12,266 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Chen Y, Deng M, Xie L et al. · 2026 · Journal of translational medicine
Background The rarity of right heart masses challenges diagnostic proficiency, while reproducibility is affected by the echocardiography operator. Artificial intelligence (AI)-based imaging tools may help address these limitations. Methods…
View details →Ibarretxe D, Tameish S, González-Lleó A et al. · 2026 · Clinica e investigacion en arteriosclerosis : publicacion oficial de la Sociedad Espanola de Arteriosclerosis
Introduction and objectives Preeclampsia (PE) is a multisystem hypertensive disorder affecting 2-8% of pregnancies worldwide and represents a major cause of maternal and fetal morbidity and mortality. Its pathophysiology involves placental…
View details →de la Torre JD, Blázquez Sanchez V, Bonnin Arias C et al. · 2026 · Journal francais d'ophtalmologie
Purpose To evaluate the differences and interchangeability of white-to-white (WTW) distance and anterior chamber depth (ACD) measurements among three devices: Anterion (Heidelberg Engineering, Heidelberg, Germany), IOL Master 700 (Carl…
View details →Li Y, Keqie Y, Peng C et al. · 2026 · Frontiers in genetics
Chromosomal inversion is one of the common types of chromosomal structural rearrangements. For couples with chromosomal inversions, the appropriate recommendations for preimplantation genetic testing (PGT) remain a subject of ongoing…
View details →Gönüllü İ, Devrimci EE, Singün B et al. · 2026 · Journal of clinical medicine
Background: The aim of this study was to evaluate the whitening efficacy and long-term stability of different in-office bleaching agents containing high concentrations of hydrogen peroxide (HP). Methods: Records of 50 patients who…
View details →Landi FS, Gholami M, Abdollahzadeh N et al. · 2026 · Journal of materials science. Materials in medicine
Topical minoxidil is typically administered over an extended period for the therapeutic management of androgenic alopecia. Given the adverse effects of commercial preparations of minoxidil (i.e., minoxidil solution), researchers are…
View details →Sun H, Du M, Guo S et al. · 2026 · Frontiers in endocrinology
Objective To investigate the impact of three endometrial preparation protocols-hormone replacement therapy (HRT), natural cycle (NC), and down-regulation HRT-on pregnancy outcomes in frozen embryo transfer (FET) cycles among patients with…
View details →Perng PS, Chang Y, Chuang MT et al. · 2026 · Stroke and vascular neurology
Background Dual antiplatelet therapy (DAPT) is often necessary following endovascular treatment for ruptured cerebral aneurysms; however, the optimal drug combination and treatment duration remain uncertain. Method Patients with…
View details →Long Q, Wen Y, Li J · 2026 · BMC gastroenterology
Background Anemia is a common complication of long-term hematochezia in patients with mixed hemorrhoids. This study aimed to evaluate the effect of preoperative anemia on the prognosis of mixed hemorrhoids after Milligan-Morgan…
View details →Liu L, Wang C, Chen X et al. · 2026 · International journal of women's health
Objective To investigate the association between methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and subclinical hypothyroidism (SCH) in early pregnancy. Methods This retrospective case-control study included 100 pregnant…
View details →Zhu Y, Lin J, Zhang R et al. · 2026 · BMC oral health
BACKGROUND: This pilot study evaluated the repeatability and consistency of three methods—conventional, ultrasonic, and optical—for measuring mandibular functional parameters, with the goal of providing guidance for clinical…
View details →Wang Y, Xu X, Shen WJ et al. · 2026 · Zhonghua yi xue za zhi
Objective: To investigate the effects of oliceridine versus sufentanil for anesthesia induction and postoperative patient-controlled intravenous analgesia (PCIA) on postoperative nausea and vomiting (PONV) in patients undergoing…
View details →Garcés-Pellejero M, Torres-Ferrús M, Mas-de-Les-Valls R et al. · 2026 · European journal of neurology
Objectives To compare response (reduction in headache frequency and differences in patient-reported outcomes) between Erenumab and OnabotulinumtoxinA from two phase-IV trials after 6 months of treatment. Materials/methods A prospective…
View details →Ramírez-Pérez L, Cuesta-Vargas AI · 2026 · Physiotherapy research international : the journal for researchers and clinicians in physical therapy
Kinematic movement analysis is highly relevant in patients with glenohumeral instability, a pathology characterized by fatigue-induced slowing of repetitive movements. However, the optimal exercise approach for this symptom remains…
View details →Özdemir BG, Agakishiyeva L, Bilgi A et al. · 2026 · Journal of lower genital tract disease
Objectives Assessment of clitoral artery flow parameters (eg, pulsation and resistance indices) is important for individual patient evaluation of sexual function quality. Selected hormonal treatments may also influence these vascular…
View details →Hernández-Rodríguez D, Contreras A, Melgar Lalanne G et al. · 2026 · PeerJ
Background The gut microbiota maturation extends beyond the first two years of life. Early perinatal and postnatal factors may influence the child's nutritional status, which, in turn, can affect the composition of their gut microbiota.…
View details →Sugase T, Kanemura T, Matsuura N et al. · 2026 · Annals of surgical oncology
Background Adjuvant nivolumab has become a standard treatment after curative resection for locally advanced esophageal cancer; however, postoperative recurrence remains common. The efficacy of immune checkpoint inhibitor (ICI)-based…
View details →Cañones-Zafra R, Allendes-Urquiza G, Muñiz C et al. · 2026 · Journal of ophthalmology
Purpose Our purpose is to report the results of a prospective study on ocular discomfort and objective tear film parameters (osmolarity and NIKBUT), in myopic patients, and observe the possible differences at 1 month between randomized…
View details →Still MEH, Alberts A, Nagda P et al. · 2026 · The Journal of craniofacial surgery
Introduction Craniosynostosis is a common pediatric condition that results in variable symptoms that range from asymptomatic cosmetic deformities to severe signs of intracranial hypertension. Little is understood about the relationship…
View details →Azriel M, Shohat H, Blinderman D et al. · 2026 · Journal of experimental botany
Dehydration-responsive element-binding (DREB) transcription factors play an important role in plant responses to drought. DREB subfamily A4 contains a subgroup named TINY. Previous studies in Arabidopsis suggest that TINYs suppress plant…
View details →Johnson CM, Kenne KA, Bradley CS et al. · 2026 · Urogynecology (Philadelphia, Pa.)
Importance Perioperative gabapentin is widely used in gynecology ERAS protocols, but evidence for its use for vaginal prolapse procedures is very limited. Objective The objective of this study was to evaluate the effect of preoperative…
View details →Zeng X, Huang Z, Shen H et al. · 2026 · BMC urology
Background Catheter displacement during urodynamic studies remains a common challenge, potentially introducing artifacts, compromising test accuracy, and decreasing patient comfort. Despite the clinical significance of stable catheter…
View details →Bendtsen AW, Lykkebirk L, Behrens CM et al. · 2026 · Ophthalmic epidemiology
Purpose To examine changes in macular ganglion cell layer (GCL) thickness over five years in a community-based birth cohort of children without ophthalmic disease. Methods This prospective study included 660 children without ophthalmic…
View details →Bandiaky ON, Volteau C, Bihan A et al. · 2026 · The International journal of prosthodontics
Purpose The aim of this study was to evaluate the effect of using the VirTeaSy Dental simulator in conjunction with a virtual reality headset on student performance in conventional fixed prosthodontics simulations. Material and methods The…
View details →Asano T, Uemura K, Higuchi R et al. · 2026 · Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs
Purpose Closed suction drainage has been used after total hip arthroplasty (THA) to prevent hematoma, muscle swelling, and complications, but its effectiveness remains controversial. This study evaluated the effects of drains on…
View details →Osawa Y, Funahashi H, Ido H et al. · 2026 · International orthopaedics
Background Recent advances in navigation systems have enabled more precise osteotomies. However, the clinical outcomes of navigation-assisted transtrochanteric rotational osteotomy (TRO) for osteonecrosis of the femoral head (ONFH) remain…
View details →Sarıyılmaz E, Sarıyılmaz Ö, Sessiz R et al. · 2026 · BMC oral health
Background This study aimed to compare the filling volume and surface area of Biodentine placed in mandibular molar isthmuses using three different compaction techniques (manual, ultrasonic, and sonic endomotor system). Materials and…
View details →Dong M, Liu Y, Wei C · 2026 · BMC surgery
Background To evaluate whether constrained acetabular liners (CAL) used in total hip arthroplasty (THA) reduce the risk of dislocation and related complications in patients with neuromuscular disorders and unstable comminuted femoral…
View details →Marchi MB, Al Harami A, Maher A et al. · 2026 · European journal of ophthalmology
PurposeTo compare the clinical outcomes of conventional photorefractive keratectomy (PRK) and transepithelial PRK (TransPRK) for the correction of myopic refractive errors.MethodsThis prospective, paired-eye comparative study included 48…
View details →Farhadi F, Ahmadpour F, Nezafati S et al. · 2026 · Aesthetic plastic surgery
Background and aim The nasal tip plays a central role in facial aesthetics, and achieving long-term tip stability is a key objective in rhinoplasty. This study compared postoperative tip stability between structural rhinoplasty using a…
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