e-ISSN: Pending

Browse the failure-mode index

12,266 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Quick returns, sleep, sleepiness and stress - An intra-individual field study on objective sleep and diary data.

Öster K, Tucker P, Söderström M et al. · 2024 · Scandinavian journal of work, environment & health

Objectives Quick returns ( Methods Of 225 nurses and assistant nurses who wore actigraphy wristbands and kept a diary of work and sleep for seven days, a subsample of 90 individuals with one observation of both a quick return and a control…

View details →
Negative / Null Result ReportMedicine

Serum heat shock protein concentrations are not associated with amyotrophic lateral sclerosis risk or survival in three European populations.

Rooney JPK, Geoghegan G, O'Reilly F et al. · 2024 · Amyotrophic lateral sclerosis & frontotemporal degeneration

Introduction : Serum heat shock protein (HSP) concentrations have been reported as potential biomarkers for amyotrophic lateral sclerosis (ALS). Here, we investigate the role of serum HSP70, HSP90, and DNAJC7 as biomarkers for ALS. Methods…

View details →
Negative / Null Result ReportMedicine

Social Determinants of Health and Health-Related Quality of Life Following Pediatric Septic Shock: Secondary Analysis of the Life After Pediatric Sepsis Evaluation Dataset, 2014-2017.

Lenz KB, McDade J, Petrozzi M et al. · 2024 · Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

Objectives Social determinants of health (SDOH) are associated with disparities in disease severity and in-hospital outcomes among critically ill children. It is unknown whether SDOH are associated with later outcomes. We evaluated…

View details →
Negative / Null Result ReportOpen accessMedicine

Stable White Matter Structure in the First Three Years After Psychosis Onset.

Van Dyken PC, Yang K, Faria AV et al. · 2025 · Biological psychiatry global open science

Background White matter alterations observed using diffusion weighted imaging have become a hallmark of chronic schizophrenia, but it is unclear when these changes arise over the course of the disease. Nearly all studies reported to date…

View details →
Replication FailureMedicine

Targeted Temperature Management After Pediatric Cardiac Arrest: A Quality Improvement Program With Multidisciplinary Implementation in the PICU.

McMullin MP, Cadotte NB, Fuchs EM et al. · 2025 · Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

Objectives We aimed to implement a post-cardiac arrest targeted temperature management (TTM) bundle to reduce the percent of time with a fever from 7% to 3.5%. Design A prospective, quality improvement (QI) initiative utilizing the Method…

View details →
Failed Experiment ReportMedicine

[Study of a fetus with confined placental mosaicism for trisomy 2 in conjunct with fetal uniparental disomy and a literature review].

Liu C, Lyu Y, Jiang Y et al. · 2023 · Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics

Objective To carry out genetic analysis for a fetus with confined placental mosaicism (CPM) for trisomy 2 (T2) in conjunct with fetal uniparental disomy (UPD). Methods Amniocentesis and chromosomal karyotyping was carried out for a…

View details →
Negative / Null Result ReportOpen accessMedicine

The Airway, Breathing, Circulation-Plan, Risk, Options (ABC-PRO) Handover Tool in the PICU: Retrospective Evaluation of Pre- Versus Post-Implementation and Occurrence Rate of Cardiac Arrests, 2020-2023.

De Gaudenzi M, Mozun R, Schlapbach LJ et al. · 2026 · Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

Objectives Healthcare improvement studies indicate a potential to reduce cardiac arrests in the PICU through anticipatory care and shared awareness. We developed a structured risk-assessment and anticipation tool (i.e., the Airway,…

View details →
Negative / Null Result ReportOpen accessMedicine

Association between maternal serum levels of Alpha-Fetoprotein and eruption timing of the first central deciduous tooth: a cross-sectional study.

Faghihian E, Ghobadi S, Rezaei R et al. · 2025 · The Saudi dental journal

The current study investigated the relationship between the first central deciduous tooth eruption time and serum levels of maternal alpha-fetoprotein and related multiple of the median (MoM). The cross-sectional study was performed on a…

View details →
Negative / Null Result ReportOpen accessMedicine

Exploring the effects of faecal microbiota transplantation on cognitive function: A review of clinical trials.

Alaeddin S, Chatterjee A, Roberts TL et al. · 2025 · Brain, behavior, & immunity - health

Faecal Microbiota Transplantation (FMT) is a widely used microbiota-modulation technique to treat recurrent Clostridioides difficile infections (rCDI). Rodent studies and clinical trials on probiotic interventions indicate that alterations…

View details →
Negative / Null Result ReportMedicine

Effects of HIV and Adverse Childhood Experiences on Neurocognition.

Inman EM, Inman EM, Ramsammy CW et al. · 2026 · Journal of acquired immune deficiency syndromes (1999)

Background Both HIV and adverse childhood experiences (ACEs) can affect neurocognitive performance. Among youth with perinatal HIV (PHIV), living with a chronic viral infection and experiencing ACEs simultaneously may result in an…

View details →
Negative / Null Result ReportOpen accessMedicine

Use of alteplase continuous rate infusion, pentoxifylline, and cyproheptadine in association or not, in acute feline aortic thromboembolism: a study of nine cats.

Ray CC, Wolf J, Guillaumin J · 2025 · Frontiers in veterinary science

Introduction Locomotion improvement without serious complications is the main goal of treatment for feline aortic thromboembolism (FATE). We aimed to describe the survival and functional recovery of cardiogenic FATE treated with tissue…

View details →
Negative / Null Result ReportOpen accessMedicine

The effect of intraoperative low-dose ketamine versus dexmedetomidine infusion on postoperative bowel recovery in patients undergoing gastrointestinal malignancy surgeries: Placebo-controlled, randomized trial.

Kumar SK, Misra S, Behera BK et al. · 2025 · Journal of anaesthesiology, clinical pharmacology

Background and aims No studies have compared the effects of ketamine and dexmedetomidine on bowel recovery. We evaluated the effects of intraoperative low-dose ketamine or dexmedetomidine infusion on postoperative bowel recovery in…

View details →
Negative / Null Result ReportMedicine

Extent of Lymphadenectomy for Surgical Management of Right-Sided Colon Cancer: The Randomized Phase III RELARC Trial.

Lu J, Xing J, Zang L et al. · 2024 · Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Purpose Complete mesocolic excision (CME) is being increasingly used for the treatment of right-sided colon cancer, although there is still no strong evidence that CME provides better long-term oncological outcomes than D2 dissection. The…

View details →
Negative / Null Result ReportOpen accessMedicine

The relationship between glaucoma and an electronic frailty index with the cumulative incidence of healthcare encounters for falls and fractures in older adults.

Duy WD, Pajewski NM, Williamson JD et al. · 2025 · The Journal of frailty & aging

Objective To compare the association of glaucoma and glaucoma suspect diagnoses with frailty, quantified via an electronic frailty index (eFI), and to evaluate whether a glaucoma diagnosis moderates the association between frailty and the…

View details →
Negative / Null Result ReportMedicine

Racial and ethnic disparities in the usage and outcomes of ischemic stroke treatment in the United States.

Metcalf D, Zhang D · 2023 · Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

Objectives This study explores racial and ethnic differences in 1) receiving tissue plasminogen activator (tPA) and endovascular thrombectomy (EVT) as treatment for ischemic stroke and 2) outcomes and quality of care after use of tPA or…

View details →
Negative / Null Result ReportOpen accessMedicine

The Effects of Repeated Finger Flexion Movements on Self-Reported Affect and Reward System Activation Are Weak and Inconsistent.

Vander Missen MR, Giovanetti AK, Fisher JS et al. · 2025 · Journal of clinical psychology

Recent research has called into question the robustness and reliability of using body movements to activate motivational systems like approach-reward. The purpose of the current studies was to test the effect of a repeated flexion movement…

View details →
Negative / Null Result ReportOpen accessMedicine

What is the effect of alarmist media and radiofrequency electromagnetic field (RF-EMF) exposure on salivary cortisol and non-specific symptoms?

Verrender A, Wallace NK, Loughran SP et al. · 2025 · Applied psychology. Health and well-being

While there is consistent evidence that the symptoms reported by people who experience Idiopathic Environmental Intolerance attributed to Electromagnetic Fields (IEI-EMF) are closely associated with a nocebo effect, and that alarmist media…

View details →
Negative / Null Result ReportOpen accessMedicine

The Effects of CenteringPregnancy: A Quasi-Experimental Evaluation.

Park CH, Driver N, Richards RC Jr et al. · 2025 · Healthcare (Basel, Switzerland)

Background/Objectives : CenteringPregnancy (CP) is a group prenatal care model that empowers pregnant women through risk assessment, education, and social support. CP participants have more contact time with providers compared to those in…

View details →