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WASTE Journal

Browse the failure-mode index

12,384 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Regional disparities in insurance-covered cognitive behavioural therapy in Japan: a nationwide cross-sectional study using National Database Open Data, 2015-2023.

Fujii T, Nogami Y, Seo T · 2026 · BMJ open

Objectives Cognitive behavioural therapy (CBT) is recommended as a first-line treatment for depression and anxiety disorders, but its utilisation under Japan's national health insurance remains poorly understood. This study aimed to…

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Negative / Null Result ReportMedicine

Microneedling accelerates burn wound healing and promotes collagen remodeling: Insights from a rodent model.

Alpat SE, Kaya B, Nakkaş HG et al. · 2026 · Burns : journal of the International Society for Burn Injuries

Objective Despite notable advancements in burn care, morbidity and mortality remain high, with progressive tissue loss typically occurring in the first 48 h post-injury. While microneedling and topical retinyl palmitate are recognized for…

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Negative / Null Result ReportMedicine

Effect of post-mating TAK-683 (Kisspeptin analog) treatment on luteal morphology and function in suckling goats with lactational anestrus.

Uyanık G, Yüksel M, Abay M et al. · 2026 · Animal reproduction science

This study aimed to evaluate the effects of TAK-683 administered to suckling goats in lactational anestrus on the 4th day (D4) after mating on luteal function, serum progesterone (P₄) levels, and reproductive performance. Forty-five Aleppo…

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Negative / Null Result ReportOpen accessMedicine

Endoscopic intervention for patients of renal insufficiency with upper gastrointestinal bleeding: efficacy evaluation and predictive model construction.

Huang Y, Chen Q, Chen R et al. · 2025 · BMC gastroenterology

OBJECTIVE: To explore disease severity thresholds beyond which endoscopic intervention fails to reduce mortality in the context of renal insufficiency and upper gastrointestinal bleeding (UGIB), and to develop predictive models for…

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Negative / Null Result ReportOpen accessMedicine

Exploring engagement with a web-based self-directed psychoeducational program for advanced cancer patients and their caregivers (iFOCUS): A sub study analysis of the DIAdIC trial.

Schmidt US, Van Rickstal R, Van Goethem V et al. · 2026 · Palliative medicine

Background Supporting psychoeducational functioning for advanced cancer patients and informal caregivers (dyads) can be challenging. Self-managed digital interventions offer a possible cost-effective alternative but often face low…

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Replication FailureOpen accessMedicine

Evaluation of the quality of life of children and adolescents with type 1 diabetes mellitus before and after an intervention with a remote multiprofessional educational program.

Fritz CK, de Leão AAP, Sbalqueiro FVF et al. · 2026 · Jornal de pediatria

Objective This study aims to evaluate the quality of life (QoL) and glycemic control of children and adolescents living with type 1 diabetes mellitus (T1D) before and after an intervention with a multidisciplinary educational program.…

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Replication FailureMedicine

Spinal Cord Stimulation Failed to Improve Parkinson's Disease Symptoms in Randomized Crossover Double-Blinded Evaluation.

Carra RB, Garcia LÁL, Menezes JR et al. · 2025 · Movement disorders : official journal of the Movement Disorder Society

Background Epidural electrical spinal cord stimulation has been studied for more than a decade for Parkinson's disease symptoms, but compelling evidence for its effectiveness is still lacking. Objective The aim of this study was to…

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Negative / Null Result ReportOpen accessMedicine

Use of a slow-release GnRH implant in an adult billy goat.

Demattio L, Fietz D, Schuler G et al. · 2024 · Tierarztliche Praxis. Ausgabe G, Grosstiere/Nutztiere

A 9.4 mg deslorelin slow-release implant was inserted into an adult, healthy billy goat to achieve temporary infertility and a reduction in sexual behavior. The implant was inserted in late autumn. No significant change in testis size was…

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Negative / Null Result ReportMedicine

Artificial intelligence-generated patient information on shoulder instability remains suboptimal: DeepSeek outperforms ChatGPT in completeness of content while ChatGPT is more readable.

Öğümsöğütlü E, Bozgeyik B, Huri G · 2026 · Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA

Purpose This study aimed to evaluate and compare the performance of the Chat Generative Pre-Trained Transformer (ChatGPT) and DeepSeek artificial intelligence (AI) models for patient information on shoulder instability. Methods Sixteen…

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Negative / Null Result ReportOpen accessMedicine

Vitamin D receptor gene polymorphism and its association with the susceptibility to Helicobacter pylori infection in the Egyptian population with hepatocellular carcinoma.

Ibrahim A, Abdelhady SA, Rageh F et al. · 2026 · BMC gastroenterology

OBJECTIVE: This study aimed to estimate the frequency of H. pylori infection in patients with liver disorders, and identify the relationship between vitamin D receptor gene variants and susceptibility to H. pylori infections and HCC in…

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Negative / Null Result ReportOpen accessMedicine

CBCT in Evaluation of Root Canal Preparation-A Scoping Review.

Vidal A, Teles AM, Cardoso M et al. · 2026 · Dentistry journal

Cone-beam computed tomography (CBCT) is widely utilized in endodontics for evaluating root canal shaping outcomes, offering critical three-dimensional imaging capabilities. This study aims to assess the differences in apical and root canal…

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Negative / Null Result ReportMedicine

Postoperative antibiotic prophylaxis following cardiac implantable electronic device implantation and the risk of device infection.

Mandler I, Krutik T, Biham O et al. · 2026 · Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing

BACKGROUND AND AIMS: Cardiac implantable electronic devices (CIEDs) are essential for the management of cardiac arrhythmias. Device infection is one of the most dismal complications of CIED implantation. The aim of this study is to assess…

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Negative / Null Result ReportOpen accessMedicine

Are Skip Laminectomy and Oblique Corpectomy Effective Options to Treat Degenerative Cervical Myelopathy While Preserving Motion? Results of a Scoping Review.

Lomax JL, Mehta A, Vedantam A et al. · 2026 · Global spine journal

Study DesignScoping Literature Review.ObjectiveThe aim of this literature review is to examine the results of both skip laminectomy and oblique corpectomy in the setting of degenerative cervical myelopathy (DCM).MethodsA scoping review of…

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Null DatasetOpen accessMedicine

A quantitative method to assess DNA extraction efficiency.

Mullen LE, Romsos EL, Vallone PM · 2026 · Journal of forensic sciences

Obtaining an accepted minimum amount of extracted and purified DNA is critical for generating complete forensic short tandem repeat (STR) profiles. Certain sample types encountered in forensic laboratories may pose challenges in obtaining…

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Negative / Null Result ReportOpen accessMedicine

Health-related quality of life scores of ultralow rectal cancer patients after conformal sphincter preservation operation compared to newly derived preoperative EORTC QLQ-C30, CR38 reference values and EORTC QLQ-C30 norm.

Ding HB, Sun G, Yu GY et al. · 2026 · Frontiers in oncology

Background Postoperative quality of life (Post-QoL) is the key to measuring the effectiveness of sphincter-preserving operation such as Conformal sphincter preservation operation (CSPO) for ultralow rectal cancer. This study aimed to…

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Negative / Null Result ReportMedicine

Correlation Between Morphology of Reinke's Edema and Disease Regression After Office-Based Laser Therapy and Steroid Injection.

Hamdan AL, Abou Raji Feghali P, Lababidi G et al. · 2026 · Journal of voice : official journal of the Voice Foundation

Objective To investigate the association between the morphology and the severity of Reinke's edema (RE) and disease regression following office-based blue laser therapy (OBLT) and steroid injection. Study design Retrospective Review…

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Negative / Null Result ReportOpen accessMedicine

Retrograde Intrarenal Renal Surgery versus Supine Mini Percutaneous Nephrolithotripsy in Treatment of Renal Pelvic Stones Less than 2 cm, Randomized Clinical Study.

Abdelgawad AH, Elhawy MA, Hussein AAHF et al. · 2026 · Urology research & practice

Objective Retrograde intrarenal surgery (RIRS) is the first-line treatment for kidney stones between 1 and 2 cm and can serve as an alternative to percutaneous nephrolithotomy for larger stones in high-risk patients, including those with…

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Negative / Null Result ReportOpen accessMedicine

Two-year outcomes of fenestrated and branched stent grafts in patients ≤65 years: A bicenter retrospective study.

Van Weydevelt E, Alrajhi Z, Vannier C et al. · 2026 · Journal of vascular surgery cases and innovative techniques

Objective Fenestrated and branched endovascular aortic repair (F/BEVAR) is increasingly used to treat complex abdominal aortic aneurysms and thoracoabdominal aortic aneurysms (TAAAs) because of their minimally invasive nature compared with…

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