12,266 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Olluri A · 2025 · Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
Experimental drugs lowering brain tau are heralded as improvements in the treatment of Alzheimer's disease. However, the outcomes in clinical trials testing these agents have consistently failed to improve patient outcomes, i.e. slow down…
View details →Petr V, Tichanek F, Liu SL et al. · 2025 · American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Targeting peritransplant inflammation via tumor necrosis factor alpha blockade failed to improve kidney transplantation outcomes in the CTOT-19 trial that tested infliximab (IFX) induction. As natural antibodies (nAbs) to cardiolipin and…
View details →Lähteenmäki EI, Lehti S, Jauhiainen M et al. · 2025 · American journal of physiology. Endocrinology and metabolism
Although high-density lipoprotein (HDL) has cardiometabolic protecting properties, interventions to raise HDL cholesterol concentration have failed to improve cardiometabolic health. Hence, HDL composition and functionality might be key…
View details →El Jalkh J, Obeid PM, Guermazi D et al. · 2025 · Dermatopathology (Basel, Switzerland)
A 64-year-old patient presented for management of symptomatic skin-colored papules symmetrically distributed over the lateral neck over the past two years, which failed to improve on multiple topical corticosteroids, antifungal creams, and…
View details →Mohammed SA, Gorica E, Albiero M et al. · 2025 · Diabetes
Revascularization strategies failed to improve outcome in patients with diabetes with peripheral artery disease (PAD). Histone modifications are key modulators of gene expression and could play a role in angiogenic response. This study…
View details →Zhang H, Yang Y, Sun S · 2024 · Acta psychologica
In response to the public's puzzle about why maternity leave has unexpectedly failed to improve fertility problem in the Chinese context of a widespread extension of maternity leave, our study concentrates on a prevailing stigmatization…
View details →Glynatsis MN, Economou M, Papadopoulou K et al. · 2024 · Cureus
This report presents a rare case of a central retinal artery occlusion in an eight-year-old girl attributed to an undiagnosed patent ductus arteriosus (PDA). Despite intensive treatment, the patient's eyesight failed to improve. Cases of…
View details →Barakzie A, Jansen AJG, Cavalcante F et al. · 2025 · Journal of thrombosis and haemostasis : JTH
Background Intravenous thrombolysis (IVT) using recombinant tissue plasminogen activator prior to endovascular thrombectomy treatment (EVT) failed to improve treatment effect in acute ischemic stroke (AIS) patients compared with EVT alone.…
View details →Sanabria A, Rodrigo JP, Araújo ALD et al. · 2025 · Cancers
Background/Objectives : Oropharyngeal squamous cell carcinoma (OPSCC) management has shifted following recognition of HPV-driven disease. Neoadjuvant chemotherapy (NAC) has historically failed to improve overall survival (OS) in mixed head…
View details →Li H, Man X, Cai T · 2024 · Journal of Environmental Management
Despite decades of recovery, soil carbon in heavily burned areas has failed to reach pre-fire levels. It is unclear whether stand management practices can promote soil organic carbon accumulation at such sites. This study evaluated the…
View details →Li H, Man X, Cai T · 2024 · Journal of environmental management
Despite decades of recovery, soil carbon in heavily burned areas has failed to reach pre-fire levels. It is unclear whether stand management practices can promote soil organic carbon accumulation at such sites. This study evaluated the…
View details →Calabrese SK, Bor J, Dukashe M et al. · 2025 · Journal of the International AIDS Society
Introduction The Undetectable = Untransmittable (U = U) message has failed to reach many people living with HIV (PLHIV) and their communities despite evidence of its favourable impacts. Discussion We describe and contextualize six global…
View details →Gordon EJ, Gacki-Smith J, Smith JD et al. · 2026 · Clinical journal of the American Society of Nephrology : CJASN
Key points Apolipoprotein L1 genetic testing did not reduce potential living donors' willingness to donate, supporting integration of testing into practice. The Apolipoprotein L1 Testing and Counseling Program did not reduce potential…
View details →Kittipibul V, Nguyen M, Welsh P et al. · 2026 · American heart journal
Background In the EXSCEL trial, exenatide did not reduce major adverse cardiovascular events (MACE), but heterogeneity of benefit and the role of cardiac biomarkers remain uncertain. We evaluated the prognostic value of baseline and 1-year…
View details →Sanna AC, Gendreau S, Desnos C et al. · 2026 · American journal of respiratory and critical care medicine
Rationale Patients with severe antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV)-related diffuse alveolar hemorrhage (DAH) face high mortality. In the PEXIVAS trial, plasma exchange (PLEX) did not reduce death or…
View details →Gorka J, Putowski Z, Wludarczyk A et al. · 2025 · Anaesthesiology intensive therapy
Background The PREVENT-MINS trial investigated whether perioperative heart rate reduction with ivabradine could prevent myocardial injury after noncardiac surgery (MINS). Although ivabradine modestly reduced heart rate, it did not reduce…
View details →Liu Y, Ren Y, Yang Y et al. · 2025 · Acta cardiologica
Background In 2012, the randomised trial IABP SHOCK II demonstrated that IABP did not reduce 30-day mortality in patients with acute myocardial infarction complicating cardiogenic shock (CS). However, SCAI proposed a new standardised…
View details →Perkins JA, Price RS, Vizcarra JA · 2026 · Neurology
We describe a 70-year-old man with no significant medical history who developed progressive left leg numbness, gait dysfunction, and recurrent falls. Within a year, he reported difficulty with both initiating steps and perceiving his left…
View details →Yamaguchi T, Akai S, Uozumi N et al. · 2026 · Gan to kagaku ryoho. Cancer & chemotherapy
A 53-year-old male patient presented with dyspnea and was admitted with the diagnosis of bacterial pneumonia.His respiratory condition did not improve despite the resolution of fever with antibiotic therapy, and he was eventually diagnosed…
View details →Diprose W, Fahed R, Volders D et al. · 2026 · Journal of neurointerventional surgery
Background Randomized trials showed that endovascular thrombectomy (EVT) did not improve outcomes in medium vessel occlusion (MeVO) stroke compared with usual care. We investigated whether patients randomized to EVT who achieved…
View details →Olatunji BO, Cusack CE, Levinson CA · 2026 · Journal of anxiety disorders
Although disgust proneness has been implicated in the development of obsessive-compulsive disorder (OCD), studies to date have failed to identify the core symptom of disgust proneness that may be most strongly associated with OCD and its…
View details →Turner D, DeMaet MA, Bundage D et al. · 2026 · American journal of infection control
During an 87-week interrupted time series, we evaluated screening positivity after de-escalating dedicated cohort units for Candida auris and later implementing enhanced nursing engagement. Discontinuing cohort units did not increase…
View details →Balziano S, Margalit I, Kollender R et al. · 2026 · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
Fever often delays urgent hip fracture surgery due to infection concerns. This study found that operating early, despite fever, did not increase complications or death compared to waiting. Thus, early surgery appears to be a feasible…
View details →Diz-Lopes M, Rovetta CF, Pollastri F et al. · 2026 · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
We evaluated how romosozumab affects bone structure, density, and strength at the wrist over 12 months. Volumetric bone mineral density did not increase, but high-resolution quantitative computed tomography imaging showed modest…
View details →Parisi T, Santibanez Ocampo B, Adelman J et al. · 2026 · JCI insight
Age-related blood cell mutations (clonal hematopoiesis) reshape immune cells and lung tumor immune structures, but did not increase lung cancer growth in a genetically engineered mouse model. .
View details →Yata N, Hollό G, Ishida T et al. · 2026 · Journal of glaucoma
Précis Combined phacoemulsification and Kahook Dual Blade goniotomy significantly increased the iridocorneal angle dimensions in POAG/NTG, but postoperative pilocarpine instillation did not further increase the dimensions, suggesting that…
View details →Li Z, Hu X, Feng H et al. · 2026 · Animals : an open access journal from MDPI
We evaluated the effects of different levels of DON (LD 441 and HD 1223 μg DON/kg in diet) on the growth performance, immunity, reproductive hormones, and intestinal health of immature gilts. No significant differences were observed in…
View details →Fisher JP, Roche J, Duffy AG et al. · 2026 · Autonomic neuroscience : basic & clinical
We investigated whether three days of hypoxic exposure in a hypobaric chamber, and the associated nocturnal periodic breathing (nPB), reduce sympathetic nerve activity (MSNA) transduction to blood pressure (BP). While hypoxia did not…
View details →Liu CX, Blair BA, Tenney ER · 2026 · Psychological science
In 2012, Livingston et al. found that Black women were buffered against gender backlash; whether Black women were dominant or supportive toward an employee did not affect people's perceptions of them as leaders in an organization.…
View details →Wang L, Sardella BR, Aronson EK et al. · 2026 · NPJ breast cancer
We utilized the K14-Cre Brca1 f/f Tp53 f/f mouse model to investigate whether a pulse of PARP inhibitor (PARPi) ± an AKT inhibitor (AKTi) can prevent Brca1-related breast cancer. PARPi alone did not intercept or prevent tumor development.…
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