Negative / Null Result ReportOpen accessMedicine
Duncan G.J. Green, Jinhee Kim, Stephen J. Kish et al. · 2021 · Journal of Psychiatry and Neuroscience
Background: Upregulation of the endocannabinoid enzyme fatty acid amide hydrolase (FAAH) has been linked to abnormal activity in frontoamygdalar circuits, a hallmark of posttraumatic stress disorder. We tested the hypothesis that FAAH…
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Eisaku Miyauchi, Tatsuo Matsuda, Kazuma Kiyotani et al. · 2018 · Cancer Science
Recent clinical trials of non-small cell lung cancer with immune checkpoint inhibitors revealed that patients with epidermal growth factor receptor (EGFR) mutations had more unfavorable outcomes compared with those with wild-type EGFR.…
View details →Negative / Null Result ReportOpen accessMedicine
Gabriëlle J. M. Tuijthof, M. M. de Vaal, I. N. Sierevelt et al. · 2011 · Knee Surgery Sports Traumatology Arthroscopy
PURPOSE: During arthroscopies, bleeding episodes occur as a result of tissue damage. Irrigation systems assist in minimizing these disturbances. The performance of three arthroscopic irrigation systems in clearing bleeding episodes was…
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Geovani de Oliveira Ribeiro, Antônio Charlys da Costa, Danielle Elise Gill et al. · 2021 · Scientific Reports
Classical insect-flaviviruses (cISFVs) and dual host-related insect-specific flavivirus (dISFV) are within the major group of insect-specific flavivirus. Remarkably dISFV are evolutionarily related to some of the pathogenic flavivirus, such as Zika and dengue viruses. The Evolutionary relatedness of dISFV to flavivirus allowed us to investigate the evolutionary principle of host adaptation. Additionally, dISFV can be used for the development of flavivirus vaccines and to explore underlying principles of mammalian pathogenicity. Here we describe the genetic characterization of a novel putative
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Michelle Beam, Angela G. Spencer, Lauralee Fernandez et al. · 2018 · American Journal of Tropical Medicine and Hygiene
larvae (neurocysticercosis) is a leading cause of preventable epilepsy worldwide. Effective and sustainable strategies to control parasite transmission in rural endemic communities are needed to prevent the disease. Surveillance and…
View details →Negative / Null Result ReportOpen accessMedicine
Tomoaki Natsukawa, Norikazu Maeda, Shiro Fukuda et al. · 2017 · Journal of Atherosclerosis and Thrombosis
AIMS: Adiponectin, an adipocyte-specific secretory protein, abundantly exists in the blood stream while its concentration paradoxically decreases in obesity. Hypoadiponectinemia is one of risks of cardiovascular diseases. However, impact…
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Yue Yang, Dominic B. Rowe, Heather McCann et al. · 2023 · Neuropathology and Applied Neurobiology
AIMS: Although the orally available brain-penetrant copper compound CuATSM has demonstrated promising effects in SOD1-linked mouse models, the impact of CuATSM on disease pathology in patients with amyotrophic lateral sclerosis (ALS) remains unknown. METHODS: The present study set out to address this deficit by performing the first pilot comparative analysis of ALS pathology in patients that had been administered CuATSM and riluzole [N = 6 cases composed of ALS-TDP (n = 5) and ALS-SOD1 (n = 1)] versus riluzole only [N = 6 cases composed of ALS-TDP (n = 4) and ALS-SOD1 (n = 2)]. RESULTS: Our re
View details →Negative / Null Result ReportOpen accessMedicine
Sorena Keihani, Douglas Rogers, Bryn Putbrese et al. · 2019 · The Journal of Trauma: Injury, Infection, and Critical Care
BACKGROUND: In 2018, the American Association for the Surgery of Trauma (AAST) published revisions to the renal injury grading system to reflect the increased reliance on computed tomography scans and non-operative management of high-grade…
View details →Negative / Null Result ReportOpen accessMedicine
Junyi Chen, Jiao Li, Chuanliang Xu et al. · 2012 · BMC Cancer
BACKGROUND: Gamma-synuclein (SNCG) has previously been demonstrated to be significantly correlated with metastatic malignancies; however, in-depth investigation of SNCG in prostate cancer is still lacking. In the present study, we evaluated the role of SNCG in prostate cancer progression and explored the underlying mechanisms. METHODS: First, alteration of SNCG expression in LNCaP cell line to test the ability of SNCG on cellular properties in vitro and vivo whenever exposing with androgen or not. Subsequently, the Dual-luciferase reporter assays were performed to evaluate whether the role of
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Toshiki Kuno, Takahisa Mikami, Yuki Sahashi et al. · 2022 · Scientific Reports
Acute kidney injury (AKI) after percutaneous coronary intervention (PCI) is associated with a significant risk of morbidity and mortality. The traditional risk model provided by the National Cardiovascular Data Registry (NCDR) is useful for predicting the preprocedural risk of AKI, although the scoring system requires a number of clinical contents. We sought to examine whether machine learning (ML) techniques could predict AKI with fewer NCDR-AKI risk model variables within a comparable PCI database in Japan. We evaluated 19,222 consecutive patients undergoing PCI between 2008 and 2019 in a Ja
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Axel Åkerblom, Lars Wallentin, Anders Larsson et al. · 2013 · Clinical Chemistry
BACKGROUND: The estimated glomerular filtration rate (eGFR) independently predicts cardiovascular death or myocardial infarction (MI) and can be estimated by creatinine and cystatin C concentrations. We evaluated 2 different cystatin C…
View details →Negative / Null Result ReportOpen accessMedicine
Herbert S. B. Baraf, Puja Khanna, Alan Kivitz et al. · 2023 · Lara D. Veeken
OBJECTIVES: Serum urate (SU) lowering with PEGylated uricases in gout can reduce flares and tophi. However, treatment-emergent anti-drug antibodies adversely affect safety and efficacy and the currently approved PEGylated uricase…
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Stefanie G. Beesems, Jocelyn Berdowski, Michiel Hulleman et al. · 2016 · Resuscitation
BACKGROUND: Previous large retrospective analyses have found an association between duration of peri-shock pauses in cardiopulmonary resuscitation (CPR) and survival. In a randomized trial, we tested whether shortening these pauses…
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Manjusha Kulkarni, Sanjay Varikuti, César Terrazas et al. · 2014 · Immunology
The control of Trypanosoma cruzi infection is related to interferon-γ (IFN-γ) activation leading to intracellular clearance of parasites. The transcription factor signal transducer and activator of transcription 1 (STAT-1) is a key…
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Anna Katri, Aneta Dąbrowska, Henrik Löfvall et al. · 2019 · Arthritis Research & Therapy
BACKGROUND: Pain is a debilitating symptom of rheumatoid arthritis (RA), caused by joint inflammation and cartilage and bone destruction. Nonsteroidal anti-inflammatory drugs (NSAIDs) are used to treat pain and inflammation in RA, but are not disease-modifying and do not prevent joint destruction when administered alone. KBPs (Key Bioscience peptides) are synthetic peptides based on salmon calcitonin and are expected to inhibit bone resorption and to be chondroprotective. In this study, we investigated if combining a standard of care NSAID (naproxen) with a KBP resulted in improvement in pain
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Hidehiko Okazawa, Tetsuya Tsujikawa, Yoshifumi Higashino et al. · 2019 · EJNMMI Research
Accurate attenuation correction (AC) is one of the most important issues to be addressed in quantitative brain PET/MRI imaging. Atlas-based MRI AC (AB-MRAC), one of the representative MRAC methods, has been used to estimate the skull attenuation in brain scans. The zero echo time (ZTE) pulse sequence is also expected to provide a better MRAC estimation in brain PET scans. The difference in quantitative measurements of cerebral blood flow (CBF) using H215O-PET/MRI was compared between the two MRAC methods, AB and ZTE. Twelve patients with cerebrovascular disease (4 males, 43.2 ± 11.7 years) und
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Leah Wetherill, Dongbing Lai, Emma C. Johnson et al. · 2019 · Genes Brain & Behavior
Abstract Genetic influences on alcohol and drug dependence partially overlap, however, specific loci underlying this overlap remain unclear. We conducted a genome‐wide association study (GWAS) of a phenotype representing alcohol or illicit…
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Jonathan Tucci, Waseem Alhushki, Ting Chen et al. · 2018 · Cancer & Metabolism
BACKGROUND: It is becoming increasingly recognized that weight and nutritional status can impact cancer survival. We have previously shown that obese mice with syngeneic acute lymphoblastic leukemia (ALL) have poorer response to chemotherapy treatment than control mice. We therefore investigated whether dietary intervention could improve outcome from the most common pediatric cancer, ALL. METHODS: Diet-induced obese (DIO) mice raised on a 60% calories from fat diet and control mice were implanted with syngeneic ALL cells. Some DIO mice were switched to the low-fat control diet. Survival from A
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Valerie A. Smith, Joan E. Cunningham, Eric J. Lentsch · 2012 · Otolaryngology
OBJECTIVE: Determine if completion lymph node dissection (CLND) is associated with improved survival in sentinel lymph node (SLN)-positive cutaneous melanoma of the head and neck (CMHN) patients. STUDY DESIGN: Retrospective analysis of…
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Wanzhu Tu, Samer Gawrieh, Srinivasan Dasarathy et al. · 2023 · Contemporary Clinical Trials Communications
Background: Mortality is high for severe alcohol-associated hepatitis (AH). Corticosteroids are the standard of care for patients without contraindications. Recent data showed that interleukin-1β receptor antagonist anakinra attenuated…
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Charlotte Lindblad Wollmann, Kyle D. Hart, Can Liu et al. · 2020 · Acta Obstetricia Et Gynecologica Scandinavica
INTRODUCTION: Predicting a woman's probability of vaginal birth after cesarean could facilitate the antenatal decision-making process. Having a previous vaginal birth strongly predicts vaginal birth after cesarean. Delivery outcome in…
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Steven J. Kiddle, Nicola Voyle, Richard J.B. Dobson · 2018 · Journal of Alzheimer s Disease
Ever since the discovery of APOEɛ4 around 25 years ago, researchers have been excited about the potential of a blood test for Alzheimer's disease (AD). Since then researchers have looked for genetic, protein, metabolite, and/or gene…
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Anthony Bentley, Samantha Gillard, Michael Spino et al. · 2013 · PharmacoEconomics
BACKGROUND: Patients with β-thalassaemia major experience chronic iron overload due to regular blood transfusions. Chronic iron overload can be treated using iron-chelating therapies such as desferrioxamine (DFO), deferiprone (DFP) and…
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Arran T. Reader, Victoria S. Trifonova, H. Henrik Ehrsson · 2021 · European Journal of Neuroscience
Body ownership refers to the distinct sensation that our observed body belongs to us, which is believed to stem from multisensory integration. This is commonly shown through the rubber hand illusion (RHI), which induces a sense of ownership over a false limb. Whilst the RHI may interfere with object-directed action and alter motor cortical activity, it is not yet clear whether a sense of ownership over an artificial hand has functional consequences for movement production per se. As such, we performed two motion-tracking experiments (n = 117) to examine the effects of the RHI on the reaction t
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Victor Virlogeux, Rebecca E. Graff, Thomas J. Hoffmann et al. · 2015 · Cancer Epidemiology Biomarkers & Prevention
BACKGROUND: Prostate cancer incidence and mortality rates vary across populations, with African American men exhibiting the highest rates. To date, genome-wide association studies have identified 104 SNPs independently associated with…
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Tamar Sofer, Leslie S. Emery, Deepti Jain et al. · 2019 · Scientific Reports
Abstract Lower extremity peripheral artery disease (PAD) burden differs by race/ethnicity. Although familial aggregation and heritability studies suggest a genetic basis, little is known about the genetic susceptibility to PAD, especially in non-European descent populations. Genome-wide association studies (GWAS) of the ankle brachial index (ABI) and PAD (defined as an ABI < 0.90) have not been conducted in Hispanics/Latinos. We performed a GWAS of PAD and the ABI in 7,589 participants aged >45 years from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). We also performed
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Muhammad Furqan, Yu-Yu Tien, Mary C. Schroeder et al. · 2018 · Journal of Thoracic Disease
Background: The optimal surgery for resectable pulmonary typical carcinoid (TC), e.g., lobar resection (L-R) vs. sub-lobar resection (SL-R), is controversial. This is further explored in this population-based study. Methods: The…
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John D. Morrey, Venkatraman Siddharthan, Hong Wang et al. · 2012 · PLoS ONE
West Nile virus (WNV) disease can be fatal for high-risk patients. Since WNV or its antigens have been identified in multiple anatomical locations of the central nervous system of persons or rodent models, one cannot know where to investigate the actual mechanism of mortality without careful studies in animal models. In this study, depressed respiratory functions measured by plethysmography correlated strongly with mortality. This respiratory distress, as well as reduced oxygen saturation, occurred beginning as early as 4 days before mortality. Affected medullary respiratory control cells may
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Melvin L.K. Chua, Grace Kusumawidjaja, Patricia Gan et al. · 2016 · OncoTargets and Therapy
BACKGROUND: Glioblastoma multiforme (GBM) is the most aggressive primary brain tumor with high relapse rate. In this study, we aimed to determine if dose-escalated (DE) radiotherapy improved tumor control and survival in GBM patients.…
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Juan José Yepes-Núñez, Anita Rajasekhar, Maryam Rahman et al. · 2020 · Blood Advances
The impact of pharmacologic prophylaxis for venous thromboembolism in patients undergoing neurosurgical intervention remains uncertain. We reviewed the efficacy and safety of pharmacologic compared with nonpharmacologic thromboprophylaxis…
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