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Browse the failure-mode index

12,264 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Connectedness to Nature, Ceremonial Participation, and Mental and Physical Health Among Rural and Urban Wixárika in Jalisco, Mexico.

Shattuck EC, McKinnon L, Herrera IR et al. · 2026 · American journal of human biology : the official journal of the Human Biology Council

Objectives Research in Western samples has repeatedly demonstrated a link between exposure to nature and natural stimuli and improved health. We sought to test these relationships in a sample of Indigenous Wixárika, whose traditional…

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Negative / Null Result ReportMedicine

Prognostic factors and outcome measures after BRAF-directed targeted therapy of unresectable metastatic BRAF<sup>V600E</sup> colorectal cancer: a study cohort-level analysis.

Colloca GA, Venturino A · 2026 · Investigational new drugs

BRAF V600E mutation in metastatic colorectal cancer (mCRC) is associated with a poor prognosis. BRAF V600E inhibitors (BRAFi) plus EGFR inhibitors + / - MEK inhibitors regimens prolonged overall survival (OS), but prognosis remains…

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Negative / Null Result ReportMedicine

The association of non-alcoholic fatty liver index, plasma metal levels, and genetic susceptibility using genome-wide type analysis.

Yu SH, Luo KH, Yang CC et al. · 2026 · Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)

Background & aims This study aimed to explore the relationship between heavy metal exposure and the occurrence of non-alcoholic fatty liver disease (NAFLD), an area with conflicting existing research and unexplored genetic implications.…

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Negative / Null Result ReportMedicine

Serial homicide offenders and the lunar cycle.

Salafranca Barreda D, González JA · 2026 · Chronobiology international

The purpose of this research is to establish whether there are factors that contribute to the predatory activation of serial homicide offenders (SHOs) in relation to the lunar cycles. In order to move the discussion away from the media…

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Negative / Null Result ReportOpen accessMedicine

Exploring the role of ankle torque fluctuations and intramuscular coherence in gait function among older adults.

Yaguchi-Horiuchi A, Tsuji T, Takeuchi H et al. · 2025 · Aging clinical and experimental research

Objective This study aimed to investigate the relationship between ankle joint function and walking performance in older adults by assessing qualitative ankle functions through torque fluctuation analysis and tibialis anterior (TA)…

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Negative / Null Result ReportMedicine

The Impact of Operative Timing on Postoperative Complications in Laparoscopic Appendectomy for Uncomplicated Acute Appendicitis: A Retrospective Cohort Study.

Bozkurt H, Taşkın M, Özcan C et al. · 2026 · Journal of laparoendoscopic & advanced surgical techniques. Part A

Background Acute appendicitis (AA) is one of the most common surgical conditions presenting as acute abdomen. Delaying appendectomy can increase the risk of perforation. However, patients admitted or treated at night have been found to…

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Failed Experiment ReportMedicine

Plate configuration in midshaft clavicle fractures: influence of working length, screw number, and plate length-a retrospective cohort study of 355 patients.

Hinkelmann MA, Schibler D, Frei F et al. · 2026 · European journal of orthopaedic surgery & traumatology : orthopedie traumatologie

INTRODUCTION: Midshaft clavicle fractures are commonly treated with plate fixation; however, the selected plate working length varies widely. Biomechanical principles suggest potential effects on fracture healing, but clinical evidence…

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Negative / Null Result ReportMedicine

Composite dietary antioxidant index and cardiovascular diseases and all-cause mortality in Iranian adults: a prospective cohort study.

Farhadnejad H, Mokhtari E, Dianati Z et al. · 2026 · Nutrition, metabolism, and cardiovascular diseases : NMCD

Background and aims Antioxidants are known to combat oxidative stress, a key factor in the development of cardiovascular diseases(CVDs) and mortality. In the current study, we aimed to prospectively investigate the relationship between the…

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Negative / Null Result ReportOpen accessMedicine

Is Demographic Concordance Between Lifestyle Coach and Participant Associated With Participant Retention and Weight Change in the National Diabetes Prevention Program Lifestyle Change Intervention?

Smart BP, Forte A, Jacobs J et al. · 2026 · Journal of diabetes research

Objective The goal of this study is to explore the association between racial/ethnic, sex, and age category concordance and participant retention and weight loss among participants enrolled in the National Diabetes Prevention Program…

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Negative / Null Result ReportMedicine

The Relationship Between Neurofilament Light Chain and B Lymphocyte Chemoattractant and Cognition in Multiple Sclerosis.

Bakırcıoglu-Duman E, Petek-Balcı FB, Calıskan-Dolu N et al. · 2026 · Noro psikiyatri arsivi

Introduction Multiple sclerosis (MS) is a chronic inflammatory, autoimmune, demyelinating disease of the central nervous system that is often associated with cognitive impairment. This study aims to investigate whether Neurofilament light…

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Negative / Null Result ReportMedicine

Investigating the effect of probiotics on seizure-related symptoms in children with medication-resistant epilepsy: a randomized clinical trial.

Mohammadi M, Zahiroddin H, Mohammadi MS et al. · 2026 · Clinical neurology and neurosurgery

Introduction Antiseizure Medications (ASMs) can be beneficial for many patients with epilepsy; however, some individuals with medication-resistant epilepsy (MRE) may not experience effective seizure control. Although effective alternative…

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Negative / Null Result ReportMedicine

Unmasking the Relationship Between Cyber Dating Abuse and Fear of Intimacy: Insights From a Cross-Sectional Study of Undergraduate Students.

Büyüktopaç Çakici H, Çiçek Gümüş E, Dişli E et al. · 2026 · Journal of interpersonal violence

The increasing digitalization of the world has led to a rise in cyber dating abuse among undergraduate students, who are transitioning into young adulthood and will be part of the future workforce. Additionally, identifying the…

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Negative / Null Result ReportMedicine

The Relationship Between Biological Age and Emotional Intelligence in Young Swimmers.

Badzińska J, Żegleń M, Słowik J et al. · 2026 · American journal of human biology : the official journal of the Human Biology Council

Objectives Emotional intelligence is crucial for young athletes, affecting their psychosocial well-being and performance. Biological development, which includes physiological changes, is also important for athletes, affecting their…

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Negative / Null Result ReportMedicine

How Corruption Influences Population Health.

Kyriopoulos I, Minos D, Vandoros S et al. · 2026 · The Milbank quarterly

Policy Points This study examines the link between corruption and mortality. We find that corruption is associated with higher mortality, particularly in low-income countries. It is also linked to lower government revenue and distorted…

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Negative / Null Result ReportMedicine

Radiation Exposure and Local Diagnostic Reference Levels During Endovascular Treatment of Cerebral Arteriovenous Malformations and Dural Arteriovenous Fistulas.

Sowa MS, Sowa J, Budzanowski M · 2026 · Biomedicines

Background/Objectives: Endovascular treatment of cerebral arteriovenous malformations (AVMs) and arteriovenous fistulas (AVFs) is associated with substantial radiation exposure due to procedural complexity and repeated angiographic…

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Negative / Null Result ReportMedicine

Associations Between Complementary Feeding Approach, Dietary Intake, and Growth: A Secondary Analysis of the Maternal and Infant Nutrition Trial.

Matzeller KL, Hernandez ML, Glime GNE et al. · 2026 · Journal of the Academy of Nutrition and Dietetics

Background Minimal research has assessed the adequacy of baby-led weaning (BLW) as a complementary feeding (CF) approach in infant nutrient intake and growth. Objective This study assesses growth between infants following BLW and…

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Negative / Null Result ReportOpen accessMedicine

Inhaled budesonide and beclomethasone for the prevention and treatment of bronchopulmonary dysplasia in very preterm infants: a prospective randomized controlled trial.

Wang B, Xu S, Li Z et al. · 2026 · Frontiers in pediatrics

Background To investigate the clinical efficacy and safety of inhaled budesonide and beclomethasone for the prevention and treatment of bronchopulmonary dysplasia (BPD) in very preterm infants. Methods From October 2024 to November 2025,…

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