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Browse the failure-mode index

12,266 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

The association of third molars with mandibular incisor crowding in a group of the Yemeni population in Sana'a city: cone-beam computed tomography.

Aldhorae K, Ishaq R, Alhaidary S et al. · 2025 · BMC oral health

Background Multiple factors contribute to mandibular incisor crowding. However, the role of wisdom teeth in these irregularities remains a controversial issue among clinicians. Therefore, this study aimed to determine the potential…

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Negative / Null Result ReportOpen accessMedicine

Transcriptional evidence of pluripotency during development of the leaf gall formed by grape phylloxera (Daktulosphaira vitifoliae).

Schultz JC, Body MJA, Edger PP et al. · 2025 · The New phytologist

Galls are structures formed by plants in response to stimuli by parasitic insects. Because galls require altered gene expression to change cell fates, their initiation requires pluripotent or 'reactive' cells. We used RNA sequencing to…

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Negative / Null Result ReportMedicine

Association Between Continuous Kidney Replacement Therapy Clearance and Outcome in Pediatric Patients With Hyperammonemia Not Due to Inborn Error of Metabolism.

Starr MC, Cater DT, Wilson AC et al. · 2022 · Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

Objectives To describe a single-center experience of pediatric patients with hyperammonemia not due to inborn errors of metabolism and determine the association between use of continuous kidney replacement therapy (CKRT) treatment and…

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Negative / Null Result ReportOpen accessMedicine

Discrete Repetition Effects for Visual Words Compared to Faces and Animals, but No Modulation by Expectation: An Event-Related Potential Study.

Song B, Sommer W, Maurer U · 2025 · The European journal of neuroscience

Repetition suppression (RS) refers to the reduction of neuronal responses to repeated stimuli as compared to nonrepeated stimuli. The predictive coding account of RS proposes that its magnitude is modulated by repetition probability…

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Negative / Null Result ReportMedicine

Devaluation of NoGo stimuli is both robust and fragile.

Liu H, Holland RW, Blechert J et al. · 2022 · Cognition & emotion

Consistently not responding to stimuli during go/no-go training leads to lower evaluations of these NoGo stimuli. How this NoGo-devaluation-effect can be explained has remained unclear. Here, we ran three experiments to test the hypothesis…

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Negative / Null Result ReportMedicine

Impact of antibiotic cured chronic endometritis on perinatal outcomes: Re-evaluation of a cohort study with a detailed follow-up.

Zhang Q, Yang G, Xiong Y et al. · 2023 · American journal of reproductive immunology (New York, N.Y. : 1989)

Problem The impact of antibiotic-cured chronic endometritis (CE) on perinatal outcomes of patients conceived with frozen embryo transfer (FET) was unclear. Method This study was to re-evaluate the perinatal outcomes of a cohort of…

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Negative / Null Result ReportOpen accessMedicine

Association between maternal and perinatal outcomes and histological changes in the placenta of patients with Covid-19: A cohort study.

Rocha de Souza L, Ramos Amorim MM, Souza AS et al. · 2024 · Medicine

Although studies evaluated placental involvement in Covid-19 patients, few have assessed its association with clinical repercussions. The study aimed to determine the association between the clinical status and maternal and perinatal…

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Negative / Null Result ReportOpen accessMedicine

Evaluating the impact of statin therapy on chronic obstructive pulmonary disease outcomes: A retrospective cohort study from a tertiary care hospital in India.

Chari HS, Padukone AM, Magazine R et al. · 2026 · The Journal of international medical research

ObjectiveChronic obstructive pulmonary disease is a common condition marked by significant disability and frequent exacerbations. Statins, owing to their anti-inflammatory and immunomodulatory effects, may offer therapeutic benefits in…

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Negative / Null Result ReportOpen accessMedicine

Impact of pulsed stimulation on objective and subjective visual acuity measurements in nystagmus.

Quanz EV, Al-Nosairy KO, Stolle FH et al. · 2026 · Documenta ophthalmologica. Advances in ophthalmology

Purpose Quanz et al. (Sci Rep 14:16797, 2024) reported that participants with nystagmus had higher objective visual evoked potential visual acuity estimates (VA VEP ) by 0.12 logMAR relative compared to standard psychophysical VA (VA…

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Negative / Null Result ReportOpen accessMedicine

Comparison of effectiveness of common targeting heuristics in repetitive transcranial magnetic stimulation treatment of depression.

Sakreida K, Trapp NT, Kreuzer S et al. · 2025 · BMJ mental health

Background Repetitive transcranial magnetic stimulation (rTMS) of the left dorsolateral prefrontal cortex (DLPFC) is an effective non-pharmacological, non-invasive intervention for depression. However, the optimal strategy for localising…

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Negative / Null Result ReportOpen accessMedicine

Corneal biomechanics are not exclusively compromised in high myopia.

Yii F, Strang N, Bernabeu MO et al. · 2024 · Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)

Introduction Research assuming linearity has concluded that corneal biomechanics are compromised in high myopia. We investigated whether this assumption was appropriate and re-examined these associations across different levels of myopia.…

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Failed Experiment ReportMedicine

Morphea after Silicone Implants.

Wollina U, Schönlebe J · 2023 · Acta dermatovenerologica Croatica : ADC

Dear Editor, Silicone is a hydrophobic polymer containing silicon. Silicon is an essential compound of soft tissue proteoglycans. Reports about morphea and other autoimmune connective tissue disorders in association with silicone implants…

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Failed Experiment ReportMedicine

Seeing color following gene augmentation therapy in achromatopsia.

McKyton A, Marks Ohana D, Nahmany E et al. · 2023 · Current biology : CB

How will people who spent their visual lives with only rods respond to cone function restoration? Will they be able suddenly see the colors of the rainbow? CNGA3-achromatopsia is a congenital hereditary disease in which cone dysfunction…

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Negative / Null Result ReportMedicine

The distribution of the Lansing Effect across animal species.

Ivimey-Cook ER, Shorr S, Moorad JA · 2023 · Evolution; international journal of organic evolution

Maternal senescence is the reduction in individual performance associated with increased maternal age at conception. When manifested on adult lifespan, this phenomenon is known as the "Lansing Effect." Single-species studies report both…

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Negative / Null Result ReportOpen accessMedicine

An Exploratory Analysis of Essential Tremor and Associated Phenotypes.

Gharibian D, Medeiros M, Dion PA et al. · 2026 · Tremor and other hyperkinetic movements (New York, N.Y.)

Essential Tremor (ET) is a highly heterogeneous movement disorder with a strong genetic basis. However, the etiology of ET is unclear, largely due to its clinical heterogeneity and frequently observed comorbidities. We conducted a…

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Negative / Null Result ReportMedicine

New Morbidities During Critical Illness and Associated Risk of ICU Readmission: Virtual Pediatric Systems Cohort, 2017-2020.

Heneghan JA, Akande MY, Ramgopal S et al. · 2024 · Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

Objectives To describe change in Functional Status Scale (FSS) associated with critical illness and assess associated development of new morbidities with PICU readmission. Design Retrospective, cross-sectional cohort study using the…

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