Negative / Null Result ReportOpen accessMedicine
Noriyuki Otsuki, Yuichiro Nakatsu, Toru Kubota et al. · 2013 · PLoS ONE
Canine distemper virus (CDV) becomes able to use human receptors through a single amino acid substitution in the H protein. In addition, CDV strains possessing an intact C protein replicate well in human epithelial H358 cells. The present study showed that CDV strain 007Lm, which was isolated from lymph node tissue of a dog with distemper, failed to replicate in H358 cells, although it possessed an intact C protein. Sequence analyses suggested that a cysteine-to-tyrosine substitution at position 267 of the V protein caused this growth defect. Analyses using H358 cells constitutively expressing
View details →Negative / Null Result ReportOpen accessMedicine
P. Gamborg Nielsen, S Madsen, L. Strömberg · 2026 · Acta Dermato Venereologica
The effects of a hydrocolloid dressing (Comfeel Ulcus) on the physical environment of chronic leg ulcers in 58 consecutive out-patients were investigated. Patients were subdivided into two groups of which Group 1 included 31 (53.4%) and…
View details →Negative / Null Result ReportOpen accessMedicine
Michelle Curran, John P. Campbell, Mark T. Drayson et al. · 2026 · PubMed
Type 1 diabetes (T1D) is a T cell mediated autoimmune disease that targets and destroys insulin-secreting pancreatic beta cells. Beta cell specific T cells are highly differentiated and show evidence of previous antigen exposure.…
View details →Negative / Null Result ReportOpen accessMedicine
Le Zhang, Tianyu Liu, Chuan H. He et al. · 2026 · Journal of Alzheimer s Disease
Abstract Alzheimer’s disease, the most common age-related neurodegenerative disease, is closely associated with both amyloid-ß plaque and neuroinflammation. Two thirds of Alzheimer’s disease patients are females and they have a higher…
View details →Negative / Null Result ReportMedicine
Hayato Omori, Yutaka Tanizawa, Rie Makuuchi et al. · 2018 · World Journal of Surgery
BACKGROUND: The REGATTA trial showed that gastrectomy followed by chemotherapy for advanced gastric cancer with a single non-curable factor did not improve survival outcomes in comparison with chemotherapy alone. Chemotherapy is therefore…
View details →Negative / Null Result ReportOpen accessMedicine
Bruce Cree, Joseph R. Berger, Benjamin Greenberg · 2025 · CNS Drugs
B-cell depletion with CD20-targeted agents is commonly used for treatment of multiple sclerosis (MS), other autoimmune diseases, and certain hematologic malignancies. Initial apparent success with rituximab in MS and neuromyelitis optica…
View details →Negative / Null Result ReportOpen accessMedicine
Ma Soledad Fernández-Pachón, Débora Villaño, Ana M. Troncoso et al. · 2026 · Archivos Latinoamericanos de Nutrición
El objetivo de esta revisión es el estudio de la actividad antioxidante del vino, analizando los distintos métodos que se han empleado en su evaluación. Esta actividad se relacionará, tanto desde el punto de vista cualitativo como…
View details →Replication FailureOpen accessMedicine
Triin Kikas, Kristiina Rull, Robin N. Beaumont et al. · 2019 · Frontiers in Genetics
= 6830) did not replicate these findings. In summary, the study emphasizes the role of genetic variation in driving the transcriptome profile of the human placenta and the importance to explore further its functional implications.
View details →Negative / Null Result ReportOpen accessMedicine
Natalia Spasova, Desislava Somleva, Bozhidar Krastev et al. · 2024 · Folia Medica
Introduction : Trimethylamine-N-oxide (TMAO) is a metabolite produced by intestinal microbiota. It is well recognized as an independent risk marker for cardiovascular and renal diseases and mortality. Aim : The aim of the present study was…
View details →Negative / Null Result ReportOpen accessMedicine
Osama Sobhi Moaket, Sarah Eyad Obaid, Fawaz Eyad Obaid et al. · 2025 · International Journal of Molecular Sciences
Neurodegenerative disorders, including Alzheimer's disease (AD), Parkinson's disease (PD), stroke, and depression, are marked by progressive neuronal dysfunction and loss, yet current treatments remain largely symptomatic with limited disease-modifying efficacy. Glucagon-like peptide-1 (GLP-1), an incretin hormone traditionally associated with metabolic regulation, has emerged as a promising neuroprotective agent. Its receptor, GLP-1R, is expressed in key brain regions implicated in cognition, emotion, and motor control, including the hippocampus, frontal cortex, and substantia nigra. GLP-1R a
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Juan He, Mi Chen, Jia Li et al. · 2025 · International Journal of Gynecological Cancer
Antibody-drug conjugates (ADCs) are an emerging class of targeted therapies that combine monoclonal antibodies with potent cytotoxic payloads, demonstrating significant potential in the treatment of gynecologic malignancies. By selectively targeting tumor-associated antigens, ADCs enable precise drug delivery while minimizing off-target toxicity. Currently, mirvetuximab soravtansine and tisotumab vedotin have been approved by the Food and Drug Administration for the treatment of folate receptor-alpha-positive, platinum-resistant ovarian cancer and recurrent cervical cancer, respectively, exhib
View details →Negative / Null Result ReportOpen accessMedicine
Xiaodong Wang, Jing He, Gouping Ding et al. · 2025 · Frontiers in Immunology
Immune checkpoint inhibitors (ICIs) targeting PD-1 and CTLA-4 have achieved groundbreaking clinical success in multiple cancers; however, a large proportion of patients experience primary or acquired resistance. This review synthesizes the complex mechanisms underlying resistance to PD-1/CTLA-4 blockade and surveys emerging strategies to overcome them. Resistance arises from multifaceted interactions among tumor-intrinsic alterations (e.g., epigenetic silencing of antigen presentation machinery via EZH2/PRC2, oncogenic pathway-driven upregulation of PD-L1, genetic loss of IFNγ pathway componen
View details →Failed Experiment ReportOpen accessMedicine
Robert E. Coleman, Ying Zhou, Danielle Jandial et al. · 2021 · Advances in Therapy
INTRODUCTION: D-CARE, an international, phase 3, randomized, double-blind, placebo-controlled study in women with early-stage breast cancer at high risk of disease recurrence, failed to meet its primary endpoint-improvement in bone…
View details →Negative / Null Result ReportOpen accessMedicine
Muna Canales, Terri Blackwell, Areef Ishani et al. · 2016 · American Journal of Nephrology
<b><i>Background:</i></b> Recently, the first estimated glomerular filtration rate (eGFR) formula specifically developed for community-dwelling older adults, the Berlin Initiative Study Equation 2 (BIS2), was…
View details →Negative / Null Result ReportOpen accessMedicine
Kushala Abeysekera, James Orr, Paul Madley‐Dowd et al. · 2021 · The Lancet Regional Health - Europe
BACKGROUND: The importance of the maternal-infant dyad in the genesis of nonalcoholic fatty liver disease (NAFLD) is of increasing interest. The Avon Longitudinal Study of Parents and Children (ALSPAC) showed that at age 24, 1 in 5 had…
View details →Negative / Null Result ReportOpen accessMedicine
Alexander Filatenkov, Jeanette Baker, Antonia Müller et al. · 2014 · Radiation Research
The goal of this study was to determine whether a combination of local tumor irradiation and autologous T-cell transplantation can effectively treat metastatic 4T1 breast cancer in mice. BALB/c mice were injected subcutaneously with…
View details →Replication FailureMedicine
Anthony T.�C. Chan, Edwin P. Hui, Roger K.C. Ngan et al. · 2017 · Journal of Clinical Oncology
6002 Background: The benefit of adjuvant CT in NPC is unclear. Post-RT EBV DNA predicts poor survival and may be a biomarker of subclinical residual disease. We conducted a biomarker driven RCT using post-RT EBV DNA to select high risk NPC…
View details →Negative / Null Result ReportMedicine
Sebastian Richards-Taylor, Charles Tilley, Eleanor Jaynes et al. · 2017 · Pancreas
OBJECTIVE: Pancreatic neuroendocrine tumors (NETs) (pNETs) have a varied prognosis according to their grade. The European Neuroendocrine Tumor Society grading system uses assessment of the proliferation index via Ki-67 immunohistochemistry…
View details →Negative / Null Result ReportOpen accessMedicine
Thiago Pereira Diniz, Wilson Luiz da Costa, Victor Hugo Fonseca de Jesus et al. · 2019 · Journal of Surgical Oncology
BACKGROUND: Hyperthermic intraperitoneal chemotherapy (HIPEC) has been associated with improved survival when compared with surgery alone for non-metastatic gastric cancer patients in randomized trials and meta-analyses. However, little evidence is available regarding the use of HIPEC in nonmetastatic patients who are treated with perioperative chemotherapy and radical surgery. The aim of this study was to investigate the putative survival benefit of HIPEC in the subgroup of gastric cancer patients treated with perioperative chemotherapy and surgery. PATIENTS AND METHODS: This was a retrospect
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Duncan G.J. Green, Jinhee Kim, Stephen J. Kish et al. · 2021 · Journal of Psychiatry and Neuroscience
Background: Upregulation of the endocannabinoid enzyme fatty acid amide hydrolase (FAAH) has been linked to abnormal activity in frontoamygdalar circuits, a hallmark of posttraumatic stress disorder. We tested the hypothesis that FAAH…
View details →Negative / Null Result ReportOpen accessMedicine
Eisaku Miyauchi, Tatsuo Matsuda, Kazuma Kiyotani et al. · 2018 · Cancer Science
Recent clinical trials of non-small cell lung cancer with immune checkpoint inhibitors revealed that patients with epidermal growth factor receptor (EGFR) mutations had more unfavorable outcomes compared with those with wild-type EGFR.…
View details →Negative / Null Result ReportOpen accessMedicine
Gabriëlle J. M. Tuijthof, M. M. de Vaal, I. N. Sierevelt et al. · 2011 · Knee Surgery Sports Traumatology Arthroscopy
PURPOSE: During arthroscopies, bleeding episodes occur as a result of tissue damage. Irrigation systems assist in minimizing these disturbances. The performance of three arthroscopic irrigation systems in clearing bleeding episodes was…
View details →Negative / Null Result ReportOpen accessMedicine
Geovani de Oliveira Ribeiro, Antônio Charlys da Costa, Danielle Elise Gill et al. · 2021 · Scientific Reports
Classical insect-flaviviruses (cISFVs) and dual host-related insect-specific flavivirus (dISFV) are within the major group of insect-specific flavivirus. Remarkably dISFV are evolutionarily related to some of the pathogenic flavivirus, such as Zika and dengue viruses. The Evolutionary relatedness of dISFV to flavivirus allowed us to investigate the evolutionary principle of host adaptation. Additionally, dISFV can be used for the development of flavivirus vaccines and to explore underlying principles of mammalian pathogenicity. Here we describe the genetic characterization of a novel putative
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Michelle Beam, Angela G. Spencer, Lauralee Fernandez et al. · 2018 · American Journal of Tropical Medicine and Hygiene
larvae (neurocysticercosis) is a leading cause of preventable epilepsy worldwide. Effective and sustainable strategies to control parasite transmission in rural endemic communities are needed to prevent the disease. Surveillance and…
View details →Negative / Null Result ReportOpen accessMedicine
Tomoaki Natsukawa, Norikazu Maeda, Shiro Fukuda et al. · 2017 · Journal of Atherosclerosis and Thrombosis
AIMS: Adiponectin, an adipocyte-specific secretory protein, abundantly exists in the blood stream while its concentration paradoxically decreases in obesity. Hypoadiponectinemia is one of risks of cardiovascular diseases. However, impact…
View details →Negative / Null Result ReportOpen accessMedicine
Yue Yang, Dominic B. Rowe, Heather McCann et al. · 2023 · Neuropathology and Applied Neurobiology
AIMS: Although the orally available brain-penetrant copper compound CuATSM has demonstrated promising effects in SOD1-linked mouse models, the impact of CuATSM on disease pathology in patients with amyotrophic lateral sclerosis (ALS) remains unknown. METHODS: The present study set out to address this deficit by performing the first pilot comparative analysis of ALS pathology in patients that had been administered CuATSM and riluzole [N = 6 cases composed of ALS-TDP (n = 5) and ALS-SOD1 (n = 1)] versus riluzole only [N = 6 cases composed of ALS-TDP (n = 4) and ALS-SOD1 (n = 2)]. RESULTS: Our re
View details →Negative / Null Result ReportOpen accessMedicine
Sorena Keihani, Douglas Rogers, Bryn Putbrese et al. · 2019 · The Journal of Trauma: Injury, Infection, and Critical Care
BACKGROUND: In 2018, the American Association for the Surgery of Trauma (AAST) published revisions to the renal injury grading system to reflect the increased reliance on computed tomography scans and non-operative management of high-grade…
View details →Negative / Null Result ReportOpen accessMedicine
Junyi Chen, Jiao Li, Chuanliang Xu et al. · 2012 · BMC Cancer
BACKGROUND: Gamma-synuclein (SNCG) has previously been demonstrated to be significantly correlated with metastatic malignancies; however, in-depth investigation of SNCG in prostate cancer is still lacking. In the present study, we evaluated the role of SNCG in prostate cancer progression and explored the underlying mechanisms. METHODS: First, alteration of SNCG expression in LNCaP cell line to test the ability of SNCG on cellular properties in vitro and vivo whenever exposing with androgen or not. Subsequently, the Dual-luciferase reporter assays were performed to evaluate whether the role of
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Toshiki Kuno, Takahisa Mikami, Yuki Sahashi et al. · 2022 · Scientific Reports
Acute kidney injury (AKI) after percutaneous coronary intervention (PCI) is associated with a significant risk of morbidity and mortality. The traditional risk model provided by the National Cardiovascular Data Registry (NCDR) is useful for predicting the preprocedural risk of AKI, although the scoring system requires a number of clinical contents. We sought to examine whether machine learning (ML) techniques could predict AKI with fewer NCDR-AKI risk model variables within a comparable PCI database in Japan. We evaluated 19,222 consecutive patients undergoing PCI between 2008 and 2019 in a Ja
View details →Negative / Null Result ReportOpen accessMedicine
Axel Åkerblom, Lars Wallentin, Anders Larsson et al. · 2013 · Clinical Chemistry
BACKGROUND: The estimated glomerular filtration rate (eGFR) independently predicts cardiovascular death or myocardial infarction (MI) and can be estimated by creatinine and cystatin C concentrations. We evaluated 2 different cystatin C…
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