12,231 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Shahar Shelly, Pritikanta Paul, Hong‐Yan Bi et al. · 2020 · Neurology
OBJECTIVE: To improve myasthenia gravis (MG) autoantibody testing. METHODS: MG serologic tests with confirmatory or refuting clinical-electrodiagnostic (EDX) testing and cancer evaluations were reviewed over 4 years (2012-2015). All…
View details →Wouter M. IJgosse, Harry van Goor, Camiel Rosman et al. · 2020 · JMIR Serious Games
Background Surgical residents underutilize opportunities for traditional laparoscopic simulation training. Serious gaming may increase residents’ motivation to practice laparoscopic skills. However, little is known about the effectiveness of serious gaming for laparoscopic skills training. Objective The aim of this study was to establish construct validity for the laparoscopic serious game Underground. Methods All study participants completed 2 levels of Underground. Performance for 2 novel variables (time and error) was compared between novices (n=65, prior experience <10 laparoscopic proc
View details →Maria L.V. Dizon, Rakesh Rao, Shannon E. G. Hamrick et al. · 2019 · BMC Pediatrics
BACKGROUND: While intercenter variation (ICV) in anti-epileptic drug (AED) use in neonates with seizures has been previously reported, variation in AED practices across regional NICUs has not been specifically and systematically evaluated. This is important as these centers typically have multidisciplinary neonatal neurocritical care teams and protocolized approaches to treating conditions such as hypoxic ischemic encephalopathy (HIE), a population at high risk for neonatal seizures. To identify opportunities for quality improvement (QI), we evaluated ICV in AED utilization for neonates with H
View details →Camila S. Halal, Diego G. Bassani, Iná S. Santos et al. · 2020 · Journal of Sleep Research
This study used data from 2,222 mothers and infants participating in a population-based birth cohort to verify whether maternal depression in the perinatal period was associated with poor infant sleep. Mothers who scored ≥13 points on the…
View details →Troels Yndigegn, Bertil Lindahl, Joakim Alfredsson et al. · 2022 · European Heart Journal - Cardiovascular Pharmacotherapy
AIMS: Most trials showing benefit of beta-blocker treatment after myocardial infarction (MI) included patients with large MIs and are from an era before modern biomarker-based MI diagnosis and reperfusion treatment. The aim of the…
View details →Päivi Merjonen, Liisa Keltikangas‐Järvinen, Markus Jokela et al. · 2011 · Translational Psychiatry
Hostility is a multidimensional personality trait with changing expression over the life course. We performed a genome-wide association study (GWAS) of the components of hostility in a population-based sample of Finnish men and women for…
View details →David Baumeister, Wolfgang Eich, Silvia Saft et al. · 2019 · Scientific Reports
There has been a surging interest in the putative role of peripheral growth factors in the pathophysiology of fibromyalgia, specifically in the peripheral sensitization that occurs in chronic pain disorders. This cross-sectional study set out to assess and compare brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in plasma samples from fibromyalgia patients and healthy controls. Plasma BDNF and NGF were measured in 89 fibromyalgia patients and 36 pain-free controls, and compared using ANCOVA controlling for potential confounders, as well as Bayesian methods for parameter e
View details →Fang He, Huai‐Qiang Ju, Yi Ding et al. · 2020 · British Journal of Cancer
BACKGROUND: For patients with locally advanced rectal cancer (LARC), it is unclear whether neoadjuvant chemoradiotherapy-induced pathologic complete response (pCR) individuals would further benefit from adjuvant chemotherapy (ACT). METHODS: The pCR individuals who received different ACT cycles were paired by propensity score matching. Overall survival (OS), disease-free survival (DFS), local recurrence-free survival (LRFS), and distant metastasis-free survival (DMFS) were calculated by Kaplan-Meier and log-rank test. RESULTS: In total, 1041 pCR individuals were identified from 5567 LARC cases.
View details →Federica De Corti, Gianni Bisogno, Patrizia Dall’Igna et al. · 2011 · Pediatric Blood & Cancer
PURPOSE: Patients with non-metastatic rhabdomyosarcoma (RMS) have a cure rate of 50-90%, but up to one-third of them experience mostly a local recurrence. Second-line treatment is not standardized as for newly diagnosed tumors. We…
View details →Weikun Li, Murat Yalçın, Dhruba J. Bharali et al. · 2019 · Scientific Reports
Abstract The anti-angiogenic agent, diamino propane tetraiodothyroacetic acid (DAT), is a thyro-integrin (integrin αvβ3) antagonist anticancer agent that works via genetic and nongenetic actions. Tetraiodothyroacetic acid (tetrac) and DAT as thyroid hormone derivatives influence gene expression after they transport across cellular membranes. To restrict the action of DAT to the integrin αvβ3 receptors on the cell surface, we used DAT-conjugated PLGA nanoparticles (NDAT) in an active targeting mode to bind to these receptors. Preparation and characterization of NDAT is described, and both in vi
View details →Natalie Kashefi, Jonathan I. Nathan, Sharmila Dissanaike · 2014 · Plastic & Reconstructive Surgery Global Open
BACKGROUND: Smoke inhalation is a major source of morbidity and mortality. Heparin and N-acetylcysteine treatment has potential efficacy in inhalation injury. We investigated the impact of a heparin/N-acetylcysteine/albuterol nebulization…
View details →Andreas Carus, Howard Gurney, Val Gebski et al. · 2013 · Journal of Translational Medicine
Chronic inflammation has been recognized to foster tumour development. Whether chemotherapy can be used to neutralize chronic inflammation is unclear. We evaluated baseline and nadir neutrophils in 111 patients (pts.) with non-small cell lung cancer (NSCLC) and 118 pts. with ovarian cancer (OC) treated with chemotherapy administered with dose-individualization to achieve nadir neutropenia of 1.5. We used predefined baseline neutrophil cut-offs 4.5 × 109/L (NSCLC) and 3.9 × 109/L (OC). Absence of chemotherapy-induced nadir neutropenia (CTCAE grade 0, neutrophils ≥ LLN) was seen in 23% of OC and
View details →Richard Parker, Gene Y. Im, Fiona Jones et al. · 2017 · Journal of Gastroenterology
BACKGROUND: Previous studies have described the clinical impact of infection in alcoholic hepatitis (AH) but none have comprehensively explored the aetiopathogenesis of infection in this setting. We examined the causes, consequences and treatment of infection in a cohort of patients with AH. METHODS: We undertook a retrospective cohort study of patients with AH admitted between 2009 and 2014 to seven centres in Europe and the USA. Clinical and microbiological data were extracted from medical records. Survival was analysed with Kaplan-Meier analysis and Cox proportional hazards analysis to cont
View details →Nilgün Mendil, Şahin Temel, Recep Civan Yüksel et al. · 2021 · TURKISH JOURNAL OF MEDICAL SCIENCES
Background/aim: High flow nasal cannula (HFNC) was mostly used in intensive care units (ICUs) with few studies in other departments. We hypothesized that HFNC applied at wards is beneficial for acute respiratory failure in hematological malignancy patients. Materials and methods: The study is a single center, randomized controlled study. Inclusion criteria were hypoxemic respiratory failure and hematological malignancy. Patients were randomized to either venturi mask/nasal cannula oxygen treatment or HFNC. Results: One hundred patients were included in the study. Median age was 58.5 (18–86) ye
View details →Þórunn Rafnar, Patrick Sulem, Søren Besenbacher et al. · 2011 · Cancer Research
Genome-wide association studies (GWAS) have identified 3 genomic regions, at 15q24-25.1, 5p15.33, and 6p21.33, which associate with the risk of lung cancer. Large meta-analyses of GWA data have failed to find additional associations of…
View details →Amy Armstrong, Fleur Coburn, Yanyamba Nsereko et al. · 2025 · Journal of Peptide Science
Peptide-drug conjugates (PDCs) are advancing as targeted cancer therapies, leveraging lessons from antibody-drug conjugates (ADCs) to improve tumour specificity. These molecules combine a homing peptide with a cytotoxic payload via a linker, enabling precise drug delivery while sparing healthy tissue. Despite their potential, PDCs face challenges including metabolic instability, premature payload release and rapid clearance, limiting clinical success. Only Lutathera remains FDA-approved after Pepaxto's withdrawal, though Pepaxto retains EMA and MHRA approval-highlighting regulatory and technic
View details →Dae-Sang Lee, Mi Yeon Lee, Chi-Min Park et al. · 2018 · PLoS ONE
Delirium is a common complication of vascular surgery. The protective effect of preoperative statins on delirium after vascular surgery is controversial. The authors hypothesized that preoperative statin administration would decrease the incidence of delirium after vascular surgery. From May 2010 to May 2015, 1,132 patients underwent vascular surgery. Postoperative delirium was diagnosed from patients' medical records. The incidence of delirium was 11.5%. The preoperative statin exposure was not associated with reduced delirium in the univariate analysis. After adjusting for covariates, preope
View details →Tamara Beres Lederer Goldberg, Carla Cristiane da Silva, Luciana Peres et al. · 2026 · Archivos Latinoamericanos de Nutrición
Adolescents' eating habits are determined by social, psychological, economic, political, and educational influences. They tend to prefer foods with inadequate nutritional value and high fat and carbohydrate content which leads to excessive…
View details →Alexandra Calmy, Mark Bloch, Handan Wand et al. · 2010 · HIV Medicine
BACKGROUND: Lipoatrophy can complicate thymidine analogue nucleoside reverse transcriptase inhibitor (tNRTI)-based antiretroviral therapy (ART). Lipoatrophy may be less likely with ART including ritonavir-boosted lopinavir (LPV/r). Small,…
View details →Meghan A. Baker, Bethany Baer, Martin Kulldorff et al. · 2019 · PLoS Medicine
BACKGROUND: Kawasaki disease is an acute vasculitis that primarily affects children younger than 5 years of age. Its etiology is unknown. The United States Vaccine Safety Datalink conducted postlicensure safety surveillance for 13-valent pneumococcal conjugate vaccine (PCV13), comparing the risk of Kawasaki disease within 28 days of PCV13 vaccination with the historical risk after 7-valent PCV (PCV7) vaccination and using chart-validation. A relative risk (RR) of 2.38 (95% CI 0.92-6.38) was found. Concurrently, the Food and Drug Administration (FDA) conducted a postlicensure safety review that
View details →Jessica Oi‐Ling Tsang, Jie Zhou, Xiaoyu Zhao et al. · 2021 · Biomedicines
Enteroviruses are important causes of hand, foot, and mouth disease, respiratory infections, and neurological infections in human. A major hurdle for the development of anti-enterovirus agents is the lack of physiologically relevant evaluation platforms that closely correlate with the in vivo state. We established the human small intestinal organoids as a novel platform for characterizing the viral replication kinetics and evaluating candidate antivirals for enteroviruses. The organoids supported productive replication of enterovirus (EV)-A71, coxsackievirus B2, and poliovirus type 3, as evide
View details →Samuel Antwi‐Baffour, Jonathan Kofi Adjei, Peter Owadee Forson et al. · 2019 · Anemia
BACKGROUND: Glucose-6-phosphate dehydrogenase (G6PD) converts glucose-6-phosphate into 6-phosphogluconate in the pentose phosphate pathway and protects red blood cells (RBCs) from oxidative damage. Their deficiency therefore makes RBCs prone to haemolysis. Sickle cell disease (SCD) on the other hand is a hereditary blood disorder in which there is a single nucleotide substitution in the codon for amino acid 6 substituting glutamic acid with valine. SCD patients are prone to haemolysis due to the shape of their red blood cells and if they are deficient in G6PD, the haemolysis may escalate. Repo
View details →Boris Blechacz, Gregory J. Gores · 2010 · Hepatology
A 66-year-old male patient who is hepatitis C RNA–positive without cirrhosis has been found to have a mass on ultrasound examination of the liver. The physical examination is unremarkable. The hemoglobin, white cell count, and platelet…
View details →Elise Boele-Schutte, Ron T. Gansevoort · 2016 · Nephrology Dialysis Transplantation
Because of the circadian rhythm in kidney function the true glomerular filtration rate (GFR) is historically considered to be the average GFR measured by urinary inulin clearance over a 24-h period [1]. In clinical practice, it is…
View details →Christopher J. Green, Jeffrey M P Holly, Antony Bayer et al. · 2014 · Journal of Alzheimer s Disease
BACKGROUND: The increasing incidence of cognitive impairment and dementia in an aging population poses a significant burden on healthcare. Consequently, identifying modifiable physiological factors which may influence the onset of…
View details →James D. Chalmers · 2017 · COPD Journal of Chronic Obstructive Pulmonary Disease
Bronchiectasis is a long-neglected disease currently experiencing a surge in interest. It is a highly complex condition with numerous aetiologies, co-morbidities and a heterogeneous disease presentation and clinical course. The past few…
View details →Fortunato Giustra, Francesco Bosco, Giorgio Cacciola et al. · 2022 · Journal of Clinical Medicine
In the last decades, several surgical techniques, such as medial pivot (MP) philosophy and kinematic alignment (KA), have been introduced in total knee arthroplasty (TKA) to improve patients’ outcomes. This retrospective study aims to evaluate the clinical, radiographic, and functional results of PCL preservation or sacrifice in KA MP-TKA. A consecutive series of 147 patients older than 60, with a minimum follow-up of two years, were treated with TKA for severe primary knee osteoarthritis (OA) at the Department of Orthopedics and Traumatology between 1 January 2019, and 1 July 2020. After excl
View details →Hyun Woo Jeon, Young‐Du Kim, Sung Bo Sim et al. · 2021 · Thoracic Cancer
BACKGROUND: Patients with early lung cancer are the best candidates for surgical resection. However, those patients with high grade patterns (micropapillary or solid) do not have a good prognosis, even if they have been diagnosed with…
View details →Mario Musella, Giovanna Berardi, Nunzio Velotti et al. · 2021 · Obesity Surgery
BACKGROUND: The laparoscopic sleeve gastrectomy (LSG) is the most common bariatric procedure performed worldwide while the laparoscopic adjustable gastric banding (LAGB) has been almost abandoned. Aim of this study was to retrospectively assess 10-year outcomes of LSG through a matched comparison with LAGB. MATERIALS AND METHODS: Retrospective search of prospectively maintained database of our university was carried out to find all patients that underwent LSG before December 2010. Each subject with LSG was matched one-to-one with a patient that had undergone LAGB in the same period with corres
View details →Kana Yoshioka, Akira Miyauchi, Mitsuhiro Fukushima et al. · 2016 · World Journal of Surgery
BACKGROUND: We reported phonatory recovery in the majority of 88 patients after recurrent laryngeal nerve (RLN) reconstruction. Here we analyzed factors that might influence the recovery, in a larger patient series. METHODS: At Kuma Hospital, 449 patients (354 females and 95 males) underwent RLN reconstruction with direct anastomosis, ansa cervicalis-to-RLN anastomosis, free nerve grafting, or vagus-to-RLN anastomosis; 47.4 % had vocal cord paralysis (VCP) preoperatively. Maximum phonation time (MPT) and mean airflow rate during phonation (MFR) were measured 1 year post surgery. Forty patients
View details →