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WASTE Journal

Browse the failure-mode index

12,266 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Metformin Is Associated With a Reduced Risk of Gastric Cancer, but Not Dysplasia, in Patients With Diabetes.

Lee HS, Kang SH, Eun HS et al. · 2026 · The Korean journal of helicobacter and upper gastrointestinal research

Objectives Metformin has been suggested to exert chemopreventive effects against gastric cancer. However, epidemiologic evidence remains inconsistent, and its impact on histologically confirmed precursor lesions, such as gastric dysplasia,…

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Negative / Null Result ReportMedicine

Outcomes of a Foundational Sciences Daily Engagement Game in Medical Education.

Schmidt M · 2026 · Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology

Daily engagement games are widely used as motivational tools in applications ranging from language learning to medical licensing board preparations. In medical education, continuous engagement with basic science concepts has benefits for…

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Negative / Null Result ReportMedicine

Efficacy of leukocyte-platelet-rich fibrin (L-PRF) and injectable platelet-rich fibrin (i-PRF) on the rate of canine retraction: a split mouth, randomized controlled trial.

Kamrani A, Khera AK, Raghav P et al. · 2026 · The Angle orthodontist

Objectives To evaluate and compare the effects of leukocyte-platelet-rich fibrin (L-PRF), injectable platelet-rich fibrin (i-PRF; submucosal), and i-PRF (intraligamental) on the rate of maxillary canine retraction. Materials and methods A…

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Negative / Null Result ReportMedicine

How hostile attribution bias affects attachment anxiety/avoidance and relationship satisfaction: a cross-cultural perspective during the COVID pandemic.

Li D, Carnelley KB, Crawford MT et al. · 2026 · The Journal of social psychology

This is the first cross-cultural study of the contribution of romantic hostile attribution bias to relationship satisfaction that takes into account the role of attachment orientation. In two studies conducted 1 year apart, data were…

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Negative / Null Result ReportMedicine

<i>In vivo</i> and <i>in vitro</i> anthelmintic activity of quebracho-chestnut tannin extract against <i>Haemonchus contortus</i> in lambs.

Bruttomesso MF, Morici GE, Arias MR et al. · 2026 · Journal of helminthology

Haemonchus contortus is considered the most pathogenic gastrointestinal nematode of sheep and, due to the increasing resistance to synthetic anthelmintics, it poses a serious challenge to small ruminant production systems. The aim of this…

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Negative / Null Result ReportMedicine

Immune checkpoint inhibitors in pediatric central nervous system tumors: biology, clinical experience, and translational pathways to precision immunotherapy.

Yenidogan I, Tabori U, Das A · 2026 · Journal of neuro-oncology

Purpose Immune checkpoint inhibitors (ICI) have transformed cancer therapy but remain of limited efficacy in pediatric central nervous system tumors, which are characterized by low tumor mutational burden, sparse antigen presentation, and…

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Negative / Null Result ReportMedicine

Endovascular thrombectomy in addition to intravenous thrombolysis versus intravenous thrombolysis alone in medium distal vessel occlusions: Results from the SITS International Stroke Treatment Register.

Keselman B, Mazya MV, Strbian D et al. · 2026 · International journal of stroke : official journal of the International Stroke Society

Background Endovascular thrombectomy (EVT) is the standard of care for large-vessel occlusion stroke. Medium distal vessel occlusions (MDVO) account for 25-40% of acute ischemic stroke cases, but recanalization rates with intravenous…

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Failed Experiment ReportMedicine

Bladder region-specific analysis of the diagnostic performance of oral 5-aminolevulinic acid fluorescence cystoscopy in non-muscle-invasive bladder cancer.

Ishikawa Y, Tanaka H, Kobayashi M et al. · 2026 · Japanese journal of clinical oncology

Background Fluorescence cystoscopy (FL) using 5-aminolevulinic acid (ALA) enhances the detection of urothelial carcinoma compared to white-light endoscopy (WL). The location of bladder tumors may affect the diagnostic performance of FL;…

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Negative / Null Result ReportMedicine

Surgical nodal staging in rhabdomyosarcoma of the bladder and/or prostate with or without nodal or metastatic spread. A report from the European Paediatric Soft-Tissue Sarcoma Study Group (EpSSG).

Smeulders N, Gaze MN, Guérin F et al. · 2026 · Journal of pediatric surgery

Background Risk stratification of rhabdomyosarcoma (RMS) requires accurate staging, with histological nodal assessment being of critical importance for specific tumour sites. This report explores the value of surgical nodal staging in…

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Negative / Null Result ReportOpen accessMedicine

Residual Wrist Pain and Cyst Recurrence Following Removal of Dorsal Ganglion With and Without Posterior Interosseous Nerve Neurectomy.

Furlong CT, Stanton HL, Yin R et al. · 2026 · Journal of hand surgery global online

Purpose Pain from dorsal wrist ganglion cysts may result from irritation of the terminal branch of the posterior interosseous nerve. Excision of this branch is often used to treat wrist pain from various etiologies, including recurrent…

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Negative / Null Result ReportMedicine

A Fine Balance: Anticoagulation for Non-Valvular Atrial Fibrillation After Cerebral Amyloid Angiopathy-Related Intracranial Haemorrhage.

Turner D, Kamadasala K, McGarity B · 2025 · Heart, lung & circulation

The management of anticoagulation in patients with non-valvular atrial fibrillation at high risk of bleeding complications can be challenging. One such group is elderly patients with previous intracranial haemorrhage secondary to cerebral…

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Negative / Null Result ReportMedicine

Atrial shunt therapy for heart failure: an update review.

Giorgi J, Flores-Bravo Y, Dandamudi M et al. · 2025 · Heart failure reviews

Interatrial shunt devices (IASDs) and implant-free strategies have emerged as novel approaches for heart failure (HF) management by mechanically unloading the left atrium (LA) to reduce left atrial pressure (LAP), a key driver of pulmonary…

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Negative / Null Result ReportMedicine

Male partner treatment and the potential sexual transmission of bacterial vaginosis: considerations for patient counseling and clinical application in the United States.

Yazdy GM, Workowski KA, Ghanem KG et al. · 2026 · American journal of obstetrics and gynecology

Bacterial vaginosis, the most common cause of vaginal complaints among reproductive-aged women, is highly recurrent and often challenging to treat. Whether bacterial vaginosis is sexually transmissible has long been questioned by patients,…

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Negative / Null Result ReportMedicine

PACAP and migraine.

Diener HC · 2025 · Brain : a journal of neurology

A number of neuropeptides, including pituitary adenylate cyclase-activating polypeptide (PACAP), play an important role in the pathophysiology of migraine. Infusions of PACAP in patients with migraine can provoke migraine attacks. A…

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