12,266 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Li SL, Lin HL, Mi HF et al. · 2024 · Practical laboratory medicine
Objectives To evaluate the diagnostic performance of different brands of immunochromatographic test (ICT) reagents for Chlamydia trachomatis using homogenized samples to provide a reference for reagent quality control. Methods Eight…
View details →Schilter KF, Kapoor S, Smith BA et al. · 2024 · Laboratory medicine
Objective The aim of this study was to compare the performance of direct amplification of viral nucleic acid from transport medium to extracted nucleic acid for polymerase chain reaction (PCR), sequencing, and genotyping applications.…
View details →Sakaki K, Murakami T, Fujimoto H et al. · 2025 · Frontiers in endocrinology
Background Insulinomas, the most common functional pancreatic neuroendocrine tumors, cause hypoglycemia due to excessive insulin production, leading to severe clinical symptoms like coma or death. Resection surgery is the major curative…
View details →Mac PA, Anderson KD, Dakul DA · 2026 · Scientific reports
Schistosomiasis and soil-transmitted helminthiasis elimination programmes depend heavily on microscopic diagnostics, yet these methods may fail to detect low-intensity infections that sustain transmission. Molecular techniques could reveal…
View details →Maestrini I, Viganò A, Di Stefano G et al. · 2024 · Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
Background The association between paroxysmal hemicrania (PH) and trigeminal neuralgia-the so-called PH-tic syndrome-has rarely been described. However, a correct diagnosis is crucial since both disorders require specific treatments.…
View details →Craver R, Collier S, Anderson M · 2024 · Fetal and pediatric pathology
Background: We investigated the utilization of cell free microbial DNA (cfDNA) at a Children's Hospital. Materials and Methods: cfDNA results were assessed regarding the contribution to therapeutic decisions. Results: Of 80 tests on 59…
View details →Fruhauf F, Cibula D, Kocian R et al. · 2024 · International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
Objectives To assess the diagnostic performance of ultrasonography in pre-operative assessment of lymph nodes in patients with cervical cancer, to compare the outcomes for pelvic and para-aortic regions, and to detect macrometastases and…
View details →Li XE · 2026 · The Canadian veterinary journal = La revue veterinaire canadienne
A 3-year-old neutered male domestic shorthair cat was evaluated for hematuria. Ultrasonography and CT scanning identified moderate right-side hydronephrosis associated with right proximal and distal ureteral strictures, as well as partial…
View details →Kang A, Tian X, Mi Z et al. · 2026 · Environmental science & technology
Improving carbon productivity is essential for simultaneously achieving sustainable development goals and tackling climate change. While the Global Value Chains (GVCs) division enhances productive efficiency, its impact on carbon…
View details →Xing L, Lu B, Zhu X et al. · 2026 · Inflammation and regeneration
Background Mesenchymal stromal cells (MSCs) possess therapeutic potential largely reliant on intact mitochondrial function to maintain reparative function. However, obesity compromises MSC metabolism and reparative capacity. MOTS-c, a…
View details →Zheng B · 2026 · Current molecular medicine
Background/objective Patients with renal artery stenosis (RAS) exhibit increased risk of cardiovascular death and all-cause death. Our previous finding showed that the presence of RAS is associated with poor coronary collateral development…
View details →Luda KM, Agerholm M, Sonne SB et al. · 2026 · Molecular metabolism
Background White adipose tissue (WAT) plays a central role in maintaining systemic metabolic homeostasis by buffering lipid flux throughout the body. Impairment of this lipid-buffering capacity is a hallmark of obesity and has also been…
View details →Wang H, Kang L, Mu Y et al. · 2026 · Archives of animal nutrition
Light weaning body weight (LWBW) piglets exhibit inferior growth performance, and their energy requirement vary dynamically with increasing body weight. Although high-energy diets improve growth, they risk impairing liver health.…
View details →Walsh RW, Meledeo MA, Nicolson SE et al. · 2026 · Transfusion
Background Hypocalcemia is correlated with poor outcomes in trauma patients and is considered the fourth component in the "diamond of death" alongside acidosis, coagulopathy, and hypothermia. Study design and methods We characterized the…
View details →Pelletier M, Yang J, Joshi M et al. · 2026 · Clinical cancer research : an official journal of the American Association for Cancer Research
Background Transforming Growth Factor Beta (TGFβ) plays a dual role in cancer, acting as a tumor suppressor early in disease but promoting progression and immune evasion when dysregulated. In pancreatic ductal adenocarcinoma (PDAC),…
View details →De S Ferreira JM, Rodrigues HP, Alba HDR et al. · 2026 · Animal : an international journal of animal bioscience
High-concentrate diets supplemented with rumen-protected fats are widely used in feedlot lamb systems to improve energy supply and performance; however, the metabolic efficacy of these lipid sources may depend on the availability of…
View details →· 2025 · Nephron
In the article "Immunosuppressant Agents as Add-On Therapy Failed to Improve the Outcome of Immunoglobulin A Nephropathy with Crescent Score C1" [Nephron. 2024;148:587-600; https://doi.org/10.1159/000534788] by Bi et al., the funding grant…
View details →Ngeve SM, Khoury AL, Long JM · 2026 · Journal of visualized experiments : JoVE
Vanishing Lung Syndrome (VLS) is a rare, severe form of bullous pulmonary disease characterized by giant bullae occupying more than 30% of the hemithorax, which can easily be misdiagnosed as a pneumothorax. While cigarette smoking is the…
View details →Stahl M, Zeidan AM · 2026 · Blood
Abstract Aside from allogeneic transplantation, the current standard-of-care approach for higher-risk myelodysplastic syndromes/neoplasms (HR-MDS) remains monotherapy with a hypomethylating agent (HMA), including azacitidine, decitabine,…
View details →Matsushita H, Oba K, Kurono K et al. · 2026 · Shock (Augusta, Ga.)
Introduction In cardiogenic shock (CS), persistent microcirculatory impairment despite improved macrocirculatory parameters is associated with poor outcomes. Therapeutic strategies must therefore address both macro- and micro-circulation.…
View details →Florens N · 2026 · Nephrologie & therapeutique
Cardiovascular mortality among hemodialysis patients remains strikingly high—around 10% per year—despite substantial advances in dialysis technology and medical care. Historically, several strategies extrapolated from the general…
View details →Sekiguchi Y, Tsutsumi H, Kudo M et al. · 2026 · Gan to kagaku ryoho. Cancer & chemotherapy
84-year-old male was diagnosed with diffuse large B-cell lymphoma.He had Stage Ⅳ, performance status was 2, and 'high risk' according to the International Prognostic Index.He was started on Pola-R-mini-CHP.The day after completion of the 4…
View details →Al Hindawi MA, Omran NE, Mostafa MH et al. · 2026 · European journal of pharmacology
In metastatic melanoma with a BRAF V600 mutation, inhibitors of BRAF and MEK have improved survival. Resistance may be acquired through late genetic alterations that restore mitogen-activated protein kinase (MAPK) signaling. Resistance can…
View details →Chen H, Wang J, Fan C et al. · 2026 · Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
Background and aim The benefit of combining linaclotide with polyethylene glycol (PEG) for improving bowel preparation quality and adenoma detection in patients at risk for inadequate bowel preparation remains uncertain. This study aimed…
View details →Xu K, Zhang R, Yuan Y et al. · 2026 · European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
Aims Gallbladder carcinoma (GBC) has a poor prognosis, with lymph node metastasis (LNM) being a key prognostic factor. Controversies remain regarding lymph node dissection (LND) utility and prognostic differences of direct (DGBC) vs.…
View details →Li A, Liu C, Xing R et al. · 2026 · Carbohydrate research
Phenol-sulfuric acid method, a classical approach for total sugar quantification, suffers from substantial variation in the colorimetric efficiency among different monosaccharides, which may result in significant measurement bias. In this…
View details →August D, Marsh N, Hall S et al. · 2026 · The Journal of perinatal & neonatal nursing
Purpose Implement and evaluate near-infrared (NIR) huddles for neonatal peripheral intravenous catheter (PIVC) insertion. Methods An implementation project investigated PIVC insertion attempts, site, inserter designation, dwell, and…
View details →Huang JQ, Xiao HM, Ma CX et al. · 2026 · Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
To compare survival outcomes and safety between concurrent chemoradiotherapy (CCRT) and CCRT with concurrent immune checkpoint inhibitor (ICI) in patients with locally advanced esophageal squamous cell carcinoma. This multicenter cohort…
View details →Moura RP, Mwema A, Bottemanne P et al. · 2026 · Journal of controlled release : official journal of the Controlled Release Society
Multiple sclerosis (MS) is a chronic neuroinflammatory disease affecting over 2.5 million people worldwide. Despite available therapies, no current treatment halts disease progression or specifically targets remyelination. Here, we…
View details →Wu F, Wu R, Chen L et al. · 2026 · New biotechnology
Enhancing enzyme thermostability is crucial for industrial applications requiring robust performance under extreme conditions. Structure-based protein design models excel at improving thermal stability but often compromise enzymatic…
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