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Browse the failure-mode index

12,266 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

In Vitro Evaluation of the Fracture Resistance of CAD/CAM-Manufactured Zirconia Crowns on Primary Teeth: A Comparison of Two Different Cement Types and Gap Widths.

Güngör İlhan GM, Erdoğan Y, Özbey İpek H et al. · 2026 · Nigerian journal of clinical practice

Background This study aimed to evaluate the effect of different cement types on the fracture strength of zirconia crowns fabricated at varying occlusal cement gap widths for primary molars using a computer-aided design and manufacturing…

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Negative / Null Result ReportMedicine

Foliar application of inorganic fertilizers mitigates mercury and methylmercury accumulation in dryland Crops: A plant-soil-microorganism synergistic regulation.

Luo G, He T, Yin D et al. · 2026 · Journal of environmental management

Foliar application technology has received considerable research attention due to its potential to mitigate the accumulation of heavy metals such as cadmium and lead in crops. However, to date, there are very few inorganic foliar sprays…

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Negative / Null Result ReportMedicine

Global Postural Re-Education Versus Deep Neck Flexor Activation on Chronic Nonspecific Neck Pain with Forward Head Posture.

Abd Elhamed HB, Mohamed Ahmed EA, Youssif EF et al. · 2026 · Journal of clinical medicine

Background and Objectives : Chronic nonspecific neck pain (NSNP) is among the most common musculoskeletal disorders. Global postural re-education (GPR) might be effective in decreasing neck pain (NP) and dysfunction and improving forward…

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Negative / Null Result ReportMedicine

ACL Reconstruction for Combined ACL/MCL Injuries in Professional Soccer and Rugby Players: No Difference in Career Longevity Compared to Uninjured Matched Controls.

Jones M, Motesharei A, Abdul W et al. · 2026 · The American journal of sports medicine

Background Combined anterior cruciate ligament (ACL) and medial collateral ligament (MCL) injuries are common in professional sport, but there is little evidence available regarding the long-term impact of them on players' sporting…

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Negative / Null Result ReportOpen accessMedicine

Comparison of two olfactory tests in young children: A study of crayon sniffing (C-Sniff) and short U-Sniff (qU-Sniff).

Gellrich J, Jatzek A, Galvao C et al. · 2026 · European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

AIMS: This study aimed to evaluate and compare the feasibility and reliability of two olfactory tests for toddlers aged 30 to 48 months: the established short Universal Sniff (qU-Sniff) and the novel Crayon-Sniff (C-Sniff). METHODS: The…

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Negative / Null Result ReportOpen accessMedicine

Optimization of biological sulfuric acid generation by Acidithiobacillus thiooxidans in a stirred-tank reactor system.

Frueholz R, Habermaier C, Heibl L et al. · 2026 · Applied microbiology and biotechnology

Conventional sulfuric acid production is tied heavily to the fossil fuel industry, where it is typically obtained from the desulfurization of fuels. Here, the biological production of sulfuric acid by Acidithiobacillus thiooxidans in a…

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Negative / Null Result ReportMedicine

Spatial variability and environmental controls of trace elements (Co, Cu, Mo, Ni, and Zn) in topsoils of Cao Bang Province, Northern Vietnam.

Anh TT, Lim DT, Dang PT et al. · 2026 · Environmental monitoring and assessment

Understanding the distribution and controlling factors of trace elements in topsoils is essential for evaluating soil quality and potential environmental risks. This study investigated the concentrations, spatial distribution, enrichment…

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Negative / Null Result ReportMedicine

The Association Between Childhood Neighborhood Environment and Depressive Symptoms Among Chinese Rural Older Adults: A Gender-Moderated Analysis from a Life Course Perspective.

Chen L, Wang Y, Sun N et al. · 2026 · Journal of gerontological social work

Life course theory links early-life experiences to late-life depression, yet research on childhood neighborhood effects among rural older adults-especially gendered differences-remains limited. Analyzing 2014-2018 CHARLS data of 8,034…

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Negative / Null Result ReportMedicine

Hemoglobin glycation index may contextualize the association between time-varying stress hyperglycemia ratio and mortality in critically ill patients with heart failure: a multicenter retrospective cohort study.

Chen Y, Cai Y, Sha Y et al. · 2026 · Cardiovascular diabetology

Background Stress hyperglycemia is associated with adverse outcomes in critically ill patients, yet the optimal metric and the influence of chronic glycemic background remain unclear. The stress hyperglycemia ratio (SHR) adjusts acute…

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Negative / Null Result ReportMedicine

Time is of the Essence! Long-Term Functional, Motor and Sensory Outcomes After Surgical Fixation of Pediatric Medial Epicondyle Fractures: A Retrospective Cohort Study.

Akın AE, Erkan S, Okcu G · 2026 · Journal of pediatric orthopedics

Background Medial epicondyle fractures represent a common pediatric elbow injury, yet a definitive consensus on treatment remains absent. In literature, long-term sensory and motor outcomes after surgical fixation remain underreported.…

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Negative / Null Result ReportMedicine

Impacts of a Gamified Nutrition and Physical Activity Curriculum for High Schoolers from Communities with Low Income: Rev It Up!

Bastian GE, Desai-Shah H, Fitzgerald N et al. · 2026 · Journal of nutrition education and behavior

Objective Evaluate the impacts of an evidence-based, school-based, gamified nutrition education curriculum (Rev It Up!) for high schoolers from communities with low income. Methods Secondary analysis of 2021-2022 New Jersey Expanded Food…

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Negative / Null Result ReportOpen accessMedicine

Willingness to work for sucrose: Impact of schedules, reinforcer alternatives, homeostatic value, and individual differences in male mice.

Arias-Sandoval E, Carratalá-Ros C, Matas-Navarro P et al. · 2026 · Learning & behavior

Motivated behavior is characterized by a high degree of behavioral activation and effort. Preclinical models of operant effort-based decision-making are useful for studying motivational symptoms seen in many psychopathologies as well as…

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Negative / Null Result ReportOpen accessMedicine

Adjuvant chemotherapy for breast cancer after preoperative chemotherapy: A propensity score matched analysis.

Julie Labrosse, Marie Osdoit, Anne-Sophie Hamy et al. · 2020 · PLoS ONE

Although identified to be at a higher risk of relapse, no consensus exists on the treatment of breast cancer (BC) patients with no pathological complete response after neoadjuvant chemotherapy (NAC). The benefit of adjuvant chemotherapy (ADJ) in this context has scarcely been studied. We evaluated the benefit of administrating adjuvant chemotherapy in a real life cohort of BC patients with invasive residual disease after NAC. 1199 female BC patients with T1-3NxM0 invasive tumors receiving NAC at Institut Curie from 2002 to 2012 were included in the analysis. 1061 had been treated by NAC only,

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Negative / Null Result ReportOpen accessMedicine

Growth and development in Chinese pre-schoolers with picky eating behaviour: a cross-sectional study.

Yong Xue, Ai Zhao, Li Cai et al. · 2015 · PLoS ONE

OBJECTIVE:To explore the associations between picky eating behaviour and pre-schoolers' growth and development. Corresponding potential mechanisms, such as nutrient and food subgroup intake, as well as micronutrients in the blood, will be considered. METHODS:Picky eating behaviour was present if it was reported by parents. From various areas of China, 937 healthy children of 3-7 years old were recruited using a multi-stage stratified cluster sampling method. Children and their mothers' socio-demographic information and children's anthropometry, intelligence, blood samples, one 24-hour dietary

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Negative / Null Result ReportOpen accessMedicine

Eccentric Peak Torque Analysis of Subjects Suffering from Chronic Ankle Instability

Amr Almaz Abdel-aziem, Amira Hussin Draz · 2013 · Medicine Science

The purpose of this study was to examine the effect of chronic ankle instability (CAI) on eccentric peak torque of the ankle musculature. The study included fifty participants divided into two groups; the first group consisted of twenty five subjects suffering from CAI, the second group consisted of twenty five subjects with no prior history of ankle injury as control group. Eccentric peak torque of invertors, evertors, plantar-flexors and dorsiflexors was recorded for each participant at angular velocities 30 and 90o/sec by using (Biodex Medical Systems, Inc, Shirley, NY, USA). Analysis of va

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