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Browse the failure-mode index

12,266 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Inhaled budesonide and beclomethasone for the prevention and treatment of bronchopulmonary dysplasia in very preterm infants: a prospective randomized controlled trial.

Wang B, Xu S, Li Z et al. · 2026 · Frontiers in pediatrics

Background To investigate the clinical efficacy and safety of inhaled budesonide and beclomethasone for the prevention and treatment of bronchopulmonary dysplasia (BPD) in very preterm infants. Methods From October 2024 to November 2025,…

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Negative / Null Result ReportOpen accessMedicine

Exploring how weight stigma relates to psychological distress, physical activity, and eating behaviors over time: a longitudinal study among young adults in Hong Kong.

Fung XCC, Siu AMH, Ye J et al. · 2026 · Journal of eating disorders

Background Many researchers have expressed concerns that weight stigma may cause adverse health effects and worsen weight issues in a vicious cycle. However, empirical evidence evaluating this cycle is scarce, especially among Eastern…

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Negative / Null Result ReportOpen accessMedicine

The effect of moral distress experienced by intensive care nurses on end-of-life care attitudes and care behaviours: a single-centre cross-sectional and correlational study.

Özyürek P, Kılıç İ, Akarsu A et al. · 2026 · BMC nursing

OBJECTIVES: This study aimed to evaluate the effect of moral distress experienced by intensive care nurses on their attitudes toward end-of-life care and their care behaviors. METHODS: This cross-sectional and correlational study was…

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Negative / Null Result ReportMedicine

Examining the relationship between attachment styles, stress coping styles, and psychological resilience levels in adults seeking treatment for alcohol and substance use disorders.

Duran S, Demirci HT · 2025 · Journal of ethnicity in substance abuse

This relational survey study aims to examine the relationship between attachment styles, coping styles, and psychological resilience levels in adults seeking treatment for alcohol and substance use disorders. The study was conducted with…

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Negative / Null Result ReportOpen accessMedicine

Patterns in meperidine distribution and associations with income and obesity in the USA and Puerto Rico between 2019 and 2023: a retrospective study.

Gonzalez B, Healy LG, Harrison LR et al. · 2026 · BMJ open

Objectives Meperidine, once viewed as relatively safe, is now discouraged in clinical settings due to its associated risks. Previous studies have identified a significant decrease in meperidine distribution across the USA from 2000 to…

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Negative / Null Result ReportOpen accessMedicine

Modeling Factors Affecting Physicians' Acceptance of E-Prescriptions Using Structural Equation Modeling-Partial Least Squares Analysis: A Cross-Sectional Study.

Zahiri M, Yazdani A, Honarvar B et al. · 2026 · Health science reports

Background and aims The acceptance of technology is a critical factor influencing the success of health information systems. This study aimed to investigate the key factors affecting physicians' acceptance of electronic prescription…

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Negative / Null Result ReportMedicine

Impact of cone-beam computed tomography image quality on artificial intelligence-driven three-dimensional tooth segmentation and evaluation of external apical root resorption.

Senén-Carramolino R, Navarro-Fraile E, Dehesa-Santos A et al. · 2026 · The Angle orthodontist

Objectives To assess the reliability of the diagnostic method using Diagnocat artificial intelligence (AI)-generated standard tessellation language (STL) files and Geomagic Wrap software and to evaluate whether cone-beam computed…

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Negative / Null Result ReportMedicine

Phacoemulsification combined with bent ab interno needle goniectomy versus high-frequency deep sclerotomy: a comparative study of surgical outcomes in open-angle glaucoma.

Yayla U, Orenc P · 2026 · BMC ophthalmology

Background This study aims to compare intraocular pressure (IOP) reduction, surgical success, antiglaucoma medication (AGM) usage, complication profiles, and structural and functional outcomes between phacoemulsification combined with bent…

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Methods Dead-EndOpen accessMedicine

27-Week avocado-soybean unsaponifiables treatment in a knee osteoarthritis rabbit model: histomorphometric assessment of potential disease-modifying effects.

Sabucedo-Suárez A, Muñoz F, Permuy M et al. · 2026 · Frontiers in veterinary science

Osteoarthritis is a chronic degenerative joint disease that affects cartilage and subchondral bone, and there is growing interest in nutraceuticals such as avocado-soybean unsaponifiables as potential disease-modifying agents and possible…

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Negative / Null Result ReportMedicine

An effective strategy for rare microdissection testicular sperm involves utilizing a micro-cryopreservation technique combined with laser-assisted selection of immotile sperm after thawing.

Lin R, Wang C, Xu K et al. · 2026 · Cryobiology

The challenge with spermatozoa retrieval in non-obstructive azoospermia (NOA) patients is that testicular spermatozoa are frequently immotile and exceedingly scarce. The cryopreservation of these limited spermatozoa and the subsequent…

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Negative / Null Result ReportMedicine

Cable versus cerclage wire in weber tension band fixation for transverse olecranon fractures: a biomechanical study in a synthetic ulna model.

Eyceyurt RS, Suer O, Uzakgider M et al. · 2026 · Scientific reports

Stable fixation of displaced simple transverse olecranon fractures is required to maintain reduction under triceps traction and enable early elbow motion. Although Weber tension band fixation is widely used, the biomechanical influence of…

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Negative / Null Result ReportOpen accessMedicine

Evaluation of physicomechanical and optical properties of bioactive glass (BAG)-filled resin composites: an <i>in vitro</i> study.

de Santana YVS, Vasconcelos EEM, de Melo Monteiro GQ et al. · 2026 · Biomaterial investigations in dentistry

Objective To evaluate the behavior of bioactive glass (BAG)-filled resin composites (Beautifil II / Shofu-BR and Beautifil Flow Plus / Shofu-BF) compared with conventional resin composites (Filtek Z350 XT / Solventum-ZR and Filtek Supreme…

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Negative / Null Result ReportMedicine

Comparison of functional outcomes between medialized and lateralized reverse shoulder prostheses in acute proximal humerus fractures.

Delgado-Flores L, Pérez-Abad M, Di Felice Ardente P et al. · 2026 · Journal of orthopaedic surgery and research

Hypothesis/background Reverse shoulder arthroplasty (RSA) is increasingly used for complex proximal humerus fractures (PHFs). Although lateralized designs have demonstrated advantages in elective indications, their role in acute PHFs…

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Negative / Null Result ReportMedicine

Analysis of Contrast-enhanced CT Radiation Dose in Children.

Wang F, Sheng J, Zhang G et al. · 2026 · Health physics

Reducing radiation exposure in pediatric imaging is a key focus globally, and it is necessary to establish diagnostic reference levels (DRLs) for contrast-enhanced computed tomography (CT) in children. This study assesses typical radiation…

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Negative / Null Result ReportMedicine

Investigation of the effectiveness of different suture materials used in impacted mandibular third molar extractions on wound healing and clinical features.

Ömezli MM, Torul D, Doğanay Z · 2026 · Quintessence international (Berlin, Germany : 1985)

Purpose The aim of this study was to explore the physical and clinical efficacy of different suture materials used following impacted third molar surgery. Patients and methods This retrospective study included patients who underwent…

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Negative / Null Result ReportOpen accessMedicine

Metabolic profiles show few differences in serum amino acid, one-carbon, and fatty acid compounds in dogs fed a plant-based ("vegan") or meat-based diet.

Dodd SAS, Adolphe JL, Shoveller AK et al. · 2025 · Frontiers in veterinary science

Introduction Dogs are omnivores, not herbivores, and yet entirely plant-based diets are formulated to meet their current known nutrient recommendations. However, little is known about the metabolic effects of feeding diets containing no…

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