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Browse the failure-mode index

12,264 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Evaluation of rotational profile and foot loading in the uninvolved leg of children with unilateral clubfoot treated with foot abduction orthoses.

Lawing CR, Bailey CE, Garg S et al. · 2026 · Journal of pediatric orthopedics. Part B

Ponseti treatment of congenital clubfoot utilizes foot abduction bracing to prevent recurrence. In unilateral clubfoot, families have expressed concern about inducing deformity in the uninvolved leg. This study evaluated rotational…

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Negative / Null Result ReportMedicine

Impact of the COVID-19 pandemic on pediatric hemolytic uremic syndrome: Epidemiology, complications, and outcomes.

Jarosz-Wójcik E, Zajączkowski MA, Drożdż D et al. · 2026 · Advances in clinical and experimental medicine : official organ Wroclaw Medical University

Background Hemolytic-uremic syndrome (HUS) is a thrombotic microangiopathy that is most commonly caused by infection with Shiga toxin-producing Escherichia coli (STEC-HUS). Atypical HUS (aHUS) is associated with inappropriate activation of…

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Failed Experiment ReportMedicine

Impact of a home-based obesity prevention intervention on children's eating behaviours: Findings from the Guelph Family Health Study randomised controlled trial.

Jacob R, Walton K, Buchholz AC et al. · 2026 · Appetite

Children's eating behaviours are important determinants of childhood obesity; however, few studies have examined whether early childhood obesity prevention interventions influence these behaviours. This study investigated the impact of a…

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Negative / Null Result ReportMedicine

Effect of a multifaceted hospital fluid conservation approach to intravenous fluid shortages on patient outcomes.

Xu O, Graven P, Downs S et al. · 2026 · American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists

Purpose In September 2024, Hurricane Helene disrupted a key North Carolina facility producing 60% of medical-grade fluids in the United States, causing a nationwide intravenous fluid (IVF) shortage and prompting urgent conservation in…

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Negative / Null Result ReportMedicine

Effect of Basal Septal Hypertrophy on TAVR Outcomes: Evidence From a Large Cohort Study.

Arow Z, Oliva O, Iwata J et al. · 2026 · Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

Background Basal septal hypertrophy (BSH) is commonly encountered in elderly patients undergoing transcatheter aortic valve replacement (TAVR). However, its impact on periprocedural and procedural outcomes remains unclear. Aims The aim of…

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Negative / Null Result ReportMedicine

Improving Medication Adherence in Kidney Transplant Recipients Through Educational Intervention and Monitoring: A Randomized Clinical Trial.

Heinrich de Oliveira C, Schweig A, Gonçalves BP et al. · 2026 · Transplantation proceedings

Background Kidney graft survival after transplantation is highly dependent on continuous adherence to immunosuppressive therapy. Poor adherence is a significant cause of graft loss, and educational interventions to optimize care have been…

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Negative / Null Result ReportOpen accessMedicine

The association between sleep quality and postoperative pain after half-impacted mandibular third molar extraction: comparison of three statistical models.

Hu L, Zhao C, Wang T et al. · 2026 · BMC oral health

BACKGROUND: Pain is the common complication after tooth extraction, while the reasons behind it still remains. Insomnia, another prevalent issue, negatively affects physical, mental health, and quality of life. The relations between…

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Negative / Null Result ReportOpen accessMedicine

Dose and clinical impact of delineation variability in brain metastases treated with stereotactic radiotherapy.

Perrot A, Dissaux B, Roux AC et al. · 2026 · Clinical and translational radiation oncology

Introduction Accurate delineation is critical for stereotactic radiotherapy (SRT) of brain metastases. We evaluated how inter-reader delineation variability affects target dose coverage and local relapse-free survival (LRFS). Methods and…

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Negative / Null Result ReportMedicine

Outcomes of a penicillin allergy de-labelling implementation intervention in a UK hospital: a prospective, single centre, type 2 hybrid effectiveness-implementation study evaluated using mixed methods.

Powell N, Hearsey D, West R et al. · 2026 · Implementation science communications

Background Non-allergy specialist healthcare workers removing low-risk penicillin allergy (penA) records, enabling patients to receive penicillin antibiotics, is safe but not common practice. We developed a behavioural change…

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Failed Experiment ReportMedicine

The Impact of the Geriatric Emergency Department Initiative on Older Community Dwelling Adults Presenting to the Emergency Department With a Completed Delirium Screen.

Williams K, Craswell A, Tsao H et al. · 2026 · Emergency medicine Australasia : EMA

Objective Australia's ageing population resulted in increasing Emergency Department (ED) presentations among older adults, particularly frail and those at risk of adverse outcomes. Delirium contributes significantly to morbidity in this…

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Negative / Null Result ReportMedicine

Pre-processing and thermal treatment modulate structure, solubility and digestibility of faba bean protein isolates: A structure–function perspective

Sharma N, Gwala S, Owens RA et al. · 2026 · Food Hydrocolloids.

Despite growing interest in faba bean (Vicia faba L.) as a sustainable plant protein source, limited studies address process-induced structural mechanisms linking functionality with gastro-intestinal (GI) digestion. This study elucidates…

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Negative / Null Result ReportMedicine

Do steroids improve outcomes of idiopathic sixth nerve palsy in children?

Sternfeld A, Goren L, Ehrenberg M et al. · 2026 · Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

Purpose To analyze the effect of systemic steroid treatment in children with benign acquired isolated sixth nerve palsy (BAISNP) regarding healing, recurrence risk and late sequelae. Methods A retrospective cohort design was used. The…

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Negative / Null Result ReportMedicine

Climatic impact on ram lamb reproductive development: the effect of solar radiation.

Gómez-Vargas JC, Parra-Bracamonte GM, Muñoz-García C et al. · 2026 · Animal : an international journal of animal bioscience

Climate change has a significant impact on global animal production. The objective was to evaluate the long-term effects of direct solar radiation on reproductive development in Pelibuey ram lambs under heat stress. Eighteen ram lambs (6.9…

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Negative / Null Result ReportMedicine

Interhospital transfer dynamics in foreign body aspiration: Age-stratified nationwide retrospective cohort study.

Deniz MS, Çiflik KB, Özdemir Çiflik B et al. · 2026 · Turk gogus kalp damar cerrahisi dergisi

Background Foreign body aspiration (FBA) is an acute clinical emergency that is particularly common in the pediatric population and, if not managed promptly, can lead to serious morbidity and mortality across all age groups. The need for…

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Negative / Null Result ReportMedicine

Evaluating the predictive utility of European-based and transethnic polygenic risk scores for kidney function in older Black adults: insights from the Health and Retirement Study.

Cobb RJ, Thorpe RJ Jr, Norris KC · 2026 · The journals of gerontology. Series A, Biological sciences and medical sciences

Background Black populations in the U.S. experience a disproportionately faster progression of chronic kidney disease than the general population. Polygenic risk scores (PRS) are a promising tool for risk stratification, yet their utility…

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