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Browse the failure-mode index

12,264 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Effect of silver diamine fluoride and potassium iodide pretreatment on microleakage, penetration depth, and color changes of fissure sealants: an in vitro study.

Cömert H, Çege EE · 2026 · BMC oral health

Background This in vitro study aimed to evaluate and compare the effects of SDF- and SDF + KI-based pretreatment protocols, with or without NaOCl surface preparation, on microleakage, discoloration, and fissure sealant penetration depth in…

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Negative / Null Result ReportOpen accessMedicine

Examination of the Diameter of the Rectum and the Thickness of the Anterior Wall of the Rectum by Ultrasound in Children With Chronic Constipation and Abdominal Pain in the Age Range of 2-18 Years.

Aldaghi MA, Yazdi NS, Abadi MEA et al. · 2025 · JGH open : an open access journal of gastroenterology and hepatology

Abdominal pain is one of the most common complaints to the pediatric clinic and can be challenging for the physician. Among children who present with abdominal pain, constipation is one of the main causes of abdominal pain, and its…

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Negative / Null Result ReportMedicine

Evaluating the Influence of Injury-Induced Microstructural Variations on the Efficacy of a Diffusion MRI-Derived Axon Diameter Surrogate.

Alderson HE, Mu C, Chen LM et al. · 2026 · Magnetic resonance in medicine

Purpose To investigate the utility of a recently demonstrated diffusion MRI derived axon diameter surrogate measure (∆D ⟂ ) under pathologic conditions induced by a spinal cord injury model. Methods Contusion injuries were performed on the…

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Negative / Null Result ReportMedicine

Maternal blood lead level and its association with birthweight and preterm birth in Adjara, Georgia: An inverse probability of selection weighting analysis of a population-based cohort study.

Manjavidze T, Anda E, Nedberg IH et al. · 2026 · International journal of hygiene and environmental health

Background Lead exposure poses significant health risks, particularly during pregnancy, as lead affects fetal development. This study aimed to evaluate the association between maternal blood lead levels (BLL), birthweight and preterm birth…

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Negative / Null Result ReportMedicine

Effect of age, sex, and BMI on serum olanzapine levels and their correlation with metabolic parameters and serum pro-inflammatory cytokine levels in schizophrenia patients.

Gao W, He X, Xu Y et al. · 2026 · BMC psychiatry

Objective Olanzapine is an atypical antipsychotic drug which is effective in the treatment of schizophrenia (SCZ). Olanzapine exhibits significant pharmacokinetic variability and is associated with a higher propensity for metabolic…

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Negative / Null Result ReportMedicine

Reversed sound symbolism in speech sound disorders: Evidence for atypical cross-modal integration in a transparent language (Turkish).

Sözüçok BA, Sözüçok T, Seven I et al. · 2026 · Cortex; a journal devoted to the study of the nervous system and behavior

This study examined sound-shape matching performance (the bouba-kiki effect) in Turkish-speaking children with speech sound disorders (SSD) and their typically developing (TD) peers. Participants included 60 children aged 51-71 months: 30…

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Negative / Null Result ReportOpen accessMedicine

The Association Between Height-Related Novel Anthropometric Indices and Cardiovascular Events: A Cross-Sectional Insight From the MASHAD Cohort Study.

Imannezhad M, Saberi-Karimian M, Darroudi S et al. · 2026 · Health science reports

Background and aims Cardiovascular diseases (CVDs) are a worldwide health concern, with factors like poor nutrition and environmental conditions contributing to the burden of CVD and its mortality. Height and other anthropometric indices…

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Negative / Null Result ReportMedicine

Determining jump and change of direction inter-limb asymmetries over pre-season in basketball players: An individualised approach.

Barrera-Domínguez FJ, Talpey S, Li F et al. · 2026 · Journal of sports sciences

Asymmetries are practical indicators of basketball players performance; however, longitudinal evidence remains limited. The aims of this study were to: (i) examine the variation of inter-limb asymmetry across three different time points…

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Negative / Null Result ReportOpen accessMedicine

In relation to anxiety severity, puberty moderates functional connectivity between the amygdala and anterior cingulate cortex for negative relative to neutral stimuli during an emotional categorization task.

Suss SJ Jr, Kimbler A, Baker AE et al. · 2026 · Developmental cognitive neuroscience

Anxiety symptoms often escalate in peri-adolescence (ages 10-13 years), a sensitive period when puberty-related changes occur in neural systems implicated in psychopathology. Greater amygdala activation and altered functional connectivity…

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Negative / Null Result ReportOpen accessMedicine

Predicting treatment outcomes by door-to-device time and baseline characteristics in STEMI patients undergoing PPCI: a cross-sectional study in southern Iran.

Vosoughi S, Adineh M, Kardooni A et al. · 2026 · ARYA atherosclerosis

Background Primary percutaneous coronary intervention (PPCI) is considered the gold standard for ST-elevation myocardial infarction (STEMI) treatment. While door-to-device (DTD) time critically influences outcomes, its combined impact with…

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Negative / Null Result ReportOpen accessMedicine

A Retrospective Study of the Presentation, Imaging Findings, and Outcomes in 195 Patients with Maxillofacial Fractures Treated with Closed Reduction or Open Reduction with Internal Fixation.

Durmuş Hİ, Polat ME · 2025 · Medical science monitor : international medical journal of experimental and clinical research

BACKGROUND Maxillofacial fractures represent one of the most common forms of traumatic injuries, affecting both function and aesthetics, and are associated with significant morbidity and long-term sequelae. The incidence and distribution…

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Negative / Null Result ReportOpen accessMedicine

Clinical characteristics, medication use, and mortality outcomes in pediatric chronic kidney disease: A retrospective study at national hospital in Jakarta.

Eff ARY, Yuliana S, Afifah NN et al. · 2026 · Journal of advanced pharmaceutical technology & research

Chronic kidney disease (CKD) in children necessitates the use of a variety of drugs to reduce disease progression and manage complications. Polypharmacy is common in children with CKD, which can increase the occurrence of harmful drug…

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