e-ISSN: Pending

Browse the failure-mode index

12,266 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Association between rs2787094 Genetic Variants in ADAM33 Gene and Asthma in Indonesian Population: Preliminary study

Kencono Viyati, Kinasih Prayuni, Yenni Zulhamidah et al. · 2023 · Makara Journal of Health Research

Background: Asthma is a multifactorial disease that encompasses a multitude of genetic and environmental factors. One such factor is the disintegrin and metalloprotein-33 (ADAM33) gene, which is correlated with asthma and bronchial hyperresponsiveness. Previous studies conducted on Asian populations have reported a significant association between rs2787094 polymorphism in the ADAM33 gene and asthma. Methods: Our study involved 153 Indonesian participants. TaqMan genotyping assay was used to analyze rs2787094 polymorphism in the ADAM33 gene. Results: No significant association was detected betw

View details →
Negative / Null Result ReportOpen accessMedicine

Joint hypermobility in children with and without functional constipation

Seyed Mohammadreza Fatemi Khorasgani, Neda Ramezani, Negar Ebrahimi Varnousfaderani · 2020 · Journal of Research in Medical Sciences

Background: Previous studies report an association between joint hypermobility (JH), as a hallmark of connective tissue disorder, and autonomic dysfunction, digestive problems, and irritable bowel syndrome. However, its association with functional constipation (FC) has not been evaluated. This study is run and implemented to justify this theme/topic. Materials and Methods: In this case–control study among 200 subjects, 100 were of FC according to the ROME III Criteria (case group) and each child was matched for age and gender with a healthy control that did not meet criteria for FC (control gr

View details →
Negative / Null Result ReportOpen accessMedicine

Reform and exploration of the “4+4” clinical medical talent training model

LU Yongping, PAN Tingfang · 2025 · Jichu yixue yu linchuang

In order to cultivate interdisciplinary innovative medical talents who can adapt to the development of the needs of national medical care and of global file of medical education, Peking Union Medical College has initiated the project of the “4+4” model, which covers a series of education remodeling like candidate trainees’ enrollment, curriculum integration application of new teaching methods, assessment and evaluation, etc., and has made a great progress. The existing evaluation data show that there is no significant difference between the academic performance of students in the “4+4” trainin

View details →
Negative / Null Result ReportOpen accessMedicine

Compatibility and Marital Satisfaction in Disabled Couples Compared to Healthy Ones

Azam Abed, Aliasghar Asghar Nezhad, Hamidreza Hatami · 2015 · Iranian Rehabilitation Journal

Objectives: The aim of current study was the evaluation and comparison of compatibility and marital satisfaction between handicapped couples and healthy ones. Methods: In this study, 50 handicapped couples and 50 healthy couples were examined with Enrich’s marital satisfaction questionnaire and Bell’s adjustment questionnaire. The data were analyzed, using SPSS 15, correlation tests and ANOVA. Results: The results showed that there was no significant difference between handicapped and healthy couples in compatibility and marital satisfaction. Discussion: It is concluded that people

View details →
Negative / Null Result ReportMedicine

Perioperative denosumab exposure and risk of revision after total hip and knee arthroplasty in osteoarthritis: a registry-based data linkage study.

Ciaffi J, Bordini B, Cosentino M et al. · 2026 · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

Osteoarthritis patients undergoing THA or TKA were studied to compare the cumulative incidence of revision after perioperative denosumab versus alendronate. Denosumab was not associated with differences in the incidence of revision after…

View details →
Negative / Null Result ReportMedicine

Artificial intelligence-generated patient information on shoulder instability remains suboptimal: DeepSeek outperforms ChatGPT in completeness of content while ChatGPT is more readable.

Öğümsöğütlü E, Bozgeyik B, Huri G · 2026 · Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA

Purpose This study aimed to evaluate and compare the performance of the Chat Generative Pre-Trained Transformer (ChatGPT) and DeepSeek artificial intelligence (AI) models for patient information on shoulder instability. Methods Sixteen…

View details →
Negative / Null Result ReportOpen accessMedicine

Vitamin D receptor gene polymorphism and its association with the susceptibility to Helicobacter pylori infection in the Egyptian population with hepatocellular carcinoma.

Ibrahim A, Abdelhady SA, Rageh F et al. · 2026 · BMC gastroenterology

OBJECTIVE: This study aimed to estimate the frequency of H. pylori infection in patients with liver disorders, and identify the relationship between vitamin D receptor gene variants and susceptibility to H. pylori infections and HCC in…

View details →
Negative / Null Result ReportOpen accessMedicine

CBCT in Evaluation of Root Canal Preparation-A Scoping Review.

Vidal A, Teles AM, Cardoso M et al. · 2026 · Dentistry journal

Cone-beam computed tomography (CBCT) is widely utilized in endodontics for evaluating root canal shaping outcomes, offering critical three-dimensional imaging capabilities. This study aims to assess the differences in apical and root canal…

View details →
Negative / Null Result ReportMedicine

Postoperative antibiotic prophylaxis following cardiac implantable electronic device implantation and the risk of device infection.

Mandler I, Krutik T, Biham O et al. · 2026 · Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing

BACKGROUND AND AIMS: Cardiac implantable electronic devices (CIEDs) are essential for the management of cardiac arrhythmias. Device infection is one of the most dismal complications of CIED implantation. The aim of this study is to assess…

View details →
Negative / Null Result ReportOpen accessMedicine

Are Skip Laminectomy and Oblique Corpectomy Effective Options to Treat Degenerative Cervical Myelopathy While Preserving Motion? Results of a Scoping Review.

Lomax JL, Mehta A, Vedantam A et al. · 2026 · Global spine journal

Study DesignScoping Literature Review.ObjectiveThe aim of this literature review is to examine the results of both skip laminectomy and oblique corpectomy in the setting of degenerative cervical myelopathy (DCM).MethodsA scoping review of…

View details →
Null DatasetOpen accessMedicine

A quantitative method to assess DNA extraction efficiency.

Mullen LE, Romsos EL, Vallone PM · 2026 · Journal of forensic sciences

Obtaining an accepted minimum amount of extracted and purified DNA is critical for generating complete forensic short tandem repeat (STR) profiles. Certain sample types encountered in forensic laboratories may pose challenges in obtaining…

View details →
Negative / Null Result ReportOpen accessMedicine

Health-related quality of life scores of ultralow rectal cancer patients after conformal sphincter preservation operation compared to newly derived preoperative EORTC QLQ-C30, CR38 reference values and EORTC QLQ-C30 norm.

Ding HB, Sun G, Yu GY et al. · 2026 · Frontiers in oncology

Background Postoperative quality of life (Post-QoL) is the key to measuring the effectiveness of sphincter-preserving operation such as Conformal sphincter preservation operation (CSPO) for ultralow rectal cancer. This study aimed to…

View details →
Negative / Null Result ReportMedicine

Correlation Between Morphology of Reinke's Edema and Disease Regression After Office-Based Laser Therapy and Steroid Injection.

Hamdan AL, Abou Raji Feghali P, Lababidi G et al. · 2026 · Journal of voice : official journal of the Voice Foundation

Objective To investigate the association between the morphology and the severity of Reinke's edema (RE) and disease regression following office-based blue laser therapy (OBLT) and steroid injection. Study design Retrospective Review…

View details →
Negative / Null Result ReportOpen accessMedicine

Retrograde Intrarenal Renal Surgery versus Supine Mini Percutaneous Nephrolithotripsy in Treatment of Renal Pelvic Stones Less than 2 cm, Randomized Clinical Study.

Abdelgawad AH, Elhawy MA, Hussein AAHF et al. · 2026 · Urology research & practice

Objective Retrograde intrarenal surgery (RIRS) is the first-line treatment for kidney stones between 1 and 2 cm and can serve as an alternative to percutaneous nephrolithotomy for larger stones in high-risk patients, including those with…

View details →
Negative / Null Result ReportOpen accessMedicine

Two-year outcomes of fenestrated and branched stent grafts in patients ≤65 years: A bicenter retrospective study.

Van Weydevelt E, Alrajhi Z, Vannier C et al. · 2026 · Journal of vascular surgery cases and innovative techniques

Objective Fenestrated and branched endovascular aortic repair (F/BEVAR) is increasingly used to treat complex abdominal aortic aneurysms and thoracoabdominal aortic aneurysms (TAAAs) because of their minimally invasive nature compared with…

View details →
Negative / Null Result ReportOpen accessMedicine

Protein Creatinine ratio versus 24-h test in HIV-positive and HIV-negative women with pre-eclampsia.

Mkhize SF, Moodley J, Khaliq OP et al. · 2026 · South African family practice : official journal of the South African Academy of Family Practice/Primary Care

Background Pre-eclampsia (PE) is a major contributing factor to high rates of maternal and perinatal morbidity and mortality in South Africa. Early diagnosis is currently a challenge. The objective is to assess the diagnostic accuracy of…

View details →
Negative / Null Result ReportMedicine

Low-Dose Aspirin is Not Associated with Increased Risk of Postpartum Hemorrhage.

Ali M, Higginbotham A, Sabri E et al. · 2026 · Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC

Objectives Aspirin (ASA) is recommended for preeclampsia prophylaxis, but it is uncertain whether higher doses, such as the 150 mg/day used in the ASPRE trial, increase the risk of postpartum hemorrhage (PPH). In Canada, the available…

View details →
Negative / Null Result ReportOpen accessMedicine

Effects of dried Azolla pinnata supplementation on growth, biochemistry, and reproduction in female rabbits.

Abd-Elfadiel Hagag OY, Ahmed-Helmy El-Rayes M, El-Hawy AS et al. · 2026 · Tropical animal health and production

This study evaluated the impact of incorporating varying levels of dried Azolla pinnata as a partial or full substitute for soybean meal protein on growth performance, productivity, and selected biochemical, immunological, hormonal, and…

View details →
Negative / Null Result ReportOpen accessMedicine

The interplay of night eating syndrome with resting metabolic rate, anthropometric measures, and sleep quality in normal-weight female university students: a case-control study.

Aslan S, Sozlu S, Bozkurt O et al. · 2026 · Journal of eating disorders

Aims Night eating syndrome (NES) is characterized by food consumption during bedtime or late night. This study aimed to evaluate the relationship between NES and resting metabolic rate (RMR), anthropometric measurements, and sleep quality.…

View details →
Negative / Null Result ReportOpen accessMedicine

Corticosteroids with or without antiviral therapy in elderly patients hospitalized with COVID-19 during the Omicron era: A multicenter real-world study.

Xu S, Huang Z, Zou X et al. · 2026 · Journal of virus eradication

Background Elderly patients remain at high risk for adverse outcomes from COVID-19 despite the generally reduced pathogenicity of the Omicron variant. Corticosteroids are commonly used in hospitalized patients with COVID-19, particularly…

View details →