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Browse the failure-mode index

12,266 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Bactericidal Efficacy of So-Called Sanitizers in Japan.

Funaki R, Nomura S, Ushima A et al. · 2024 · Biological & pharmaceutical bulletin

Commercially available so-called sanitizers in Japan are often touted as having remarkable "sanitizing (jokin)" effect, "virus-removal" capabilities, and "99.99%" removal rate of microbes and pathogens. In this study, we investigated the…

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Negative / Null Result ReportOpen accessMedicine

Single Enema Fecal Microbiota Transplantation in Cats With Chronic Enteropathy.

Karra DA, Suchodolski JS, Newman SJ et al. · 2025 · Journal of veterinary internal medicine

Background Chronic enteropathies (CE) are common in cats, and alterations of the intestinal microbiota might be involved in the pathogenesis. Hypothesis/objectives To evaluate the efficacy of a single enema fecal microbiota transplantation…

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Negative / Null Result ReportMedicine

The Effects of Differential Learning on the Standing Broad Jump.

Rivera D, Robinson T, King AC · 2024 · Perceptual and motor skills

In this investigation, we examined the influence of two approaches of motor skill learning (differential learning and repetition-based) for an explosive motor skill. Twenty-seven individuals completed four training sessions of a standing…

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Negative / Null Result ReportOpen accessMedicine

Preventing relapse in patients with major depressive disorder after an effective acute course of electroconvulsive therapy.

Song M, Launder NH, Phutane VH et al. · 2026 · Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists

ObjectiveMajor depressive disorder (MDD) is a highly prevalent debilitating mental health disorder with a lifetime risk of 11-15% in Australia. The most effective treatment for severe depression is electroconvulsive therapy (ECT), but it…

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Negative / Null Result ReportOpen accessMedicine

Curcumin's effect in advanced and metastatic breast cancer patients treated with first or second-line docetaxel: A randomized trial.

Judith PJ, Maureen B, Mélanie P et al. · 2024 · Health science reports

Background In this study, we investigated whether the association of curcumin and docetaxel among advanced and metastatic breast cancer patients in first or second-line treatment potentiated the objective response rate. Patients/methods A…

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Negative / Null Result ReportOpen accessMedicine

Eosinophilic myocarditis in dilated cardiomyopathy: a case report.

Li M, Chen H · 2025 · BMC cardiovascular disorders

Background Eosinophilic myocarditis (EM) is a rare cardiac condition that is often difficult to diagnose. Although endocardial myocardial biopsy is considered the gold standard for diagnosis, sampling errors can lead to false-negative…

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Negative / Null Result ReportMedicine

"Back to the Future": Testing the "Individual Problems and Strengths" Scale With a Stepwise Confirmatory Factor Analysis Approach.

Zahl-Olsen R, Gausel N, Håland ÅT et al. · 2026 · Journal of clinical psychology

Routine Outcome Monitoring systems have been developed to monitor how clients' lives change over the course of therapy. However, for such systems to be effective, they must possess sufficient construct validity and scale-reliability to…

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Negative / Null Result ReportMedicine

Weight Suppression, Brain Reward Response to Food Cues, and Bulimic Behaviours: A Pilot fMRI Study.

Singh S, Jagannathan K, Childress AR et al. · 2026 · European eating disorders review : the journal of the Eating Disorders Association

Objective Weight suppression (WS), or the difference between one's highest past and current weights, may help maintain bulimia nervosa (BN) by altering reward response to food cues. This pilot study tested associations among WS, brain…

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Negative / Null Result ReportOpen accessMedicine

Alcohol

· 2006

The effects of maternal alcohol (ethanol) ingestion during lactation are complex and depend on the pattern of maternal drinking. With casual alcohol use (such as 1 glass of wine or beer) it is best to wait 2 to 2.5 hours per drink before…

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Negative / Null Result ReportMedicine

An Exploratory Analysis of Eye-Tracking During a Virtual Reality Social Cognition Intervention for Children with Autism Spectrum Disorders.

Gámez Martínez S, Lovatón Romero G, Alcañiz Raya M et al. · 2026 · Cyberpsychology, behavior and social networking

The diagnosis of autism spectrum disorder is based on clinical judgment, as there are no clearly identified markers to determine the presence of this condition. Gaze patterns have been proposed as a potential biomarker for autism. This…

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Negative / Null Result ReportMedicine

Aphantasia and visual working memory: No direct evidence of impaired visual working memory in aphantasics, either in behavioral performance or the accuracy of a multivoxel pattern classifier.

Knight KF, Milton F, Zeman A · 2026 · Neuropsychologia

Visual mental imagery and visual working memory are often thought to be closely related. After all, both have been argued to involve the temporary maintenance of visual representations in conscious awareness. We might expect, therefore,…

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Negative / Null Result ReportMedicine

Associations of fear, anger, happiness, and hope with risk judgments: Revisiting appraisal-tendency framework with a replication and extensions registered report of Lerner and Keltner (2001).

Lu S, Efendić E, Feldman G · 2025 · Journal of personality and social psychology

The appraisal-tendency framework proposed that specific emotions predispose individuals to appraise future events corresponding to the core appraisal themes of the emotions. In a registered report with a U.S. American online Amazon…

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Negative / Null Result ReportMedicine

Lung ultrasound score and prediction of patient outcomes in hypoxaemic intubated and mechanically ventilated critically ill: A cohort study.

Ntoumenopoulos G, Hansell L, Neindre AL et al. · 2026 · Australian critical care : official journal of the Confederation of Australian Critical Care Nurses

Background The extent of pulmonary aeration present on admission to the intensive care unit (ICU) as determined by the lung ultrasound score (LUSS) may be useful to predict weaning from mechanical ventilation. The aim of this study was to…

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Negative / Null Result ReportMedicine

Longitudinal relations between parental burden, adolescent externalizing symptoms, and mental health service use in the year following adolescent psychiatric hospitalization.

Harris KM, Curby TW, Goldston DB et al. · 2026 · Psychological services

Rates of adolescent psychiatric hospitalization have increased significantly over the last decade. Despite heightened risk for life-threatening behavior and readmission in the year following hospitalization, mental health service use has…

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Negative / Null Result ReportMedicine

Outcome of Severe Adenoviral Respiratory Infection Supported With Extracorporeal Membrane Oxygenation: A Multicenter PICU Study From Colombia (2018-2022).

Acevedo L, Fernández-Sarmiento J, Mulett H et al. · 2026 · Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

Objectives To compare survival, clinical characteristics, complications, and duration of extracorporeal membrane oxygenation (ECMO) support in pediatric patients with severe adenoviral respiratory infections vs. those with other viral…

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Negative / Null Result ReportOpen accessMedicine

What Is the Impact of Second Language Exposure and Intellectual Disability Status on Executive Function and Functional Communication Outcomes in Children and Adolescents With and Without Autism Spectrum Disorder (ASD)?

Hutchison SM, DiazPinzon N, Oberlander TF et al. · 2025 · Autism research : official journal of the International Society for Autism Research

Over the past 10 years, research has suggested no negative effect on second language exposure in children with autism spectrum disorder (ASD), yet, parents and professionals may be concerned that using a second language with a child with…

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Negative / Null Result ReportOpen accessMedicine

Immune Globulin

· 2006

Immune globulin G (IgG) is a normal component of breastmilk. Data from 2 mothers indicate that IgG concentrations in milk are normal or higher and IgM levels in milk are normal or lower during intravenous immunoglobulin (IVIG) therapy. The…

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Negative / Null Result ReportMedicine

Caregiver emotional support and youth mental health after sexual abuse.

Sitton MJ, McDonald R, Rosenfield D et al. · 2026 · Journal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association (Division 43)

Emotional support from a caregiver is theorized to benefit adolescents after sexual abuse, yet the empirical evidence for this is inconsistent. The present study examines the cross-sectional relation between caregiver emotional support and…

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Negative / Null Result ReportMedicine

Mobile App Use in Clinical Care for Cleft Patients in the UK and Republic of Ireland.

de Berker HT, Rivers CM · 2026 · The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association

ObjectiveTo establish whether mobile applications (apps) are used as part of routine care for patients with cleft lip and palate in the UK and Republic of Ireland and to determine what role apps could play in the delivery of care.DesignA…

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Negative / Null Result ReportMedicine

Tumor-induced rickets/osteomalacia (TIO): diagnostic pitfalls and therapeutic options.

Ito N, Fukumoto S · 2025 · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

A 10-year-old girl developed bilateral gonalgia and waddling gait. Biochemical and imaging studies showed hypophosphatemia with impaired proximal tubular phosphate reabsorption and high intact fibroblast growth factor 23 (FGF23) level,…

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Negative / Null Result ReportOpen accessMedicine

Randomized controlled trial of intravenous dexamethasone to prevent relapse in the treatment of migraine in a pediatric emergency department.

Tourigny-Ruel G, Bailey B, Jean-Charles S et al. · 2026 · Headache

Objective This study aimed to evaluate whether a single dose of intravenous dexamethasone, when added to standard abortive therapy, reduces relapse of migraine after emergency department (ED) discharge in children and adolescents.…

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