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WASTE Journal

Browse the failure-mode index

12,214 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Cetuximab and First-Line Taxane/Carboplatin Chemotherapy in Advanced Non–Small-Cell Lung Cancer: Results of the Randomized Multicenter Phase III Trial BMS099

Thomas J. Lynch, Taral Patel, Luke Dreisbach et al. · 2010 · Journal of Clinical Oncology

PURPOSE To evaluate the efficacy of cetuximab plus taxane/carboplatin (TC) as first-line treatment of advanced non-small-cell lung cancer (NSCLC). PATIENTS AND METHODS This multicenter, open-label, phase III study enrolled 676…

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Negative / Null Result ReportOpen accessMedicine

Effect of General Anesthesia and Conscious Sedation During Endovascular Therapy on Infarct Growth and Clinical Outcomes in Acute Ischemic Stroke

Claus Z. Simonsen, Albert J. Yoo, Leif H. Sørensen et al. · 2018 · JAMA Neurology

Importance: Endovascular therapy (EVT) is the standard of care for select patients who had a stroke caused by a large vessel occlusion in the anterior circulation, but there is uncertainty regarding the optimal anesthetic approach during…

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Negative / Null Result ReportOpen accessMedicine

Overall survival in the OlympiA phase III trial of adjuvant olaparib in patients with germline pathogenic variants in BRCA1/2 and high-risk, early breast cancer

Charles E. Geyer, Judy E. Garber, Richard D. Gelber et al. · 2022 · Annals of Oncology

BACKGROUND: The randomized, double-blind OlympiA trial compared 1 year of the oral poly(adenosine diphosphate-ribose) polymerase inhibitor, olaparib, to matching placebo as adjuvant therapy for patients with pathogenic or likely pathogenic variants in germline BRCA1 or BRCA2 (gBRCA1/2pv) and high-risk, human epidermal growth factor receptor 2-negative, early breast cancer (EBC). The first pre-specified interim analysis (IA) previously demonstrated statistically significant improvement in invasive disease-free survival (IDFS) and distant disease-free survival (DDFS). The olaparib group had fewe

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Negative / Null Result ReportOpen accessMedicine

Effects of Off-Pump and On-Pump Coronary-Artery Bypass Grafting at 1 Year

André Lamy, P.J. Devereaux, Dorairaj Prabhakaran et al. · 2013 · New England Journal of Medicine

BACKGROUND: Previously, we reported that there was no significant difference at 30 days in the rate of a primary composite outcome of death, myocardial infarction, stroke, or new renal failure requiring dialysis between patients who…

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Negative / Null Result ReportOpen accessMedicine

Vagotomy and Parkinson disease

Bojing Liu, Fang Fang, Nancy L. Pedersen et al. · 2017 · Neurology

OBJECTIVE: To examine whether vagotomy decreases the risk of Parkinson disease (PD). METHODS: Using data from nationwide Swedish registers, we conducted a matched-cohort study of 9,430 vagotomized patients (3,445 truncal and 5,978…

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Negative / Null Result ReportOpen accessMedicine

Durvalumab With or Without Tremelimumab in Combination With Chemotherapy as First-Line Therapy for Metastatic Non–Small-Cell Lung Cancer: The Phase III POSEIDON Study

Melissa L. Johnson, Byoung Chul Cho, Alexander Luft et al. · 2022 · Journal of Clinical Oncology

PURPOSE The open-label, phase III POSEIDON study evaluated tremelimumab plus durvalumab and chemotherapy (T + D + CT) and durvalumab plus chemotherapy (D + CT) versus chemotherapy alone (CT) in first-line metastatic non–small-cell lung…

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Negative / Null Result ReportOpen accessMedicine

Residual tumor volume versus extent of resection: predictors of survival after surgery for glioblastoma

Matthew M. Grabowski, Pablo F. Recinos, Amy S. Nowacki et al. · 2014 · Journal of neurosurgery

OBJECT: The impact of extent of resection (EOR) on survival for patients with glioblastoma (GBM) continues to be a point of debate despite multiple studies demonstrating that increasing EOR likely extends survival for these patients. In…

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Negative / Null Result ReportOpen accessMedicine

Body-Mass Index and Mortality among Adults with Incident Type 2 Diabetes

Deirdre K. Tobias, An Pan, Chandra L. Jackson et al. · 2014 · New England Journal of Medicine

BACKGROUND: The relation between body weight and mortality among persons with type 2 diabetes remains unresolved, with some studies suggesting decreased mortality among overweight or obese persons as compared with normal-weight persons (an…

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Negative / Null Result ReportOpen accessMedicine

Comorbidity-Age Index: A Clinical Measure of Biologic Age Before Allogeneic Hematopoietic Cell Transplantation

Mohamed L. Sorror, Rainer Storb, Brenda M. Sandmaier et al. · 2014 · Journal of Clinical Oncology

PURPOSE: Age has long been used as a major factor for assessing suitability for allogeneic hematopoietic cell transplantation (HCT). The HCT-comorbidity index (HCT-CI) was developed as a measure of health status to predict mortality risk…

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Negative / Null Result ReportOpen accessMedicine

Social Cognition in Schizophrenia, Part 1: Performance Across Phase of Illness

Michael F. Green, Carrie E. Bearden, Tyrone D. Cannon et al. · 2011 · Schizophrenia Bulletin

Social cognitive impairments are consistently reported in schizophrenia and are associated with functional outcome. We currently know very little about whether these impairments are stable over the course of illness. In the current study,…

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Negative / Null Result ReportOpen accessMedicine

Glial cells in the mouse enteric nervous system can undergo neurogenesis in response to injury

Cátia Laranjeira, Katarina Sandgren, Nicoletta Kessaris et al. · 2011 · Journal of Clinical Investigation

The enteric nervous system (ENS) in mammals forms from neural crest cells during embryogenesis and early postnatal life. Nevertheless, multipotent progenitors of the ENS can be identified in the adult intestine using clonal cultures and in…

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Negative / Null Result ReportOpen accessMedicine

Bacillus coagulans: a viable adjunct therapy for relieving symptoms of rheumatoid arthritis according to a randomized, controlled trial

David R. Mandel, Katy Eichas, J Holmes · 2010 · BMC Complementary and Alternative Medicine

BACKGROUND: Lactic acid-producing bacteria (LAB) probiotics demonstrate immunomodulating and anti-inflammatory effects and the ability to lessen the symptoms of arthritis in both animals and humans. This randomized, double-blind, placebo-controlled, parallel-design, clinical pilot trial was conducted to evaluate the effects of the LAB probiotic preparation, Bacillus coagulans GBI-30, 6086, on symptoms and measures of functional capacity in patients with rheumatoid arthritis (RA) in combination with pharmacological anti-arthritic medications. METHODS: Forty-five adult men and women with symptom

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Negative / Null Result ReportOpen accessMedicine

Incidence of and risk factors for perineal trauma: a prospective observational study

L. A. Smith, Natalia Price, Vanessa Simonite et al. · 2013 · BMC Pregnancy and Childbirth

BACKGROUND: Our aim was to describe the range of perineal trauma in women with a singleton vaginal birth and estimate the effect of maternal and obstetric characteristics on the incidence of perineal tears. METHODS: We conducted a prospective observational study on all women with a planned singleton vaginal delivery between May and September 2006 in one obstetric unit, three freestanding midwifery-led units and home settings in South East England. Data on maternal and obstetric characteristics were collected prospectively and analysed using univariable and multivariable logistic regression. Th

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Negative / Null Result ReportMedicine

Central Nervous System Metastases in Patients with HER2-Positive Metastatic Breast Cancer: Incidence, Treatment, and Survival in Patients from registHER

Adam Brufsky, Musa Mayer, Hope S. Rugo et al. · 2011 · Clinical Cancer Research

PURPOSE: registHER is a prospective, observational study of 1,023 newly diagnosed HER2-positive metastatic breast cancer (MBC) patients. EXPERIMENTAL DESIGN: Baseline characteristics of patients with and without central nervous system…

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Negative / Null Result ReportMedicine

Laparoscopic vs Open Pancreaticoduodenectomy: Overall Outcomes and Severity of Complications Using the Accordion Severity Grading System

Horacio J. Asbun, John Stauffer · 2012 · Journal of the American College of Surgeons

BACKGROUND: Minimal access surgery techniques have evolved to include complex surgical procedures. Laparoscopic pancreaticoduodenectomy (LPD) is a complex operation that pancreas surgeons have been slow to adopt. This article reviews our…

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Negative / Null Result ReportOpen accessMedicine

Screening for Pancreatic Cancer

US Preventive Services Task Force, Douglas K Owens, Karina W. Davidson et al. · 2019 · JAMA

Importance: Pancreatic cancer is an uncommon cancer with an age-adjusted annual incidence of 12.9 cases per 100 000 person-years. However, the death rate is 11.0 deaths per 100 000 person-years because the prognosis of pancreatic cancer is…

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Negative / Null Result ReportOpen accessMedicine

Multimorbidity Patterns in the Elderly: A New Approach of Disease Clustering Identifies Complex Interrelations between Chronic Conditions

Ingmar Schäfer, Eike-Christin von Leitner, Gerhard Schön et al. · 2010 · PLoS ONE

OBJECTIVE: Multimorbidity is a common problem in the elderly that is significantly associated with higher mortality, increased disability and functional decline. Information about interactions of chronic diseases can help to facilitate diagnosis, amend prevention and enhance the patients' quality of life. The aim of this study was to increase the knowledge of specific processes of multimorbidity in an unselected elderly population by identifying patterns of statistically significantly associated comorbidity. METHODS: Multimorbidity patterns were identified by exploratory tetrachoric factor ana

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Negative / Null Result ReportOpen accessMedicine

Are Pretreatment 18F-FDG PET Tumor Textural Features in Non–Small Cell Lung Cancer Associated with Response and Survival After Chemoradiotherapy?

Gary Cook, Connie Yip, Muhammad Siddique et al. · 2012 · Journal of Nuclear Medicine

UNLABELLED: There is evidence in some solid tumors that textural features of tumoral uptake in (18)F-FDG PET images are associated with response to chemoradiotherapy and survival. We have investigated whether a similar relationship exists…

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Negative / Null Result ReportOpen accessMedicine

PD-1/PD-L1 Blockade Together With Vaccine Therapy Facilitates Effector T-Cell Infiltration Into Pancreatic Tumors

Kevin C. Soares, Agnieszka A. Rucki, Annie A. Wu et al. · 2014 · Journal of Immunotherapy

Pancreatic ductal adenocarcinoma (PDA) has a poor prognosis due to late detection and resistance to conventional therapies. Published studies show that the PDA tumor microenvironment is predominantly infiltrated with immune suppressive…

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Negative / Null Result ReportOpen accessMedicine

Randomized Phase III Trial of Induction Chemotherapy With Docetaxel, Cisplatin, and Fluorouracil Followed by Surgery Versus Up-Front Surgery in Locally Advanced Resectable Oral Squamous Cell Carcinoma

Lai-ping Zhong, Chen-ping Zhang, Guo-xin Ren et al. · 2012 · Journal of Clinical Oncology

PURPOSE: To evaluate induction chemotherapy with docetaxel, cisplatin, and fluorouracil (TPF) followed by surgery and postoperative radiotherapy versus up-front surgery and postoperative radiotherapy in patients with locally advanced…

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