams M, Dastghaib S et al. · 2023 · BioMed research international
Background Recent researches have failed to uncover a clear explanation for proton pump inhibitors' bone-loss effects. In light of pantoprazole's effects on gastrin secretion, the goal of this study was to see if it caused bone loss…
View details →Gauthier PT, Mackova M, Hirji A et al. · 2023 · American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
In lung transplantation, antibody-mediated rejection (AMR) diagnosed using the International Society for Heart and Lung Transplantation criteria is uncommon compared with other organs, and previous studies failed to find molecular AMR…
View details →Platts CR, Groh AM, Runze J et al. · 2026 · Attachment & human development
Initial molecular genetic studies identified specific genes that contribute to variation in associations between maternal sensitivity and infant attachment, but these findings from small samples failed to replicate in larger-sample…
View details →Kong SH · 2026 · Endocrinology and metabolism (Seoul, Korea)
For decades, vitamin D has been a cornerstone of preventive medicine. However, recent large-scale randomized controlled trials have failed to replicate the broad benefits previously observed in epidemiological studies, particularly with…
View details →Salwei M, Tang LA, Vogus TJ et al. · 2026 · Health care management review
Background Health care organizations have failed to replicate the performance of high-reliability organizations (HROs), systems that operate nearly error-free despite inherently complex, interdependent, and time-pressured environments.…
View details →Zhang X, Gunderson EA · 2025 · Developmental psychology
Spatial skills in early childhood are key predictors of mathematical achievement. Previous studies have found that training mental rotation can transfer to arithmetic skills; however, some studies have failed to replicate this transfer…
View details →Odintsova VV, van Dongen J, van Beijsterveldt CEM et al. · 2023 · Twin research and human genetics : the official journal of the International Society for Twin Studies
In studies of singletons, a range of early-life characteristics have been reported to be associated with handedness, but some of these associations have failed to replicate. We examined associations between 23 early life characteristics…
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